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421. Uterus Transplant in Women With Absolute Uterine-Factor Infertility.
作者: Giuliano Testa.;Greg J McKenna.;Anji Wall.;Johanna Bayer.;Anthony R Gregg.;Ann Marie Warren.;Seung Hee S Lee.;Eric Martinez.;Amar Gupta.;Robert Gunby.;Liza Johannesson.
来源: JAMA. 2024年332卷10期817-824页
Uterus transplant in women with absolute uterine-factor infertility offers the possibility of carrying their own pregnancy.
423. Edetate Disodium-Based Chelation for Patients With a Previous Myocardial Infarction and Diabetes: TACT2 Randomized Clinical Trial.
作者: Gervasio A Lamas.;Kevin J Anstrom.;Ana Navas-Acien.;Robin Boineau.;Hayley Nemeth.;Zhen Huang.;Jun Wen.;Yves Rosenberg.;Mario Stylianou.;Teresa L Z Jones.;Bonnie R Joubert.;Qilu Yu.;Regina M Santella.;Ana C Mon.;Francisco Ujueta.;Esteban Escolar.;David M Nathan.;Vivian A Fonseca.;Y Wady Aude.;Jonathan K Ehrman.;Thomas Elliott.;Rakesh Prashad.;Eldrin F Lewis.;Renato D Lopes.;Michael E Farkouh.;Anne-Marie Elliott.;Jonathan D Newman.;Daniel B Mark.; .
来源: JAMA. 2024年332卷10期794-803页
In 2013, the Trial to Assess Chelation Therapy (TACT) reported that edetate disodium (EDTA)-based chelation significantly reduced cardiovascular disease (CVD) events by 18% in 1708 patients with a prior myocardial infarction (MI).
426. Comparative Safety of In Utero Exposure to Buprenorphine Combined With Naloxone vs Buprenorphine Alone.
作者: Loreen Straub.;Brian T Bateman.;Sonia Hernández-Díaz.;Yanmin Zhu.;Elizabeth A Suarez.;Seanna M Vine.;Hendrée E Jones.;Hilary S Connery.;Jonathan M Davis.;Kathryn J Gray.;Barry Lester.;Mishka Terplan.;Heidi Zakoul.;Helen Mogun.;Krista F Huybrechts.
来源: JAMA. 2024年332卷10期805-816页
Buprenorphine combined with naloxone is commonly used to treat opioid use disorders outside of pregnancy. In pregnancy, buprenorphine alone is generally recommended because of limited perinatal safety data on the combination product.
430. Oral Antibiotics and Risk of Serious Cutaneous Adverse Drug Reactions.
作者: Erika Y Lee.;Tara Gomes.;Aaron M Drucker.;Nick Daneman.;Ayesha Asaf.;Fangyun Wu.;Vincent Piguet.;David N Juurlink.
来源: JAMA. 2024年332卷9期730-737页
Serious cutaneous adverse drug reactions (cADRs) are potentially life-threatening drug hypersensitivity reactions involving the skin and internal organs. Antibiotics are a recognized cause of these reactions, but no studies have compared relative risks across antibiotic classes.
432. A Vaping Cessation Text Message Program for Adolescent E-Cigarette Users: A Randomized Clinical Trial.
作者: Amanda L Graham.;Sarah Cha.;Megan A Jacobs.;Michael S Amato.;Anna L Funsten.;Giselle Edwards.;George D Papandonatos.
来源: JAMA. 2024年332卷9期713-721页
E-cigarettes are the most commonly used tobacco product among adolescents. Despite known harms of nicotine exposure among teens, there are no empirically tested vaping cessation interventions.
434. Diagnostic Accuracy of an Integrated AI Tool to Estimate Gestational Age From Blind Ultrasound Sweeps.
作者: Jeffrey S A Stringer.;Teeranan Pokaprakarn.;Juan C Prieto.;Bellington Vwalika.;Srihari V Chari.;Ntazana Sindano.;Bethany L Freeman.;Bridget Sikapande.;Nicole M Davis.;Yuri V Sebastião.;Nelly M Mandona.;Elizabeth M Stringer.;Chiraz Benabdelkader.;Mutinta Mungole.;Filson M Kapilya.;Nariman Almnini.;Arieska N Diaz.;Brittany A Fecteau.;Michael R Kosorok.;Stephen R Cole.;Margaret P Kasaro.
来源: JAMA. 2024年332卷8期649-657页
Accurate assessment of gestational age (GA) is essential to good pregnancy care but often requires ultrasonography, which may not be available in low-resource settings. This study developed a deep learning artificial intelligence (AI) model to estimate GA from blind ultrasonography sweeps and incorporated it into the software of a low-cost, battery-powered device.
437. Midcareer Satisfaction and Likelihood of Leaving Current Position of Former Career Development Awardees.
作者: Reshma Jagsi.;Kent A Griffith.;Kelly C Paradis.;Patricia Mae G Santos.;Mylin A Torres.;Rochelle D Jones.;Eve A Kerr.
来源: JAMA. 2024年332卷8期666-667页 438. Projected Changes in Statin and Antihypertensive Therapy Eligibility With the AHA PREVENT Cardiovascular Risk Equations.
作者: James A Diao.;Ivy Shi.;Venkatesh L Murthy.;Thomas A Buckley.;Chirag J Patel.;Emma Pierson.;Robert W Yeh.;Dhruv S Kazi.;Rishi K Wadhera.;Arjun K Manrai.
来源: JAMA. 2024年332卷12期989-1000页
Since 2013, the American College of Cardiology (ACC) and American Heart Association (AHA) have recommended the pooled cohort equations (PCEs) for estimating the 10-year risk of atherosclerotic cardiovascular disease (ASCVD). An AHA scientific advisory group recently developed the Predicting Risk of cardiovascular disease EVENTs (PREVENT) equations, which incorporated kidney measures, removed race as an input, and improved calibration in contemporary populations. PREVENT is known to produce ASCVD risk predictions that are lower than those produced by the PCEs, but the potential clinical implications have not been quantified.
439. Blood Biomarkers to Detect Alzheimer Disease in Primary Care and Secondary Care.
作者: Sebastian Palmqvist.;Pontus Tideman.;Niklas Mattsson-Carlgren.;Suzanne E Schindler.;Ruben Smith.;Rik Ossenkoppele.;Susanna Calling.;Tim West.;Mark Monane.;Philip B Verghese.;Joel B Braunstein.;Kaj Blennow.;Shorena Janelidze.;Erik Stomrud.;Gemma Salvadó.;Oskar Hansson.
来源: JAMA. 2024年332卷15期1245-1257页
An accurate blood test for Alzheimer disease (AD) could streamline the diagnostic workup and treatment of AD.
440. Changes in Alzheimer Disease Blood Biomarkers and Associations With Incident All-Cause Dementia.
作者: Yifei Lu.;James Russell Pike.;Jinyu Chen.;Keenan A Walker.;Kevin J Sullivan.;Bharat Thyagarajan.;Michelle M Mielke.;Pamela L Lutsey.;David Knopman.;Rebecca F Gottesman.;A Richey Sharrett.;Josef Coresh.;Thomas H Mosley.;Priya Palta.
来源: JAMA. 2024年332卷15期1258-1269页
Plasma biomarkers show promise for identifying Alzheimer disease (AD) neuropathology and neurodegeneration, but additional examination among diverse populations and throughout the life course is needed.
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