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4341. Inflammation, pravastatin, and the risk of coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events (CARE) Investigators.
作者: P M Ridker.;N Rifai.;M A Pfeffer.;F M Sacks.;L A Moye.;S Goldman.;G C Flaker.;E Braunwald.
来源: Circulation. 1998年98卷9期839-44页
We studied whether inflammation after myocardial infarction (MI) is a risk factor for recurrent coronary events and whether randomized treatment with pravastatin reduces that risk.
4342. Successful irrigated-tip catheter ablation of atrial flutter resistant to conventional radiofrequency ablation.
作者: P Jaïs.;M Haïssaguerre.;D C Shah.;A Takahashi.;M Hocini.;T Lavergne.;S Lafitte.;A Le Mouroux.;B Fischer.;J Clémenty.
来源: Circulation. 1998年98卷9期835-8页
Catheter ablation of typical right atrial flutter is now widely performed. The best end point has been demonstrated to be bidirectional isthmus block. We investigated the use of irrigated-tip catheters in a small subset of patients who failed isthmus ablation with conventional radiofrequency (RF) ablation.
4343. Assessment of atrioventricular junction ablation and VVIR pacemaker versus pharmacological treatment in patients with heart failure and chronic atrial fibrillation: a randomized, controlled study.
作者: M Brignole.;C Menozzi.;L Gianfranchi.;G Musso.;R Mureddu.;N Bottoni.;G Lolli.
来源: Circulation. 1998年98卷10期953-60页
Uncontrolled studies have suggested that atrioventricular junction ablation and pacemaker implantation have beneficial effects on quality of life in patients with chronic atrial fibrillation (AF).
4344. Long-term oral anticoagulant therapy in patients with unstable angina or suspected non-Q-wave myocardial infarction: organization to assess strategies for ischemic syndromes (OASIS) pilot study results.
Patients with acute ischemic syndromes (AIS) suffer high rates of recurrent ischemic events despite aspirin treatment. Long-term therapy with oral anticoagulants in addition to aspirin may reduce this risk. We studied the effects of long-term warfarin at 2 intensities in patients with AIS without ST elevation in 2 consecutive randomized controlled studies.
4346. Preformed IgG antibodies against major histocompatibility complex class II antigens are major risk factors for high-grade cellular rejection in recipients of heart transplantation.
作者: S Itescu.;T C Tung.;E M Burke.;A Weinberg.;N Moazami.;J H Artrip.;N Suciu-Foca.;E A Rose.;M C Oz.;R E Michler.
来源: Circulation. 1998年98卷8期786-93页
Preformed anti-HLA antibodies reacting specifically with donor lymphocytes have been associated with acute vascular rejection and early cardiac allograft failure. However, the effect of preformed anti-HLA antibodies directed against allogeneic major histocompatibility complex (MHC) class I or II antigens of a donor panel on heart transplantation outcome has not been extensively studied.
4347. Acute hemodynamic interaction of aspirin and ticlopidine with enalapril: results of a double-blind, randomized comparative trial.
作者: C Spaulding.;B Charbonnier.;A Cohen-Solal.;Y Juillière.;E P Kromer.;K Benhamda.;R Cador.;S Weber.
来源: Circulation. 1998年98卷8期757-65页
Coprescription of aspirin and ACE inhibitors is frequent in heart failure caused by coronary artery disease. Negative interaction between aspirin and enalapril has been reported, presumably through inhibition by aspirin of ACE inhibitor-induced prostaglandin synthesis. Ticlopidine is a potent antiplatelet agent without interaction with prostaglandin synthesis.
4348. Randomized, double-blind crossover study to investigate the effects of amlodipine and isosorbide mononitrate on the time course and severity of exercise-induced myocardial stunning.
作者: C A Rinaldi.;A Z Linka.;N D Masani.;P G Avery.;E Jones.;H Saunders.;R J Hall.
来源: Circulation. 1998年98卷8期749-56页
Myocardial stunning may cause prolonged left ventricular dysfunction after exercise-induced ischemia that can be attenuated by calcium antagonists in animal models. To assess their effects in humans, we performed a randomized, double-blind crossover study comparing the calcium antagonist amlodipine (10 mg once daily) versus isosorbide mononitrate (ISMN, 50 mg once daily) on postexercise stunning.
4349. Randomized, placebo-controlled trial of platelet glycoprotein IIb/IIIa blockade with primary angioplasty for acute myocardial infarction. ReoPro and Primary PTCA Organization and Randomized Trial (RAPPORT) Investigators.
作者: S J Brener.;L A Barr.;J E Burchenal.;S Katz.;B S George.;A A Jones.;E D Cohen.;P C Gainey.;H J White.;H B Cheek.;J W Moses.;D J Moliterno.;M B Effron.;E J Topol.
来源: Circulation. 1998年98卷8期734-41页
The benefit of catheter-based reperfusion for acute myocardial infarction (MI) is limited by a 5% to 15% incidence of in-hospital major ischemic events, usually caused by infarct artery reocclusion, and a 20% to 40% need for repeat percutaneous or surgical revascularization. Platelets play a key role in the process of early infarct artery reocclusion, but inhibition of aggregation via the glycoprotein IIb/IIIa receptor has not been prospectively evaluated in the setting of acute MI.
