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4082. Use of florbetapir-PET for imaging beta-amyloid pathology.
作者: Christopher M Clark.;Julie A Schneider.;Barry J Bedell.;Thomas G Beach.;Warren B Bilker.;Mark A Mintun.;Michael J Pontecorvo.;Franz Hefti.;Alan P Carpenter.;Matthew L Flitter.;Michael J Krautkramer.;Hank F Kung.;R Edward Coleman.;P Murali Doraiswamy.;Adam S Fleisher.;Marwan N Sabbagh.;Carl H Sadowsky.;Eric P Reiman.;Simone P Zehntner.;Daniel M Skovronsky.; .
来源: JAMA. 2011年305卷3期275-83页
The ability to identify and quantify brain β-amyloid could increase the accuracy of a clinical diagnosis of Alzheimer disease.
4083. Efficacy of escitalopram for hot flashes in healthy menopausal women: a randomized controlled trial.
作者: Ellen W Freeman.;Katherine A Guthrie.;Bette Caan.;Barbara Sternfeld.;Lee S Cohen.;Hadine Joffe.;Janet S Carpenter.;Garnet L Anderson.;Joseph C Larson.;Kristine E Ensrud.;Susan D Reed.;Katherine M Newton.;Sheryl Sherman.;Mary D Sammel.;Andrea Z LaCroix.
来源: JAMA. 2011年305卷3期267-74页
Concerns regarding the risks associated with estrogen and progesterone to manage menopausal symptoms have resulted in its declining use and increased interest in nonhormonal treatments with demonstrated efficacy for hot flashes.
4084. Association of plasma beta-amyloid level and cognitive reserve with subsequent cognitive decline.
作者: Kristine Yaffe.;Andrea Weston.;Neill R Graff-Radford.;Suzanne Satterfield.;Eleanor M Simonsick.;Steven G Younkin.;Linda H Younkin.;Lewis Kuller.;Hilsa N Ayonayon.;Jingzhong Ding.;Tamara B Harris.
来源: JAMA. 2011年305卷3期261-6页
Lower plasma β-amyloid 42 and 42/40 levels have been associated with incident dementia, but results are conflicting and few have investigated cognitive decline among elders without dementia.
4085. Deciphering the clinical presentations, pathogenesis, and treatment of the idiopathic inflammatory myopathies.
The idiopathic inflammatory myopathies or myositis syndromes (the most common forms are polymyositis, dermatomyositis, and inclusion body myositis) are systemic autoimmune diseases defined by chronic muscle weakness and inflammation of unknown etiology and result in significant morbidity and mortality. Research suggests that categorizing heterogeneous myositis syndromes into mutually exclusive and stable phenotypes by using clinical and immune response features is useful for predicting clinical signs and symptoms, associated genetic and environmental risk factors, and responses to therapy and prognosis. Knowledge of myositis phenotypes should enhance clinicians' ability to recognize and manage these rare disorders.
4086. Behavioral therapy with or without biofeedback and pelvic floor electrical stimulation for persistent postprostatectomy incontinence: a randomized controlled trial.
作者: Patricia S Goode.;Kathryn L Burgio.;Theodore M Johnson.;Olivio J Clay.;David L Roth.;Alayne D Markland.;Jeffrey H Burkhardt.;Muta M Issa.;L Keith Lloyd.
来源: JAMA. 2011年305卷2期151-9页
Although behavioral therapy has been shown to improve postoperative recovery of continence, there have been no controlled trials of behavioral therapy for postprostatectomy incontinence persisting more than 1 year.
4087. DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors.
作者: Thomas Rio Frio.;Amin Bahubeshi.;Chryssa Kanellopoulou.;Nancy Hamel.;Marek Niedziela.;Nelly Sabbaghian.;Carly Pouchet.;Lucy Gilbert.;Paul K O'Brien.;Kim Serfas.;Peter Broderick.;Richard S Houlston.;Fabienne Lesueur.;Elena Bonora.;Stefan Muljo.;R Neil Schimke.;Dorothée Bouron-Dal Soglio.;Jocelyne Arseneau.;Kris Ann Schultz.;John R Priest.;Van-Hung Nguyen.;H Rubén Harach.;David M Livingston.;William D Foulkes.;Marc Tischkowitz.
