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4101. Effect of intracoronary gamma-radiation therapy on in-stent restenosis: An intravascular ultrasound analysis from the gamma-1 study.
作者: G S Mintz.;N J Weissman.;P S Teirstein.;S G Ellis.;R Waksman.;R J Russo.;I Moussa.;P Tripuraneni.;S Jani.;Y Kobayashi.;J A Giorgianni.;C Pappas.;R A Kuntz.;J Moses.;M B Leon.
来源: Circulation. 2000年102卷24期2915-8页
The aim of this study was to use serial volumetric intravascular ultrasound to evaluate the effect of gamma-radiation on recurrent in-stent restenosis.
4102. Nitroglycerin tolerance in human vessels: evidence for impaired nitroglycerin bioconversion.
作者: P R Sage.;I S de la Lande.;I Stafford.;C L Bennett.;G Phillipov.;J Stubberfield.;J D Horowitz.
来源: Circulation. 2000年102卷23期2810-5页
The basis for progressive attenuation of the effects of organic nitrates during long-term therapy (nitrate tolerance) remains controversial; proposed mechanisms include impaired nitrate bioconversion resulting in decreased release of nitric oxide (NO) from nitrates and/or increased NO clearance through a reaction with incrementally generated superoxide (O(2)(-)).
4103. Ambulatory ventricular arrhythmias in patients with heart failure do not specifically predict an increased risk of sudden death. PROMISE (Prospective Randomized Milrinone Survival Evaluation) Investigators.
作者: J R Teerlink.;M Jalaluddin.;S Anderson.;M L Kukin.;E J Eichhorn.;G Francis.;M Packer.;B M Massie.
来源: Circulation. 2000年101卷1期40-6页
Ventricular arrhythmias are a frequent finding in congestive heart failure (CHF) patients and a cause of concern for physicians caring for them. Previous studies have reached conflicting conclusions regarding the importance of ventricular arrhythmias as predictors of sudden death in patients with CHF. This study examined the independent predictive value of ventricular arrhythmias for sudden death and all-cause mortality in PROMISE (Prospective Randomized Milrinone Survival Evaluation).
4104. Risk factors, angiographic patterns, and outcomes in patients with ventricular septal defect complicating acute myocardial infarction. GUSTO-I (Global Utilization of Streptokinase and TPA for Occluded Coronary Arteries) Trial Investigators.
作者: B S Crenshaw.;C B Granger.;Y Birnbaum.;K S Pieper.;D C Morris.;N S Kleiman.;A Vahanian.;R M Califf.;E J Topol.
来源: Circulation. 2000年101卷1期27-32页
Ventricular septal defect (VSD) complicating acute myocardial infarction has been studied primarily in small, prethrombolytic-era trials. Our goal was to determine clinical predictors and angiographic and clinical outcomes of this complication in the thrombolytic era.
4105. Short- and intermediate-term results of (32)P radioactive beta-emitting stent implantation in patients with coronary artery disease: The Milan Dose-Response Study.
作者: R Albiero.;M Adamian.;N Kobayashi.;A Amato.;M Vaghetti.;C Di Mario.;A Colombo.
来源: Circulation. 2000年101卷1期18-26页
Radioactive (32)P beta-emitting stents have been shown to reduce intrastent neointimal hyperplasia in a substantial dose-related manner in the animal model. The aim of this dose-response study was to evaluate, in the clinical setting, the safety and efficacy at 6-month follow-up of this approach to reducing restenosis.
4106. Pharmacology and biological efficacy of a recombinant, humanized, single-chain antibody C5 complement inhibitor in patients undergoing coronary artery bypass graft surgery with cardiopulmonary bypass.
作者: J C Fitch.;S Rollins.;L Matis.;B Alford.;S Aranki.;C D Collard.;M Dewar.;J Elefteriades.;R Hines.;G Kopf.;P Kraker.;L Li.;R O'Hara.;C Rinder.;H Rinder.;R Shaw.;B Smith.;G Stahl.;S K Shernan.
来源: Circulation. 1999年100卷25期2499-506页
Cardiopulmonary bypass (CPB) induces a systemic inflammatory response that causes substantial clinical morbidity. Activation of complement during CPB contributes significantly to this inflammatory process. We examined the capability of a novel therapeutic complement inhibitor to prevent pathological complement activation and tissue injury in patients undergoing CPB.
4107. Heparin blunts endotoxin-induced coagulation activation.
作者: T Pernerstorfer.;U Hollenstein.;J Hansen.;M Knechtelsdorfer.;P Stohlawetz.;W Graninger.;H G Eichler.;W Speiser.;B Jilma.
