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401. Endothelin-1 contributes to maintenance of systemic but not portal haemodynamics in patients with early cirrhosis: a randomised controlled trial.
作者: D Tripathi.;G Therapondos.;J W Ferguson.;D E Newby.;D J Webb.;P C Hayes.
来源: Gut. 2006年55卷9期1290-5页
Increased endothelin (ET)-1 activity may contribute to the complications of cirrhosis and portal hypertension. The aim of this study was to assess the systemic and portal haemodynamic effects of selective ET-A and ET-B receptor antagonism in patients with cirrhosis.
402. Eradication of Helicobacter pylori infection reverses E-cadherin promoter hypermethylation.
作者: A O O Chan.;J Z Peng.;S K Lam.;K C Lai.;M F Yuen.;H K L Cheung.;Y L Kwong.;A Rashid.;C K Chan.;B C-Y Wong.
来源: Gut. 2006年55卷4期463-8页
E-cadherin methylation is important in gastric carcinogenesis. Reversing hypermethylation may halt the carcinogenic process. We have previously reported that Helicobacter pylori infection is associated with E-cadherin methylation in chronic gastritis patients.
403. A controlled crossover study of the selective serotonin reuptake inhibitor citalopram in irritable bowel syndrome.
作者: J Tack.;D Broekaert.;B Fischler.;L Van Oudenhove.;A M Gevers.;J Janssens.
来源: Gut. 2006年55卷8期1095-103页
Selective serotonin reuptake inhibitors (SSRIs) are frequently used in the treatment of irritable bowel syndrome (IBS) although evidence of their efficacy is scarce.
404. Bacterial and fungal microbiota in relation to probiotic therapy (VSL#3) in pouchitis.
作者: T Kühbacher.;S J Ott.;U Helwig.;T Mimura.;F Rizzello.;B Kleessen.;P Gionchetti.;M Blaut.;M Campieri.;U R Fölsch.;M A Kamm.;S Schreiber.
来源: Gut. 2006年55卷6期833-41页
The intestinal microbiota plays a critical role in the pathophysiology of pouchitis, a major complication after ileal pouch anal anastomosis in patients with ulcerative colitis. Recently, controlled trials have demonstrated that probiotics are effective in maintenance of remission in pouchitis patients. However, the mechanism by which therapy with probiotics works remains elusive. This study explores the role of the bacterial and fungal flora in a controlled trial for maintenance of remission in pouchitis patients with the probiotic VSL#3 compound.
405. Ineffectiveness of Lactobacillus johnsonii LA1 for prophylaxis of postoperative recurrence in Crohn's disease: a randomised, double blind, placebo controlled GETAID trial.
作者: P Marteau.;M Lémann.;P Seksik.;D Laharie.;J F Colombel.;Y Bouhnik.;G Cadiot.;J C Soulé.;A Bourreille.;E Metman.;E Lerebours.;F Carbonnel.;J L Dupas.;M Veyrac.;B Coffin.;J Moreau.;V Abitbol.;S Blum-Sperisen.;J Y Mary.
来源: Gut. 2006年55卷6期842-7页
Early endoscopic recurrence is frequent after intestinal resection for Crohn's disease. Bacteria are involved, and probiotics may modulate immune responses to the intestinal flora. Here we tested the probiotic strain Lactobacillus johnsonii LA1 in this setting.
407. Effect of polyethylene glycol electrolyte balanced solution on patients with acute colonic pseudo obstruction after resolution of colonic dilation: a prospective, randomised, placebo controlled trial.
作者: S N Sgouros.;J Vlachogiannakos.;K Vassiliadis.;C Bergele.;G Stefanidis.;H Nastos.;A Avgerinos.;A Mantides.
来源: Gut. 2006年55卷5期638-42页
Conservative therapy for patients with acute colonic pseudo obstruction (Ogilvie's syndrome) may be successful initially but relapses are common. The aim of the present study was to evaluate the effect of polyethylene glycol (PEG) electrolyte balanced solution on the relapse rate of the syndrome after initial resolution with neostigmine or endoscopic decompression.
408. Successful antibiotic treatment of Helicobacter pylori negative gastric mucosa associated lymphoid tissue lymphomas.
The role of antibiotic treatment in early stage gastric mucosa associated lymphoid tissue (MALT) lymphoma not associated with Helicobacter pylori infection has not been investigated.
409. Influence of ghrelin on interdigestive gastrointestinal motility in humans.
作者: J Tack.;I Depoortere.;R Bisschops.;C Delporte.;B Coulie.;A Meulemans.;J Janssens.;T Peeters.
来源: Gut. 2006年55卷3期327-33页
Recent studies in animals have shown that ghrelin stimulates upper gastrointestinal motility through the vagus and enteric nervous system. The aim of the present study therefore was to simultaneously investigate the effect of administration of ghrelin on upper gastrointestinal motility and to elucidate its mode of action by measuring plasma levels of gastrointestinal hormones in humans.
410. Cerebral processing of painful oesophageal stimulation: a study based on independent component analysis of the EEG.
作者: A M Drewes.;S A K Sami.;G Dimcevski.;K D Nielsen.;P Funch-Jensen.;M Valeriani.;L Arendt-Nielsen.
来源: Gut. 2006年55卷5期619-29页
Independent component analysis (ICA) of the electroencephalogram (EEG) overcomes many of the classical problems in EEG analysis. We used ICA to determine the brain responses to painful stimulation of the oesophagus.
411. Infliximab for the treatment of pyoderma gangrenosum: a randomised, double blind, placebo controlled trial.
作者: T N Brooklyn.;M G S Dunnill.;A Shetty.;J J Bowden.;J D L Williams.;C E M Griffiths.;A Forbes.;R Greenwood.;C S Probert.
