当前位置: 首页 >> 检索结果
4301. Interleukin-6 receptor gene, plasma C-reactive protein, and diabetes risk in women.
Recent genome-wide association studies (GWASs) related common variants in the interleukin-6 (Il-6) receptor (IL6R) gene to plasma C-reactive protein (CRP) concentrations. Because IL6R variants were previously associated with IL-6 levels, we tested whether the associations with CRP were independent of IL-6 and the interactions between IL6R variants and CRP in relation to diabetes risk.
4302. Cortisol release from adipose tissue by 11beta-hydroxysteroid dehydrogenase type 1 in humans.
作者: Roland H Stimson.;Jonas Andersson.;Ruth Andrew.;Doris N Redhead.;Fredrik Karpe.;Peter C Hayes.;Tommy Olsson.;Brian R Walker.
来源: Diabetes. 2009年58卷1期46-53页
11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) regenerates cortisol from cortisone. 11beta-HSD1 mRNA and activity are increased in vitro in subcutaneous adipose tissue from obese patients. Inhibition of 11beta-HSD1 is a promising therapeutic approach in type 2 diabetes. However, release of cortisol by 11beta-HSD1 from adipose tissue and its effect on portal vein cortisol concentrations have not been quantified in vivo.
4303. Retinol-binding protein 4 in twins: regulatory mechanisms and impact of circulating and tissue expression levels on insulin secretion and action.
作者: Rasmus Ribel-Madsen.;Martin Friedrichsen.;Allan Vaag.;Pernille Poulsen.
来源: Diabetes. 2009年58卷1期54-60页
Retinol-binding protein (RBP) 4 is an adipokine of which plasma levels are elevated in obesity and type 2 diabetes. The aims of the study were to identify determinants of plasma RBP4 and RBP4 mRNA expression in subcutaneous adipose tissue (SAT) and skeletal muscle and to investigate the association between RBP4 and in vivo measures of glucose metabolism.
4304. Liver is the site of splanchnic cortisol production in obese nondiabetic humans.
作者: Rita Basu.;Ananda Basu.;Meagan Grudzien.;Paul Jung.;Peer Jacobson.;Michael Johnson.;Ravinder Singh.;Michael Sarr.;Robert A Rizza.
来源: Diabetes. 2009年58卷1期39-45页
To determine the contribution of liver and viscera to splanchnic cortisol production in humans.
4305. Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice.
作者: Jing Xu.;David J Lloyd.;Clarence Hale.;Shanaka Stanislaus.;Michelle Chen.;Glenn Sivits.;Steven Vonderfecht.;Randy Hecht.;Yue-Sheng Li.;Richard A Lindberg.;Jin-Long Chen.;Dae Young Jung.;Zhiyou Zhang.;Hwi-Jin Ko.;Jason K Kim.;Murielle M Véniant.
来源: Diabetes. 2009年58卷1期250-9页
Fibroblast growth factor 21 (FGF21) has emerged as an important metabolic regulator of glucose and lipid metabolism. The aims of the current study are to evaluate the role of FGF21 in energy metabolism and to provide mechanistic insights into its glucose and lipid-lowering effects in a high-fat diet-induced obesity (DIO) model.
4306. Inhibition of dipeptidyl peptidase-4 by vildagliptin during glucagon-like Peptide 1 infusion increases liver glucose uptake in the conscious dog.
作者: Dale S Edgerton.;Kathryn M S Johnson.;Doss W Neal.;Melanie Scott.;Charles H Hobbs.;Xia Zhang.;Alokesh Duttaroy.;Alan D Cherrington.
来源: Diabetes. 2009年58卷1期243-9页
This study investigated the acute effects of treatment with vildagliptin on dipeptidyl peptidase-4 (DPP-4) activity, glucagon-like peptide 1 (GLP-1) concentration, pancreatic hormone levels, and glucose metabolism. The primary aims were to determine the effects of DPP-4 inhibition on GLP-1 clearance and on hepatic glucose uptake.
4307. Insulin reduces cerebral ischemia/reperfusion injury in the hippocampus of diabetic rats: a role for glycogen synthase kinase-3beta.
作者: Massimo Collino.;Manuela Aragno.;Sara Castiglia.;Chiara Tomasinelli.;Christoph Thiemermann.;Giuseppe Boccuzzi.;Roberto Fantozzi.
来源: Diabetes. 2009年58卷1期235-42页
There is evidence that insulin reduces brain injury evoked by ischemia/reperfusion (I/R). However, the molecular mechanisms underlying the protective effects of insulin remain unknown. Insulin is a well-known inhibitor of glycogen synthase kinase-3beta (GSK-3beta). Here, we investigate the role of GSK-3beta inhibition on I/R-induced cerebral injury in a rat model of insulinopenic diabetes.
