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401. Pulmonary Vein Isolation vs Sham Intervention in Symptomatic Atrial Fibrillation: The SHAM-PVI Randomized Clinical Trial.
作者: Rajdip Dulai.;Neil Sulke.;Nick Freemantle.;Pier D Lambiase.;David Farwell.;Neil T Srinivasan.;Stuart Tan.;Nikhil Patel.;Adam Graham.;Rick A Veasey.
来源: JAMA. 2024年332卷14期1165-73页
There are concerns that pulmonary vein isolation for atrial fibrillation may have a profound placebo effect, but no double-blind randomized clinical trials have been conducted.
402. Potassium Supplementation and Prevention of Atrial Fibrillation After Cardiac Surgery: The TIGHT K Randomized Clinical Trial.
作者: Benjamin O'Brien.;Niall G Campbell.;Elizabeth Allen.;Zahra Jamal.;Joanna Sturgess.;Julie Sanders.;Charles Opondo.;Neil Roberts.;Jonathan Aron.;Maria Rita Maccaroni.;Richard Gould.;Bilal H Kirmani.;Ben Gibbison.;Gudrun Kunst.;Alexander Zarbock.;Maren Kleine-Brüggeney.;Christian Stoppe.;Keith Pearce.;Mark Hughes.;Laura Van Dyck.;Richard Evans.;Hugh E Montgomery.;Diana Elbourne.; .
来源: JAMA. 2024年332卷12期979-988页
Supplementing potassium in an effort to maintain high-normal serum concentrations is a widespread strategy used to prevent atrial fibrillation after cardiac surgery (AFACS), but is not evidence-based, carries risks, and is costly.
404. Low-Dose Triple-Pill vs Standard-Care Protocols for Hypertension Treatment in Nigeria: A Randomized Clinical Trial.
作者: Dike B Ojji.;Abdul Salam.;Mahmoud U Sani.;Okechukwu S Ogah.;Aletta E Schutte.;Mark D Huffman.;Rashmi Pant.;Arpita Ghosh.;Rupasvi Dhurjati.;Josyula K Lakshmi.;Nanna R Ripiye.;Ikechukwu A Orji.;Shehu A Kana.;Tijjani Abdussalam.;Abdulgafar L Olawumi.;Isiaka M Alfa.;Olanike Allison Orimolade.;Moses O Ajayi.;Anthony Rodgers.
来源: JAMA. 2024年332卷13期1070-1079页
With the high burden of hypertension in sub-Saharan Africa, there is a need for effective, safe and scalable treatment strategies.
405. Continuation vs Discontinuation of Renin-Angiotensin System Inhibitors Before Major Noncardiac Surgery: The Stop-or-Not Randomized Clinical Trial.
作者: Matthieu Legrand.;Jérémy Falcone.;Bernard Cholley.;Hélène Charbonneau.;Amélie Delaporte.;Adrien Lemoine.;Matthias Garot.;Alexandre Joosten.;Claude Meistelman.;Delphine Cheron-Leroy.;Jean-Philippe Rives.;Bruno Pastene.;Antoine Dewitte.;Stéphanie Sigaut.;Marc Danguy des Deserts.;Cyrille Truc.;Matthieu Boisson.;Sigismond Lasocki.;Philippe Cuvillon.;Ugo Schiff.;Samir Jaber.;Morgan Le Guen.;Anaïs Caillard.;Stéphane Bar.;Edmundo Pereira de Souza Neto.;Vincent Colas.;Florin Dimache.;Thibaut Girardot.;Elsa Jozefowicz.;Simon Viquesnel.;Francis Berthier.;Eric Vicaut.;Etienne Gayat.; .
来源: JAMA. 2024年332卷12期970-978页
Before surgery, the best strategy for managing patients who are taking renin-angiotensin system inhibitors (RASIs) (angiotensin-converting enzyme inhibitors or angiotensin receptor blockers) is unknown. The lack of evidence leads to conflicting guidelines.
