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4181. Relationship between delay in performing direct coronary angioplasty and early clinical outcome in patients with acute myocardial infarction: results from the global use of strategies to open occluded arteries in Acute Coronary Syndromes (GUSTO-IIb) trial.
作者: P B Berger.;S G Ellis.;D R Holmes.;C B Granger.;D A Criger.;A Betriu.;E J Topol.;R M Califf.
来源: Circulation. 1999年100卷1期14-20页
Time to treatment with thrombolytic therapy is a critical determinant of mortality in acute myocardial infarction. Little is known about the relationship between the time to treatment with direct coronary angioplasty and clinical outcome. The objectives of this study were to determine both the time required to perform direct coronary angioplasty in the Global Use of Strategies to Open Occluded Arteries in Acute Coronary Syndromes (GUSTO-IIb) trial and its relationship to clinical outcome.
4182. Five-year outcome in patients with isolated proximal left anterior descending coronary artery stenosis treated by angioplasty or left internal mammary artery grafting. A prospective trial.
作者: J J Goy.;E Eeckhout.;C Moret.;B Burnand.;P Vogt.;J C Stauffer.;M Hurni.;F Stumpe.;P Ruchat.;L von Segesser.;P Urban.;L Kappenberger.
来源: Circulation. 1999年99卷25期3255-9页
Percutaneous transluminal coronary angioplasty (PTCA) and coronary artery bypass surgery (CABG) improve the clinical status of patients with isolated proximal left anterior descending coronary artery stenosis. At 2 years, only additional revascularization was more frequently required after PTCA.
4183. Long-term ascorbic acid administration reverses endothelial vasomotor dysfunction in patients with coronary artery disease.
作者: N Gokce.;J F Keaney.;B Frei.;M Holbrook.;M Olesiak.;B J Zachariah.;C Leeuwenburgh.;J W Heinecke.;J A Vita.
来源: Circulation. 1999年99卷25期3234-40页
Loss of endothelium-derived nitric oxide (EDNO) contributes to the clinical expression of coronary artery disease (CAD). Increased oxidative stress has been linked to impaired endothelial vasomotor function in atherosclerosis, and recent studies demonstrated that short-term ascorbic acid treatment improves endothelial function.
4184. Cholesterol reduction rapidly improves endothelial function after acute coronary syndromes. The RECIFE (reduction of cholesterol in ischemia and function of the endothelium) trial.
Cholesterol lowering reduces coronary events. One mechanism could be improvement of endothelial function. In line with this hypothesis, this study investigates whether cholesterol reduction can result in rapid improvement of endothelial function after acute coronary syndromes.
4185. Safety and efficacy of a soluble P75 tumor necrosis factor receptor (Enbrel, etanercept) in patients with advanced heart failure.
作者: A Deswal.;B Bozkurt.;Y Seta.;S Parilti-Eiswirth.;F A Hayes.;C Blosch.;D L Mann.
来源: Circulation. 1999年99卷25期3224-6页
Although previous studies suggested that TNF may contribute to heart failure progression, it is unclear whether antagonizing TNF is beneficial in heart failure patients.
4186. Health-related quality of life after angioplasty and stent placement in patients with iliac artery occlusive disease: results of a randomized controlled clinical trial. The Dutch Iliac Stent Trial Study Group.
To assess the quality of life in patients with iliac artery occlusive disease, we compared primary stent placement versus primary angioplasty followed by selective stent placement in a multicenter randomized controlled trial.
4187. Preintervention arterial remodeling as an independent predictor of target-lesion revascularization after nonstent coronary intervention: an analysis of 777 lesions with intravascular ultrasound imaging.
作者: G Dangas.;G S Mintz.;R Mehran.;A J Lansky.;R Kornowski.;A D Pichard.;L F Satler.;K M Kent.;G W Stone.;M B Leon.
来源: Circulation. 1999年99卷24期3149-54页
Pathological and intravascular ultrasound (IVUS) studies have documented arterial remodeling during atherogenesis. However, the impact of this remodeling process on the long-term outcome after percutaneous intervention is unknown.
4188. Improved coronary artery definition with T2-weighted, free-breathing, three-dimensional coronary MRA.
作者: R M Botnar.;M Stuber.;P G Danias.;K V Kissinger.;W J Manning.
