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4261. Alpha-adrenergic blockade improves recovery of myocardial perfusion and function after coronary stenting in patients with acute myocardial infarction.
作者: L Gregorini.;J Marco.;M Kozàkovà.;C Palombo.;G B Anguissola.;I Marco.;M Bernies.;B Cassagneau.;A Distante.;I M Bossi.;J Fajadet.;G Heusch.
来源: Circulation. 1999年99卷4期482-90页
AMI reperfusion by thrombolysis does not improve TIMI flow and LV function. The role of infarct-related artery (IRA) stenosis and superimposed changes in coronary vasomotor tone in maintaining LV dysfunction must be elucidated.
4262. Use of an extended monitoring strategy in patients with problematic syncope. Reveal Investigators.
The conventional investigation of patients who present with syncope involves short-term ECG monitoring or provocative testing with head-up tilt and electrophysiological testing. A symptom-rhythm correlation is often difficult to obtain during spontaneous syncope because of its sporadic, infrequent, and unpredictable nature.
4263. Vascular effects of estrogen and cholesterol-lowering therapies in hypercholesterolemic postmenopausal women.
作者: K K Koh.;C Cardillo.;M N Bui.;L Hathaway.;G Csako.;M A Waclawiw.;J A Panza.;R O Cannon.
来源: Circulation. 1999年99卷3期354-60页
Lipoproteins affect endothelium-dependent vasomotor responsiveness. Because lipoprotein effects of estrogen and cholesterol-lowering therapies differ, we studied the vascular responses to these therapies in hypercholesterolemic postmenopausal women.
4264. Prospective evaluation of the angiotensin-converting enzyme insertion/deletion polymorphism and the risk of stroke.
作者: R Y Zee.;P M Ridker.;M J Stampfer.;C H Hennekens.;K Lindpaintner.
来源: Circulation. 1999年99卷3期340-3页
The D/I polymorphism of the ACE gene has been studied in relation to a variety of cardiovascular disorders, including stroke. A number of small studies have been conducted, with inconsistent results. We investigated the association between ACE genotype and the incidence of stroke in a large, prospective, matched case-control sample from the Physicians' Health Study.
4265. Catheter ablation of accessory pathways, atrioventricular nodal reentrant tachycardia, and the atrioventricular junction: final results of a prospective, multicenter clinical trial. The Atakr Multicenter Investigators Group.
作者: H Calkins.;P Yong.;J M Miller.;B Olshansky.;M Carlson.;J P Saul.;S K Huang.;L B Liem.;L S Klein.;S A Moser.;D A Bloch.;P Gillette.;E Prystowsky.
来源: Circulation. 1999年99卷2期262-70页
The purpose of this study was to evaluate the safety and efficacy of a temperature-controlled radiofrequency catheter ablation system.
4266. Safety and efficacy of ticlopidine for only 2 weeks after successful intracoronary stent placement.
作者: P B Berger.;M R Bell.;D Hasdai.;D E Grill.;S Melby.;D R Holmes.
来源: Circulation. 1999年99卷2期248-53页
In patients receiving intracoronary stents, stent thrombosis is reduced when ticlopidine therapy is combined with aspirin after the procedure. However, ticlopidine causes neutropenia in 1% of patients when administered for >2 weeks, and little is known about the duration that ticlopidine needs be administered to prevent stent thrombosis.
4267. Two-year follow-up after catheter-based radiotherapy to inhibit coronary restenosis.
作者: P S Teirstein.;V Massullo.;S Jani.;R J Russo.;D A Cloutier.;R A Schatz.;E M Guarneri.;S Steuterman.;K Sirkin.;S Norman.;P Tripuraneni.
来源: Circulation. 1999年99卷2期243-7页
Although early trials indicate the treatment of restenosis with radiation therapy is safe and effective, the long-term impact of this new technology has been questioned. The possibility of late untoward consequences, such as aneurysm formation, perforation, and accelerated vascular disease, is of significant concern. Furthermore, it is not known whether the beneficial effects of radiation therapy will be durable or whether radiation will only delay restenosis.
4268. C-Reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort Study, 1984 to 1992.
作者: W Koenig.;M Sund.;M Fröhlich.;H G Fischer.;H Löwel.;A Döring.;W L Hutchinson.;M B Pepys.
