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4184. Type 1 diabetes in the BB rat: a polygenic disease.
作者: Robert H Wallis.;KeSheng Wang.;Leili Marandi.;Eugene Hsieh.;Terri Ning.;Gary Y C Chao.;Janice Sarmiento.;Andrew D Paterson.;Philippe Poussier.
来源: Diabetes. 2009年58卷4期1007-17页
Two type 1 diabetes susceptibility genes have been identified in the spontaneously diabetic biobreeding diabetes-prone (BBDP) rat, the major histocompatibility complex (MHC) (RT1) class II u haplotype (Iddm1) and Gimap5 (Iddm2). The strong effects of these have impeded previous efforts to map additional loci. We tested the hypothesis that type 1 diabetes is a polygenic disease in the BBDP rat.
4185. FOXO1 plays an important role in enhanced microvascular cell apoptosis and microvascular cell loss in type 1 and type 2 diabetic rats.
作者: Yugal Behl.;Padmaja Krothapalli.;Tesfahun Desta.;Sayon Roy.;Dana T Graves.
来源: Diabetes. 2009年58卷4期917-25页
To investigate early events leading to microvascular cell loss in diabetic retinopathy.
4186. BMI changes during childhood and adolescence as predictors of amount of adult subcutaneous and visceral adipose tissue in men: the GOOD Study.
作者: Jenny M Kindblom.;Mattias Lorentzon.;Asa Hellqvist.;Lars Lönn.;John Brandberg.;Staffan Nilsson.;Ensio Norjavaara.;Claes Ohlsson.
来源: Diabetes. 2009年58卷4期867-74页
The amount of visceral adipose tissue is a risk factor for the metabolic syndrome. It is unclear how BMI changes during childhood and adolescence predict adult fat distribution. We hypothesized that there are critical periods during development for the prediction of adult subcutaneous and visceral fat mass by BMI changes during childhood and adolescence.
4187. TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells.
作者: Gabriela da Silva Xavier.;Merewyn K Loder.;Angela McDonald.;Andrei I Tarasov.;Raffaella Carzaniga.;Katrin Kronenberger.;Sebastian Barg.;Guy A Rutter.
来源: Diabetes. 2009年58卷4期894-905页
Polymorphisms in the human TCF7L2 gene are associated with reduced insulin secretion and an increased risk of type 2 diabetes. However, the mechanisms by which TCF7L2 affect insulin secretion are still unclear. We define the effects of TCF7L2 expression level on mature beta-cell function and suggest a potential mechanism for its actions.
4188. Common variants of hepatocyte nuclear factor 1beta are associated with type 2 diabetes in a Chinese population.
作者: Congrong Wang.;Cheng Hu.;Rong Zhang.;Yuqian Bao.;Xiaojing Ma.;Jingyi Lu.;Wen Qin.;Xinyu Shao.;Junxi Lu.;Jing Xu.;Huijuan Lu.;Kunsan Xiang.;Weiping Jia.
来源: Diabetes. 2009年58卷4期1023-7页
Hepatocyte nuclear factor 1beta (HNF1beta) is a transcription factor that is critical for pancreatic cell formation and glucose homeostasis. Previous studies have reported that common variants of HNF1beta were associated with type 2 diabetes in Caucasians and West Africans. However, analysis in the subjects from the Botnia study and Malmö Preventive Project produced conflicting results, and the role for HNF1beta in type 2 diabetes susceptibility remains unclear. We therefore investigated common variants across the HNF1beta gene in a Chinese population.
4189. Mice with hyperghrelinemia are hyperphagic and glucose intolerant and have reduced leptin sensitivity.
作者: Gavin A Bewick.;Aysha Kent.;Daniel Campbell.;Michael Patterson.;Mohammed A Ghatei.;Stephen R Bloom.;James V Gardiner.
来源: Diabetes. 2009年58卷4期840-6页
Ghrelin is the only known peripheral hormone to increase ingestive behavior. However, its role in the physiological regulation of energy homeostasis is unclear because deletion of ghrelin or its receptor does not alter food intake or body weight in mice fed a normal chow diet. We hypothesized that overexpression of ghrelin in its physiological tissues would increase food intake and body weight.