来源: Circulation. 1999年99卷24期3139-48页
Three-dimensional (3D) navigator-gated and prospectively corrected free-breathing coronary magnetic resonance angiography (MRA) allows for submillimeter image resolution but suffers from poor contrast between coronary blood and myocardium. Data collected over >100 ms/heart beat are also susceptible to bulk cardiac and respiratory motion. To address these problems, we examined the effect of a T2 preparation prepulse (T2prep) for myocardial suppression and a shortened acquisition window on coronary definition.
4189. G894T polymorphism in the endothelial nitric oxide synthase gene is associated with an enhanced vascular responsiveness to phenylephrine.
作者: I Philip.;G Plantefeve.;S Vuillaumier-Barrot.;E Vicaut.;C LeMarie.;D Henrion.;O Poirier.;B I Levy.;J M Desmonts.;G Durand.;J Benessiano.
来源: Circulation. 1999年99卷24期3096-8页
Differences in vascular reactivity to phenylephrine (PE) responsiveness have been largely evidenced in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Because nitric oxide (NO) strongly affects modulation of the vascular tone in response to vasopressor agents, we hypothesized that the G894T polymorphism of the endothelial NO synthase gene (eNOS) could be related to changes in the pressor response to PE.
4190. Effect of pacing chamber and atrioventricular delay on acute systolic function of paced patients with congestive heart failure. The Pacing Therapies for Congestive Heart Failure Study Group. The Guidant Congestive Heart Failure Research Group.
作者: A Auricchio.;C Stellbrink.;M Block.;S Sack.;J Vogt.;P Bakker.;H Klein.;A Kramer.;J Ding.;R Salo.;B Tockman.;T Pochet.;J Spinelli.
来源: Circulation. 1999年99卷23期2993-3001页
Previous studies of pacing therapy for dilated congestive heart failure (CHF) have not established the relative importance of pacing site, AV delay, and patient heterogeneity on outcome. These variables were compared by a novel technique that evaluated immediate changes in hemodynamic function during brief periods of atrial-synchronous ventricular pacing.
4191. Effects of acute angiotensin II type 1 receptor antagonism and angiotensin converting enzyme inhibition on plasma fibrinolytic parameters in patients with heart failure.
Angiotensin converting enzyme (ACE) inhibition after myocardial infarction is associated with an improvement in plasma fibrinolytic parameters. The aim of the present study was to determine whether acute ACE inhibition and angiotensin II type 1 (AT1) receptor antagonism have similar effects in patients with heart failure.
4192. Assessment of permanent dual-chamber pacing as a treatment for drug-refractory symptomatic patients with obstructive hypertrophic cardiomyopathy. A randomized, double-blind, crossover study (M-PATHY).
作者: B J Maron.;R A Nishimura.;W J McKenna.;H Rakowski.;M E Josephson.;R S Kieval.
来源: Circulation. 1999年99卷22期2927-33页
Dual-chamber pacing (DDD) has been proposed as a treatment alternative to surgery for severely symptomatic patients with obstructive hypertrophic cardiomyopathy (HCM), based largely on uncontrolled studies.
4193. Clinical significance of thrombocytopenia during a non-ST-elevation acute coronary syndrome. The platelet glycoprotein IIb/IIIa in unstable angina: receptor suppression using integrilin therapy (PURSUIT) trial experience.
作者: M W McClure.;S D Berkowitz.;R Sparapani.;R Tuttle.;N S Kleiman.;L G Berdan.;A M Lincoff.;J Deckers.;R Diaz.;K R Karsch.;D Gretler.;M Kitt.;M Simoons.;E J Topol.;R M Califf.;R A Harrington.
来源: Circulation. 1999年99卷22期2892-900页
The significance of thrombocytopenia in patients experiencing an acute coronary syndrome (ACS) has not been examined systematically. We evaluated this condition in a large non-ST-elevation ACS clinical trial, with particular interest paid to its correlation with clinical outcomes.
4194. Improvement in coronary flow reserve determined by positron emission tomography after 6 months of cholesterol-lowering therapy in patients with early stages of coronary atherosclerosis.
