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4221. Effect of atrial natriuretic peptide on muscle sympathetic activity and its reflex control in human heart failure.
The purpose of this study was to determine if atrial natriuretic peptide (ANP) exerts a relative inhibitory effect on muscle sympathetic nerve activity (MSNA) at rest and during nonhypotensive lower body negative pressure (LBNP) in heart failure, as in healthy subjects.
4222. Endothelium-dependent and -independent perfusion reserve and the effect of L-arginine on myocardial perfusion in patients with syndrome X.
Impaired vasodilatation capacity in patients with angina pectoris and a normal coronary arteriogram (syndrome X [SX]) has been reported. Most studies report on the response in epicardial vessels. This does not necessarily reflect compromised myocardial microcirculation. Lack of the NO precursor L-arginine has been suggested as a possible cause.
4223. Augmented sympathetic activation during short-term hypoxia and high-altitude exposure in subjects susceptible to high-altitude pulmonary edema.
作者: H Duplain.;L Vollenweider.;A Delabays.;P Nicod.;P Bärtsch.;U Scherrer.
来源: Circulation. 1999年99卷13期1713-8页
Pulmonary hypertension is a hallmark of high-altitude pulmonary edema and may contribute to its pathogenesis. Cardiovascular adjustments to hypoxia are mediated, at least in part, by the sympathetic nervous system, and sympathetic activation promotes pulmonary vasoconstriction and alveolar fluid flooding in experimental animals.
4224. Abnormal norepinephrine clearance and adrenergic receptor sensitivity in idiopathic orthostatic intolerance.
作者: G Jacob.;J R Shannon.;F Costa.;R Furlan.;I Biaggioni.;R Mosqueda-Garcia.;R M Robertson.;D Robertson.
来源: Circulation. 1999年99卷13期1706-12页
Chronic orthostatic intolerance (OI) is characterized by symptoms of inadequate cerebral perfusion with standing, in the absence of significant orthostatic hypotension. A heart rate increase of >/=30 bpm is typical. Possible underlying pathophysiologies include hypovolemia, partial dysautonomia, or a primary hyperadrenergic state. We tested the hypothesis that patients with OI have functional abnormalities in autonomic neurons regulating cardiovascular responses.
4225. Design and results of the antiarrhythmics vs implantable defibrillators (AVID) registry. The AVID Investigators.
作者: J L Anderson.;A P Hallstrom.;A E Epstein.;S L Pinski.;Y Rosenberg.;M O Nora.;D Chilson.;D S Cannom.;R Moore.
来源: Circulation. 1999年99卷13期1692-9页
The Antiarrhythmics Versus Implantable Defibrillators (AVID) Study compared treatment with implantable cardioverter-defibrillators versus antiarrhythmic drugs in patients with life-threatening ventricular arrhythmias (VAs). AVID maintained a Registry on all patients, randomized or not, with any VA or unexplained syncope who could be considered for either of the treatment strategies. Trial-eligible arrhythmias were the categories of VF cardiac arrest, Syncopal VT, and Symptomatic VT, below.
4226. Coronary flow reserve in young men with familial combined hyperlipidemia.
作者: O P Pitkänen.;P Nuutila.;O T Raitakari.;K Porkka.;H Iida.;I Nuotio.;T Rönnemaa.;J Viikari.;M R Taskinen.;C Ehnholm.;J Knuuti.
来源: Circulation. 1999年99卷13期1678-84页
Familial combined hyperlipidemia (FCHL) is a common hereditary disorder of lipoprotein metabolism estimated to cause 10% to 20% of premature coronary heart disease. We investigated whether functional abnormalities exist in coronary reactivity in asymptomatic patients with FCHL.
4227. Acute anti-ischemic effect of testosterone in men with coronary artery disease.
作者: G M Rosano.;F Leonardo.;P Pagnotta.;F Pelliccia.;G Panina.;E Cerquetani.;P L della Monica.;B Bonfigli.;M Volpe.;S L Chierchia.
