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401. Effect of a Nutritional and Behavioral Intervention on Energy-Reduced Mediterranean Diet Adherence Among Patients With Metabolic Syndrome: Interim Analysis of the PREDIMED-Plus Randomized Clinical Trial.
作者: Carmen Sayón-Orea.;Cristina Razquin.;Mónica Bulló.;Dolores Corella.;Montserrat Fitó.;Dora Romaguera.;Jesús Vioque.;Ángel M Alonso-Gómez.;Julia Wärnberg.;J Alfredo Martínez.;Luís Serra-Majem.;Ramón Estruch.;Francisco J Tinahones.;José Lapetra.;Xavier Pintó.;Josep A Tur.;José López-Miranda.;Aurora Bueno-Cavanillas.;Miguel Delgado-Rodríguez.;Pilar Matía-Martín.;Lidia Daimiel.;Vicente Martín Sánchez.;Josep Vidal.;Clotilde Vázquez.;Emilio Ros.;Miguel Ruiz-Canela.;José V Sorlí.;Olga Castañer.;Miquel Fiol.;Eva M Navarrete-Muñoz.;Fernando Arós.;Enrique Gómez-Gracia.;M Angeles Zulet.;Almudena Sánchez-Villegas.;Rosa Casas.;Rosa Bernal-López.;José M Santos-Lozano.;Emili Corbella.;Cristina Bouzas.;Ana García-Arellano.;Josep Basora.;Eva M Asensio.;Helmut Schröder.;Manuel Moñino.;Manoli García de la Hera.;Lucas Tojal-Sierra.;Estefanía Toledo.;Andrés Díaz-López.;Albert Goday.;Jordi Salas-Salvadó.;Miguel A Martínez-González.
来源: JAMA. 2019年322卷15期1486-1499页
High-quality dietary patterns may help prevent chronic disease, but limited data exist from randomized trials about the effects of nutritional and behavioral interventions on dietary changes.
402. Effect of Intra-Articular Sprifermin vs Placebo on Femorotibial Joint Cartilage Thickness in Patients With Osteoarthritis: The FORWARD Randomized Clinical Trial.
作者: Marc C Hochberg.;Ali Guermazi.;Hans Guehring.;Aida Aydemir.;Stephen Wax.;Patricia Fleuranceau-Morel.;Asger Reinstrup Bihlet.;Inger Byrjalsen.;Jeppe Ragnar Andersen.;Felix Eckstein.
来源: JAMA. 2019年322卷14期1360-1370页
Sprifermin is under investigation as a disease-modifying osteoarthritis drug.
403. Effect of a Hospital-Initiated Program Combining Transitional Care and Long-term Self-management Support on Outcomes of Patients Hospitalized With Chronic Obstructive Pulmonary Disease: A Randomized Clinical Trial.
作者: Hanan Aboumatar.;Mohammad Naqibuddin.;Suna Chung.;Hina Chaudhry.;Samuel W Kim.;Jamia Saunders.;Lee Bone.;Ayse P Gurses.;Amy Knowlton.;Peter Pronovost.;Nirupama Putcha.;Cynthia Rand.;Debra Roter.;Carol Sylvester.;Carol Thompson.;Jennifer L Wolff.;Judith Hibbard.;Robert A Wise.
来源: JAMA. 2019年322卷14期1371-1380页
Patients hospitalized for chronic obstructive pulmonary disease (COPD) exacerbations have high rehospitalization rates and reduced quality of life.
404. Effect of Postextubation High-Flow Nasal Oxygen With Noninvasive Ventilation vs High-Flow Nasal Oxygen Alone on Reintubation Among Patients at High Risk of Extubation Failure: A Randomized Clinical Trial.
作者: Arnaud W Thille.;Grégoire Muller.;Arnaud Gacouin.;Rémi Coudroy.;Maxens Decavèle.;Romain Sonneville.;François Beloncle.;Christophe Girault.;Laurence Dangers.;Alexandre Lautrette.;Séverin Cabasson.;Anahita Rouzé.;Emmanuel Vivier.;Anthony Le Meur.;Jean-Damien Ricard.;Keyvan Razazi.;Guillaume Barberet.;Christine Lebert.;Stephan Ehrmann.;Caroline Sabatier.;Jeremy Bourenne.;Gael Pradel.;Pierre Bailly.;Nicolas Terzi.;Jean Dellamonica.;Guillaume Lacave.;Pierre-Éric Danin.;Hodanou Nanadoumgar.;Aude Gibelin.;Lassane Zanre.;Nicolas Deye.;Alexandre Demoule.;Adel Maamar.;Mai-Anh Nay.;René Robert.;Stéphanie Ragot.;Jean-Pierre Frat.; .