来源: Gut. 2006年55卷4期505-9页
Pyoderma gangrenosum (PG) is a chronic ulcerating skin condition that often occurs in association with inflammatory bowel disease. There have been a number of reports of PG responding to infliximab, a monoclonal antibody against tumour necrosis factor alpha.
412. Treatment of active Crohn's disease in children using partial enteral nutrition with liquid formula: a randomised controlled trial.
Total enteral nutrition (TEN) with a liquid formula can suppress gut inflammation and induce remission in active Crohn's disease. The mechanism is obscure. Studies have suggested that long term nutritional supplementation with a liquid formula (partial enteral nutrition (PEN)) may also suppress inflammation and prevent relapse. The aim of this study was to compare PEN with conventional TEN in active Crohn's disease.
413. Clinical, microbiological, and immunological effects of fructo-oligosaccharide in patients with Crohn's disease.
作者: J O Lindsay.;K Whelan.;A J Stagg.;P Gobin.;H O Al-Hassi.;N Rayment.;M A Kamm.;S C Knight.;A Forbes.
来源: Gut. 2006年55卷3期348-55页
The intestinal microbiota play a pivotal role in the inflammation associated with Crohn's disease through their interaction with the mucosal immune system. Some bifidobacteria species are immunoregulatory and induce increased dendritic cell interleukin 10 (IL-10) release in vitro. Fructo-oligosaccharides (FOS) increase faecal and mucosal bifidobacteria in healthy volunteers. The aim of this study was to assess the effect of FOS administration on disease activity, bifidobacteria concentrations, and mucosal dendritic cell function in patients with moderately active Crohn's disease.
414. Accuracy of breath tests using low doses of 13C-urea to diagnose Helicobacter pylori infection: a randomised controlled trial.
作者: L Gatta.;C Ricci.;A Tampieri.;J Osborn.;F Perna.;V Bernabucci.;D Vaira.
来源: Gut. 2006年55卷4期457-62页
The 13C-urea breath test (UBT) for detecting Helicobacter pylori infection is a non-invasive method based on the organism's urease activity. Since its first description, the method has been extensively modified. However, only the dose of 13C-urea and the measurement equipment are directly related to the cost of the test.
415. Sporadic adenomatous polyp regression with exisulind is effective but toxic: a randomised, double blind, placebo controlled, dose-response study.
A 12 month, multicentre, randomised, double blind, placebo controlled, phase 3, dose-response study was carried out. Exisulind inhibits tumour growth by induction of apoptosis. The aim of our study was to investigate if exisulind induces regression of sporadic colonic adenomas.
416. Association of pretreatment serum interferon gamma inducible protein 10 levels with sustained virological response to peginterferon plus ribavirin therapy in genotype 1 infected patients with chronic hepatitis C.
作者: M Diago.;G Castellano.;J García-Samaniego.;C Pérez.;I Fernández.;M Romero.;O L Iacono.;C García-Monzón.
来源: Gut. 2006年55卷3期374-9页
Increased serum and intrahepatic interferon gamma inducible protein 10 (IP-10) levels in patients with chronic hepatitis C (CHC) have been described.
417. Acupuncture treatment in irritable bowel syndrome.
作者: A Schneider.;P Enck.;K Streitberger.;C Weiland.;S Bagheri.;S Witte.;H-C Friederich.;W Herzog.;S Zipfel.
来源: Gut. 2006年55卷5期649-54页
Despite occasional positive reports on the efficacy of acupuncture (AC) on functions of the gastrointestinal tract, there is no conclusive evidence that AC is effective in the treatment of irritable bowel syndrome (IBS).
418. Teduglutide (ALX-0600), a dipeptidyl peptidase IV resistant glucagon-like peptide 2 analogue, improves intestinal function in short bowel syndrome patients.
作者: P B Jeppesen.;E L Sanguinetti.;A Buchman.;L Howard.;J S Scolapio.;T R Ziegler.;J Gregory.;K A Tappenden.;J Holst.;P B Mortensen.
来源: Gut. 2005年54卷9期1224-31页
Glucagon-like peptide 2 (GLP-2) may improve intestinal absorption in short bowel syndrome (SBS) patients with an end jejunostomy. Teduglutide (ALX-0600), a dipeptidyl peptidase IV resistant GLP-2 analogue, prolongs the intestinotrophic properties of GLP-2 in animal models. The safety and effect of teduglutide were investigated in SBS patients with and without a colon in continuity.
419. A randomised controlled trial of self-help interventions in patients with a primary care diagnosis of irritable bowel syndrome.
作者: A Robinson.;V Lee.;A Kennedy.;L Middleton.;A Rogers.;D G Thompson.;D Reeves.
来源: Gut. 2006年55卷5期643-8页
Functional abdominal symptoms are very common and account for nearly two million primary care consultations in Britain every year and produce significant morbidity. The aims of this study were to evaluate the impact of two self-help interventions on consultation rates and symptom severity in patients with a primary care diagnosis of irritable bowel syndrome.
420. Ghrelin enhances gastric emptying in diabetic gastroparesis: a double blind, placebo controlled, crossover study.
作者: C D R Murray.;N M Martin.;M Patterson.;S A Taylor.;M A Ghatei.;M A Kamm.;C Johnston.;S R Bloom.;A V Emmanuel.
来源: Gut. 2005年54卷12期1693-8页
Diabetic gastroparesis is a disabling condition with no consistently effective treatment. In animals, ghrelin increases gastric emptying and reverses postoperative ileus. We present the results of a double blind, placebo controlled, crossover study of ghrelin in gastric emptying in patients with diabetic gastroparesis.
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