406. Characterizing Long COVID in Children and Adolescents.
作者: Rachel S Gross.;Tanayott Thaweethai.;Lawrence C Kleinman.;Jessica N Snowden.;Erika B Rosenzweig.;Joshua D Milner.;Kelan G Tantisira.;Kyung E Rhee.;Terry L Jernigan.;Patricia A Kinser.;Amy L Salisbury.;David Warburton.;Sindhu Mohandas.;John C Wood.;Jane W Newburger.;Dongngan T Truong.;Valerie J Flaherman.;Torri D Metz.;Elizabeth W Karlson.;Lori B Chibnik.;Deepti B Pant.;Aparna Krishnamoorthy.;Richard Gallagher.;Michelle F Lamendola-Essel.;Denise C Hasson.;Stuart D Katz.;Shonna Yin.;Benard P Dreyer.;Megan Carmilani.;K Coombs.;Megan L Fitzgerald.;Nick Güthe.;Mady Hornig.;Rebecca J Letts.;Aimee K Peddie.;Brittany D Taylor.;Venkataraman Balaraman.;Amanda Bogie.;Hulya Bukulmez.;Allen J Dozor.;Daniel Eckrich.;Amy J Elliott.;Danielle N Evans.;Jonathan S Farkas.;E Vincent S Faustino.;Laura Fischer.;Sunanda Gaur.;Ashraf S Harahsheh.;Uzma N Hasan.;Daniel S Hsia.;Gredia Huerta-Montañez.;Kathy D Hummel.;Matt P Kadish.;David C Kaelber.;Sankaran Krishnan.;Jessica S Kosut.;Jerry Larrabee.;Peter Paul C Lim.;Ian C Michelow.;Carlos R Oliveira.;Hengameh Raissy.;Zaira Rosario-Pabon.;Judith L Ross.;Alice I Sato.;Michelle D Stevenson.;Maria M Talavera-Barber.;Ronald J Teufel.;Kathryn E Weakley.;Emily Zimmerman.;Marie-Abele C Bind.;James Chan.;Zoe Guan.;Richard E Morse.;Harrison T Reeder.;Natascha Akshoomoff.;Judy L Aschner.;Rakesh Bhattacharjee.;Lesley A Cottrell.;Kelly Cowan.;Viren A D'Sa.;Alexander G Fiks.;Maria L Gennaro.;Katherine Irby.;Manaswitha Khare.;Jeremy Landeo Guttierrez.;Russell J McCulloh.;Shalu Narang.;Manette Ness-Cochinwala.;Sheila Nolan.;Paul Palumbo.;Julie Ryu.;Juan C Salazar.;Rangaraj Selvarangan.;Cheryl R Stein.;Alan Werzberger.;William T Zempsky.;Robin Aupperle.;Fiona C Baker.;Marie T Banich.;Deanna M Barch.;Arielle Baskin-Sommers.;James M Bjork.;Susan Y Bookheimer.;Sandra A Brown.;B J Casey.;Linda Chang.;Duncan B Clark.;Anders M Dale.;Mirella Dapretto.;Thomas M Ernst.;Damien A Fair.;Sarah W Feldstein Ewing.;John J Foxe.;Edward G Freedman.;Naomi P Friedman.;Hugh Garavan.;Dylan G Gee.;Raul Gonzalez.;Kevin M Gray.;Mary M Heitzeg.;Megan M Herting.;Joanna Jacobus.;Angela R Laird.;Christine L Larson.;Krista M Lisdahl.;Monica Luciana.;Beatriz Luna.;Pamela A F Madden.;Erin C McGlade.;Eva M Müller-Oehring.;Bonnie J Nagel.;Michael C Neale.;Martin P Paulus.;Alexandra S Potter.;Perry F Renshaw.;Elizabeth R Sowell.;Lindsay M Squeglia.;Susan Tapert.;Lucina Q Uddin.;Sylia Wilson.;Deborah A Yurgelun-Todd.;Andrea S Foulkes.;Melissa S Stockwell.; .; .
来源: JAMA. 2024年332卷14期1174-88页
Most research to understand postacute sequelae of SARS-CoV-2 infection (PASC), or long COVID, has focused on adults, with less known about this complex condition in children. Research is needed to characterize pediatric PASC to enable studies of underlying mechanisms that will guide future treatment.
408. Renal Cell Carcinoma: A Review.
Renal cell carcinoma (RCC) is a common malignancy, with an estimated 434 840 incident cases worldwide in 2022. In the US, it is the sixth most common cancer among males and ninth among females.
409. Long-Term Prognosis of Patients With Myocarditis Attributed to COVID-19 mRNA Vaccination, SARS-CoV-2 Infection, or Conventional Etiologies.
