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4161. Developmental and neurological status of children at 4 years of age after heart surgery with hypothermic circulatory arrest or low-flow cardiopulmonary bypass.
作者: D C Bellinger.;D Wypij.;K C Kuban.;L A Rappaport.;P R Hickey.;G Wernovsky.;R A Jonas.;J W Newburger.
来源: Circulation. 1999年100卷5期526-32页
It is not known whether developmental and neurological outcomes in the preschool period differ depending on whether the predominant vital organ support strategy used in infant heart surgery was total circulatory arrest (CA) or low-flow cardiopulmonary bypass.
4162. Angiogenesis gene therapy: phase I assessment of direct intramyocardial administration of an adenovirus vector expressing VEGF121 cDNA to individuals with clinically significant severe coronary artery disease.
作者: T K Rosengart.;L Y Lee.;S R Patel.;T A Sanborn.;M Parikh.;G W Bergman.;R Hachamovitch.;M Szulc.;P D Kligfield.;P M Okin.;R T Hahn.;R B Devereux.;M R Post.;N R Hackett.;T Foster.;T M Grasso.;M L Lesser.;O W Isom.;R G Crystal.
来源: Circulation. 1999年100卷5期468-74页
Therapeutic angiogenesis, a new experimental strategy for the treatment of vascular insufficiency, uses the administration of mediators known to induce vascular development in embryogenesis to induce neovascularization of ischemic adult tissues. This report summarizes a phase I clinical experience with a gene-therapy strategy that used an E1(-)E3(-) adenovirus (Ad) gene-transfer vector expressing human vascular endothelial growth factor (VEGF) 121 cDNA (Ad(GV)VEGF121.10) to induce therapeutic angiogenesis in the myocardium of individuals with clinically significant coronary artery disease.
4163. Trandolapril reduces the incidence of atrial fibrillation after acute myocardial infarction in patients with left ventricular dysfunction.
Studies have suggested that ACE inhibitors have an antiarrhythmic effect on ventricular arrhythmias. Whether they have an effect on atrial fibrillation is unknown.
4164. Efficacy and safety of ibutilide fumarate for the conversion of atrial arrhythmias after cardiac surgery.
作者: J T VanderLugt.;T Mattioni.;S Denker.;D Torchiana.;T Ahern.;L K Wakefield.;K T Perry.;P R Kowey.
来源: Circulation. 1999年100卷4期369-75页
Atrial arrhythmias occur commonly after cardiac surgery and are a cause of significant morbidity and increased hospital costs, yet there is no well-studied treatment strategy to deal with them expeditiously. The purpose of this study was to determine the efficacy and safety of ibutilide fumarate, an approved drug for the rapid conversion of atrial fibrillation and flutter, in patients after cardiac surgery.
4165. Effects of oral folic acid supplementation on endothelial function in familial hypercholesterolemia. A randomized placebo-controlled trial.
作者: M C Verhaar.;R M Wever.;J J Kastelein.;D van Loon.;S Milstien.;H A Koomans.;T J Rabelink.
来源: Circulation. 1999年100卷4期335-8页
Folates have been suggested to be of benefit in reducing cardiovascular risk. The present study was designed to examine whether oral folic acid supplementation could improve endothelial function as an intermediate end point for cardiovascular risk in patients with increased risk of atherosclerosis due to familial hypercholesterolemia (FH).
4166. Effects of lovastatin and warfarin on early carotid atherosclerosis: sex-specific analyses. Asymptomatic Carotid Artery Progression Study (ACAPS) Research Group.
作者: R P Byington.;G W Evans.;M A Espeland.;W B Applegate.;D B Hunninghake.;J Probstfield.;C D Furberg.
来源: Circulation. 1999年100卷3期e14-7页
Few clinical trials have documented the efficacy of preventive treatment in asymptomatic women.
4167. Discoordinate modulation of natriuretic peptides during acute cardiac allograft rejection in humans.
作者: R G Masters.;R A Davies.;J P Veinot.;P J Hendry.;S J Smith.;A J de Bold.
来源: Circulation. 1999年100卷3期287-91页
Increased circulating levels of the cardiac polypeptide hormones atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) may be observed after orthotopic cardiac transplantation. Both the hypertrophic and inflammatory processes in the allograft may contribute to this increase, but no mechanistic explanation has been suggested for this observation.
4168. Parasympathetic control of cardiac sympathetic activity: normal ventricular function versus congestive heart failure.
Muscarinic receptors on adrenergic nerve terminals attenuate norepinephrine release. The role of these receptors in the modulation of cardiac norepinephrine release in humans remains uncertain.
4169. Role of bradykinin in the vasodilator effects of losartan and enalapril in patients with heart failure.
ACE inhibitors have been shown to potentiate the effects of exogenous bradykinin by inhibition of its breakdown. Despite this, there is little evidence that inhibition of endogenous bradykinin breakdown actually contributes to the effects of ACE inhibitors, or indeed, other inhibitors of the renin-angiotensin system, such as angiotensin II type I receptor (AT(1)) antagonists, and no evidence at all that it does so in patients with heart failure.
4170. Enhanced sympathetic and ventilatory responses to central chemoreflex activation in heart failure.
作者: K Narkiewicz.;C A Pesek.;P J van de Borne.;M Kato.;V K Somers.
来源: Circulation. 1999年100卷3期262-7页
Sympathetic activation and respiratory abnormalities may each be implicated in the pathophysiology of congestive heart failure (CHF). Chemoreflexes are an important mechanism regulating both sympathetic drive and breathing. We therefore tested the hypothesis that chemoreflex function is altered in CHF.