4190. Rapamycin prevents and breaks the anti-CD3-induced tolerance in NOD mice.
作者: Andrea Valle.;Tatiana Jofra.;Angela Stabilini.;Mark Atkinson.;Maria-Grazia Roncarolo.;Manuela Battaglia.
来源: Diabetes. 2009年58卷4期875-81页
Non-Fc-binding anti-CD3-specific antibodies represent a promising therapy for preserving C-peptide production in subjects with recent-onset type 1 diabetes. However, the mechanisms by which anti-CD3 exerts its beneficial effect are still poorly understood, and it is questionable whether this therapeutic approach will prove durable with regard to its ability to impart metabolic preservation without additional actions designed to maintain immunological tolerance. We used the NOD mouse model to test whether rapamycin, a compound well-known for its immunomodulatory activity in mice and humans, could increase the therapeutic effectiveness of anti-CD3 treatment in type 1 diabetes.
4191. GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice.
作者: Mohammad Hossein Noyan-Ashraf.;M Abdul Momen.;Kiwon Ban.;Al-Muktafi Sadi.;Yu-Qing Zhou.;Ali M Riazi.;Laurie L Baggio.;R Mark Henkelman.;Mansoor Husain.;Daniel J Drucker.
来源: Diabetes. 2009年58卷4期975-83页
Glucagon-like peptide-1 receptor (GLP-1R) agonists are used to treat type 2 diabetes, and transient GLP-1 administration improved cardiac function in humans after acute myocardial infarction (MI) and percutaneous revascularization. However, the consequences of GLP-1R activation before ischemic myocardial injury remain unclear.
4192. Successful versus failed adaptation to high-fat diet-induced insulin resistance: the role of IAPP-induced beta-cell endoplasmic reticulum stress.
作者: Aleksey V Matveyenko.;Tatyana Gurlo.;Marie Daval.;Alexandra E Butler.;Peter C Butler.
来源: Diabetes. 2009年58卷4期906-16页
Obesity is a known risk factor for type 2 diabetes. However, most obese individuals do not develop diabetes because they adapt to insulin resistance by increasing beta-cell mass and insulin secretion. Islet pathology in type 2 diabetes is characterized by beta-cell loss, islet amyloid derived from islet amyloid polypeptide (IAPP), and increased beta-cell apoptosis characterized by endoplasmic reticulum (ER) stress. We hypothesized that IAPP-induced ER stress distinguishes successful versus unsuccessful islet adaptation to insulin resistance.
4193. Relationship of metabolic syndrome with incident aortic valve calcium and aortic valve calcium progression: the Multi-Ethnic Study of Atherosclerosis (MESA).
作者: Ronit Katz.;Matthew J Budoff.;Junichiro Takasu.;David M Shavelle.;Alain Bertoni.;Roger S Blumenthal.;Pamela Ouyang.;Nathan D Wong.;Kevin D O'Brien.
来源: Diabetes. 2009年58卷4期813-9页
Metabolic syndrome (MetS) has been associated with increased prevalence of aortic valve calcium (AVC) and with increased progression of aortic stenosis. The purpose of this study was to determine whether MetS is associated with increased risks for the development of new ("incident") AVC or for progression of established AVC as assessed by CT.
4194. Location of arterial stiffening differs in those with impaired fasting glucose versus diabetes: implications for left ventricular hypertrophy from the Multi-Ethnic Study of Atherosclerosis.
作者: Pairoj Rerkpattanapipat.;Ralph B D'Agostino.;Kerry M Link.;Eyal Shahar.;Joao A Lima.;David A Bluemke.;Shantanu Sinha.;David M Herrington.;W Gregory Hundley.
来源: Diabetes. 2009年58卷4期946-53页
To determine whether middle-aged and older individuals with impaired fasting glucose (IFG), but no clinical evidence of cardiovascular disease, exhibit abnormal changes in proximal thoracic aortic stiffness or left ventricular (LV) mass when compared with healthy counterparts.
4195. Beta-Cell hyperplasia induced by hepatic insulin resistance: role of a liver-pancreas endocrine axis through insulin receptor A isoform.
