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4281. Phase 2 studies of adenosine cardioplegia.
作者: G Cohen.;R Feder-Elituv.;J Iazetta.;P Bunting.;H Mallidi.;J Bozinovski.;C Deemar.;G T Christakis.;E A Cohen.;B I Wong.;R D McLean.;M Myers.;C D Morgan.;C D Mazer.;T S Smith.;B S Goldman.;C D Naylor.;S E Fremes.
来源: Circulation. 1998年98卷19 Suppl期II225-33页
Laboratory evidence supports the use of adenosine-supplemented cardioplegia. An initial phase 1 dose-ranging clinical evaluation demonstrated that an adenosine concentration of 15 mumol/L could be safely administered with warm blood cardioplegia and suggested that phase 2 studies were warranted.
4282. Anticoagulation is unnecessary after biological aortic valve replacement.
作者: K Moinuddeen.;J Quin.;R Shaw.;M Dewar.;G Tellides.;G Kopf.;J Elefteriades.
来源: Circulation. 1998年98卷19 Suppl期II95-8; discussion II98-9页
Opinion differs as to whether anticoagulation is beneficial in preventing ischemic stroke in the early postoperative period after biological aortic valve replacement (AVR). The purpose of this study was to determine whether early anticoagulation with heparin and warfarin confers any significant advantage for patients undergoing such replacement.
4283. Effect of implantable cardioverter-defibrillator implantation on surgical morbidity in the CABG Patch Trial. Surgical Investigators of the Coronary Artery Bypass Graft Patch Trial.
作者: H M Spotnitz.;J M Herre.;S T Raza.;J W Hammon.;L D Baker.;D M Fitzgerald.;I L Kron.;J T Bigger.
来源: Circulation. 1998年98卷19 Suppl期II77-80页
The Coronary Artery Bypass Graft (CABG) Patch Trial tested the hypothesis that prophylactic insertion of an implantable cardioverter-defibrillator (ICD) improves survival rates after high-risk CABG. We compared group-specific perioperative morbidity and mortality rates.
4284. Transmyocardial revascularization in patients with refractory, unstable angina.
作者: R D Dowling.;M R Petracek.;S L Selinger.;K B Allen.
来源: Circulation. 1998年98卷19 Suppl期II73-5; discussion II75-6页
Previous reports of transmyocardial revascularization (TMR) indicate a significant mortality in patients with refractory, unstable angina. We hypothesized that TMR with a holmium laser would result in significant angina relief with acceptable mortality in this patient population.
4285. Central serotonergic responsiveness in neurocardiogenic syncope: a clomipramine test challenge.
作者: G N Theodorakis.;M Markianos.;E G Livanis.;E Zarvalis.;P Flevari.;D T Kremastinos.
来源: Circulation. 1998年98卷24期2724-30页
Central serotonergic mechanisms appear to participate in the pathogenesis of recurrent neurally mediated syncope. The aim of the study was to investigate the responsiveness of the central serotonergic system by measuring the prolactin and cortisol responses to intravenous administration of the serotonin reuptake inhibitor clomipramine.
4286. Electrophysiological mechanisms and determinants of vagal maneuvers for termination of paroxysmal supraventricular tachycardia.
作者: Z C Wen.;S A Chen.;C T Tai.;C E Chiang.;C W Chiou.;M S Chang.
来源: Circulation. 1998年98卷24期2716-23页
The vagal maneuvers used for termination of paroxysmal supraventricular reentrant tachycardia (PSVT) appear to involve more complex mechanisms than we have known, and further study should be done to explore the possible mechanisms.
4287. Regular physical exercise corrects endothelial dysfunction and improves exercise capacity in patients with chronic heart failure.
作者: R Hambrecht.;E Fiehn.;C Weigl.;S Gielen.;C Hamann.;R Kaiser.;J Yu.;V Adams.;J Niebauer.;G Schuler.
来源: Circulation. 1998年98卷24期2709-15页
The purpose of this study was to determine the effects of systemic exercise training on endothelium-mediated arteriolar vasodilation of the lower limb and its relation to exercise capacity in chronic heart failure (CHF). Endothelial dysfunction is a key feature of CHF, contributing to increased peripheral vasoconstriction and impaired exercise capacity. Local handgrip exercise has previously been shown to enhance endothelium-dependent vasodilation in conduit and resistance vessels in CHF.