来源: Circulation. 1999年99卷13期1666-70页
The role of testosterone on the development of coronary artery disease in men is controversial. The evidence that men have a greater incidence of coronary artery disease than women of a similar age suggests a possible causal role of testosterone. Conversely, recent studies have shown that the hormone improves endothelium-dependent relaxation of coronary arteries in men. Accordingly, the aim of the present study was to evaluate the effect of acute administration of testosterone on exercise-induced myocardial ischemia in men.
4228. Effects of intracoronary beta-radiation therapy after coronary angioplasty: an intravascular ultrasound study.
作者: D Meerkin.;J C Tardif.;I R Crocker.;A Arsenault.;M Joyal.;G Lucier.;S B King.;D O Williams.;P W Serruys.;R Bonan.
来源: Circulation. 1999年99卷13期1660-5页
Endovascular radiation is emerging as a potential solution for the prevention and treatment of restenosis. Its effects on the morphology of unstented vessels cannot be determined by angiography and therefore require the use of intravascular ultrasound.
4229. Prospective randomized study of ablation and pacing versus medical therapy for paroxysmal atrial fibrillation: effects of pacing mode and mode-switch algorithm.
作者: H J Marshall.;Z I Harris.;M J Griffith.;R L Holder.;M D Gammage.
来源: Circulation. 1999年99卷12期1587-92页
Atrioventricular (AV) node ablation and pacing has become accepted therapy for drug-refractory paroxysmal atrial fibrillation (PAF). However, few data demonstrate its superiority over continued medical therapy. The influence of pacing mode and mode-switch algorithm has not been investigated.
4230. Long-term clinical and echocardiographic follow-up after percutaneous mitral valvuloplasty with the Inoue balloon.
作者: R Hernandez.;C Bañuelos.;F Alfonso.;J Goicolea.;A Fernández-Ortiz.;J Escaned.;L Azcona.;C Almeria.;C Macaya.
来源: Circulation. 1999年99卷12期1580-6页
The objective of this study was to assess the long-term clinical outcome and valvular changes (area and regurgitation) after percutaneous mitral valvuloplasty (PMV).
4231. Improved left ventricular mechanics from acute VDD pacing in patients with dilated cardiomyopathy and ventricular conduction delay.
作者: D A Kass.;C H Chen.;C Curry.;M Talbot.;R Berger.;B Fetics.;E Nevo.
来源: Circulation. 1999年99卷12期1567-73页
Ventricular pacing can improve hemodynamics in heart failure patients, but direct effects on left ventricular (LV) function from varying pacing site and atrioventricular (AV) delay remain unknown. We hypothesized that the magnitude and location of basal intraventricular conduction delay critically influences pacing responses and that single-site pacing in the delay-activated region yields similar or better responses to biventricular pacing.
4232. Treatment of Helicobacter pylori and Chlamydia pneumoniae infections decreases fibrinogen plasma level in patients with ischemic heart disease.
作者: G Torgano.;R Cosentini.;C Mandelli.;R Perondi.;F Blasi.;G Bertinieri.;T V Tien.;G Ceriani.;P Tarsia.;C Arosio.;M L Ranzi.
来源: Circulation. 1999年99卷12期1555-9页
Chronic Chlamydia pneumoniae and Helicobacter pylori infections could be a risk factor for ischemic heart disease (IHD), possibly by increasing fibrinogen levels. The aim of our study was to evaluate changes in fibrinogen level in patients with IHD and H pylori and/or C pneumoniae positivity randomly assigned to antibiotic treatment.
4233. Clinical and angiographic follow-Up after primary stenting in acute myocardial infarction: the Primary Angioplasty in Myocardial Infarction (PAMI) stent pilot trial.
作者: G W Stone.;B R Brodie.;J J Griffin.;C Costantini.;M C Morice.;F G St Goar.;P A Overlie.;J J Popma.;J McDonnell.;D Jones.;W W O'Neill.;C L Grines.
来源: Circulation. 1999年99卷12期1548-54页
Restenosis has been reported in as many as 50% of patients within 6 months after PTCA in acute myocardial infarction (AMI), which necessitates repeat target-vessel revascularization (TVR) in approximately 20% of patients during this time period. Routine (primary) stent implantation after PTCA has the potential to further improve late outcomes.