作者: D Baller.;G Notohamiprodjo.;U Gleichmann.;J Holzinger.;R Weise.;J Lehmann.
来源: Circulation. 1999年99卷22期2871-5页
Early stages of coronary atherosclerosis are characterized by a mainly functional impairment of coronary vasodilator capacity under the impact of such risk factors as hypercholesterolemia. The goal of this study was to determine whether 6-month cholesterol-lowering therapy improves coronary flow reserve in patients with angina, reduced flow reserve despite minimally diseased coronary vessels or even normal angiogram, and mild to moderately elevated LDL levels on average.
4195. HLA class II associations with rheumatic heart disease are more evident and consistent among clinically homogeneous patients.
作者: Y Guédez.;A Kotby.;M El-Demellawy.;A Galal.;G Thomson.;S Zaher.;S Kassem.;M Kotb.
来源: Circulation. 1999年99卷21期2784-90页
Discrepancies in reported HLA class II associations with rheumatic heart disease (RHD) may have been due to inaccuracies of serological typing reagents and/or lack of defined clinical classification of patients analyzed. The molecular association between HLA and RHD was investigated in patients with defined clinical outcome.
4196. Rate-dependent conduction block of the crista terminalis in patients with typical atrial flutter: influence on evaluation of cavotricuspid isthmus conduction block.
作者: A Arenal.;J Almendral.;J M Alday.;J Villacastín.;J M Ormaetxe.;J L Sande.;N Perez-Castellano.;S Gonzalez.;M Ortiz.;J L Delcán.
来源: Circulation. 1999年99卷21期2771-8页
The crista terminalis (CT) has been identified as the posterior boundary of typical atrial flutter (AFL) in the lateral wall (LW) of the right atrium (RA). To study conduction properties across the CT, rapid pacing was performed at both sides of the CT after bidirectional conduction block was achieved in the cavotricuspid isthmus by radiofrequency catheter ablation.
4197. Double-blind placebo-controlled trial of digoxin in symptomatic paroxysmal atrial fibrillation.
作者: F D Murgatroyd.;S M Gibson.;X Baiyan.;S O'Nunain.;J D Poloniecki.;D E Ward.;M Malik.;A J Camm.
来源: Circulation. 1999年99卷21期2765-70页
Digoxin is commonly prescribed in symptomatic paroxysmal atrial fibrillation (AF) but has never been evaluated in this condition.
4198. Significance of myocytes with positive DNA in situ nick end-labeling (TUNEL) in hearts with dilated cardiomyopathy: not apoptosis but DNA repair.
作者: M Kanoh.;G Takemura.;J Misao.;Y Hayakawa.;T Aoyama.;K Nishigaki.;T Noda.;T Fujiwara.;K Fukuda.;S Minatoguchi.;H Fujiwara.
来源: Circulation. 1999年99卷21期2757-64页
The presence of apoptotic myocytes has been reported in human hearts with dilated cardiomyopathy (DCM) on the basis of a positive finding of DNA in situ nick end-labeling (TUNEL). However, ultrastructural evidence of myocyte apoptosis has not been obtained.
4199. Dilated cardiomyopathy is associated with significant changes in collagen type I/III ratio.
作者: M Pauschinger.;D Knopf.;S Petschauer.;A Doerner.;W Poller.;P L Schwimmbeck.;U Kühl.;H P Schultheiss.
来源: Circulation. 1999年99卷21期2750-6页
It is controversial whether myocardial fibrosis in end-stage dilated cardiomyopathy (DCM) is associated with altered collagen type I/type III (Col I/Col III) ratio.
4200. Multicenter clinical trial to evaluate the efficacy of correction for photon attenuation and scatter in SPECT myocardial perfusion imaging.
作者: R C Hendel.;D S Berman.;S J Cullom.;W Follansbee.;G V Heller.;H Kiat.;M W Groch.;J J Mahmarian.
来源: Circulation. 1999年99卷21期2742-9页
Soft tissue attenuation is a prominent cause of single-photon emission computed tomography (SPECT) imaging artifacts, which may result in reduced diagnostic accuracy of myocardial perfusion imaging. A method incorporating simultaneously acquired transmission data permits nonuniform attenuation correction and when incorporating scatter correction and resolution compensation may substantially reduce interpretive errors.
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