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421. A randomised controlled trial assessing the efficacy and safety of repeated tegaserod therapy in women with irritable bowel syndrome with constipation.
作者: J Tack.;S Müller-Lissner.;P Bytzer.;R Corinaldesi.;L Chang.;A Viegas.;S Schnekenbuehl.;C Dunger-Baldauf.;P Rueegg.
来源: Gut. 2005年54卷12期1707-13页
It has been proposed that treatments for irritable bowel syndrome with constipation (IBS-C) should provide rapid symptomatic relief, be intermittent, and effective upon repeated use.
422. Effect of ondansetron, a 5-HT3 receptor antagonist, on fatigue in chronic hepatitis C: a randomised, double blind, placebo controlled study.
作者: T Piche.;G Vanbiervliet.;F Cherikh.;Z Antoun.;P M Huet.;E Gelsi.;J-F Demarquay.;F-X Caroli-Bosc.;S Benzaken.;M-C Rigault.;C Renou.;P Rampal.;A Tran.
来源: Gut. 2005年54卷8期1169-73页
There are no available effective therapies for fatigue associated with chronic hepatitis C (CHC). The serotonin antagonist ondansetron has been shown to be effective in the chronic fatigue syndrome. In this randomised, placebo controlled, double blind trial, we investigated the effect of orally administered ondansetron on fatigue in CHC.
423. Randomised controlled trial comparing percutaneous radiofrequency thermal ablation, percutaneous ethanol injection, and percutaneous acetic acid injection to treat hepatocellular carcinoma of 3 cm or less.
The aim of this study was to compare the outcomes of radiofrequency thermal ablation (RFTA), percutaneous ethanol injection (PEI), and percutaneous acetic acid injection (PAI) in the treatment of hepatocellular carcinoma (HCC).
424. Cost effectiveness of interferon alpha or peginterferon alpha with ribavirin for histologically mild chronic hepatitis C.
作者: R Grieve.;J Roberts.;M Wright.;M Sweeting.;D DeAngelis.;W Rosenberg.;M Bassendine.;J Main.;H Thomas.
来源: Gut. 2006年55卷9期1332-8页
For patients with mild chronic hepatitis C the cost effectiveness of antiviral therapy is unknown.
425. Long term follow up of patients treated for Helicobacter pylori infection.
作者: R Mera.;E T H Fontham.;L E Bravo.;J C Bravo.;M B Piazuelo.;M C Camargo.;P Correa.
来源: Gut. 2005年54卷11期1536-40页
Helicobacter pylori infection induces progressive inflammatory changes in the gastric mucosa that may lead to gastric cancer. Understanding long term effects resulting from the cure of this infection is needed to design cancer prevention strategies.
426. Randomised controlled trial of azathioprine and 5-aminosalicylic acid for treatment of steroid dependent ulcerative colitis.
There are limited evidence based data concerning the use of azathioprine in ulcerative colitis. We aimed to compare the efficacy of azathioprine and oral 5-aminosalicylic acid in inducing remission of steroid dependent ulcerative colitis.
427. Retarded release phosphatidylcholine benefits patients with chronic active ulcerative colitis.
We examined the hypothesis of an anti-inflammatory effect of phosphatidylcholine in ulcerative colitis.
428. Combined oral and enema treatment with Pentasa (mesalazine) is superior to oral therapy alone in patients with extensive mild/moderate active ulcerative colitis: a randomised, double blind, placebo controlled study.
作者: P Marteau.;C S Probert.;S Lindgren.;M Gassul.;T G Tan.;A Dignass.;R Befrits.;G Midhagen.;J Rademaker.;M Foldager.
来源: Gut. 2005年54卷7期960-5页
Oral aminosalicylates are well established in the treatment of active mild/moderate ulcerative colitis (UC) when the disease is extensive (that is, beyond the splenic flexure). The majority of clinical symptoms relate to disease activity in the distal part of the colon and therefore this study was designed to investigate if adding a mesalazine enema to oral mesalazine has additional benefit for patients with extensive mild/moderate active UC.
429. Flares in chronic hepatitis B patients induced by the host or the virus? Relation to treatment response during Peg-interferon {alpha}-2b therapy.
作者: H J Flink.;D Sprengers.;B E Hansen.;M van Zonneveld.;R A de Man.;S W Schalm.;H L A Janssen.; .
来源: Gut. 2005年54卷11期1604-9页
Flares are a well known phenomenon during antiviral treatment for chronic hepatitis B. Little is known about the effect of flares on response. We investigated the timing and characteristics of flares, in relation to treatment response (hepatitis B e antigen loss).
430. Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised, double blind, placebo controlled study.
Melatonin, a sleep promoting agent, is involved in the regulation of gastrointestinal motility and sensation. We aimed to determine if melatonin was effective in improving bowel symptoms and sleep disturbances in irritable bowel syndrome (IBS) patients with sleep disturbance.
