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4021. Appropriateness of percutaneous coronary intervention.
作者: Paul S Chan.;Manesh R Patel.;Lloyd W Klein.;Ronald J Krone.;Gregory J Dehmer.;Kevin Kennedy.;Brahmajee K Nallamothu.;W Douglas Weaver.;Frederick A Masoudi.;John S Rumsfeld.;Ralph G Brindis.;John A Spertus.
来源: JAMA. 2011年306卷1期53-61页
Despite the widespread use of percutaneous coronary intervention (PCI), the appropriateness of these procedures in contemporary practice is unknown.
4022. Quality of care and patient outcomes in critical access rural hospitals.
Critical access hospitals (CAHs) play a crucial role in the US rural safety net. Current policy efforts have focused primarily on helping these small, isolated hospitals remain financially viable to ensure access for individuals living in rural areas in the United States; however, little is known about the quality of care they provide or the outcomes their patients achieve.
4024. Smoking and prostate cancer survival and recurrence.
作者: Stacey A Kenfield.;Meir J Stampfer.;June M Chan.;Edward Giovannucci.
来源: JAMA. 2011年305卷24期2548-55页
Studies of smoking in relation to prostate cancer mortality or recurrence in prostate cancer patients are limited, with few prostate cancer-specific outcomes.
4025. Temporal trends in the prevalence of diabetic kidney disease in the United States.
作者: Ian H de Boer.;Tessa C Rue.;Yoshio N Hall.;Patrick J Heagerty.;Noel S Weiss.;Jonathan Himmelfarb.
来源: JAMA. 2011年305卷24期2532-9页
Diabetes is the leading cause of kidney disease in the developed world. Over time, the prevalence of diabetic kidney disease (DKD) may increase due to the expanding size of the diabetes population or decrease due to the implementation of diabetes therapies.
4026. Television viewing and risk of type 2 diabetes, cardiovascular disease, and all-cause mortality: a meta-analysis.
Prolonged television (TV) viewing is the most prevalent and pervasive sedentary behavior in industrialized countries and has been associated with morbidity and mortality. However, a systematic and quantitative assessment of published studies is not available.
4027. Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease.
作者: Tamara Isakova.;Huiliang Xie.;Wei Yang.;Dawei Xie.;Amanda Hyre Anderson.;Julia Scialla.;Patricia Wahl.;Orlando M Gutiérrez.;Susan Steigerwalt.;Jiang He.;Stanley Schwartz.;Joan Lo.;Akinlolu Ojo.;James Sondheimer.;Chi-yuan Hsu.;James Lash.;Mary Leonard.;John W Kusek.;Harold I Feldman.;Myles Wolf.; .
来源: JAMA. 2011年305卷23期2432-9页
A high level of the phosphate-regulating hormone fibroblast growth factor 23 (FGF-23) is associated with mortality in patients with end-stage renal disease, but little is known about its relationship with adverse outcomes in the much larger population of patients with earlier stages of chronic kidney disease.
4028. Association between ambulance diversion and survival among patients with acute myocardial infarction.
Ambulance diversion, a practice in which emergency departments (EDs) are temporarily closed to ambulance traffic, might be problematic for patients experiencing time-sensitive conditions, such as acute myocardial infarction (AMI). However, there is little empirical evidence to show whether diversion is associated with worse patient outcomes.
4029. KIT as a therapeutic target in metastatic melanoma.
作者: Richard D Carvajal.;Cristina R Antonescu.;Jedd D Wolchok.;Paul B Chapman.;Ruth-Ann Roman.;Jerrold Teitcher.;Katherine S Panageas.;Klaus J Busam.;Bartosz Chmielowski.;Jose Lutzky.;Anna C Pavlick.;Anne Fusco.;Lauren Cane.;Naoko Takebe.;Swapna Vemula.;Nancy Bouvier.;Boris C Bastian.;Gary K Schwartz.
来源: JAMA. 2011年305卷22期2327-34页
Some melanomas arising from acral, mucosal, and chronically sun-damaged sites harbor activating mutations and amplification of the type III transmembrane receptor tyrosine kinase KIT. We explored the effects of KIT inhibition using imatinib mesylate in this molecular subset of disease.
4030. Association of BMD and FRAX score with risk of fracture in older adults with type 2 diabetes.
作者: Ann V Schwartz.;Eric Vittinghoff.;Douglas C Bauer.;Teresa A Hillier.;Elsa S Strotmeyer.;Kristine E Ensrud.;Meghan G Donaldson.;Jane A Cauley.;Tamara B Harris.;Annemarie Koster.;Catherine R Womack.;Lisa Palermo.;Dennis M Black.; .; .; .