来源: Circulation. 1999年100卷25期2485-90页
Lipopolysaccharide (LPS) is a major trigger of sepsis-induced disseminated intravascular coagulation (DIC) via the tissue factor (TF)/factor VIIa-dependent pathway of coagulation. Experimental endotoxemia has been used repeatedly to explore this complex pathophysiology, but little is known about the effects of clinically used anticoagulants in this setting. Therefore, we compared with placebo the effects of unfractionated heparin (UFH) and low-molecular-weight heparin (LMWH) on LPS-induced coagulation.
4108. Optimizing the percutaneous interventional outcomes for patients with diabetes mellitus: results of the EPISTENT (Evaluation of platelet IIb/IIIa inhibitor for stenting trial) diabetic substudy.
作者: S P Marso.;A M Lincoff.;S G Ellis.;D L Bhatt.;J F Tanguay.;N S Kleiman.;T Hammoud.;J E Booth.;S K Sapp.;E J Topol.
来源: Circulation. 1999年100卷25期2477-84页
Stenting likely decreases the need for target-vessel revascularization procedures in diabetic patients compared with balloon angioplasty. However, the efficacy of stenting with platelet glycoprotein IIb/IIIa blockade has not yet been assessed in diabetics.
4109. Ventilatory and heart rate responses to exercise : better predictors of heart failure mortality than peak oxygen consumption.
作者: M Robbins.;G Francis.;F J Pashkow.;C E Snader.;K Hoercher.;J B Young.;M S Lauer.
来源: Circulation. 1999年100卷24期2411-7页
An abnormally low chronotropic response and an abnormally high ventilatory response (V(E)/V(CO2)) to exercise are common in patients with severe heart failure, but their relative prognostic impacts have not been well explored.
4110. Threshold values for preserved viability with a noninvasive measurement of collateral blood flow during acute myocardial infarction treated by direct coronary angioplasty.
作者: T F Christian.;P B Berger.;M K O'Connor.;D O Hodge.;R J Gibbons.
来源: Circulation. 1999年100卷24期2392-5页
Quantitative measures of myocardial perfusion defect severity from acute (99m)Tc-sestamibi tomographic images (nadir) have correlated closely with collateral and residual antegrade blood flow during acute myocardial infarction. The purpose of this study was to determine whether a viability threshold could be identified from this measure in patients with acute myocardial infarction treated in a homogeneous manner with successful reperfusion therapy.
4111. Frequency of early occlusion and stenosis in a left internal mammary artery to left anterior descending artery bypass graft after surgery through a median sternotomy on conventional bypass: benchmark for minimally invasive direct coronary artery bypass.
Uncertainty exists regarding the frequency of early occlusion when the left internal mammary artery (LIMA) is anastomosed to the left anterior descending artery (LAD) through a sternotomy with conventional coronary artery bypass grafting (CABG). The issue has gained importance for comparison with less invasive surgical approaches in which operative exposure may be limited and graft anastomosis more difficult.
4112. Risks of spontaneous injury and extraction of an active fixation pacemaker lead: report of the Accufix Multicenter Clinical Study and Worldwide Registry.
作者: G N Kay.;J A Brinker.;D T Kawanishi.;C J Love.;M A Lloyd.;R C Reeves.;G Pioger.;J A Fee.;M K Overland.;L G Ensign.;G L Grunkemeier.
来源: Circulation. 1999年100卷23期2344-52页
The Telectronics Accufix pacing leads were recalled in November 1994 after 2 deaths and 2 nonfatal injuries were reported. This multicenter clinical study (MCS) of patients with Accufix leads was designed to determine the rate of spontaneous injury related to the J retention wire and results of lead extraction.
4113. Nocturnal continuous positive airway pressure decreases daytime sympathetic traffic in obstructive sleep apnea.
作者: K Narkiewicz.;M Kato.;B G Phillips.;C A Pesek.;D E Davison.;V K Somers.
来源: Circulation. 1999年100卷23期2332-5页
Patients with obstructive sleep apnea (OSA) have high levels of muscle sympathetic nerve activity (MSNA). We tested the hypothesis that long-term continuous positive airway pressure (CPAP) treatment will decrease MSNA in OSA patients.
4114. Comparative effects of low and high doses of the angiotensin-converting enzyme inhibitor, lisinopril, on morbidity and mortality in chronic heart failure. ATLAS Study Group.
作者: M Packer.;P A Poole-Wilson.;P W Armstrong.;J G Cleland.;J D Horowitz.;B M Massie.;L Rydén.;K Thygesen.;B F Uretsky.