4288. Modulation by dietary salt of verapamil disposition in humans.
作者: D Darbar.;M F Fromm.;S Dell'Orto.;R B Kim.;H K Kroemer.;M Eichelbaum.;D M Roden.
来源: Circulation. 1998年98卷24期2702-8页
The intestine is an increasingly well-recognized site of first-pass drug metabolism. In this study, we determined the influence of dietary salt on the steady-state disposition of verapamil, a drug that undergoes extensive first-pass metabolism.
4289. Effect of glycoprotein IIb/IIIa receptor blockade on recovery of coronary flow and left ventricular function after the placement of coronary-artery stents in acute myocardial infarction.
作者: F J Neumann.;R Blasini.;C Schmitt.;E Alt.;J Dirschinger.;M Gawaz.;A Kastrati.;A Schömig.
来源: Circulation. 1998年98卷24期2695-701页
Apart from its established effects on vessel patency after percutaneous coronary revascularization, glycoprotein IIb/IIIa receptor blockade by abciximab may improve myocardial perfusion by inhibition of the interaction of platelets and platelet aggregates with the microvasculature. We investigated the effect of abciximab with stent placement in acute myocardial infarction.
4290. Long-term prognostic value of exercise echocardiography compared with exercise 201Tl, ECG, and clinical variables in patients evaluated for coronary artery disease.
作者: L I Olmos.;H Dakik.;R Gordon.;J K Dunn.;M S Verani.;M A Quiñones.;W A Zoghbi.
来源: Circulation. 1998年98卷24期2679-86页
The accuracy of exercise echocardiography and 201Tl single photon emission computed tomography (SPECT) is similar in the diagnosis of coronary artery disease (CAD). However, comparative data on long-term prognosis are lacking.
4291. Development of transplantation vasculopathy and progression of donor-transmitted atherosclerosis: comparison by serial intravascular ultrasound imaging.
作者: S R Kapadia.;S E Nissen.;K M Ziada.;V Guetta.;T D Crowe.;R E Hobbs.;R C Starling.;J B Young.;E M Tuzcu.
来源: Circulation. 1998年98卷24期2672-8页
Transplant coronary artery disease is a combination of atherosclerosis transmitted from the donor and new lesions of allograft vasculopathy. We sought to determine the morphological characteristics of allograft vasculopathy and differentiate it from donor-transmitted atherosclerosis with serial intravascular ultrasound.
4292. Ten-year follow-up of the first megatrial testing thrombolytic therapy in patients with acute myocardial infarction: results of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto-1 study. The GISSI Investigators.
作者: M G Franzosi.;E Santoro.;C De Vita.;E Geraci.;A Lotto.;A P Maggioni.;F Mauri.;F Rovelli.;L Santoro.;L Tavazzi.;G Tognoni.
来源: Circulation. 1998年98卷24期2659-65页
We conducted a 10-year follow-up of the 11 712 patients with acute myocardial infarction randomized in the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto-1 study, the first large trial assessing thrombolytic therapy.
4293. Nonischemic chest pain induced by coronary interventions: a prospective study comparing coronary angioplasty and stent implantation.
作者: A Jeremias.;S Kutscher.;M Haude.;D Heinen.;G Holtmann.;W Senf.;R Erbel.
来源: Circulation. 1998年98卷24期2656-8页
Chest pain frequently occurs without any signs of ischemia within the first 24 hours after coronary interventions. To test the hypothesis that this pain may be due to local vessel injury ("stretch pain"), we performed a prospective study enrolling patients after PTCA, stent implantation, or diagnostic coronary angiography alone.
4294. Spontaneous conversion and maintenance of sinus rhythm by amiodarone in patients with heart failure and atrial fibrillation: observations from the veterans affairs congestive heart failure survival trial of antiarrhythmic therapy (CHF-STAT). The Department of Veterans Affairs CHF-STAT Investigators.
作者: P C Deedwania.;B N Singh.;K Ellenbogen.;S Fisher.;R Fletcher.;S N Singh.
来源: Circulation. 1998年98卷23期2574-9页
In a multicenter, double-blind, placebo-controlled study, the long-term effects of amiodarone on morbidity and mortality in patients with congestive heart failure (CHF) and atrial fibrillation (AF) were evaluated during a 4-year period.
