当前位置: 首页 >> 检索结果
421. Effect of Peroral Endoscopic Myotomy vs Pneumatic Dilation on Symptom Severity and Treatment Outcomes Among Treatment-Naive Patients With Achalasia: A Randomized Clinical Trial.
作者: Fraukje A Ponds.;Paul Fockens.;Aaltje Lei.;Horst Neuhaus.;Torsten Beyna.;Jennis Kandler.;Thomas Frieling.;Philip W Y Chiu.;Justin C Y Wu.;Vivien W Y Wong.;Guido Costamagna.;Pietro Familiari.;Peter J Kahrilas.;John E Pandolfino.;André J P M Smout.;Albert J Bredenoord.
来源: JAMA. 2019年322卷2期134-144页
Case series suggest favorable results of peroral endoscopic myotomy (POEM) for treatment of patients with achalasia. Data comparing POEM with pneumatic dilation, the standard treatment for patients with achalasia, are lacking.
422. Effect of Tanezumab on Joint Pain, Physical Function, and Patient Global Assessment of Osteoarthritis Among Patients With Osteoarthritis of the Hip or Knee: A Randomized Clinical Trial.
作者: Thomas J Schnitzer.;Richard Easton.;Shirley Pang.;Dennis J Levinson.;Glenn Pixton.;Lars Viktrup.;Isabelle Davignon.;Mark T Brown.;Christine R West.;Kenneth M Verburg.
来源: JAMA. 2019年322卷1期37-48页
Patients with osteoarthritis (OA) may remain symptomatic with traditional OA treatments.
423. Effect of P2Y12 Inhibitor Monotherapy vs Dual Antiplatelet Therapy on Cardiovascular Events in Patients Undergoing Percutaneous Coronary Intervention: The SMART-CHOICE Randomized Clinical Trial.
作者: Joo-Yong Hahn.;Young Bin Song.;Ju-Hyeon Oh.;Woo Jung Chun.;Yong Hawn Park.;Woo Jin Jang.;Eul-Soon Im.;Jin-Ok Jeong.;Byung Ryul Cho.;Seok Kyu Oh.;Kyeong Ho Yun.;Deok-Kyu Cho.;Jong-Young Lee.;Young-Youp Koh.;Jang-Whan Bae.;Jae Woong Choi.;Wang Soo Lee.;Hyuck Jun Yoon.;Seung Uk Lee.;Jang Hyun Cho.;Woong Gil Choi.;Seung-Woon Rha.;Joo Myung Lee.;Taek Kyu Park.;Jeong Hoon Yang.;Jin-Ho Choi.;Seung-Hyuck Choi.;Sang Hoon Lee.;Hyeon-Cheol Gwon.; .
来源: JAMA. 2019年321卷24期2428-2437页
Data on P2Y12 inhibitor monotherapy after short-duration dual antiplatelet therapy (DAPT) in patients undergoing percutaneous coronary intervention are limited.
424. Effect of 1-Month Dual Antiplatelet Therapy Followed by Clopidogrel vs 12-Month Dual Antiplatelet Therapy on Cardiovascular and Bleeding Events in Patients Receiving PCI: The STOPDAPT-2 Randomized Clinical Trial.
作者: Hirotoshi Watanabe.;Takenori Domei.;Takeshi Morimoto.;Masahiro Natsuaki.;Hiroki Shiomi.;Toshiaki Toyota.;Masanobu Ohya.;Satoru Suwa.;Kensuke Takagi.;Mamoru Nanasato.;Yoshiki Hata.;Masahiro Yagi.;Nobuhiro Suematsu.;Takafumi Yokomatsu.;Itaru Takamisawa.;Masayuki Doi.;Toshiyuki Noda.;Hideki Okayama.;Yoshitane Seino.;Tomohisa Tada.;Hiroki Sakamoto.;Kiyoshi Hibi.;Mitsuru Abe.;Kazuya Kawai.;Koichi Nakao.;Kenji Ando.;Kengo Tanabe.;Yuji Ikari.;Keiichi Igarashi Hanaoka.;Yoshihiro Morino.;Ken Kozuma.;Kazushige Kadota.;Yutaka Furukawa.;Yoshihisa Nakagawa.;Takeshi Kimura.; .
来源: JAMA. 2019年321卷24期2414-2427页
Very short mandatory dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) with a drug-eluting stent may be an attractive option.
425. Effect of Pressure Support vs T-Piece Ventilation Strategies During Spontaneous Breathing Trials on Successful Extubation Among Patients Receiving Mechanical Ventilation: A Randomized Clinical Trial.