来源: Circulation. 1999年100卷23期2312-8页
Angiotensin-converting enzyme (ACE) inhibitors are generally prescribed by physicians in doses lower than the large doses that have been shown to reduce morbidity and mortality in patients with heart failure. It is unclear, however, if low doses and high doses of ACE inhibitors have similar benefits.
4115. Improvement in exercise tolerance and symptoms of congestive heart failure during treatment with candesartan cilexetil. Symptom, Tolerability, Response to Exercise Trial of Candesartan Cilexetil in Heart Failure (STRETCH) Investigators.
作者: G A Riegger.;H Bouzo.;P Petr.;J Münz.;R Spacek.;H Pethig.;V von Behren.;M George.;H Arens.
来源: Circulation. 1999年100卷22期2224-30页
The renin-angiotensin system plays an important part in the pathogenesis of congestive heart failure (CHF). This study evaluated the effect of an angiotensin II type 1 receptor antagonist on exercise tolerance and symptoms of CHF.
4116. Joint effects of an aldosterone synthase (CYP11B2) gene polymorphism and classic risk factors on risk of myocardial infarction.
作者: A Hautanen.;P Toivanen.;M Mänttäri.;L Tenkanen.;M Kupari.;V Manninen.;K M Kayes.;S Rosenfeld.;P C White.
来源: Circulation. 1999年100卷22期2213-8页
The -344C allele of a 2-allele (C or T) polymorphism in the promoter of the gene encoding aldosterone synthase (CYP11B2) is associated with increased left ventricular size and mass and with decreased baroreflex sensitivity, known risk factors for morbidity and mortality associated with myocardial infarction (MI). We hypothesized that this polymorphism was a risk factor for MI.
4117. Risk stratification for coronary bypass surgery in patients with left ventricular dysfunction: analysis of the coronary artery bypass grafting patch trial database.
作者: M Argenziano.;H M Spotnitz.;W Whang.;J T Bigger.;M Parides.;E A Rose.
来源: Circulation. 1999年100卷19 Suppl期II119-24页
Preoperative characteristics may influence morbidity and mortality in patients undergoing coronary artery bypass grafting (CABG). The CABG Patch Trial was designed to assess the impact of prophylactic insertion of an implantable cardioverter-defibrillator in patients undergoing high-risk CABG. This database was used to investigate the influence of symptomatic congestive heart failure (CHF) and angina on morbidity and mortality in CABG patients with ventricular dysfunction.
4118. Five-year follow-op of the medicine, angioplasty, or surgery study (MASS): A prospective, randomized trial of medical therapy, balloon angioplasty, or bypass surgery for single proximal left anterior descending coronary artery stenosis.
作者: W A Hueb.;P R Soares.;S Almeida De Oliveira.;S Ariê.;R H Cardoso.;D B Wajsbrot.;L A Cesar.;A D Jatene.;J A Ramires.
来源: Circulation. 1999年100卷19 Suppl期II107-13页
Although coronary angioplasty and myocardial bypass surgery are routinely used, there is no conclusive evidence that these interventional methods offer greater benefit than medical therapy alone. This study is intended to evaluate, in a prospective, randomized, and comparative analysis, the benefit of the 3 current therapeutic strategies for patients with stable angina and single proximal left anterior descending coronary artery stenosis.
4119. Pulmonary autograft versus aortic homograft for rereplacement of the aortic valve: results from a subset of a prospective randomized trial.
作者: G S Carr-White.;S Glennan.;S Edwards.;F D Ferdinand.;A C Desouza.;J R Pepper.;M H Yacoub.
来源: Circulation. 1999年100卷19 Suppl期II103-6页
The use of a pulmonary autograft for rereplacement of the aortic valve has both potential advantages and disadvantages. This study details the early results of a subset of patients enrolled in a prospective randomized trial comparing pulmonary autografts and aortic homografts who have had previous aortic valve replacements.
4120. Randomized trial of partial versus complete chordal preservation methods of mitral valve replacement: A preliminary report.
作者: K L Yun.;C F Sintek.;D C Miller.;G T Schuyler.;A D Fletcher.;T A Pfeffer.;G S Kochamba.;S Khonsari.;M R Zile.
来源: Circulation. 1999年100卷19 Suppl期II90-4页
The merits of retaining the subvalvular apparatus during mitral valve replacement for chronic mitral regurgitation have been demonstrated in numerous clinical and laboratory investigations. In this preliminary report, we analyzed the early effects of complete versus partial chordal preservation on left ventricular mechanics.
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