作者: Oscar Escribano.;Carlos Guillén.;Carmen Nevado.;Almudena Gómez-Hernández.;C Ronald Kahn.;Manuel Benito.
来源: Diabetes. 2009年58卷4期820-8页
Type 2 diabetes results from a combination of insulin resistance and impaired insulin secretion. To directly address the effects of hepatic insulin resistance in adult animals, we developed an inducible liver-specific insulin receptor knockout mouse (iLIRKO).
4196. Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium.
作者: Patrick Concannon.;Wei-Min Chen.;Cécile Julier.;Grant Morahan.;Beena Akolkar.;Henry A Erlich.;Joan E Hilner.;Jørn Nerup.;Concepcion Nierras.;Flemming Pociot.;John A Todd.;Stephen S Rich.; .
来源: Diabetes. 2009年58卷4期1018-22页
Type 1 diabetes arises from the actions of multiple genetic and environmental risk factors. Considerable success at identifying common genetic variants that contribute to type 1 diabetes risk has come from genetic association (primarily case-control) studies. However, such studies have limited power to detect genes containing multiple rare variants that contribute significantly to disease risk.
4197. Ciliary neurotrophic factor stimulates muscle glucose uptake by a PI3-kinase-dependent pathway that is impaired with obesity.
作者: Gregory R Steinberg.;Matthew J Watt.;Matthias Ernst.;Morris J Birnbaum.;Bruce E Kemp.;Sebastian Beck Jørgensen.
来源: Diabetes. 2009年58卷4期829-39页
Ciliary neurotrophic factor (CNTF) reverses muscle insulin resistance by increasing fatty acid oxidation through gp130-LIF receptor signaling to the AMP-activated protein kinase (AMPK). CNTF also increases Akt signaling in neurons and adipocytes. Because both Akt and AMPK regulate glucose uptake, we investigated muscle glucose uptake in response to CNTF signaling in lean and obese mice.
4198. Survey of the human pancreatic beta-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta-cell replication and function in vivo.
作者: Nathalie Fiaschi-Taesch.;Todd A Bigatel.;Brian Sicari.;Karen K Takane.;Fatima Salim.;Silvia Velazquez-Garcia.;George Harb.;Karen Selk.;Irene Cozar-Castellano.;Andrew F Stewart.
来源: Diabetes. 2009年58卷4期882-93页
To comprehensively inventory the proteins that control the G1/S cell cycle checkpoint in the human islet and compare them with those in the murine islet, to determine whether these might therapeutically enhance human beta-cell replication, to determine whether human beta-cell replication can be demonstrated in an in vivo model, and to enhance human beta-cell function in vivo.
4199. Sex and depot differences in adipocyte insulin sensitivity and glucose metabolism.
To investigate how insulin sensitivity and glucose metabolism differ in adipocytes between different fat depots of male and female mice and how sex steroids contribute to these differences.
4200. Pharmacological stimulation of NADH oxidation ameliorates obesity and related phenotypes in mice.
作者: Jung Hwan Hwang.;Dong Wook Kim.;Eun Jin Jo.;Yong Kyung Kim.;Young Suk Jo.;Ji Hoon Park.;Sang Ku Yoo.;Myung Kyu Park.;Tae Hwan Kwak.;Young Lim Kho.;Jin Han.;Hueng-Sik Choi.;Sang-Hee Lee.;Jin Man Kim.;InKyu Lee.;Taeyoon Kyung.;Cholsoon Jang.;Jongkyeong Chung.;Gi Ryang Kweon.;Minho Shong.
来源: Diabetes. 2009年58卷4期965-74页
Nicotinamide adenine dinucleotides (NAD+ and NADH) play a crucial role in cellular energy metabolism, and a dysregulated NAD+-to-NADH ratio is implicated in metabolic syndrome. However, it is still unknown whether a modulating intracellular NAD+-to-NADH ratio is beneficial in treating metabolic syndrome. We tried to determine whether pharmacological stimulation of NADH oxidation provides therapeutic effects in rodent models of metabolic syndrome.
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