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4361. Withdrawal syndrome after the double-blind cessation of caffeine consumption.
People who stop consuming caffeine may have symptoms, but the incidence and severity of caffeine withdrawal are not known. This study was performed to determine the effects in the general population of ending one's dietary intake of caffeine.
4362. Treatment of advanced squamous-cell carcinoma of the head and neck with alternating chemotherapy and radiotherapy.
作者: M Merlano.;V Vitale.;R Rosso.;M Benasso.;R Corvò.;M Cavallari.;G Sanguineti.;A Bacigalupo.;F Badellino.;G Margarino.
来源: N Engl J Med. 1992年327卷16期1115-21页
For patients with advanced, unresectable squamous-cell carcinoma of the head and neck, radiotherapy is the standard treatment but has poor results. We therefore designed a randomized trial to determine whether alternating chemotherapy with radiotherapy would improve the survival of such patients.
4363. A controlled trial of scheduled replacement of central venous and pulmonary-artery catheters.
作者: D K Cobb.;K P High.;R G Sawyer.;C A Sable.;R B Adams.;D A Lindley.;T L Pruett.;K J Schwenzer.;B M Farr.
来源: N Engl J Med. 1992年327卷15期1062-8页
The incidence of infection increases with the prolonged use of central vascular catheters, but it is unclear whether changing catheters every three days, as some recommend, will reduce the rate of infection, It is also unclear whether it is safer to change a catheter over a guide wire or insert it at a new site.
4364. A comparison of standard-dose and high-dose epinephrine in cardiac arrest outside the hospital. The Multicenter High-Dose Epinephrine Study Group.
作者: C G Brown.;D R Martin.;P E Pepe.;H Stueven.;R O Cummins.;E Gonzalez.;M Jastremski.
来源: N Engl J Med. 1992年327卷15期1051-5页
Experimental and uncontrolled clinical evidence suggests that intravenous epinephrine in doses higher than currently recommended may improve outcome after cardiac arrest. We conducted a prospective, multicenter study comparing standard-dose epinephrine with high-dose epinephrine in the management of cardiac arrest outside the hospital.
4365. High-dose epinephrine in adult cardiac arrest.
作者: I G Stiell.;P C Hebert.;B N Weitzman.;G A Wells.;S Raman.;R M Stark.;L A Higginson.;J Ahuja.;G E Dickinson.
来源: N Engl J Med. 1992年327卷15期1045-50页
Recent studies suggest that doses of epinephrine of 0.1 mg per kilogram of body weight or higher may improve myocardial and cerebral blood flow as well as survival in cardiac arrest. Such studies have called into question the traditional dose of epinephrine (0.007 to 0.014 mg per kilogram) recommended for advanced cardiac life support.
4366. Mifepristone (RU 486) compared with high-dose estrogen and progestogen for emergency postcoital contraception.
Mifepristone (RU 486) is a synthetic steroid with potent antiprogestational and antiglucocorticoid properties that provides an effective medical method of inducing abortion in early pregnancy. Since progesterone is essential for implantation, we tested the use of mifepristone for emergency postcoital contraception.
4367. Response to 2-chlorodeoxyadenosine in patients with B-cell chronic lymphocytic leukemia resistant to fludarabine.
Patients with untreated B-cell chronic lymphocytic leukemia have a high rate of complete remission when given the halogenated nucleoside analogue fludarabine. However, patients in whom the disease has proved refractory to primary treatment have a reduced life expectancy and a dismal outcome.
4369. Plasmapheresis for lupus nephritis.4370. Plasmapheresis for lupus nephritis.4371. Plasmapheresis for lupus nephritis. Lupus Plasmapheresis Study Group.4373. A comparison of electrophysiologically guided antiarrhythmic drug therapy with beta-blocker therapy in patients with symptomatic, sustained ventricular tachyarrhythmias.
作者: G Steinbeck.;D Andresen.;P Bach.;R Haberl.;M Oeff.;E Hoffmann.;E R von Leitner.
来源: N Engl J Med. 1992年327卷14期987-92页
Antiarrhythmic drug therapy guided by invasive electrophysiologic testing is now widely used in patients with symptomatic, sustained ventricular tachyarrhythmias.
4374. A controlled trial of a single dose of azithromycin for the treatment of chlamydial urethritis and cervicitis. The Azithromycin for Chlamydial Infections Study Group.
作者: D H Martin.;T F Mroczkowski.;Z A Dalu.;J McCarty.;R B Jones.;S J Hopkins.;R B Johnson.
来源: N Engl J Med. 1992年327卷13期921-5页
Currently, there is no single-dose therapy that is effective in the treatment of urethral or endocervical infections with Chlamydia trachomatis. Azithromycin is a new azalide antibiotic that has substantial activity against C. trachomatis, is concentrated intracellularly, and has a long half-life in serum and tissue.
4376. Anti-endotoxin monoclonal antibodies.4377. Brief report: treatment of insulin-resistant diabetic ketoacidosis with insulin-like growth factor I in an adolescent with insulin-dependent diabetes.
作者: A L Usala.;T Madigan.;B Burguera.;M K Sinha.;J F Caro.;P Cunningham.;J G Powell.;P C Butler.
来源: N Engl J Med. 1992年327卷12期853-7页 4378. Ganciclovir for cytomegalovirus after heart transplantation.
作者: A Laske.;A Gallino.;T Carrel.;M I Turina.
来源: N Engl J Med. 1992年327卷12期892; author reply 892-3页 4379. Ganciclovir for cytomegalovirus after heart transplantation. |