来源: JAMA. 2019年322卷15期1465-1475页
High-flow nasal oxygen may prevent postextubation respiratory failure in the intensive care unit (ICU). The combination of high-flow nasal oxygen with noninvasive ventilation (NIV) may be an optimal strategy of ventilation to avoid reintubation.
405. Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial.
作者: Alpha A Fowler.;Jonathon D Truwit.;R Duncan Hite.;Peter E Morris.;Christine DeWilde.;Anna Priday.;Bernard Fisher.;Leroy R Thacker.;Ramesh Natarajan.;Donald F Brophy.;Robin Sculthorpe.;Rahul Nanchal.;Aamer Syed.;Jamie Sturgill.;Greg S Martin.;Jonathan Sevransky.;Markos Kashiouris.;Stella Hamman.;Katherine F Egan.;Andrei Hastings.;Wendy Spencer.;Shawnda Tench.;Omar Mehkri.;James Bindas.;Abhijit Duggal.;Jeanette Graf.;Stephanie Zellner.;Lynda Yanny.;Catherine McPolin.;Tonya Hollrith.;David Kramer.;Charles Ojielo.;Tessa Damm.;Evan Cassity.;Aleksandra Wieliczko.;Matthew Halquist.
来源: JAMA. 2019年322卷13期1261-1270页
Experimental data suggest that intravenous vitamin C may attenuate inflammation and vascular injury associated with sepsis and acute respiratory distress syndrome (ARDS).
406. Effect of Vaginal Mesh Hysteropexy vs Vaginal Hysterectomy With Uterosacral Ligament Suspension on Treatment Failure in Women With Uterovaginal Prolapse: A Randomized Clinical Trial.
作者: Charles W Nager.;Anthony G Visco.;Holly E Richter.;Charles R Rardin.;Rebecca G Rogers.;Heidi S Harvie.;Halina M Zyczynski.;Marie Fidela R Paraiso.;Donna Mazloomdoost.;Scott Grey.;Amaanti Sridhar.;Dennis Wallace.; .
来源: JAMA. 2019年322卷11期1054-1065页
Vaginal hysterectomy with suture apical suspension is commonly performed for uterovaginal prolapse. Transvaginal mesh hysteropexy is an alternative option.
407. Effect of Behavioral and Pelvic Floor Muscle Therapy Combined With Surgery vs Surgery Alone on Incontinence Symptoms Among Women With Mixed Urinary Incontinence: The ESTEEM Randomized Clinical Trial.
作者: Vivian W Sung.;Diane Borello-France.;Diane K Newman.;Holly E Richter.;Emily S Lukacz.;Pamela Moalli.;Alison C Weidner.;Ariana L Smith.;Gena Dunivan.;Beri Ridgeway.;John N Nguyen.;Donna Mazloomdoost.;Benjamin Carper.;Marie G Gantz.; .
来源: JAMA. 2019年322卷11期1066-1076页
Mixed urinary incontinence, including both stress and urgency incontinence, has adverse effects on a woman's quality of life. Studies evaluating treatments to simultaneously improve both components are lacking.
408. Effect of a Multicomponent Home-Based Physical Therapy Intervention on Ambulation After Hip Fracture in Older Adults: The CAP Randomized Clinical Trial.
作者: Jay Magaziner.;Kathleen K Mangione.;Denise Orwig.;Mona Baumgarten.;Laurence Magder.;Michael Terrin.;Richard H Fortinsky.;Ann L Gruber-Baldini.;Brock A Beamer.;Anna N A Tosteson.;Anne M Kenny.;Michelle Shardell.;Ellen F Binder.;Kenneth Koval.;Barbara Resnick.;Ram Miller.;Sandra Forman.;Ruth McBride.;Rebecca L Craik.
来源: JAMA. 2019年322卷10期946-956页
Disability persists after hip fracture in older persons. Current rehabilitation may not be sufficient to restore ability to walk in the community.
