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4021. Magnetic resonance-based assessment of global coronary flow and flow reserve and its relation to left ventricular functional parameters: a comparison with positron emission tomography.
作者: J Schwitter.;T DeMarco.;S Kneifel.;G K von Schulthess.;M C Jörg.;H Arheden.;S Rühm.;K Stumpe.;A Buck.;W W Parmley.;T F Lüscher.;C B Higgins.
来源: Circulation. 2000年101卷23期2696-702页
Measurement of coronary sinus blood flow (CSF) by phase-contrast magnetic resonance (PC-MR) imaging at rest and during hyperemia may allow noninvasive assessment of global coronary hemodynamics.
4022. High levels of platelet inhibition with abciximab despite heightened platelet activation and aggregation during thrombolysis for acute myocardial infarction: results from TIMI (thrombolysis in myocardial infarction) 14.
作者: S A Coulter.;C P Cannon.;K A Ault.;E M Antman.;F Van de Werf.;A A Adgey.;C M Gibson.;R P Giugliano.;M A Mascelli.;J Scherer.;E S Barnathan.;E Braunwald.;N S Kleiman.
来源: Circulation. 2000年101卷23期2690-5页
We evaluated platelet activation and aggregation in patients with acute myocardial infarction (AMI) treated with thrombolytic therapy alone or with reduced-dose thrombolysis and concomitant abciximab.
4023. Predictors of mortality and mortality from cardiac causes in the bypass angioplasty revascularization investigation (BARI) randomized trial and registry. For the BARI Investigators.
作者: M M Brooks.;R H Jones.;R G Bach.;B R Chaitman.;M J Kern.;T A Orszulak.;D Follmann.;G Sopko.;E H Blackstone.;R M Califf.
来源: Circulation. 2000年101卷23期2682-9页
The impact of percutaneous transluminal coronary angioplasty (PTCA) and coronary artery bypass grafting (CABG) on long-term mortality rates in the presence of various demographic, clinical, and angiographic factors is uncertain in the population of patients suitable for both procedures.
4024. Effects of the maze operation on health-related quality of life in patients with atrial fibrillation.
作者: S Lönnerholm.;P Blomström.;L Nilsson.;S Oxelbark.;L Jideus.;C Blomström-Lundqvist.
来源: Circulation. 2000年101卷22期2607-11页
Maze surgery for atrial fibrillation (AF) is a curative therapy, but its effect on health-related quality of life has not been studied.
4025. Local pulse pressure and regression of arterial wall hypertrophy during long-term antihypertensive treatment.
作者: P Boutouyrie.;C Bussy.;D Hayoz.;J Hengstler.;N Dartois.;B Laloux.;H Brunner.;S Laurent.
来源: Circulation. 2000年101卷22期2601-6页
Local pulse pressure (PP) is an independent determinant of carotid artery wall thickness, stronger than mean blood pressure (BP). The present study was designed to assess whether a beta-adrenoceptor antagonist-based or an ACE inhibitor-based treatment was able to reduce carotid artery wall hypertrophy through a reduction in carotid PP rather than by lowering mean BP and whether the influence of local PP reduction could also be detected at the site of a muscular artery, the radial artery.
4026. Predictors of outcome in patients with acute coronary syndromes without persistent ST-segment elevation. Results from an international trial of 9461 patients. The PURSUIT Investigators.
作者: E Boersma.;K S Pieper.;E W Steyerberg.;R G Wilcox.;W C Chang.;K L Lee.;K M Akkerhuis.;R A Harrington.;J W Deckers.;P W Armstrong.;A M Lincoff.;R M Califf.;E J Topol.;M L Simoons.
来源: Circulation. 2000年101卷22期2557-67页
Appropriate treatment policies should include an accurate estimate of a patient's baseline risk. Risk modeling to date has been underutilized in patients with acute coronary syndromes without persistent ST-segment elevation.
4027. Treatment of in-stent restenosis with excimer laser coronary angioplasty versus rotational atherectomy: comparative mechanisms and results.
作者: R Mehran.;G Dangas.;G S Mintz.;R Waksman.;A Abizaid.;L F Satler.;A D Pichard.;K M Kent.;A J Lansky.;G W Stone.;M B Leon.