作者: Carles Subirà.;Gonzalo Hernández.;Antònia Vázquez.;Raquel Rodríguez-García.;Alejandro González-Castro.;Carolina García.;Olga Rubio.;Lara Ventura.;Alexandra López.;Maria-Carmen de la Torre.;Elena Keough.;Vanesa Arauzo.;Cecilia Hermosa.;Carmen Sánchez.;Ana Tizón.;Eva Tenza.;César Laborda.;Sara Cabañes.;Victoria Lacueva.;Maria Del Mar Fernández.;Anna Arnau.;Rafael Fernández.
来源: JAMA. 2019年321卷22期2175-2182页
Daily spontaneous breathing trials (SBTs) are the best approach to determine whether patients are ready for disconnection from mechanical ventilation, but mode and duration of SBT remain controversial.
426. Effect of a Home-Based Exercise Program on Subsequent Falls Among Community-Dwelling High-Risk Older Adults After a Fall: A Randomized Clinical Trial.
作者: Teresa Liu-Ambrose.;Jennifer C Davis.;John R Best.;Larry Dian.;Kenneth Madden.;Wendy Cook.;Chun Liang Hsu.;Karim M Khan.
来源: JAMA. 2019年321卷21期2092-2100页
Whether exercise reduces subsequent falls in high-risk older adults who have already experienced a fall is unknown.
427. Effect of Neladenoson Bialanate on Exercise Capacity Among Patients With Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial.
作者: Sanjiv J Shah.;Adriaan A Voors.;John J V McMurray.;Dalane W Kitzman.;Thomas Viethen.;Antonieta Bomfim Wirtz.;Erya Huang.;Akos Ferenc Pap.;Scott D Solomon.
来源: JAMA. 2019年321卷21期2101-2112页
Heart failure with preserved ejection fraction (HFpEF) lacks effective treatments. Based on preclinical studies, neladenoson bialanate, a first-in-class partial adenosine A1 receptor agonist, has the potential to improve several heart failure-related cardiac and noncardiac abnormalities but has not been evaluated to treat HFpEF.
428. Effect of Intraoperative High Positive End-Expiratory Pressure (PEEP) With Recruitment Maneuvers vs Low PEEP on Postoperative Pulmonary Complications in Obese Patients: A Randomized Clinical Trial.
作者: .;Thomas Bluth.;Ary Serpa Neto.;Marcus J Schultz.;Paolo Pelosi.;Marcelo Gama de Abreu.; .;T Bluth.;I Bobek.;J C Canet.;G Cinnella.;L de Baerdemaeker.;M Gama de Abreu.;C Gregoretti.;G Hedenstierna.;S N T Hemmes.;M Hiesmayr.;M W Hollmann.;S Jaber.;J Laffey.;M J Licker.;K Markstaller.;I Matot.;G H Mills.;J P Mulier.;P Pelosi.;C Putensen.;R Rossaint.;J Schmitt.;M J Schultz.;M Senturk.;A Serpa Neto.;P Severgnini.;J Sprung.;M F Vidal Melo.;H Wrigge.
来源: JAMA. 2019年321卷23期2292-2305页
An intraoperative higher level of positive end-expiratory positive pressure (PEEP) with alveolar recruitment maneuvers improves respiratory function in obese patients undergoing surgery, but the effect on clinical outcomes is uncertain.
429. Effect of Laparoscopic vs Open Distal Gastrectomy on 3-Year Disease-Free Survival in Patients With Locally Advanced Gastric Cancer: The CLASS-01 Randomized Clinical Trial.
作者: Jiang Yu.;Changming Huang.;Yihong Sun.;Xiangqian Su.;Hui Cao.;Jiankun Hu.;Kuan Wang.;Jian Suo.;Kaixiong Tao.;Xianli He.;Hongbo Wei.;Mingang Ying.;Weiguo Hu.;Xiaohui Du.;Yanfeng Hu.;Hao Liu.;Chaohui Zheng.;Ping Li.;Jianwei Xie.;Fenglin Liu.;Ziyu Li.;Gang Zhao.;Kun Yang.;Chunxiao Liu.;Haojie Li.;Pingyan Chen.;Jiafu Ji.;Guoxin Li.; .
来源: JAMA. 2019年321卷20期1983-1992页
Laparoscopic distal gastrectomy is accepted as a more effective approach to conventional open distal gastrectomy for early-stage gastric cancer. However, efficacy for locally advanced gastric cancer remains uncertain.
430. Effect of a Recombinant Human Soluble Thrombomodulin on Mortality in Patients With Sepsis-Associated Coagulopathy: The SCARLET Randomized Clinical Trial.
