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23. Transient Sprr1a Expression Defines a Population of Border Zone Cardiomyocytes That Survive Ischemic Injury.
作者: Emily H Marshall.;Daniel A Zuppo.;Kimberly N Burgos Villar.;Adwiteeya Misra.;Deanne M Mickelsen.;Ronald A Dirkx.;Eric M Small.
来源: Circulation. 2026年153卷13期1001-1004页 24. Response by Gao et al to Letter Regarding Article, "G Protein-Coupled Receptor Kinase 3 Exacerbates Diabetic Heart Injuries Through Direct Phosphorylation of Cannabinoid Receptor 2 in Humans and Mice".26. Letter by Wu et al Regarding Article, "G Protein-Coupled Receptor Kinase 3 Exacerbates Diabetic Heart Injuries Through Direct Phosphorylation of Cannabinoid Receptor 2 in Humans and Mice".29. Response by Hundemer and Vaidya to Letter Regarding Article, "Subclinical Primary Aldosteronism and Major Adverse Cardiovascular Events: A Longitudinal Population-Based Cohort Study".31. Adaptive AI for Cardiovascular Event Adjudication: Cardiovascular Event Adjudication Across Different Definitions in the ODYSSEY OUTCOMES and EUCLID Trials.
作者: Sreekanth Vemulapalli.;Karla Pena Guerra.;Daniel Wojdyla.;W Schuyler Jones.;Kenneth W Mahaffey.;Robert A Harrington.;Philippe Gabriel Steg.;Gregory G Schwartz.;Manesh R Patel.;Renato D Lopes.;Ricardo Henao.
来源: Circulation. 2026年
Clinical endpoint classification (CEC) is the gold standard for cardiovascular endpoint measurement in clinical trials, but adds time and cost. We developed and validated an artificial intelligence (AI) algorithm (ADAPT-CEC) that adjudicates multiple cardiovascular endpoints and adapts to new definitions.
32. Effect of APOC3 Inhibition with Olezarsen on Coronary Atherosclerosis: Essence-TIMI 73b Imaging Study.
作者: Nicholas A Marston.;Brian A Bergmark.;Thomas A Prohaska.;Filipe A Moura.;Andre Zimerman.;Veronica J Alexander.;Yu Mi Kang.;Julia Weinland.;Xinhui Ran.;Sabina A Murphy.;Shuanglu Zhang.;Dan Li.;Maciej Banach.;Erik S G Stroes.;Robert Kiss.;Daniel Gaudet.;Michal Vrablik.;Assen Goudev.;Jeroen J Bax.;Matthew J Budoff.;Borek Foldyna.;Michael T Lu.;Sotirios Tsimikas.;Robert P Giugliano.;Marc S Sabatine.
来源: Circulation. 2026年
Whether lowering triglyceride-rich lipoproteins and remnant cholesterol favorably modifies coronary atherosclerosis is unclear. Olezarsen, an antisense oligonucleotide that targets apolipoprotein C-III, reduces triglycerides by ~60% and remnant cholesterol by ~70%, has a neutral effect on LDL cholesterol (LDL-C), and reduces apolipoprotein B (apoB) by ~15% in moderate hypertriglyceridemia. We investigated the effect of olezarsen on coronary plaque in adults with largely moderate hypertriglyceridemia.
34. Prehospital Heparin Administration in Patients With STEMI Undergoing Primary PCI: HEPARIN STEMI Randomized Controlled Trial.
作者: Misa Fister.;Marko Noc.;Peter Radsel.;Matjaz Bunc.;Danilo Franco.;Tomaz Goslar.; .
来源: Circulation. 2026年
Primary PCI is the preferred reperfusion strategy in patients with ST-elevation myocardial infarction (STEMI). We investigated benefits and safety of pretreatment with unfractioned heparin (UFH) in STEMI referred to primary PCI.
35. The Role of Atrial Pacing Support in Cardiac Resynchronization Therapy: A Non-Inferiority Randomized Trial.
作者: Mauro Biffi.;Giovanni Rovaris.;Ennio Carmine Luigi Pisanò.;Valeria Calvi.;Antonio Rapacciuolo.;Matteo Santamaria.;Giampiero Maglia.;Gabriele Zanotto.;Emanuele Bertaglia.;Gerardo Nigro.;Andrea Giomi.;Francesca Notarangelo.;Patrizia Pepi.;Giuliano D'Alterio.;Davide Castagno.;Antonio Dello Russo.;Antonino Nicosia.;Massimo Zecchin.;Matteo Bertini.;Antonio Duca.;Daniele Giacopelli.;Alessio Gargaro.;Giovanni Luca Botto.; .
来源: Circulation. 2026年
The role of atrial pacing support is unclear in cardiac resynchronization therapy-defibrillator (CRT-D) patients without sinus node dysfunction.
38. Response by Oikonomou et al to Letter Regarding Article, "Artificial Intelligence-Enabled Echocardiography as a Surrogate for Multimodality Aortic Stenosis Imaging: Post Hoc Analysis of a Clinical Trial".40. Sotatercept for Combined Post- and Pre-capillary Pulmonary Hypertension Associated With Heart Failure: Results from the Phase 2, Randomized, Placebo-Controlled CADENCE Study.
作者: Mardi Gomberg-Maitland.;Ryan J Tedford.;David Langleben.;Stephan Rosenkranz.;Barry Miller.;Aaron D Jones.;Alessia Urbinati.;Ciaran J McMullan.;Alexandra G Cornell.;Jean-Luc Vachiery.
来源: Circulation. 2026年
Combined post- and pre-capillary pulmonary hypertension in heart failure with preserved ejection fraction (CpcPH-HFpEF) involves remodeling in both the heart and pulmonary vasculature. Despite significant mortality, there are no proven therapies.
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