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4282. Effects of stimulus intensity and electrode placement on the efficacy and cognitive effects of electroconvulsive therapy.
作者: H A Sackeim.;J Prudic.;D P Devanand.;J E Kiersky.;L Fitzsimons.;B J Moody.;M C McElhiney.;E A Coleman.;J M Settembrino.
来源: N Engl J Med. 1993年328卷12期839-46页
The efficacy of electroconvulsive therapy in major depression is established, but the importance of the electrical dosage and electrode placement in relation to efficacy and side effects is uncertain.
4283. The effect of varying levels of outdoor-air supply on the symptoms of sick building syndrome.
作者: R Menzies.;R Tamblyn.;J P Farant.;J Hanley.;F Nunes.;R Tamblyn.
来源: N Engl J Med. 1993年328卷12期821-7页
The sick building syndrome is the term given to a constellation of symptoms reported by workers in modern office buildings, hypothesized to occur when the supply of outdoor air is reduced, because of the accumulation of contaminants arising from within the building. We undertook this study to determine the effect of changing the supply of outdoor air in four office buildings on the symptoms reported by workers and their perception of the indoor environment.
4284. Tacrine in Alzheimer's disease.4285. Tacrine in Alzheimer's disease.4287. The effects of treatment with interleukin-1 alpha on platelet recovery after high-dose carboplatin.
作者: J W Smith.;D L Longo.;W G Alvord.;J E Janik.;W H Sharfman.;B L Gause.;B D Curti.;S P Creekmore.;J T Holmlund.;R G Fenton.
来源: N Engl J Med. 1993年328卷11期756-61页
Thrombocytopenia is a frequent side effect of cancer chemotherapy and commonly limits attempts to escalate drug doses. To determine whether interleukin-1 alpha could ameliorate carboplatin-induced thrombocytopenia, we combined it with high-dose carboplatin in 43 patients with advanced neoplasms.
4288. Cardioversion from atrial fibrillation without prolonged anticoagulation with use of transesophageal echocardiography to exclude the presence of atrial thrombi.
作者: W J Manning.;D I Silverman.;S P Gordon.;H M Krumholz.;P S Douglas.
来源: N Engl J Med. 1993年328卷11期750-5页
Because atrial thrombi are poorly detected by conventional noninvasive techniques such as transthoracic echocardiography, patients with prolonged atrial fibrillation usually receive several weeks of oral anticoagulation therapy before cardioversion is attempted. We wondered whether transesophageal echocardiography, an accurate method of detecting atrial thrombi, would allow early cardioversion to be performed safely if no thrombi were identified.
4289. A comparison of management patterns after acute myocardial infarction in Canada and the United States. The SAVE investigators.
作者: J L Rouleau.;L A Moyé.;M A Pfeffer.;J M Arnold.;V Bernstein.;T E Cuddy.;G R Dagenais.;E M Geltman.;S Goldman.;D Gordon.
来源: N Engl J Med. 1993年328卷11期779-84页
There are major differences in the organization of the health care systems in Canada and the United States. We hypothesized that these differences may be accompanied by differences in patient care.
4292. Immediate angioplasty compared with the administration of a thrombolytic agent followed by conservative treatment for myocardial infarction. The Mayo Coronary Care Unit and Catheterization Laboratory Groups.
作者: R J Gibbons.;D R Holmes.;G S Reeder.;K R Bailey.;M R Hopfenspirger.;B J Gersh.
来源: N Engl J Med. 1993年328卷10期685-91页
Immediate angioplasty and the administration of a thrombolytic agent followed by conservative treatment are two approaches to the management of acute myocardial infarction, but these methods have not been compared prospectively.
4293. A comparison of immediate coronary angioplasty with intravenous streptokinase in acute myocardial infarction.
作者: F Zijlstra.;M J de Boer.;J C Hoorntje.;S Reiffers.;J H Reiber.;H Suryapranata.
来源: N Engl J Med. 1993年328卷10期680-4页
Despite the widespread use of intravenous thrombolytic therapy and of immediate percutaneous transluminal coronary angioplasty for the treatment of acute myocardial infarction, randomized comparisons of the two approaches to reperfusion are lacking. We report the results of a prospective, randomized trial comparing immediate coronary angioplasty (without previous thrombolytic therapy) with intravenous streptokinase treatment.
4294. A comparison of immediate angioplasty with thrombolytic therapy for acute myocardial infarction. The Primary Angioplasty in Myocardial Infarction Study Group.
作者: C L Grines.;K F Browne.;J Marco.;D Rothbaum.;G W Stone.;J O'Keefe.;P Overlie.;B Donohue.;N Chelliah.;G C Timmis.
来源: N Engl J Med. 1993年328卷10期673-9页
The success of thrombolytic therapy for acute myocardial infarction is limited by bleeding complications, the impossibility of reperfusing all occluded coronary arteries, recurrent myocardial ischemia, and the relatively small number of patients who are appropriate candidates for this therapy. We hypothesized that these problems could be overcome by the use of immediate percutaneous transluminal coronary angioplasty (PTCA), without previous thrombolytic therapy.
4295. Effects of walnuts on serum lipid levels and blood pressure in normal men.
作者: J Sabaté.;G E Fraser.;K Burke.;S F Knutsen.;H Bennett.;K D Lindsted.
来源: N Engl J Med. 1993年328卷9期603-7页
In a recent six-year follow-up study, we found that frequent consumption of nuts was associated with a reduced risk of ischemic heart disease. To explore possible explanations for this finding, we studied the effects of nut consumption on serum lipids and blood pressure.
4296. Unrealistic expectations in the diagnosis and treatment of ovarian cancer.
作者: M A Friedman.;B A Chabner.;E L Trimble.;J Adams.;S G Arbuck.
来源: N Engl J Med. 1993年328卷9期664; author reply 664-5页 4297. Treatment of 171 patients with pulmonary tuberculosis resistant to isoniazid and rifampin.
作者: M Goble.;M D Iseman.;L A Madsen.;D Waite.;L Ackerson.;C R Horsburgh.
来源: N Engl J Med. 1993年328卷8期527-32页
The frequency of infection with multidrug-resistant Mycobacterium tuberculosis is increasing. We reviewed the clinical courses of 171 patients with pulmonary disease due to M. tuberculosis resistant to rifampin and isoniazid who were referred to our hospital between 1973 and 1983. The patients' records were analyzed retrospectively. Their regimens were selected individually and preferably included three medications that they had not been given previously and to which the strain was fully susceptible.
4298. Effect of calcium supplementation on bone loss in postmenopausal women.
The use of calcium supplements slows bone loss in the forearm and has a beneficial effect on the axial bone density of women in late menopause whose calcium intake is less than 400 mg per day. However, the effect of a calcium supplement of 1000 mg per day on the axial bone density of postmenopausal women with higher calcium intakes is not known.
4299. Recombinant factor VIII for the treatment of previously untreated patients with hemophilia A. Safety, efficacy, and development of inhibitors. Kogenate Previously Untreated Patient Study Group.
Although methods of viral attenuation in plasma-derived clotting-factor concentrates have improved, there is still a possibility that such concentrates may transmit certain blood-borne viruses. For this reason, the use of recombinant DNA-derived factor VIII (which is virus-free) to treat hemophilia A has generated considerable interest.
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