4308. Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damage.
作者: Ryoichi Arita.;Yasuaki Hata.;Shintaro Nakao.;Takeshi Kita.;Muneki Miura.;Shuhei Kawahara.;Souska Zandi.;Lama Almulki.;Faryan Tayyari.;Hiroaki Shimokawa.;Ali Hafezi-Moghadam.;Tatsuro Ishibashi.
来源: Diabetes. 2009年58卷1期215-26页
Leukocyte adhesion in retinal microvasuculature substantially contributes to diabetic retinopathy. Involvement of the Rho/Rho kinase (ROCK) pathway in diabetic microvasculopathy and therapeutic potential of fasudil, a selective ROCK inhibitor, are investigated.
4309. Genome-wide linkage and admixture mapping of type 2 diabetes in African American families from the American Diabetes Association GENNID (Genetics of NIDDM) Study Cohort.
作者: Steven C Elbein.;Swapan K Das.;D Michael Hallman.;Craig L Hanis.;Sandra J Hasstedt.
来源: Diabetes. 2009年58卷1期268-74页
We used a single nucleotide polymorphism (SNP) map in a large cohort of 580 African American families to identify regions linked to type 2 diabetes, age of type 2 diabetes diagnosis, and BMI.
4310. Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes.
作者: Struan F A Grant.;Hui-Qi Qu.;Jonathan P Bradfield.;Luc Marchand.;Cecilia E Kim.;Joseph T Glessner.;Rosemarie Grabs.;Shayne P Taback.;Edward C Frackelton.;Andrew W Eckert.;Kiran Annaiah.;Margaret L Lawson.;F George Otieno.;Erin Santa.;Julie L Shaner.;Ryan M Smith.;Robert Skraban.;Marcin Imielinski.;Rosetta M Chiavacci.;Robert W Grundmeier.;Charles A Stanley.;Susan E Kirsch.;Daryl Waggott.;Andrew D Paterson.;Dimitri S Monos.; .;Constantin Polychronakos.;Hakon Hakonarson.
来源: Diabetes. 2009年58卷1期290-5页
Two recent genome-wide association (GWA) studies have revealed novel loci for type 1 diabetes, a common multifactorial disease with a strong genetic component. To fully utilize the GWA data that we had obtained by genotyping 563 type 1 diabetes probands and 1,146 control subjects, as well as 483 case subject-parent trios, using the Illumina HumanHap550 BeadChip, we designed a full stage 2 study to capture other possible association signals.
4311. Effect of endothelium-specific insulin resistance on endothelial function in vivo.
作者: Edward R Duncan.;Paul A Crossey.;Simon Walker.;Narayana Anilkumar.;Lucilla Poston.;Gillian Douglas.;Vivienne A Ezzat.;Stephen B Wheatcroft.;Ajay M Shah.;Mark T Kearney.
来源: Diabetes. 2008年57卷12期3307-14页
Insulin resistance is an independent risk factor for the development of cardiovascular atherosclerosis. A key step in the development of atherosclerosis is endothelial dysfunction, manifest by a reduction in bioactivity of nitric oxide (NO). Insulin resistance is associated with endothelial dysfunction; however, the mechanistic relationship between these abnormalities and the role of impaired endothelial insulin signaling versus global insulin resistance remains unclear.
4312. Obesity-related upregulation of monocyte chemotactic factors in adipocytes: involvement of nuclear factor-kappaB and c-Jun NH2-terminal kinase pathways.
作者: Ping Jiao.;Qiu Chen.;Suketu Shah.;Jing Du.;Bo Tao.;Iphigenia Tzameli.;Weiqun Yan.;Haiyan Xu.
来源: Diabetes. 2009年58卷1期104-15页
We sought to evaluate the entire picture of all monocyte chemotactic factors that potentially contribute to adipose tissue macrophage accumulation in obesity.
4313. Resistance to high-fat diet-induced obesity but exacerbated insulin resistance in mice overexpressing preadipocyte factor-1 (Pref-1): a new model of partial lipodystrophy.
作者: Josep A Villena.;Cheol Soo Choi.;Yuhui Wang.;Sheene Kim.;Yu-Jin Hwang.;Young-Bum Kim.;Gary Cline.;Gerald I Shulman.;Hei Sook Sul.