4295. Sustained ventricular arrhythmias in patients receiving thrombolytic therapy: incidence and outcomes. The GUSTO Investigators.
作者: K H Newby.;T Thompson.;A Stebbins.;E J Topol.;R M Califf.;A Natale.
来源: Circulation. 1998年98卷23期2567-73页
Sustained ventricular tachycardia (VT) and fibrillation (VF) occur in up to 20% of patients with acute myocardial infarction (MI) and have been associated with a poor prognosis. The relationships among the type of arrhythmia (VT versus VF or both), time of VT/VF occurrence, use of thrombolytic agents, and eventual outcome are unclear.
4296. Thrombolytic therapy in acute myocardial infarction: comparison of procoagulant effects of streptokinase and alteplase regimens with focus on the kallikrein system and plasmin.
作者: H M Hoffmeister.;S Szabo.;C Kastner.;M E Beyer.;U Helber.;S Kazmaier.;H P Wendel.;W Heller.;L Seipel.
来源: Circulation. 1998年98卷23期2527-33页
Thrombolytic therapy in patients with acute myocardial infarction (AMI) is hampered by procoagulant effects. In vitro studies have indicated that plasmin stimulation activates the kallikrein-contact-phase system, resulting in thrombin activation. This prospective comparative study was designed to examine the procoagulant effects of streptokinase or alteplase in AMI.
4297. Cardiovascular events and their reduction with pravastatin in diabetic and glucose-intolerant myocardial infarction survivors with average cholesterol levels: subgroup analyses in the cholesterol and recurrent events (CARE) trial. The Care Investigators.
作者: R B Goldberg.;M J Mellies.;F M Sacks.;L A Moyé.;B V Howard.;W J Howard.;B R Davis.;T G Cole.;M A Pfeffer.;E Braunwald.
来源: Circulation. 1998年98卷23期2513-9页
Although diabetes is a major risk factor for coronary heart disease (CHD), little information is available on the effects of lipid lowering in diabetic patients. We determined whether lipid-lowering treatment with pravastatin prevents recurrent cardiovascular events in diabetic patients with CHD and average cholesterol levels.
4298. Effects of inhaled nitric oxide and oxygen in high-altitude pulmonary edema.
作者: I S Anand.;B A Prasad.;S S Chugh.;K R Rao.;D N Cornfield.;C E Milla.;N Singh.;S Singh.;W Selvamurthy.
来源: Circulation. 1998年98卷22期2441-5页
High-altitude pulmonary edema (HAPE) is characterized by pulmonary hypertension, increased pulmonary capillary permeability, and hypoxemia. Treatment is limited to descent to lower altitude and administration of oxygen.
4299. Diagnostic value of plasma levels of brain natriuretic peptide in arrhythmogenic right ventricular dysplasia.
作者: K Matsuo.;T Nishikimi.;C Yutani.;T Kurita.;W Shimizu.;A Taguchi.;K Suyama.;N Aihara.;S Kamakura.;K Kangawa.;M Takamiya.;K Shimomura.
来源: Circulation. 1998年98卷22期2433-40页
Arrhythmogenic right ventricular dysplasia (ARVD) is characterized by local or diffuse wall motion abnormalities in the right ventricle (RV), associated with recurrent ventricular tachycardia (VT) of RV origin. Brain natriuretic peptide (BNP) was first isolated from a porcine brain extract. In humans, BNP is expressed predominantly in the ventricles of failing hearts, and its expression has been observed primarily in myocytes in the interstitial fibrous area in dilated cardiomyopathy. We hypothesized that BNP is increasingly secreted from the residual myocytes within the atrophic tissue in patients with ARVD.
4300. Minimizing the inhaled dose of NO with breath-by-breath delivery of spikes of concentrated gas.
作者: Y Katayama.;T W Higenbottam.;G Cremona.;S Akamine.;E A Demoncheaux.;A P Smith.;T E Siddons.
来源: Circulation. 1998年98卷22期2429-32页
Pulmonary vasodilatation with a 100 ppm concentration of NO given as a short burst of a few milliliters at the beginning of each breath (NOmin) was compared with conventionally inhaled NO, in which a full breath of 40 ppm of NO was inhaled (NOCD).
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