431. Peginterferon {alpha}-2b and ribavirin therapy in chronic hepatitis C genotype 4: impact of treatment duration and viral kinetics on sustained virological response.
作者: S M Kamal.;A A El Tawil.;T Nakano.;Q He.;J Rasenack.;S A Hakam.;W A Saleh.;A Ismail.;A A Aziz.;M Ali Madwar.
来源: Gut. 2005年54卷6期858-66页
The response rates and duration of peginterferon alpha (PEG-IFN-alpha) and ribavirin combination therapy in chronic hepatitis C genotype 4, the prevalent genotype in the Middle East and Africa, are poorly documented.
432. Effect of folic acid supplementation on genomic DNA methylation in patients with colorectal adenoma.
作者: M Pufulete.;R Al-Ghnaniem.;A Khushal.;P Appleby.;N Harris.;S Gout.;P W Emery.;T A B Sanders.
来源: Gut. 2005年54卷5期648-53页
A low dietary folate intake can cause genomic DNA hypomethylation and may increase the risk of colorectal neoplasia. The hypothesis that folic acid supplementation increases DNA methylation in leucocytes and colorectal mucosa was tested in 31 patients with histologically confirmed colorectal adenoma using a randomised, double blind, placebo controlled, parallel design.
433. Amitriptyline reduces rectal pain related activation of the anterior cingulate cortex in patients with irritable bowel syndrome.
Irritable bowel syndrome (IBS) is a disorder of intestinal hypersensitivity and altered motility, exacerbated by stress. Functional magnetic resonance imaging (fMRI) during painful rectal distension in IBS has demonstrated greater activation of the anterior cingulate cortex (ACC), an area relevant to pain and emotions. Tricyclic antidepressants are effective for IBS. The aim of this study was to determine if low dose amitriptyline reduces ACC activation during painful rectal distension in IBS to confer clinical benefits. Secondary aims were to identify other brain regions altered by amitriptyline, and to determine if reductions in cerebral activation are greater during mental stress.
434. Thalidomide in the treatment of cancer cachexia: a randomised placebo controlled trial.
Proinflammatory cytokines, especially tumour necrosis factor alpha (TNF-alpha), play a prominent role in the pathogenesis of cancer cachexia. Thalidomide, which is an inhibitor of TNF-alpha synthesis, may represent a novel and rational approach to the treatment of cancer cachexia.
435. Homeostatic regulation of zinc transporters in the human small intestine by dietary zinc supplementation.
作者: R A Cragg.;S R Phillips.;J M Piper.;J S Varma.;F C Campbell.;J C Mathers.;D Ford.
来源: Gut. 2005年54卷4期469-78页
The role of intestinal transporter regulation in optimising nutrient absorption has been studied extensively in rodent and cell line models but not in human subjects.
436. Influence of erythromycin on gastric emptying and meal related symptoms in functional dyspepsia with delayed gastric emptying.
Although delayed gastric emptying is considered a major pathophysiological mechanism in functional dyspepsia, the efficacy of prokinetic drugs has not been established. Recent studies using macrolide prokinetics were negative but receptor desensitisation may have played a role. The aim of the present study was to evaluate the influence on meal induced symptoms of acutely administered erythromycin in patients with gastroparesis.
437. Synbiotic therapy (Bifidobacterium longum/Synergy 1) initiates resolution of inflammation in patients with active ulcerative colitis: a randomised controlled pilot trial.
作者: E Furrie.;S Macfarlane.;A Kennedy.;J H Cummings.;S V Walsh.;D A O'neil.;G T Macfarlane.
来源: Gut. 2005年54卷2期242-9页
Ulcerative colitis (UC) is an acute and chronic inflammatory disease of the large bowel with unknown aetiology. The immune response against normal commensal microorganisms is believed to drive inflammatory processes associated with UC. Therefore, modulation of bacterial communities on the gut mucosa, through the use of probiotics and prebiotics, may be used to modify the disease state.
438. Trichuris suis therapy in Crohn's disease.
Crohn's disease is common in highly industrialised Western countries where helminths are rare and uncommon in less developed areas of the world where most people carry worms. Helminths diminish immune responsiveness in naturally colonised humans and reduce inflammation in experimental colitis. Thus exposure to helminths may help prevent or even ameliorate Crohn's disease.
439. Acute tryptophan depletion affects brain-gut responses in irritable bowel syndrome patients and controls.
作者: T O C Kilkens.;A Honig.;M A van Nieuwenhoven.;W J Riedel.;R-J M Brummer.
来源: Gut. 2004年53卷12期1794-800页
Serotonin, a key denominator of the brain-gut axis, is involved in the regulation of gastrointestinal motility, secretion, and perception as well as cognition and mood.
440. Helicobacter pylori test and eradicate versus prompt endoscopy for management of dyspeptic patients: 6.7 year follow up of a randomised trial.
Dyspepsia is a chronic disease with significant impact on the use of health care resources. A management strategy based on Helicobacter pylori testing has been recommended but the long term effect is unknown.
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