4350. Prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women.
C-reactive protein (CRP) predicts risk of myocardial infarction (MI) and stroke among apparently healthy men, but in women, virtually no data are available.
4351. Cilostazol has beneficial effects in treatment of intermittent claudication: results from a multicenter, randomized, prospective, double-blind trial.
Cilostazol is a new phosphodiesterase inhibitor that suppresses platelet aggregation and also acts as a direct arterial vasodilator. This prospective, randomized, placebo-controlled, parallel-group clinical trial evaluated the efficacy of cilostazol for treatment of stable, moderately severe intermittent claudication.
4352. Adverse events with transvenous implantable cardioverter-defibrillators: a prospective multicenter study. European 7219 Jewel ICD investigators.
作者: M Rosenqvist.;T Beyer.;M Block.;K den Dulk.;J Minten.;F Lindemans.
来源: Circulation. 1998年98卷7期663-70页
A newly developed classification system relates adverse events to the surgical procedure or the function of the implantable defibrillator.
4353. Vessel dilator enhances sodium and water excretion and has beneficial hemodynamic effects in persons with congestive heart failure.
作者: D L Vesely.;J R Dietz.;J R Parks.;M Baig.;M T McCormick.;G Cintron.;D D Schocken.
来源: Circulation. 1998年98卷4期323-9页
Vessel dilator, a 37-amino acid peptide hormone synthesized in the heart, enhances urine flow 4- to 12-fold and sodium excretion 3- to 6-fold in healthy humans. The present investigation was designed to determine whether vessel dilator might have similar beneficial effects in persons with congestive heart failure (CHF).
4354. Early increase of von Willebrand factor predicts adverse outcome in unstable coronary artery disease: beneficial effects of enoxaparin. French Investigators of the ESSENCE Trial.
作者: G Montalescot.;F Philippe.;A Ankri.;E Vicaut.;E Bearez.;J E Poulard.;D Carrie.;D Flammang.;A Dutoit.;A Carayon.;C Jardel.;M Chevrot.;J P Bastard.;F Bigonzi.;D Thomas.
来源: Circulation. 1998年98卷4期294-9页
The pathogenesis of unstable angina and non-Q-wave myocardial infarction is still poorly understood, and early evaluation of prognosis remains difficult. We therefore studied the predictive value of 5 biological indicators of inflammation, thrombogenesis, vasoconstriction, and myocardial necrosis, and we examined the effects of enoxaparin and unfractionated heparin on these markers after 48 hours of treatment.
4355. Quantitative assessment of myocardial viability after infarction by dobutamine magnetic resonance tagging.
作者: G Geskin.;C M Kramer.;W J Rogers.;T M Theobald.;D Pakstis.;Y L Hu.;N Reichek.
来源: Circulation. 1998年98卷3期217-23页
The assessment of return of function within dysfunctional myocardium after acute myocardial infarction (MI) using contractile reserve has been primarily qualitative. Magnetic resonance (MR) myocardial tagging is a novel noninvasive method that measures intramyocardial function. We hypothesized that MR tagging could be used to quantify the intramyocardial response to low-dose dobutamine and relate this response to return of function in patients after first MI.
4356. Increased bioavailability of nitric oxide after lipid-lowering therapy in hypercholesterolemic patients: a randomized, placebo-controlled, double-blind study.
作者: S John.;M Schlaich.;M Langenfeld.;H Weihprecht.;G Schmitz.;G Weidinger.;R E Schmieder.
来源: Circulation. 1998年98卷3期211-6页
Impaired endothelium-dependent vasodilation is an early sign of atherosclerosis in hypercholesterolemic patients. We hypothesized that lipid-lowering therapy can improve endothelial function and that this effect is mainly mediated by increased bioavailability of nitric oxide (NO).
4357. Effect of single-drug therapy on reduction of left atrial size in mild to moderate hypertension: comparison of six antihypertensive agents.
作者: J S Gottdiener.;D J Reda.;D W Williams.;B J Materson.;W Cushman.;R J Anderson.
来源: Circulation. 1998年98卷2期140-8页
Cardiac effects of hypertension include increased left ventricular (LV) mass and LV hypertrophy, as well as increased left atrial size, a predictor of stroke and atrial fibrillation. Although literature on reduction of LV mass with antihypertensive therapy is extensive, little information is available on effects of treatment on left atrial size.
4358. Dopamine depresses minute ventilation in patients with heart failure.
Low-dose dopamine is frequently used in patients in the intensive care setting. Dopamine may inhibit chemoreceptor afferents and hence decrease chemoreflex sensitivity to hypoxia.
4359. Marked reduction in internal atrial defibrillation thresholds with dual-current pathways and sequential shocks in humans.
This study tested the ability of sequential shocks delivered through dual-current pathways to lower the atrial defibrillation threshold (ADFT) compared with a biphasic shock through a standard single-current pathway.
4360. Randomized comparison of coronary stenting with balloon angioplasty in selected patients with acute myocardial infarction.
作者: H Suryapranata.;A W van 't Hof.;J C Hoorntje.;M J de Boer.;F Zijlstra.
来源: Circulation. 1998年97卷25期2502-5页
Although the benefits of primary angioplasty in acute myocardial infarction have been demonstrated, several areas for improvement remain. Therefore, a prospective randomized trial comparing primary stenting with balloon angioplasty in patients with acute myocardial infarction was conducted.
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