4171. Long-term follow-up after percutaneous transluminal coronary angioplasty was not performed based on intravascular ultrasound findings: importance of lumen dimensions.
作者: A S Abizaid.;G S Mintz.;R Mehran.;A Abizaid.;A J Lansky.;A D Pichard.;L F Satler.;H Wu.;C Pappas.;K M Kent.;M B Leon.
来源: Circulation. 1999年100卷3期256-61页
Angiography is limited in determining the anatomic severity of coronary artery stenoses. Clinical decision-making in patients with symptoms and intermediate lesions remains challenging.
4172. Clinical potential of intravascular ultrasound for physiological assessment of coronary stenosis: relationship between quantitative ultrasound tomography and pressure-derived fractional flow reserve.
作者: A Takagi.;Y Tsurumi.;Y Ishii.;K Suzuki.;M Kawana.;H Kasanuki.
来源: Circulation. 1999年100卷3期250-5页
Little is known regarding intravascular ultrasound (IVUS) criteria to determine the functional severity of coronary stenosis. Recently, fractional flow reserve (FFR) has emerged as a lesion-specific index of the functional severity of a coronary stenosis that is independent of systemic hemodynamic variability. The present study was undertaken to determine the IVUS parameters for the physiological severity of coronary stenosis.
4173. Effects of dobutamine on coronary stenosis physiology and morphology: comparison with intracoronary adenosine.
The mechanisms leading to dobutamine-induced ischemia are not fully understood. In the present study, we investigated the effects of high-dose intravenous dobutamine on morphological and physiological indexes of coronary stenoses.
4174. Primary stenting versus balloon angioplasty in occluded coronary arteries: the Total Occlusion Study of Canada (TOSCA).
作者: C E Buller.;V Dzavik.;R G Carere.;G B Mancini.;G Barbeau.;C Lazzam.;T J Anderson.;M L Knudtson.;J F Marquis.;T Suzuki.;E A Cohen.;R S Fox.;K K Teo.
来源: Circulation. 1999年100卷3期236-42页
Balloon angioplasty (PTCA) of occluded coronary arteries is limited by high rates of restenosis and reocclusion. Although stenting improves results in anatomically simple occlusions, its effect on patency and clinical outcome in a broadly selected population with occluded coronary arteries is unknown.
4175. Long-term effects of pravastatin on plasma concentration of C-reactive protein. The Cholesterol and Recurrent Events (CARE) Investigators.
Elevated plasma concentrations of C-reactive protein (CRP) are associated with increased cardiovascular risk. We evaluated whether long-term therapy with pravastatin, an agent that reduces cardiovascular risk, might alter levels of this inflammatory parameter.
4176. Muscle and skin sympathetic nerve traffic during the "white-coat" effect.
Sphygmomanometric blood pressure measurements induce an alerting reaction and thus an increase in the patient's blood pressure and heart rate. Whether and to what extent this "white-coat" effect is accompanied by detectable changes in sympathetic nerve traffic has never been investigated.
4177. Plasma alpha-tocopherol and coronary endothelium-dependent vasodilator function.
作者: S Kinlay.;J C Fang.;H Hikita.;I Ho.;D M Delagrange.;B Frei.;J H Suh.;M Gerhard.;M A Creager.;A P Selwyn.;P Ganz.
来源: Circulation. 1999年100卷3期219-21页
In the presence of atherosclerosis, the coronary endothelial vasomotor response to acetylcholine is frequently abnormal but is variable between patients. We tested the hypothesis that the plasma concentration of alpha-tocopherol is associated with the preservation of nitric oxide-mediated endothelium-dependent vasomotion.
4178. Increased incidence of periprocedural complications among patients with peripheral vascular disease undergoing myocardial revascularization in the bypass angioplasty revascularization investigation.
作者: C S Rihal.;K Sutton-Tyrrell.;P Guo.;N M Keller.;R Jandova.;M A Sellers.;H V Schaff.;D R Holmes.
来源: Circulation. 1999年100卷2期171-7页
Risks of coronary artery bypass graft surgery (CABG) or percutaneous transluminal coronary angioplasty (PTCA) may be different in the presence of peripheral vascular disease (PVD).
4179. Impact of prophylactic immediate posttransplant ganciclovir on development of transplant atherosclerosis: a post hoc analysis of a randomized, placebo-controlled study.
作者: H A Valantine.;S Z Gao.;S G Menon.;D G Renlund.;S A Hunt.;P Oyer.;E B Stinson.;B W Brown.;T C Merigan.;J S Schroeder.
来源: Circulation. 1999年100卷1期61-6页
Coronary artery disease occurs in an accelerated fashion in the donor heart after heart transplantation (TxCAD), but the cause is poorly understood. The risk of developing TxCAD is increased by cytomegalovirus (CMV) infection and decreased by use of calcium blockers. Our group observed that prophylactic administration of ganciclovir early after heart transplantation inhibited CMV illness, and we now propose to determine whether this therapy also prevents TxCAD.
4180. Impact of cilostazol on restenosis after percutaneous coronary balloon angioplasty.
作者: E Tsuchikane.;A Fukuhara.;T Kobayashi.;M Kirino.;K Yamasaki.;T Kobayashi.;M Izumi.;S Otsuji.;H Tateyama.;M Sakurai.;N Awata.
来源: Circulation. 1999年100卷1期21-6页
Restenosis after percutaneous transluminal coronary (balloon) angioplasty (PTCA) remains a major drawback of the procedure. We previously reported that cilostazol, a platelet aggregation inhibitor, inhibited intimal proliferation after directional coronary atherectomy and reduced the restenosis rate in humans. The present study aimed to determine the effect of cilostazol on restenosis after PTCA.
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