来源: Diabetes. 2008年57卷12期3258-66页
White adipose tissue is a critical regulator of whole-body glucose metabolism. Preadipocyte factor-1 (Pref-1) is a secreted protein that inhibits adipocyte differentiation, both in vitro and in vivo. In this study, we have investigated the effects of Pref-1 overexpression on whole-body glucose homeostasis and its contribution to the development of insulin resistance.
4314. Angiogenesis associated with visceral and subcutaneous adipose tissue in severe human obesity.
作者: Séverine Ledoux.;Isabelle Queguiner.;Simon Msika.;Sophie Calderari.;Pierre Rufat.;Jean-Marie Gasc.;Pierre Corvol.;Etienne Larger.
来源: Diabetes. 2008年57卷12期3247-57页
The expansion of adipose tissue is linked to the development of its vasculature. However, the regulation of adipose tissue angiogenesis in humans has not been extensively studied. Our aim was to compare the angiogenesis associated with subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) from the same obese patients in an in vivo model.
4315. Genome-wide linkage scan in Gullah-speaking African American families with type 2 diabetes: the Sea Islands Genetic African American Registry (Project SuGAR).
作者: Michèle M Sale.;Lingyi Lu.;Ida J Spruill.;Jyotika K Fernandes.;Kerry H Lok.;Jasmin Divers.;Carl D Langefeld.;W Timothy Garvey.
来源: Diabetes. 2009年58卷1期260-7页
The Gullah-speaking African American population from the Sea Islands of South Carolina is characterized by a low degree of European admixture and high rates of type 2 diabetes and diabetic complications. Affected relative pairs with type 2 diabetes were recruited through the Sea Islands Genetic African American Registry (Project SuGAR).
4316. Ang-1 gene therapy inhibits hypoxia-inducible factor-1alpha (HIF-1alpha)-prolyl-4-hydroxylase-2, stabilizes HIF-1alpha expression, and normalizes immature vasculature in db/db mice.
Diabetic impaired angiogenesis is associated with impairment of hypoxia-inducible factor-1alpha (HIF-1alpha) as well as vasculature maturation. We investigated the potential roles and intracellular mechanisms of angiopoietin-1 (Ang-1) gene therapy on myocardial HIF-1alpha stabilization and vascular maturation in db/db mice.
4317. Lower metabolic rate in individuals heterozygous for either a frameshift or a functional missense MC4R variant.
作者: Jonathan Krakoff.;Lijun Ma.;Sayuko Kobes.;William C Knowler.;Robert L Hanson.;Clifton Bogardus.;Leslie J Baier.
来源: Diabetes. 2008年57卷12期3267-72页
Humans with functional variants in the melanocortin 4 receptor (MC4R) are obese, hyperphagic, and hyperinsulinemic but have been reported to have no difference in energy expenditure.
4318. Upregulation of mitochondrial uncoupling protein-2 by the AMP-activated protein kinase in endothelial cells attenuates oxidative stress in diabetes.
作者: Zhonglin Xie.;Junhua Zhang.;Jiliang Wu.;Benoit Viollet.;Ming-Hui Zou.
来源: Diabetes. 2008年57卷12期3222-30页
Recent evidence suggests that the AMP-activated protein kinase (AMPK) is an important therapeutic target for diabetes. The present study was conducted to determine how AMPK activation suppressed tyrosine nitration of prostacyclin synthase in diabetes.
4319. Atrial natriuretic peptide induces postprandial lipid oxidation in humans.
作者: Andreas L Birkenfeld.;Petra Budziarek.;Michael Boschmann.;Cedric Moro.;Frauke Adams.;Gabriele Franke.;Michel Berlan.;Marie A Marques.;Fred C G J Sweep.;Friedrich C Luft.;Max Lafontan.;Jens Jordan.
来源: Diabetes. 2008年57卷12期3199-204页
Atrial natriuretic peptide (ANP) regulates arterial blood pressure. In addition, ANP has recently been shown to promote human adipose tissue lipolysis through cGMP-mediated hormone-sensitive lipase activation. We hypothesized that ANP increases postprandial free fatty acid (FFA) availability and energy expenditure while decreasing arterial blood pressure.
4320. Combination therapy with glucagon-like peptide-1 and gastrin restores normoglycemia in diabetic NOD mice.
作者: Wilma L Suarez-Pinzon.;Robert F Power.;Yanhua Yan.;Clive Wasserfall.;Mark Atkinson.;Alex Rabinovitch.
来源: Diabetes. 2008年57卷12期3281-8页
Glucagon-like peptide-1 (GLP-1) and gastrin promote pancreatic beta-cell function, survival, and growth. Here, we investigated whether GLP-1 and gastrin can restore the beta-cell mass and reverse hyperglycemia in NOD mice with autoimmune diabetes.
|