409. Effect of Corticosteroid-Sparing Treatment With Mycophenolate Mofetil vs Methotrexate on Inflammation in Patients With Uveitis: A Randomized Clinical Trial.
作者: S R Rathinam.;John A Gonzales.;Radhika Thundikandy.;Anuradha Kanakath.;S Bala Murugan.;R Vedhanayaki.;Lyndell L Lim.;Eric B Suhler.;Hassan A Al-Dhibi.;Thuy Doan.;Jeremy D Keenan.;Maya M Rao.;Caleb D Ebert.;Hieu H Nguyen.;Eric Kim.;Travis C Porco.;Nisha R Acharya.; .
来源: JAMA. 2019年322卷10期936-945页
Methotrexate and mycophenolate mofetil are commonly used immunomodulatory therapies for achieving corticosteroid-sparing control of noninfectious uveitis, but there is uncertainty about which drug is more effective.
410. Effect of Low-Intensity vs Standard-Intensity Warfarin Prophylaxis on Venous Thromboembolism or Death Among Patients Undergoing Hip or Knee Arthroplasty: A Randomized Clinical Trial.
作者: Brian F Gage.;Anne R Bass.;Hannah Lin.;Scott C Woller.;Scott M Stevens.;Noor Al-Hammadi.;Jeffrey L Anderson.;Juan Li.;Tomás Rodriguez.;J Philip Miller.;Gwendolyn A McMillin.;Robert C Pendleton.;Amir K Jaffer.;Cristi R King.;Brandi Whipple.;Rhonda Porche-Sorbet.;Lynnae Napoli.;Kerri Merritt.;Anna M Thompson.;Gina Hyun.;Wesley Hollomon.;Robert L Barrack.;Ryan M Nunley.;Gerard Moskowitz.;Victor Dávila-Román.;Charles S Eby.
来源: JAMA. 2019年322卷9期834-842页
The optimal international normalized ratio (INR) to prevent venous thromboembolism (VTE) in warfarin-treated patients with recent arthroplasty is unknown.
411. N95 Respirators vs Medical Masks for Preventing Influenza Among Health Care Personnel: A Randomized Clinical Trial.
作者: Lewis J Radonovich.;Michael S Simberkoff.;Mary T Bessesen.;Alexandria C Brown.;Derek A T Cummings.;Charlotte A Gaydos.;Jenna G Los.;Amanda E Krosche.;Cynthia L Gibert.;Geoffrey J Gorse.;Ann-Christine Nyquist.;Nicholas G Reich.;Maria C Rodriguez-Barradas.;Connie Savor Price.;Trish M Perl.; .
来源: JAMA. 2019年322卷9期824-833页
Clinical studies have been inconclusive about the effectiveness of N95 respirators and medical masks in preventing health care personnel (HCP) from acquiring workplace viral respiratory infections.
412. Effect of High-Dose Vitamin D Supplementation on Volumetric Bone Density and Bone Strength: A Randomized Clinical Trial.
作者: Lauren A Burt.;Emma O Billington.;Marianne S Rose.;Duncan A Raymond.;David A Hanley.;Steven K Boyd.
来源: JAMA. 2019年322卷8期736-745页
Few studies have assessed the effects of daily vitamin D doses at or above the tolerable upper intake level for 12 months or greater, yet 3% of US adults report vitamin D intakes of at least 4000 IU per day.
413. Effect of Tandem Autologous Stem Cell Transplant vs Single Transplant on Event-Free Survival in Patients With High-Risk Neuroblastoma: A Randomized Clinical Trial.
作者: Julie R Park.;Susan G Kreissman.;Wendy B London.;Arlene Naranjo.;Susan Lerner Cohn.;Michael D Hogarty.;Sheena C Tenney.;Daphne Haas-Kogan.;Peter John Shaw.;Jacqueline M Kraveka.;Stephen S Roberts.;James Duncan Geiger.;John J Doski.;Stephan D Voss.;John M Maris.;Stephan A Grupp.;Lisa Diller.
来源: JAMA. 2019年322卷8期746-755页
Induction chemotherapy followed by high-dose therapy with autologous stem cell transplant and subsequent antidisialoganglioside antibody immunotherapy is standard of care for patients with high-risk neuroblastoma, but survival rate among these patients remains low.
414. Effect of Continuing Olanzapine vs Placebo on Relapse Among Patients With Psychotic Depression in Remission: The STOP-PD II Randomized Clinical Trial.