来源: JAMA. 2011年305卷1期68-77页
Nontoxic multinodular goiter (MNG) is frequently observed in the general population, but little is known about the underlying genetic susceptibility to this disease. Familial cases of MNG have been reported, and published reports describe 5 families that also contain at least 1 individual with a Sertoli-Leydig cell tumor of the ovary (SLCT). Germline mutations in DICER1, a gene that codes for an RNase III endoribonuclease, have been identified in families affected by pleuropulmonary blastoma (PPB), some of whom include cases of MNG and gonadal tumors such as SLCTs.
4088. Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia.
作者: Muller Fabbri.;Arianna Bottoni.;Masayoshi Shimizu.;Riccardo Spizzo.;Milena S Nicoloso.;Simona Rossi.;Elisa Barbarotto.;Amelia Cimmino.;Brett Adair.;Sylwia E Wojcik.;Nicola Valeri.;Federica Calore.;Deepa Sampath.;Francesca Fanini.;Ivan Vannini.;Gerardo Musuraca.;Marie Dell'Aquila.;Hansjuerg Alder.;Ramana V Davuluri.;Laura Z Rassenti.;Massimo Negrini.;Tatsuya Nakamura.;Dino Amadori.;Neil E Kay.;Kanti R Rai.;Michael J Keating.;Thomas J Kipps.;George A Calin.;Carlo M Croce.
来源: JAMA. 2011年305卷1期59-67页
Chromosomal abnormalities (namely 13q, 17p, and 11q deletions) have prognostic implications and are recurrent in chronic lymphocytic leukemia (CLL), suggesting that they are involved in a common pathogenetic pathway; however, the molecular mechanism through which chromosomal abnormalities affect the pathogenesis and outcome of CLL is unknown.
4089. Gait speed and survival in older adults.
作者: Stephanie Studenski.;Subashan Perera.;Kushang Patel.;Caterina Rosano.;Kimberly Faulkner.;Marco Inzitari.;Jennifer Brach.;Julie Chandler.;Peggy Cawthon.;Elizabeth Barrett Connor.;Michael Nevitt.;Marjolein Visser.;Stephen Kritchevsky.;Stefania Badinelli.;Tamara Harris.;Anne B Newman.;Jane Cauley.;Luigi Ferrucci.;Jack Guralnik.
来源: JAMA. 2011年305卷1期50-8页
Survival estimates help individualize goals of care for geriatric patients, but life tables fail to account for the great variability in survival. Physical performance measures, such as gait speed, might help account for variability, allowing clinicians to make more individualized estimates.
4090. Non-evidence-based ICD implantations in the United States.
作者: Sana M Al-Khatib.;Anne Hellkamp.;Jeptha Curtis.;Daniel Mark.;Eric Peterson.;Gillian D Sanders.;Paul A Heidenreich.;Adrian F Hernandez.;Lesley H Curtis.;Stephen Hammill.
来源: JAMA. 2011年305卷1期43-9页
Practice guidelines do not recommend use of an implantable cardioverter-defibrillator (ICD) for primary prevention in patients recovering from a myocardial infarction or coronary artery bypass graft surgery and those with severe heart failure symptoms or a recent diagnosis of heart failure.
4091. Germline epigenetic regulation of KILLIN in Cowden and Cowden-like syndrome.
Germline loss-of-function phosphatase and tensin homolog gene (PTEN) mutations cause 80% of Cowden syndrome, a rare autosomal-dominant disorder (1 in 200,000 live births), characterized by high risks of breast, thyroid, and other cancers. A large heterogeneous group of individuals with Cowden-like syndrome, who have various combinations of Cowden syndrome features but who do not meet Cowden syndrome diagnostic criteria, have PTEN mutations less than 10% of the time, making molecular diagnosis, prediction, genetic counseling, and risk management challenging. Other mechanisms of loss of function such as hypermethylation, which should result in underexpression of PTEN or of KILLIN, a novel tumor suppressor transcribed in the opposite direction, may account for the remainder of Cowden syndrome and Cowden-like syndrome.
4092. Association of a leukemic stem cell gene expression signature with clinical outcomes in acute myeloid leukemia.
作者: Andrew J Gentles.;Sylvia K Plevritis.;Ravindra Majeti.;Ash A Alizadeh.