来源: Circulation. 2000年101卷21期2484-9页
Atheroablation yields improved clinical results for balloon angioplasty (percutaneous transluminal coronary angioplasty, PTCA) in the treatment of diffuse in-stent restenosis (ISR).
4028. Increased risk of restenosis after placement of gold-coated stents: results of a randomized trial comparing gold-coated with uncoated steel stents in patients with coronary artery disease.
作者: A Kastrati.;A Schömig.;J Dirschinger.;J Mehilli.;N von Welser.;J Pache.;H Schühlen.;T Schilling.;C Schmitt.;F J Neumann.
来源: Circulation. 2000年101卷21期2478-83页
Gold is a highly biocompatible material. Experimental evidence suggests that coating the stent with a gold layer may have a beneficial influence. In this randomized trial, we assessed whether gold-coated stents were associated with a better clinical and angiographic outcome after coronary placement.
4029. Residual plaque burden, delivered dose, and tissue composition predict 6-month outcome after balloon angioplasty and beta-radiation therapy.
作者: M Sabaté.;J P Marijnissen.;S G Carlier.;I P Kay.;W J van der Giessen.;V L Coen.;J M Ligthart.;E Boersma.;M A Costa.;P C Levendag.;P W Serruys.
来源: Circulation. 2000年101卷21期2472-7页
Inhomogeneity of dose distribution and anatomic aspects of the atherosclerotic plaque may influence the outcome of irradiated lesions after balloon angioplasty (BA). We evaluated the influence of delivered dose and morphological characteristics of coronary stenoses treated with beta-radiation after BA.
4030. Edge restenosis after implantation of high activity (32)P radioactive beta-emitting stents.
作者: R Albiero.;T Nishida.;M Adamian.;A Amato.;M Vaghetti.;N Corvaja.;C Di Mario.;A Colombo.
来源: Circulation. 2000年101卷21期2454-7页
A high restenosis rate has been reported at the edges ("edge restenosis") of (32)P radioactive stents with an initial activity level of 3 to 12 microCi. This edge effect might be due to balloon injury and to a low dose of radiation at the stent margins. The aim of this study was to evaluate whether the implantation of (32)P radioactive stents with a higher activity level (12 to 21 microCi) combined with a nonaggressive stent implantation strategy could solve the problem of edge restenosis.
4031. Effects of iloprost inhalation on exercise capacity and ventilatory efficiency in patients with primary pulmonary hypertension.
The continuous infusion of prostacyclin has been shown to improve exercise capacity and survival in patients with primary pulmonary hypertension (PPH). Inhalation of iloprost, a stable analog of prostacyclin, might be an alternative therapy for PPH, selectively acting on the pulmonary vascular bed through ventilation-matched alveolar deposition of the drug. We investigated the short-term effects of iloprost inhalation on exercise capacity and gas exchange in patients with PPH.
4032. Assessment of coronary arterial restenosis with phase-contrast magnetic resonance imaging measurements of coronary flow reserve.
作者: W G Hundley.;L D Hillis.;C A Hamilton.;R J Applegate.;D M Herrington.;G D Clarke.;G A Braden.;M S Thomas.;R A Lange.;R M Peshock.;K M Link.
来源: Circulation. 2000年101卷20期2375-81页
After successful percutaneous coronary arterial revascularization, 25% to 60% of subjects have restenosis, a recurrent coronary arterial narrowing at the site of the intervention. At present, restenosis is usually detected invasively with contrast coronary angiography. This study was performed to determine if phase-contrast MRI (PC-MRI) could be used to detect restenosis noninvasively in patients with recurrent chest pain after percutaneous revascularization.
4033. Assessment of myocardial reperfusion by intravenous myocardial contrast echocardiography and coronary flow reserve after primary percutaneous transluminal coronary angioplasty [correction of angiography] in patients with acute myocardial infarction.
作者: W Lepper.;R Hoffmann.;O Kamp.;A Franke.;C C de Cock.;H P Kühl.;G T Sieswerda.;J v Dahl.;U Janssens.;P Voci.;C A Visser.;P Hanrath.
来源: Circulation. 2000年101卷20期2368-74页
This study investigated whether the extent of perfusion defect determined by intravenous myocardial contrast echocardiography (MCE) in patients with acute myocardial infarction (AMI) treated by primary percutaneous transluminal coronary angioplasty (PTCA) relates to coronary flow reserve (CRF) for assessment of myocardial reperfusion and is predictive for left ventricular recovery.