作者: Alastair J Flint.;Barnett S Meyers.;Anthony J Rothschild.;Ellen M Whyte.;George S Alexopoulos.;Matthew V Rudorfer.;Patricia Marino.;Samprit Banerjee.;Cristina D Pollari.;Yiyuan Wu.;Aristotle N Voineskos.;Benoit H Mulsant.; .
来源: JAMA. 2019年322卷7期622-631页
Psychotic depression is a severely disabling and potentially lethal disorder. Little is known about the efficacy and tolerability of continuing antipsychotic medication for patients with psychotic depression in remission.
415. Association of Intensive vs Standard Blood Pressure Control With Cerebral White Matter Lesions.
作者: .;Ilya M Nasrallah.;Nicholas M Pajewski.;Alexander P Auchus.;Gordon Chelune.;Alfred K Cheung.;Maryjo L Cleveland.;Laura H Coker.;Michael G Crowe.;William C Cushman.;Jeffrey A Cutler.;Christos Davatzikos.;Lisa Desiderio.;Jimit Doshi.;Guray Erus.;Larry J Fine.;Sarah A Gaussoin.;Darrin Harris.;Karen C Johnson.;Paul L Kimmel.;Manjula Kurella Tamura.;Lenore J Launer.;Alan J Lerner.;Cora E Lewis.;Jennifer Martindale-Adams.;Claudia S Moy.;Linda O Nichols.;Suzanne Oparil.;Paula K Ogrocki.;Mahboob Rahman.;Stephen R Rapp.;David M Reboussin.;Michael V Rocco.;Bonnie C Sachs.;Kaycee M Sink.;Carolyn H Still.;Mark A Supiano.;Joni K Snyder.;Virginia G Wadley.;Jennifer Walker.;Daniel E Weiner.;Paul K Whelton.;Valerie M Wilson.;Nancy Woolard.;Jackson T Wright.;Clinton B Wright.;Jeff D Williamson.;R Nick Bryan.
来源: JAMA. 2019年322卷6期524-534页
The effect of intensive blood pressure lowering on brain health remains uncertain.
416. Intensive vs Standard Treatment of Hyperglycemia and Functional Outcome in Patients With Acute Ischemic Stroke: The SHINE Randomized Clinical Trial.
作者: Karen C Johnston.;Askiel Bruno.;Qi Pauls.;Christiana E Hall.;Kevin M Barrett.;William Barsan.;Amy Fansler.;Katrina Van de Bruinhorst.;Scott Janis.;Valerie L Durkalski-Mauldin.; .
来源: JAMA. 2019年322卷4期326-335页
Hyperglycemia during acute ischemic stroke is common and is associated with worse outcomes. The efficacy of intensive treatment of hyperglycemia in this setting remains unknown.
417. Effect of Filgotinib vs Placebo on Clinical Response in Patients With Moderate to Severe Rheumatoid Arthritis Refractory to Disease-Modifying Antirheumatic Drug Therapy: The FINCH 2 Randomized Clinical Trial.
作者: Mark C Genovese.;Kenneth Kalunian.;Jacques-Eric Gottenberg.;Neelufar Mozaffarian.;Beatrix Bartok.;Franziska Matzkies.;Jie Gao.;Ying Guo.;Chantal Tasset.;John S Sundy.;Kurt de Vlam.;David Walker.;Tsutomu Takeuchi.
来源: JAMA. 2019年322卷4期315-325页
Patients with active rheumatoid arthritis (RA) despite treatment with biologic disease-modifying antirheumatic drug (bDMARD) therapy need treatment options.
418. Effect of an ICU Diary on Posttraumatic Stress Disorder Symptoms Among Patients Receiving Mechanical Ventilation: A Randomized Clinical Trial.