来源: JAMA. 2010年304卷24期2706-15页
In many cancers, specific subpopulations of cells appear to be uniquely capable of initiating and maintaining tumors. The strongest support for this cancer stem cell model comes from transplantation assays in immunodeficient mice, which indicate that human acute myeloid leukemia (AML) is driven by self-renewing leukemic stem cells (LSCs). This model has significant implications for the development of novel therapies, but its clinical relevance has yet to be determined.
4094. Does this older adult with lower extremity pain have the clinical syndrome of lumbar spinal stenosis?
The clinical syndrome of lumbar spinal stenosis (LSS) is a common diagnosis in older adults presenting with lower extremity pain.
4095. Effect of a lung protective strategy for organ donors on eligibility and availability of lungs for transplantation: a randomized controlled trial.
作者: Luciana Mascia.;Daniela Pasero.;Arthur S Slutsky.;M Jose Arguis.;Maurizio Berardino.;Salvatore Grasso.;Marina Munari.;Silvia Boifava.;Giuseppe Cornara.;Francesco Della Corte.;Nicoletta Vivaldi.;Paolo Malacarne.;Paolo Del Gaudio.;Sergio Livigni.;Elisabeth Zavala.;Claudia Filippini.;Erica L Martin.;Pier Paolo Donadio.;Ilaria Mastromauro.;V Marco Ranieri.
来源: JAMA. 2010年304卷23期2620-7页
Many potential donor lungs deteriorate between the time of brain death and evaluation for transplantation suitability, possibly because of the ventilatory strategy used after brain death.
4096. Spectrum and prevalence of FP/TMEM127 gene mutations in pheochromocytomas and paragangliomas.
作者: Li Yao.;Francesca Schiavi.;Alberto Cascon.;Yuejuan Qin.;Lucia Inglada-Pérez.;Elizabeth E King.;Rodrigo A Toledo.;Tonino Ercolino.;Elena Rapizzi.;Christopher J Ricketts.;Luigi Mori.;Mara Giacchè.;Antonella Mendola.;Elisa Taschin.;Francesca Boaretto.;Paola Loli.;Maurizio Iacobone.;Gian-Paolo Rossi.;Bernadette Biondi.;José Viana Lima-Junior.;Claudio E Kater.;Marie Bex.;Miikka Vikkula.;Ashley B Grossman.;Stephen B Gruber.;Marta Barontini.;Alexandre Persu.;Maurizio Castellano.;Sergio P A Toledo.;Eamonn R Maher.;Massimo Mannelli.;Giuseppe Opocher.;Mercedes Robledo.;Patricia L M Dahia.
来源: JAMA. 2010年304卷23期2611-9页
Pheochromocytomas and paragangliomas are genetically heterogeneous neural crest-derived neoplasms. We recently identified germline mutations of the novel transmembrane-encoding gene FP/TMEM127 in familial and sporadic pheochromocytomas consistent with a tumor suppressor effect.
4097. Maintaining a high physical activity level over 20 years and weight gain.
作者: Arlene L Hankinson.;Martha L Daviglus.;Claude Bouchard.;Mercedes Carnethon.;Cora E Lewis.;Pamela J Schreiner.;Kiang Liu.;Stephen Sidney.
来源: JAMA. 2010年304卷23期2603-10页
Data supporting physical activity guidelines to prevent long-term weight gain are sparse, particularly during the period when the highest risk of weight gain occurs.
4099. Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population.
作者: James A de Lemos.;Mark H Drazner.;Torbjorn Omland.;Colby R Ayers.;Amit Khera.;Anand Rohatgi.;Ibrahim Hashim.;Jarett D Berry.;Sandeep R Das.;David A Morrow.;Darren K McGuire.
来源: JAMA. 2010年304卷22期2503-12页
Detectable levels of cardiac troponin T (cTnT) are strongly associated with structural heart disease and increased risk of death and adverse cardiovascular events; however, cTnT is rarely detectable in the general population using standard assays.
4100. Integrating tobacco cessation into mental health care for posttraumatic stress disorder: a randomized controlled trial.
作者: Miles McFall.;Andrew J Saxon.;Carol A Malte.;Bruce Chow.;Sara Bailey.;Dewleen G Baker.;Jean C Beckham.;Kathy D Boardman.;Timothy P Carmody.;Anne M Joseph.;Mark W Smith.;Mei-Chiung Shih.;Ying Lu.;Mark Holodniy.;Philip W Lavori.; .
来源: JAMA. 2010年304卷22期2485-93页
Most smokers with mental illness do not receive tobacco cessation treatment.
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