4234. Randomized secondary prevention trial of azithromycin in patients with coronary artery disease and serological evidence for Chlamydia pneumoniae infection: The Azithromycin in Coronary Artery Disease: Elimination of Myocardial Infection with Chlamydia (ACADEMIC) study.
作者: J L Anderson.;J B Muhlestein.;J Carlquist.;A Allen.;S Trehan.;C Nielson.;S Hall.;J Brady.;M Egger.;B Horne.;T Lim.
来源: Circulation. 1999年99卷12期1540-7页
Chlamydia pneumoniae commonly causes respiratory infection, is vasotropic, causes atherosclerosis in animal models, and has been found in human atheromas. Whether it plays a causal role in clinical coronary artery disease (CAD) and is amenable to antibiotic therapy is uncertain.
4235. Effect of etilefrine in preventing syncopal recurrence in patients with vasovagal syncope: a double-blind, randomized, placebo-controlled trial. The Vasovagal Syncope International Study.
作者: A Raviele.;M Brignole.;R Sutton.;P Alboni.;P Giani.;C Menozzi.;A Moya.
来源: Circulation. 1999年99卷11期1452-7页
Etilefrine is an alpha-agonist agent with a potent vasoconstrictor effect, which is potentially useful in preventing vasovagal syncope by reducing venous pooling and/or by counteracting reflex arteriolar vasodilatation. The present multicenter, randomized, placebo-controlled study was designed to evaluate the efficacy of this drug for the long-term management of patients with recurrent vasovagal syncope.
4236. Atrial fibrillation detection and R-wave synchronization by Metrix implantable atrial defibrillator: implications for long-term efficacy and safety. The Metrix Investigators.
作者: H F Tse.;C P Lau.;J S Sra.;H J Crijns.;N Edvardsson.;S Kacet.;D G Wyse.
来源: Circulation. 1999年99卷11期1446-51页
The long-term efficacy of atrial fibrillation (AF) detection and R-wave synchronization are critical safety requirements for the development of an implantable atrial defibrillator (IAD) for treatment of AF.
4237. Mechanisms of death in the CABG Patch trial: a randomized trial of implantable cardiac defibrillator prophylaxis in patients at high risk of death after coronary artery bypass graft surgery.
作者: J T Bigger.;W Whang.;J N Rottman.;R E Kleiger.;C D Gottlieb.;P B Namerow.;R C Steinman.;N A Estes.
来源: Circulation. 1999年99卷11期1416-21页
The CABG Patch trial compared prophylactic implantable cardiac-defibrillator (ICD) implantation with no antiarrhythmic therapy in coronary bypass surgery patients who had a left ventricular ejection fraction <0.36 and an abnormal signal-averaged ECG. There were 102 deaths among the 446 ICD group patients and 96 deaths among the 454 control group patients, a hazard ratio of 1.07 (P=0.63). The mechanisms of death were classified, and hypotheses were tested about the effects of ICD therapy on arrhythmic and nonarrhythmic cardiac deaths in the CABG Patch Trial and the Multicenter Automatic Defibrillator Implantation Trial (MADIT).
4239. Prenatal features of ductus arteriosus constriction and restrictive foramen ovale in d-transposition of the great arteries.
作者: Y V Maeno.;S A Kamenir.;B Sinclair.;M E van der Velde.;J F Smallhorn.;L K Hornberger.
来源: Circulation. 1999年99卷9期1209-14页
Although most neonates with d-transposition of the great arteries (TGA) have an uncomplicated preoperative course, some with a restrictive foramen ovale (FO), ductus arteriosus (DA) constriction, or pulmonary hypertension may be severely hypoxemic and even die shortly after birth. Our goal was to determine whether prenatal echocardiography can identify these high-risk fetuses with TGA.
4240. Vasodilator therapy for primary pulmonary hypertension in children.
This report presents 13 years of experience with vasodilator therapy for primary pulmonary hypertension (PPH) in children. Two eras were involved: between 1982 and 1987, oral calcium channel blockers were the only agents available for long-term therapy; after 1987, prostacyclin (PGI2) has been available for long-term intravenous use.
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