来源: JAMA. 2011年305卷21期2184-92页
Type 2 diabetes mellitus (DM) is associated with higher bone mineral density (BMD) and paradoxically with increased fracture risk. It is not known if low BMD, central to fracture prediction in older adults, identifies fracture risk in patients with DM.
4032. Primary care physician workforce and Medicare beneficiaries' health outcomes.
作者: Chiang-Hua Chang.;Therese A Stukel.;Ann Barry Flood.;David C Goodman.
来源: JAMA. 2011年305卷20期2096-104页
Despite a widespread interest in increasing the numbers of primary care physicians to improve care and to moderate costs, the relationship of the primary care physician workforce to patient-level outcomes remains poorly understood.
4033. Risk of death and cardiovascular events in initially healthy women with new-onset atrial fibrillation.
作者: David Conen.;Claudia U Chae.;Robert J Glynn.;Usha B Tedrow.;Brendan M Everett.;Julie E Buring.;Christine M Albert.
来源: JAMA. 2011年305卷20期2080-7页
The risks associated with new-onset atrial fibrillation (AF) among middle-aged women and populations with a low comorbidity burden are poorly defined.
4035. Factors associated with closures of emergency departments in the United States.
Between 1998 and 2008, the number of hospital-based emergency departments (EDs) in the United States declined, while the number of ED visits increased, particularly visits by patients who were publicly insured and uninsured. Little is known about the hospital, community, and market factors associated with ED closures. Federal law requiring EDs to treat all in need regardless of a patient's ability to pay may make EDs more vulnerable to the market forces that govern US health care.
4036. A genomic predictor of response and survival following taxane-anthracycline chemotherapy for invasive breast cancer.
作者: Christos Hatzis.;Lajos Pusztai.;Vicente Valero.;Daniel J Booser.;Laura Esserman.;Ana Lluch.;Tatiana Vidaurre.;Frankie Holmes.;Eduardo Souchon.;Hongkun Wang.;Miguel Martin.;José Cotrina.;Henry Gomez.;Rebekah Hubbard.;J Ignacio Chacón.;Jaime Ferrer-Lozano.;Richard Dyer.;Meredith Buxton.;Yun Gong.;Yun Wu.;Nuhad Ibrahim.;Eleni Andreopoulou.;Naoto T Ueno.;Kelly Hunt.;Wei Yang.;Arlene Nazario.;Angela DeMichele.;Joyce O'Shaughnessy.;Gabriel N Hortobagyi.;W Fraser Symmans.
来源: JAMA. 2011年305卷18期1873-81页
Prediction of high probability of survival from standard cancer treatments is fundamental for individualized cancer treatment strategies.
4037. Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: a randomized controlled trial.
作者: Samer S Najjar.;Sunil V Rao.;Chiara Melloni.;Subha V Raman.;Thomas J Povsic.;Laura Melton.;Gregory W Barsness.;Kristi Prather.;John F Heitner.;Rakhi Kilaru.;Luis Gruberg.;Vic Hasselblad.;Adam B Greenbaum.;Manesh Patel.;Raymond J Kim.;Mark Talan.;Luigi Ferrucci.;Dan L Longo.;Edward G Lakatta.;Robert A Harrington.; .
来源: JAMA. 2011年305卷18期1863-72页
Acute ST-segment elevation myocardial infarction (STEMI) is a leading cause of morbidity and mortality. In experimental models of MI, erythropoietin reduces infarct size and improves left ventricular (LV) function.
4039. Fatal and nonfatal outcomes, incidence of hypertension, and blood pressure changes in relation to urinary sodium excretion.
作者: Katarzyna Stolarz-Skrzypek.;Tatiana Kuznetsova.;Lutgarde Thijs.;Valérie Tikhonoff.;Jitka Seidlerová.;Tom Richart.;Yu Jin.;Agnieszka Olszanecka.;Sofia Malyutina.;Edoardo Casiglia.;Jan Filipovský.;Kalina Kawecka-Jaszcz.;Yuri Nikitin.;Jan A Staessen.; .
来源: JAMA. 2011年305卷17期1777-85页
Extrapolations from observational studies and short-term intervention trials suggest that population-wide moderation of salt intake might reduce cardiovascular events.
4040. Coronary revascularization trends in the United States, 2001-2008.
作者: Andrew J Epstein.;Daniel Polsky.;Feifei Yang.;Lin Yang.;Peter W Groeneveld.
来源: JAMA. 2011年305卷17期1769-76页
Coronary revascularization is among the most common hospital-based major interventional procedures performed in the United States. It is uncertain how new revascularization technologies, new clinical evidence from trials, and updated clinical guidelines have influenced the volume and distribution of coronary revascularizations over the past decade.
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