来源: Circulation. 1999年99卷2期237-42页
Inflammatory reactions in coronary plaques play an important role in the pathogenesis of acute atherothrombotic events; inflammation elsewhere is also associated with both atherogenesis generally and its thrombotic complications. Recent studies indicate that systemic markers of inflammation can identify subjects at high risk of coronary events.
4269. Reduction of stroke incidence after myocardial infarction with pravastatin: the Cholesterol and Recurrent Events (CARE) study. The Care Investigators.
作者: J F Plehn.;B R Davis.;F M Sacks.;J L Rouleau.;M A Pfeffer.;V Bernstein.;T E Cuddy.;L A Moyé.;L B Piller.;J Rutherford.;L M Simpson.;E Braunwald.
来源: Circulation. 1999年99卷2期216-23页
The role of lipid modification in stroke prevention is controversial, although increasing evidence suggests that HMG-CoA reductase inhibition may reduce cerebrovascular events in patients with prevalent coronary artery disease.
4270. Attenuation of cyclic nucleotide-mediated smooth muscle relaxation in blacks as a cause of racial differences in vasodilator function.
Vasodilator reactivity is attenuated in normotensive blacks, and this may contribute to their enhanced susceptibility to hypertension and its complications. However, the mechanisms responsible for this phenomenon are unknown. We therefore studied nitric oxide (NO)-dependent and -independent vasorelaxation in healthy blacks and whites to investigate the nature of racial differences in vasodilator function.
4271. Recombinant hirudin (lepirudin) provides safe and effective anticoagulation in patients with heparin-induced thrombocytopenia: a prospective study.
作者: A Greinacher.;H Völpel.;U Janssens.;V Hach-Wunderle.;B Kemkes-Matthes.;P Eichler.;H G Mueller-Velten.;B Pötzsch.
来源: Circulation. 1999年99卷1期73-80页
The immunological type of heparin-induced thrombocytopenia (HIT) is the most frequent drug-induced thrombocytopenia. This study evaluated the efficacy of recombinant hirudin (r-hirudin or lepirudin), a potent thrombin inhibitor, for anticoagulation in patients with confirmed HIT.
4272. Activation of beta2-adrenergic receptors hastens relaxation and mediates phosphorylation of phospholamban, troponin I, and C-protein in ventricular myocardium from patients with terminal heart failure.
作者: A Kaumann.;S Bartel.;P Molenaar.;L Sanders.;K Burrell.;D Vetter.;P Hempel.;P Karczewski.;E G Krause.
来源: Circulation. 1999年99卷1期65-72页
Catecholamines hasten cardiac relaxation through beta-adrenergic receptors, presumably by phosphorylation of several proteins, but it is unknown which receptor subtypes are involved in human ventricle. We assessed the role of beta1- and beta2-adrenergic receptors in phosphorylating proteins implicated in ventricular relaxation.
4273. Sustained improvement in flow-mediated vasodilation after short-term administration of dobutamine in patients with severe congestive heart failure.
作者: M B Patel.;I V Kaplan.;R N Patni.;D Levy.;J A Strom.;J Shirani.;T H LeJemtel.
来源: Circulation. 1999年99卷1期60-4页
In patients with severe congestive heart failure (CHF), short-term administration of dobutamine exerts sustained clinical benefits that are partially mediated by a training-like effect on skeletal muscle. Recently, physical training has been shown to enhance endothelial function in the skeletal muscle vasculature by improving endothelial function. Whether the dobutamine-induced training effect is also associated with an improvement in endothelial function in the skeletal muscle vasculature is currently unknown.
4274. Superoxide production, risk factors, and endothelium-dependent relaxations in human internal mammary arteries.
作者: C Huraux.;T Makita.;S Kurz.;K Yamaguchi.;F Szlam.;M M Tarpey.;J N Wilcox.;D G Harrison.;J H Levy.
来源: Circulation. 1999年99卷1期53-9页
In a variety of disease states, endothelium-dependent vasodilation is abnormal. Reduced nitric oxide (NO) production, increased destruction of NO by superoxide, diminished cellular levels of L-arginine or tetrahydrobiopterin, and alterations in membrane signaling have been implicated. We examined these potential mechanisms in human vessels.