作者: Jean-Louis Vincent.;Bruno Francois.;Igor Zabolotskikh.;Mradul Kumar Daga.;Jean-Baptiste Lascarrou.;Mikhail Y Kirov.;Ville Pettilä.;Xavier Wittebole.;Ferhat Meziani.;Emmanuelle Mercier.;Suzana M Lobo.;Philip S Barie.;Mark Crowther.;Charles T Esmon.;Jawed Fareed.;Satoshi Gando.;Kenneth J Gorelick.;Marcel Levi.;Jean-Paul Mira.;Steven M Opal.;Joseph Parrillo.;James A Russell.;Hidehiko Saito.;Kazuhisa Tsuruta.;Takumi Sakai.;David Fineberg.; .
来源: JAMA. 2019年321卷20期1993-2002页
Previous research suggested that soluble human recombinant thrombomodulin may reduce mortality among patients with sepsis-associated coagulopathy.
431. Effect of Restriction of the Number of Concurrently Open Records in an Electronic Health Record on Wrong-Patient Order Errors: A Randomized Clinical Trial.
作者: Jason S Adelman.;Jo R Applebaum.;Clyde B Schechter.;Matthew A Berger.;Stan H Reissman.;Raja Thota.;Andrew D Racine.;David K Vawdrey.;Robert A Green.;Hojjat Salmasian.;Gordon D Schiff.;Adam Wright.;Adam Landman.;David W Bates.;Ross Koppel.;William L Galanter.;Bruce L Lambert.;Susan Paparella.;William N Southern.
来源: JAMA. 2019年321卷18期1780-1787页
Recommendations in the United States suggest limiting the number of patient records displayed in an electronic health record (EHR) to 1 at a time, although little evidence supports this recommendation.
432. Effect of Aclidinium Bromide on Major Cardiovascular Events and Exacerbations in High-Risk Patients With Chronic Obstructive Pulmonary Disease: The ASCENT-COPD Randomized Clinical Trial.
作者: Robert A Wise.;Kenneth R Chapman.;Benjamin M Scirica.;Deepak L Bhatt.;Sami Z Daoud.;Sofia Zetterstrand.;Colin Reisner.;Esther Garcia Gil.
来源: JAMA. 2019年321卷17期1693-1701页
There is concern that long-acting muscarinic antagonists increase cardiovascular morbidity or mortality in patients with chronic obstructive pulmonary disease (COPD).
433. Effect of a Single Aspirin Dose Prior to Fecal Immunochemical Testing on Test Sensitivity for Detecting Advanced Colorectal Neoplasms: A Randomized Clinical Trial.
作者: Hermann Brenner.;Silvia Calderazzo.;Thomas Seufferlein.;Leopold Ludwig.;Nektarios Dikopoulos.;Jörg Mangold.;Wolfgang Böck.;Thomas Stolz.;Thomas Eisenbach.;Thomas Block.;Annette Kopp-Schneider.;David Czock.;Kaja Tikk.
来源: JAMA. 2019年321卷17期1686-1692页
Fecal immunochemical tests for hemoglobin are widely used for colorectal cancer (CRC) screening. Observational studies suggested that sensitivity of fecal immunochemical tests for detecting advanced neoplasms could be increased by acetylsalicylic acid (aspirin), especially among men.
434. Effect of Trans-Nasal Evaporative Intra-arrest Cooling on Functional Neurologic Outcome in Out-of-Hospital Cardiac Arrest: The PRINCESS Randomized Clinical Trial.
作者: Per Nordberg.;Fabio Silvio Taccone.;Anatolij Truhlar.;Sune Forsberg.;Jacob Hollenberg.;Martin Jonsson.;Jerome Cuny.;Patrick Goldstein.;Nick Vermeersch.;Adeline Higuet.;Francisco Carmona Jiménes.;Fernando Rosell Ortiz.;Julia Williams.;Didier Desruelles.;Jacques Creteur.;Emelie Dillenbeck.;Caroline Busche.;Hans-Jörg Busch.;Mattias Ringh.;David Konrad.;Johan Peterson.;Jean-Louis Vincent.;Leif Svensson.
来源: JAMA. 2019年321卷17期1677-1685页
Therapeutic hypothermia may increase survival with good neurologic outcome after cardiac arrest. Trans-nasal evaporative cooling is a method used to induce cooling, primarily of the brain, during cardiopulmonary resuscitation (ie, intra-arrest).
435. Effect of Sunscreen Application Under Maximal Use Conditions on Plasma Concentration of Sunscreen Active Ingredients: A Randomized Clinical Trial.
