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4381. Influence of pravastatin and plasma lipids on clinical events in the West of Scotland Coronary Prevention Study (WOSCOPS).
来源: Circulation. 1998年97卷15期1440-5页
The West of Scotland Coronary Prevention Study was a primary prevention trial that demonstrated the effectiveness of pravastatin (40 mg/d) in reducing morbidity and mortality from coronary heart disease (CHD) in moderately hypercholesterolemic men. The present analysis examines the extent to which differences in LDL and other plasma lipids both at baseline and on treatment influenced CHD risk reduction.
4382. Effects of the intracoronary infusion of cocaine on left ventricular systolic and diastolic function in humans.
作者: W R Pitts.;W Vongpatanasin.;J E Cigarroa.;L D Hillis.;R A Lange.
来源: Circulation. 1998年97卷13期1270-3页
In dogs, a large amount of intravenous cocaine causes a profound deterioration of left ventricular (LV) systolic function and an increase in LV end-diastolic pressure. This study was done to assess the influence of a high intracoronary cocaine concentration on LV systolic and diastolic function in humans.
4383. Assessment of the contribution that direct allorecognition makes to the progression of chronic cardiac transplant rejection in humans.
作者: P I Hornick.;P D Mason.;M H Yacoub.;M L Rose.;R Batchelor.;R I Lechler.
来源: Circulation. 1998年97卷13期1257-63页
Two populations of T cells contribute to allograft rejection. T cells with direct allospecificity are activated after recognition of intact MHC alloantigens displayed at the surface of donor passenger leukocytes carried within the graft. In contrast, T cells with indirect allospecificity recognize donor alloantigens as processed peptides associated with self (recipient)-MHC class II molecules. In small animal models of transplantation, direct pathway T cells dominate the acute rejection process and are rendered tolerant to the graft after the loss of donor passenger leukocytes. It has been argued that indirect pathway T cells contribute substantially to continual graft damage after passenger cell loss. The purpose of this study was to determine whether donor-specific tolerance could be detected in T cells with direct anti-donor allospecificity in human heart transplant recipients after prolonged graft residence.
4384. Left ventricular structure and function in children infected with human immunodeficiency virus: the prospective P2C2 HIV Multicenter Study. Pediatric Pulmonary and Cardiac Complications of Vertically Transmitted HIV Infection (P2C2 HIV) Study Group.
作者: S E Lipshultz.;K A Easley.;E J Orav.;S Kaplan.;T J Starc.;J T Bricker.;W W Lai.;D S Moodie.;K McIntosh.;M D Schluchter.;S D Colan.
来源: Circulation. 1998年97卷13期1246-56页
The frequency of, course of, and factors associated with cardiovascular abnormalities in pediatric HIV are incompletely understood.
4385. Predictors of stroke complicating carotid artery stenting.
作者: A Mathur.;G S Roubin.;S S Iyer.;C Piamsonboon.;M W Liu.;C R Gomez.;J S Yadav.;H D Chastain.;L M Fox.;L S Dean.;J J Vitek.
来源: Circulation. 1998年97卷13期1239-45页
The evolving technique of carotid stenting is being evaluated as an alternative to endarterectomy. Identification of the factors that predispose a patient to neurological complications would facilitate further refinement of the technique and optimize patient selection.
4386. Combined hormone replacement therapy does not protect women against the age-related decline in endothelium-dependent vasomotor function.
Improvement in endothelial function may be an important mechanism by which estrogen replacement therapy protects postmenopausal women against coronary artery disease. However, combined hormone replacement therapy is more frequently used owing to the risk of uterine cancer with estrogen-only therapy. Concurrent progesterone treatment may attenuate the beneficial effects of estrogens not only on the lipid profile but also on the endothelium.
4388. Electrical stimulation versus coronary artery bypass surgery in severe angina pectoris: the ESBY study.
作者: C Mannheimer.;T Eliasson.;L E Augustinsson.;C Blomstrand.;H Emanuelsson.;S Larsson.;H Norrsell.;A Hjalmarsson.
来源: Circulation. 1998年97卷12期1157-63页
Spinal cord stimulation (SCS) has been shown to have antianginal and anti-ischemic effects in severe angina pectoris. The present study was performed to investigate whether SCS can be used as an alternative to coronary artery bypass grafting (CABG) in selected patient groups, ie, patients with no proven prognostic benefit from CABG and with an increased surgical risk.
4389. Comparison of antiplatelet effects of aspirin, ticlopidine, or their combination after stent implantation.
作者: H J Rupprecht.;H Darius.;U Borkowski.;T Voigtländer.;B Nowak.;S Genth.;J Meyer.
来源: Circulation. 1998年97卷11期1046-52页
This study was performed to analyze the influence of either aspirin, ticlopidine, or their combination on platelet activation and aggregation parameters after stent implantation.
4390. Heart failure and echocardiographic changes during long-term follow-up of patients with sick sinus syndrome randomized to single-chamber atrial or ventricular pacing.
作者: J C Nielsen.;H R Andersen.;P E Thomsen.;L Thuesen.;P T Mortensen.;T Vesterlund.;A K Pedersen.