4275. Effects of probucol on vascular remodeling after coronary angioplasty. Multivitamins and Protocol Study Group.
作者: G Côté.;J C Tardif.;J Lespérance.;J Lambert.;M Bourassa.;R Bonan.;G Gosselin.;M Joyal.;J F Tanguay.;S Nattel.;R Gallo.;J Crépeau.
来源: Circulation. 1999年99卷1期30-5页
We have shown that probucol reduces restenosis after balloon angioplasty. Whether probucol acted via prevention of neointimal formation or improvement in vascular remodeling could not be addressed by angiography and required the use of intravascular ultrasound (IVUS).
4276. Percutaneous transluminal therapy of occluded saphenous vein grafts: can the challenge be met with ultrasound thrombolysis?
作者: U Rosenschein.;G Gaul.;R Erbel.;F Amann.;D Velasguez.;H Stoerger.;R Simon.;G Gomez.;J Troster.;A Bartorelli.;M Pieper.;Z Kyriakides.;S Laniado.;H I Miller.;A Cribier.;J Fajadet.
来源: Circulation. 1999年99卷1期26-9页
Percutaneous transluminal treatment of a thrombotic vein graft yields poor results. We have previously reported our experience with transluminal percutaneous coronary ultrasound thrombolysis (CUT) in the setting of acute myocardial infarction (AMI). This report describes the first experience with ultrasound thrombolysis in thrombus-rich lesions in saphenous vein grafts (SVGs), most of which were occluded.
4277. Metabolic modulation of acute myocardial infarction. The ECLA (Estudios Cardiológicos Latinoamérica) Collaborative Group.
作者: R Díaz.;E A Paolasso.;L S Piegas.;C D Tajer.;M G Moreno.;R Corvalán.;J E Isea.;G Romero.
来源: Circulation. 1998年98卷21期2227-34页
Several trials have been performed in the past using glucose, insulin, and potassium infusion (GIK) for the treatment of acute myocardial infarction (AMI). Because of continuing uncertainty about the potential role of this therapeutic intervention, we conducted a randomized trial to evaluate the impact of a GIK solution during the first hours of AMI.
4278. Differential effects of quinaprilat and enalaprilat on endothelial function of conduit arteries in patients with chronic heart failure.
Chronic heart failure (CHF) is associated with endothelial dysfunction, including impaired flow-dependent (endothelium-mediated) dilation (FDD). We have previously shown that ACE inhibition improves endothelium-mediated vasodilation in healthy volunteers. The present study was designed to determine whether ACE inhibition improves the impaired FDD in patients with CHF. Because their affinity to tissue ACE may influence the ability of ACE inhibitors to affect endothelial function, we compared the effects of quinaprilat (high affinity to tissue ACE) and enalaprilat (low affinity to tissue ACE) on FDD in patients with CHF.
4279. TNK-tissue plasminogen activator compared with front-loaded alteplase in acute myocardial infarction: results of the TIMI 10B trial. Thrombolysis in Myocardial Infarction (TIMI) 10B Investigators.
作者: C P Cannon.;C M Gibson.;C H McCabe.;A A Adgey.;M J Schweiger.;R F Sequeira.;G Grollier.;R P Giugliano.;M Frey.;H S Mueller.;R M Steingart.;W D Weaver.;F Van de Werf.;E Braunwald.
来源: Circulation. 1998年98卷25期2805-14页
Bolus thrombolytic therapy is a simplified means of administering thrombolysis that facilitates rapid time to treatment. TNK-tissue plasminogen activator (TNK-tPA) is a highly fibrin-specific single-bolus thrombolytic agent.
4280. Gene therapy for myocardial angiogenesis: initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia.
作者: D W Losordo.;P R Vale.;J F Symes.;C H Dunnington.;D D Esakof.;M Maysky.;A B Ashare.;K Lathi.;J M Isner.
来源: Circulation. 1998年98卷25期2800-4页
We initiated a phase 1 clinical study to determine the safety and bioactivity of direct myocardial gene transfer of vascular endothelial growth factor (VEGF) as sole therapy for patients with symptomatic myocardial ischemia.
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