作者: Murali K Matta.;Robbert Zusterzeel.;Nageswara R Pilli.;Vikram Patel.;Donna A Volpe.;Jeffry Florian.;Luke Oh.;Edward Bashaw.;Issam Zineh.;Carlos Sanabria.;Sarah Kemp.;Anthony Godfrey.;Steven Adah.;Sergio Coelho.;Jian Wang.;Lesley-Anne Furlong.;Charles Ganley.;Theresa Michele.;David G Strauss.
来源: JAMA. 2019年321卷21期2082-2091页
The US Food and Drug Administration (FDA) has provided guidance that sunscreen active ingredients with systemic absorption greater than 0.5 ng/mL or with safety concerns should undergo nonclinical toxicology assessment including systemic carcinogenicity and additional developmental and reproductive studies.
436. Effect of Initial Management With Aflibercept vs Laser Photocoagulation vs Observation on Vision Loss Among Patients With Diabetic Macular Edema Involving the Center of the Macula and Good Visual Acuity: A Randomized Clinical Trial.
作者: Carl W Baker.;Adam R Glassman.;Wesley T Beaulieu.;Andrew N Antoszyk.;David J Browning.;Kakarla V Chalam.;Sandeep Grover.;Lee M Jampol.;Chirag D Jhaveri.;Michele Melia.;Cynthia R Stockdale.;Daniel F Martin.;Jennifer K Sun.; .
来源: JAMA. 2019年321卷19期1880-1894页
Intravitreous injections of antivascular endothelial growth factor agents are effective for treating diabetic macular edema (DME) involving the center of the macula (center-involved DME [CI-DME]) with visual acuity impairment (20/32 or worse). The best approach to treating patients with CI-DME and good visual acuity (20/25 or better) is unknown.
437. Effect of Addition of an Intimate Partner Violence Intervention to a Nurse Home Visitation Program on Maternal Quality of Life: A Randomized Clinical Trial.
作者: Susan M Jack.;Michael Boyle.;Christine McKee.;Marilyn Ford-Gilboe.;C Nadine Wathen.;Philip Scribano.;Danielle Davidov.;Diane McNaughton.;Ruth O'Brien.;Carolyn Johnston.;Mariarosa Gasbarro.;Masako Tanaka.;Melissa Kimber.;Jeffrey Coben.;David L Olds.;Harriet L MacMillan.
来源: JAMA. 2019年321卷16期1576-1585页
Intimate partner violence (IPV) is a public health problem with significant adverse consequences for women and children. Past evaluations of a nurse home visitation program for pregnant women and first-time mothers experiencing social and economic disadvantage have not consistently shown reductions in IPV.
438. Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
作者: Terence T Sio.;Jennifer G Le-Rademacher.;James L Leenstra.;Charles L Loprinzi.;Grant Rine.;Amarinthia Curtis.;Anurag K Singh.;James A Martenson.;Paul J Novotny.;Angelina D Tan.;Rui Qin.;Stephen J Ko.;Paul L Reiter.;Robert C Miller.
来源: JAMA. 2019年321卷15期1481-1490页
Oral mucositis causes substantial morbidity during head and neck radiotherapy. In a randomized study, doxepin mouthwash was shown to reduce oral mucositis-related pain. A common mouthwash comprising diphenhydramine-lidocaine-antacid is also widely used.
439. Effect of a Workplace Wellness Program on Employee Health and Economic Outcomes: A Randomized Clinical Trial.
Employers have increasingly invested in workplace wellness programs to improve employee health and decrease health care costs. However, there is little experimental evidence on the effects of these programs.
440. Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial.
作者: Kimmie Ng.;Halla S Nimeiri.;Nadine J McCleary.;Thomas A Abrams.;Matthew B Yurgelun.;James M Cleary.;Douglas A Rubinson.;Deborah Schrag.;Rebecca Miksad.;Andrea J Bullock.;Jill Allen.;Dan Zuckerman.;Emily Chan.;Jennifer A Chan.;Brian M Wolpin.;Michael Constantine.;Douglas J Weckstein.;Meredith A Faggen.;Christian A Thomas.;Chryssanthi Kournioti.;Chen Yuan.;Christine Ganser.;Brittney Wilkinson.;Christopher Mackintosh.;Hui Zheng.;Bruce W Hollis.;Jeffrey A Meyerhardt.;Charles S Fuchs.
来源: JAMA. 2019年321卷14期1370-1379页
In observational studies, higher plasma 25-hydroxyvitamin D (25[OH]D) levels have been associated with improved survival in metastatic colorectal cancer (CRC).
|