作者: Laura Semenzato.;Stéphane Le Vu.;Jérémie Botton.;Marion Bertrand.;Marie-Joelle Jabagi.;Jérôme Drouin.;François Cuenot.;Florian Zores.;Rosemary Dray-Spira.;Alain Weill.;Mahmoud Zureik.
来源: JAMA. 2024年332卷16期1367-77页
Although patients with myocarditis after COVID-19 mRNA vaccination appear to have a good prognosis near hospital discharge, their longer-term prognosis and management remain unknown.
412. Elinzanetant for the Treatment of Vasomotor Symptoms Associated With Menopause: OASIS 1 and 2 Randomized Clinical Trials.
作者: JoAnn V Pinkerton.;James A Simon.;Hadine Joffe.;Pauline M Maki.;Rossella E Nappi.;Nick Panay.;Claudio N Soares.;Rebecca C Thurston.;Cecilia Caetano.;Claudia Haberland.;Nazanin Haseli Mashhadi.;Ulrike Krahn.;Uwe Mellinger.;Susanne Parke.;Christian Seitz.;Lineke Zuurman.
来源: JAMA. 2024年332卷16期1343-54页
Safe and effective nonhormonal treatments for menopausal vasomotor symptoms (VMS) are needed.
415. Tranexamic Acid in Patients Undergoing Liver Resection: The HeLiX Randomized Clinical Trial.
作者: Paul J Karanicolas.;Yulia Lin.;Stuart A McCluskey.;Jordan Tarshis.;Kevin E Thorpe.;Alice Wei.;Elijah Dixon.;Geoff Porter.;Prosanto Chaudhury.;Sulaiman Nanji.;Leyo Ruo.;Melanie E Tsang.;Anton Skaro.;Gareth Eeson.;Sean Cleary.;Carol-Anne Moulton.;Chad G Ball.;Julie Hallet.;Natalie Coburn.;Pablo E Serrano.;Shiva Jayaraman.;Calvin Law.;Ved Tandan.;Gonzalo Sapisochin.;David Nagorney.;Douglas Quan.;Rory Smoot.;Steven Gallinger.;Peter Metrakos.;Trevor W Reichman.;Diederick Jalink.;Sean Bennett.;Francis Sutherland.;Edward Solano.;Michele Molinari.;Ephraim S Tang.;Susanne G Warner.;Oliver F Bathe.;Jeffrey Barkun.;Michael L Kendrick.;Mark Truty.;Rachel Roke.;Grace Xu.;Myriam Lafreniere-Roula.;Gordon Guyatt.; .
来源: JAMA. 2024年332卷13期1080-1089页
Tranexamic acid reduces bleeding and blood transfusion in many types of surgery, but its effect in patients undergoing liver resection for a cancer-related indication remains unclear.
417. Uterus Transplant in Women With Absolute Uterine-Factor Infertility.
作者: Giuliano Testa.;Greg J McKenna.;Anji Wall.;Johanna Bayer.;Anthony R Gregg.;Ann Marie Warren.;Seung Hee S Lee.;Eric Martinez.;Amar Gupta.;Robert Gunby.;Liza Johannesson.
来源: JAMA. 2024年332卷10期817-824页
Uterus transplant in women with absolute uterine-factor infertility offers the possibility of carrying their own pregnancy.
419. Edetate Disodium-Based Chelation for Patients With a Previous Myocardial Infarction and Diabetes: TACT2 Randomized Clinical Trial.
作者: Gervasio A Lamas.;Kevin J Anstrom.;Ana Navas-Acien.;Robin Boineau.;Hayley Nemeth.;Zhen Huang.;Jun Wen.;Yves Rosenberg.;Mario Stylianou.;Teresa L Z Jones.;Bonnie R Joubert.;Qilu Yu.;Regina M Santella.;Ana C Mon.;Francisco Ujueta.;Esteban Escolar.;David M Nathan.;Vivian A Fonseca.;Y Wady Aude.;Jonathan K Ehrman.;Thomas Elliott.;Rakesh Prashad.;Eldrin F Lewis.;Renato D Lopes.;Michael E Farkouh.;Anne-Marie Elliott.;Jonathan D Newman.;Daniel B Mark.; .
来源: JAMA. 2024年332卷10期794-803页
In 2013, the Trial to Assess Chelation Therapy (TACT) reported that edetate disodium (EDTA)-based chelation significantly reduced cardiovascular disease (CVD) events by 18% in 1708 patients with a prior myocardial infarction (MI).
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