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4161. Regional variation in health care intensity and treatment practices for end-stage renal disease in older adults.
作者: Ann M O'Hare.;Rudolph A Rodriguez.;Susan M Hailpern.;Eric B Larson.;Manjula Kurella Tamura.
来源: JAMA. 2010年304卷2期180-6页
An increasing number of older adults are being treated for end-stage renal disease (ESRD) with long-term dialysis.
4162. Effect of telecare management on pain and depression in patients with cancer: a randomized trial.
作者: Kurt Kroenke.;Dale Theobald.;Jingwei Wu.;Kelli Norton.;Gwendolyn Morrison.;Janet Carpenter.;Wanzhu Tu.
来源: JAMA. 2010年304卷2期163-71页
Pain and depression are 2 of the most prevalent and treatable cancer-related symptoms, yet they frequently go unrecognized, undertreated, or both.
4163. Tight blood pressure control and cardiovascular outcomes among hypertensive patients with diabetes and coronary artery disease.
作者: Rhonda M Cooper-DeHoff.;Yan Gong.;Eileen M Handberg.;Anthony A Bavry.;Scott J Denardo.;George L Bakris.;Carl J Pepine.
来源: JAMA. 2010年304卷1期61-8页
Hypertension guidelines advocate treating systolic blood pressure (BP) to less than 130 mm Hg for patients with diabetes mellitus; however, data are lacking for the growing population who also have coronary artery disease (CAD).
4164. Association between adiposity in midlife and older age and risk of diabetes in older adults.
作者: Mary L Biggs.;Kenneth J Mukamal.;Jose A Luchsinger.;Joachim H Ix.;Mercedes R Carnethon.;Anne B Newman.;Ian H de Boer.;Elsa S Strotmeyer.;Dariush Mozaffarian.;David S Siscovick.
来源: JAMA. 2010年303卷24期2504-12页
Adiposity is a well-recognized risk factor for type 2 diabetes among young and middle-aged adults, but the relationship between body composition and type 2 diabetes is not well described among older adults.
4165. Infection rate and acute organ dysfunction risk as explanations for racial differences in severe sepsis.
作者: Florian B Mayr.;Sachin Yende.;Walter T Linde-Zwirble.;Octavia M Peck-Palmer.;Amber E Barnato.;Lisa A Weissfeld.;Derek C Angus.
来源: JAMA. 2010年303卷24期2495-503页
Severe sepsis, defined as infection complicated by acute organ dysfunction, occurs more frequently and leads to more deaths in black than in white individuals. The optimal approach to minimize these disparities is unclear.
4166. Factors associated with decisions to undergo surgery among patients with newly diagnosed early-stage lung cancer.
作者: Samuel Cykert.;Peggye Dilworth-Anderson.;Michael H Monroe.;Paul Walker.;Franklin R McGuire.;Giselle Corbie-Smith.;Lloyd J Edwards.;Audrina Jones Bunton.
来源: JAMA. 2010年303卷23期2368-76页
Lung cancer is the leading cause of cancer death in the United States. Surgical resection for stage I or II non-small cell cancer remains the only reliable treatment for cure. Patients who do not undergo surgery have a median survival of less than 1 year. Despite the survival disadvantage, many patients with early-stage disease do not receive surgical care and rates are even lower for black patients.
4167. Risk of injury associated with body checking among youth ice hockey players.
作者: Carolyn A Emery.;Jian Kang.;Ian Shrier.;Claude Goulet.;Brent E Hagel.;Brian W Benson.;Alberto Nettel-Aguirre.;Jenelle R McAllister.;Gavin M Hamilton.;Willem H Meeuwisse.
来源: JAMA. 2010年303卷22期2265-72页
Ice hockey has one of the highest sport participation and injury rates in youth in Canada. Body checking is the predominant mechanism of injury in leagues in which it is permitted.
4168. Long-term acute care hospital utilization after critical illness.
作者: Jeremy M Kahn.;Nicole M Benson.;Dina Appleby.;Shannon S Carson.;Theodore J Iwashyna.
来源: JAMA. 2010年303卷22期2253-9页
Long-term acute care hospitals have emerged as a novel approach for the care of patients recovering from severe acute illness, but the extent and increases in their activity at the national level are unknown.
4170. Trends in length of stay and short-term outcomes among Medicare patients hospitalized for heart failure, 1993-2006.
作者: Héctor Bueno.;Joseph S Ross.;Yun Wang.;Jersey Chen.;María T Vidán.;Sharon-Lise T Normand.;Jeptha P Curtis.;Elizabeth E Drye.;Judith H Lichtman.;Patricia S Keenan.;Mikhail Kosiborod.;Harlan M Krumholz.
来源: JAMA. 2010年303卷21期2141-7页
Whether decreases in the length of stay during the past decade for patients with heart failure (HF) may be associated with changes in outcomes is unknown.
4171. Viral etiology of severe pneumonia among Kenyan infants and children.
作者: James A Berkley.;Patrick Munywoki.;Mwanajuma Ngama.;Sidi Kazungu.;John Abwao.;Anne Bett.;Ria Lassauniére.;Tina Kresfelder.;Patricia A Cane.;Marietjie Venter.;J Anthony G Scott.;D James Nokes.