来源: Circulation. 1998年97卷10期987-95页
In patients with sick sinus syndrome, choice of pacing mode has been implicated in the development of congestive heart failure.
4391. Effect of postmenopausal hormone therapy on lipoprotein(a) concentration. PEPI Investigators. Postmenopausal Estrogen/Progestin Interventions.
作者: M A Espeland.;S M Marcovina.;V Miller.;P D Wood.;C Wasilauskas.;R Sherwin.;H Schrott.;T L Bush.
来源: Circulation. 1998年97卷10期979-86页
Postmenopausal hormone therapy has been reported to decrease levels of lipoprotein (Lp)(a) in cross-sectional studies and small or short-term longitudinal studies. We report findings from a large, prospective, placebo-controlled clinical trial that allows a broad characterization of these effects for four regimens of hormone therapy.
4392. Contribution of tonic chemoreflex activation to sympathetic activity and blood pressure in patients with obstructive sleep apnea.
作者: K Narkiewicz.;P J van de Borne.;N Montano.;M E Dyken.;B G Phillips.;V K Somers.
来源: Circulation. 1998年97卷10期943-5页
Muscle sympathetic nerve activity (MSNA) is increased in patients with obstructive sleep apnea (OSA). We tested the hypothesis that tonic activation of excitatory chemoreceptor afferents contributes to the elevated sympathetic activity in OSA.
4393. Randomized, double-blind, placebo-controlled study of ascorbate on the preventive effect of nitrate tolerance in patients with congestive heart failure.
Reduced cGMP production caused by increased superoxide has been proposed as a mechanism of nitrate tolerance during continuous nitrate therapy. This study was designed to evaluate the effects of ascorbate, an antioxidant, on the development of nitrate tolerance during continuous nitrate therapy in patients with congestive heart failure.
4394. Abciximab therapy and unplanned coronary stent deployment: favorable effects on stent use, clinical outcomes, and bleeding complications. EPILOG Trial Investigators.
作者: D J Kereiakes.;A M Lincoff.;D P Miller.;J E Tcheng.;C F Cabot.;K M Anderson.;H F Weisman.;R M Califf.;E J Topol.
来源: Circulation. 1998年97卷9期857-64页
The clinical and angiographic demographics of patients requiring unplanned coronary stent deployment and the optimal adjunct pharmacotherapy in this population are not well described. This report details the EPILOG trial experience with unplanned coronary stent deployment and the effect of abciximab platelet glycoprotein IIb/IIIa blockade to improve clinical outcomes during 6 months of follow-up.
4395. Relation of seizures after cardiac surgery in early infancy to neurodevelopmental outcome. Boston Circulatory Arrest Study Group.
作者: L A Rappaport.;D Wypij.;D C Bellinger.;S L Helmers.;G L Holmes.;P D Barnes.;G Wernovsky.;K C Kuban.;R A Jonas.;J W Newburger.
来源: Circulation. 1998年97卷8期773-9页
The outcome of infants who have transient seizures after open heart surgery has not been studied. Using the database of the Boston Circulatory Arrest Study involving 171 children with D-transposition of the great arteries, we explored the relationship between early postoperative clinical and EEG seizures and neurodevelopmental outcomes at ages 1 and 2 1/2 years.
4396. Risk factors for in-hospital nonhemorrhagic stroke in patients with acute myocardial infarction treated with thrombolysis: results from GUSTO-I.
作者: K W Mahaffey.;C B Granger.;M A Sloan.;T D Thompson.;J M Gore.;W D Weaver.;H D White.;M L Simoons.;G I Barbash.;E J Topol.;R M Califf.
来源: Circulation. 1998年97卷8期757-64页
Nonhemorrhagic stroke occurs in 0.1% to 1.3% of patients with acute myocardial infarction who are treated with thrombolysis, with substantial associated mortality and morbidity. Little is known about the risk factors for its occurrence.
4397. Aspirin improves endothelial dysfunction in atherosclerosis.
The beneficial effects of aspirin in atherosclerosis are generally attributed to its antiplatelet activities, but its influence on endothelial function remains uncertain. We hypothesized that a cyclooxygenase-dependent constricting factor contributes to the endothelial dysfunction in atherosclerosis and that its action can be reversed by aspirin.
4398. Induction of neoangiogenesis in ischemic myocardium by human growth factors: first clinical results of a new treatment of coronary heart disease.
The present article is a report of our animal experiments and also of the first clinical results of a new treatment for coronary heart disease using the human growth factor FGF-I (basic fibroblast growth factor) to induce neoangiogenesis in the ischemic myocardium.
4400. Beneficial effects of leukocyte depletion of transfused blood on postoperative complications in patients undergoing cardiac surgery: a randomized clinical trial.
作者: L M van de Watering.;J Hermans.;J G Houbiers.;P J van den Broek.;H Bouter.;F Boer.;M S Harvey.;H A Huysmans.;A Brand.
来源: Circulation. 1998年97卷6期562-8页
Leukocytes in transfused blood are associated with several posttransfusion immunomodulatory effects. Although leukocytes play an important role in reperfusion injury, the contribution of leukocytes in transfused blood products has not been investigated. To estimate the role and the timing of leukocyte filtration of red cells in cardiac surgery, we performed a randomized study.
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