作者: Maité Garrouste-Orgeas.;Cécile Flahault.;Isabelle Vinatier.;Jean-Philippe Rigaud.;Nathalie Thieulot-Rolin.;Emmanuelle Mercier.;Antoine Rouget.;Hubert Grand.;Olivier Lesieur.;Fabienne Tamion.;Rebecca Hamidfar.;Anne Renault.;Erika Parmentier-Decrucq.;Yannick Monseau.;Laurent Argaud.;Cédric Bretonnière.;Alexandre Lautrette.;Julio Badié.;Eric Boulet.;Bernard Floccard.;Xavier Forceville.;Eric Kipnis.;Lilia Soufir.;Sandrine Valade.;Naike Bige.;Alain Gaffinel.;Olfa Hamzaoui.;Georges Simon.;Marina Thirion.;Lila Bouadma.;Audrey Large.;Jean-Paul Mira.;Nora Amdjar-Badidi.;Mercé Jourdain.;Paul-Henri Jost.;Virginie Maxime.;François Santoli.;Stéphane Ruckly.;Christel Vioulac.;Marie Annick Leborgne.;Lucie Bellalou.;Léonor Fasse.;Benoit Misset.;Sébastien Bailly.;Jean-François Timsit.
来源: JAMA. 2019年322卷3期229-239页
Keeping a diary for patients while they are in the intensive care unit (ICU) might reduce their posttraumatic stress disorder (PTSD) symptoms.
419. Effect of Flexible Family Visitation on Delirium Among Patients in the Intensive Care Unit: The ICU Visits Randomized Clinical Trial.
作者: Regis Goulart Rosa.;Maicon Falavigna.;Daiana Barbosa da Silva.;Daniel Sganzerla.;Mariana Martins Siqueira Santos.;Renata Kochhann.;Rafaela Moraes de Moura.;Cláudia Severgnini Eugênio.;Tarissa da Silva Ribeiro Haack.;Mirceli Goulart Barbosa.;Caroline Cabral Robinson.;Daniel Schneider.;Débora Mariani de Oliveira.;Rodrigo Wiltgen Jeffman.;Alexandre Biasi Cavalcanti.;Flávia Ribeiro Machado.;Luciano Cesar Pontes Azevedo.;Jorge Ibrain Figueira Salluh.;José Augusto Santos Pellegrini.;Rafael Barberena Moraes.;Rafael Botelho Foernges.;Andre Peretti Torelly.;Lizandra de Oliveira Ayres.;Pericles Almeida Delfino Duarte.;Wilson José Lovato.;Patrick Harrison Santana Sampaio.;Lúcio Couto de Oliveira Júnior.;Jorge Luiz da Rocha Paranhos.;Alessandro da Silva Dantas.;Pollyanna Iracema Peixoto Gouveia Gomes de Brito.;Eliane Aparecida Peixoto Paulo.;Marcos Antônio Cavalcanti Gallindo.;Janaina Pilau.;Helen Martins Valentim.;José Mario Meira Teles.;Vandack Nobre.;Daniella Cunha Birriel.;Livia Corrêa E Castro.;Andréia Martins Specht.;Gregory Saraiva Medeiros.;Tulio Frederico Tonietto.;Emersom Cicilini Mesquita.;Nilton Brandão da Silva.;Jeffrey E Korte.;Luciano Serpa Hammes.;Alberto Giannini.;Fernando Augusto Bozza.;Cassiano Teixeira.; .
来源: JAMA. 2019年322卷3期216-228页
The effects of intensive care unit (ICU) visiting hours remain uncertain.
420. Effect of Recombinant Zoster Vaccine on Incidence of Herpes Zoster After Autologous Stem Cell Transplantation: A Randomized Clinical Trial.
作者: Adriana Bastidas.;Javier de la Serna.;Mohamed El Idrissi.;Lidia Oostvogels.;Philippe Quittet.;Javier López-Jiménez.;Filiz Vural.;David Pohlreich.;Tsila Zuckerman.;Nicolas C Issa.;Gianluca Gaidano.;Je-Jung Lee.;Sunil Abhyankar.;Carlos Solano.;Jaime Perez de Oteyza.;Michael J Satlin.;Stefan Schwartz.;Magda Campins.;Alberto Rocci.;Carlos Vallejo Llamas.;Dong-Gun Lee.;Sen Mui Tan.;Anna M Johnston.;Andrew Grigg.;Michael J Boeckh.;Laura Campora.;Marta Lopez-Fauqued.;Thomas C Heineman.;Edward A Stadtmauer.;Keith M Sullivan.; .
来源: JAMA. 2019年322卷2期123-133页
Herpes zoster, a frequent complication following autologous hematopoietic stem cell transplantation (HSCT), is associated with significant morbidity. A nonlive adjuvanted recombinant zoster vaccine has been developed to prevent posttransplantation zoster.
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