来源: JAMA. 2010年303卷20期2051-7页
Pneumonia is the leading cause of childhood death in sub-Saharan Africa. Comparative estimates of the contribution of causative pathogens to the burden of disease are essential for targeted vaccine development.
4174. Association of family income supplements in adolescence with development of psychiatric and substance use disorders in adulthood among an American Indian population.
作者: E Jane Costello.;Alaattin Erkanli.;William Copeland.;Adrian Angold.
来源: JAMA. 2010年303卷19期1954-60页
In a natural experiment in which some families received income supplements, prevalence of adolescent behavioral symptoms decreased significantly. These adolescents are now young adults.
4175. Association between major depressive episodes in patients with chronic kidney disease and initiation of dialysis, hospitalization, or death.
作者: S Susan Hedayati.;Abu T Minhajuddin.;Masoud Afshar.;Robert D Toto.;Madhukar H Trivedi.;A John Rush.
来源: JAMA. 2010年303卷19期1946-53页
Patients with chronic kidney disease (CKD) experience increased rates of hospitalization and death. Depressive disorders are associated with morbidity and mortality. Whether depression contributes to poor outcomes in patients with CKD not receiving dialysis is unknown.
4176. Rates of major depressive disorder and clinical outcomes following traumatic brain injury.
作者: Charles H Bombardier.;Jesse R Fann.;Nancy R Temkin.;Peter C Esselman.;Jason Barber.;Sureyya S Dikmen.
来源: JAMA. 2010年303卷19期1938-45页
Uncertainties exist about the rates, predictors, and outcomes of major depressive disorder (MDD) among individuals with traumatic brain injury (TBI).
4177. Behavior therapy for children with Tourette disorder: a randomized controlled trial.
作者: John Piacentini.;Douglas W Woods.;Lawrence Scahill.;Sabine Wilhelm.;Alan L Peterson.;Susanna Chang.;Golda S Ginsburg.;Thilo Deckersbach.;James Dziura.;Sue Levi-Pearl.;John T Walkup.
来源: JAMA. 2010年303卷19期1929-37页
Tourette disorder is a chronic and typically impairing childhood-onset neurologic condition. Antipsychotic medications, the first-line treatments for moderate to severe tics, are often associated with adverse effects. Behavioral interventions, although promising, have not been evaluated in large-scale controlled trials.
4178. Delivery of evidence-based treatment for multiple anxiety disorders in primary care: a randomized controlled trial.
作者: Peter Roy-Byrne.;Michelle G Craske.;Greer Sullivan.;Raphael D Rose.;Mark J Edlund.;Ariel J Lang.;Alexander Bystritsky.;Stacy Shaw Welch.;Denise A Chavira.;Daniela Golinelli.;Laura Campbell-Sills.;Cathy D Sherbourne.;Murray B Stein.
来源: JAMA. 2010年303卷19期1921-8页
Improving the quality of mental health care requires moving clinical interventions from controlled research settings into real-world practice settings. Although such advances have been made for depression, little work has been performed for anxiety disorders.
4180. Genome-wide analysis of genetic loci associated with Alzheimer disease.
作者: Sudha Seshadri.;Annette L Fitzpatrick.;M Arfan Ikram.;Anita L DeStefano.;Vilmundur Gudnason.;Merce Boada.;Joshua C Bis.;Albert V Smith.;Minerva M Carassquillo.;Jean Charles Lambert.;Denise Harold.;Elisabeth M C Schrijvers.;Reposo Ramirez-Lorca.;Stephanie Debette.;W T Longstreth.;A Cecile J W Janssens.;V Shane Pankratz.;Jean François Dartigues.;Paul Hollingworth.;Thor Aspelund.;Isabel Hernandez.;Alexa Beiser.;Lewis H Kuller.;Peter J Koudstaal.;Dennis W Dickson.;Christophe Tzourio.;Richard Abraham.;Carmen Antunez.;Yangchun Du.;Jerome I Rotter.;Yurii S Aulchenko.;Tamara B Harris.;Ronald C Petersen.;Claudine Berr.;Michael J Owen.;Jesus Lopez-Arrieta.;Badri N Varadarajan.;James T Becker.;Fernando Rivadeneira.;Michael A Nalls.;Neill R Graff-Radford.;Dominique Campion.;Sanford Auerbach.;Kenneth Rice.;Albert Hofman.;Palmi V Jonsson.;Helena Schmidt.;Mark Lathrop.;Thomas H Mosley.;Rhoda Au.;Bruce M Psaty.;Andre G Uitterlinden.;Lindsay A Farrer.;Thomas Lumley.;Agustin Ruiz.;Julie Williams.;Philippe Amouyel.;Steve G Younkin.;Philip A Wolf.;Lenore J Launer.;Oscar L Lopez.;Cornelia M van Duijn.;Monique M B Breteler.; .; .; .
来源: JAMA. 2010年303卷18期1832-40页
Genome-wide association studies (GWAS) have recently identified CLU, PICALM, and CR1 as novel genes for late-onset Alzheimer disease (AD).
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