4034. Relation of phasic coronary flow velocity characteristics with TIMI perfusion grade and myocardial recovery after primary percutaneous transluminal coronary angioplasty and rescue stenting.
作者: T Akasaka.;K Yoshida.;T Kawamoto.;S Kaji.;Y Ueda.;A Yamamuro.;T Takagi.;T Hozumi.
来源: Circulation. 2000年101卷20期2361-7页
A residual stenosis and/or microvascular damage have been proposed as mechanisms of TIMI 2 flow for acute myocardial infarction. Coronary flow dynamics were assessed in patients with TIMI 2 flow to predict whether additional intervention would improve TIMI grade.
4035. Intracoronary beta-irradiation with a liquid (188)re-filled balloon: six-month results from a clinical safety and feasibility study.
作者: M Höher.;J Wöhrle.;M Wohlfrom.;H Hanke.;R Voisard.;H H Osterhues.;M Kochs.;S N Reske.;V Hombach.;J Kotzerke.
来源: Circulation. 2000年101卷20期2355-60页
Coronary irradiation is a new concept to reduce restenosis. We evaluated the feasibility and safety of intracoronary irradiation with a balloon catheter filled with (188)Re, a liquid, high-energy beta-emitter.
4036. Acute and chronic angiotensin-1 receptor antagonism reverses endothelial dysfunction in atherosclerosis.
作者: A Prasad.;T Tupas-Habib.;W H Schenke.;R Mincemoyer.;J A Panza.;M A Waclawin.;S Ellahham.;A A Quyyumi.
来源: Circulation. 2000年101卷20期2349-54页
The renin-angiotensin system may contribute to atherogenesis through the promotion of endothelial dysfunction. The present study was performed to determine whether angiotensin-1 (AT(1)) receptor inhibition improves endothelial dysfunction.
4037. Prediction of 1-year survival after thrombolysis for acute myocardial infarction in the global utilization of streptokinase and TPA for occluded coronary arteries trial.
作者: R M Califf.;K S Pieper.;K L Lee.;F Van De Werf.;R J Simes.;P W Armstrong.;E J Topol.
来源: Circulation. 2000年101卷19期2231-8页
When a patient survives thrombolysis for acute myocardial infarction, little information from large studies exists from which to estimate prognosis during follow-up visits.
4038. Safety of intracoronary gamma-radiation on uninjured reference segments during the first 6 months after treatment of in-stent restenosis: a serial intravascular ultrasound study.
作者: J M Ahmed.;G S Mintz.;R Waksman.;N J Weissman.;R Mehran.;A D Pichard.;L F Satler.;K M Kent.;M B Leon.
来源: Circulation. 2000年101卷19期2227-30页
The effects of endovascular irradiation on uninjured reference segments during the treatment of in-stent restenosis are unknown.
4039. Randomized trial of contrast media utilization in high-risk PTCA: the COURT trial.
作者: C J Davidson.;W K Laskey.;J B Hermiller.;J K Harrison.;W Matthai.;R E Vlietstra.;J A Brinker.;D J Kereiakes.;J B Muhlestein.;A Lansky.;J J Popma.;M Buchbinder.;J W Hirshfeld.
来源: Circulation. 2000年101卷18期2172-7页
Previous in vitro and in vivo studies have suggested an association between thrombus-related events and type of contrast media. Low osmolar contrast agents appear to improve the safety of diagnostic and coronary artery interventional procedures. However, no data are available on PTCA outcomes with an isosmolar contrast agent.
4040. Intracoronary gamma-radiation therapy after angioplasty inhibits recurrence in patients with in-stent restenosis.
作者: R Waksman.;R L White.;R C Chan.;B G Bass.;L Geirlach.;G S Mintz.;L F Satler.;R Mehran.;P W Serruys.;A J Lansky.;P Fitzgerald.;B Bhargava.;K M Kent.;A D Pichard.;M B Leon.
来源: Circulation. 2000年101卷18期2165-71页
Treatment of in-stent restenosis presents a critical limitation of intracoronary stent implantation. Ionizing radiation has been shown to decrease neointimal formation within stents in animal models and in initial clinical trials. We studied the effects of intracoronary gamma-radiation therapy versus placebo on the clinical and angiographic outcomes of patients with in-stent restenosis.
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