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21. Endoscopic variceal ligation versus propranolol for the primary prevention of oesophageal variceal bleeding in patients with hepatocellular carcinoma: an open-label, two-centre, randomised controlled trial.
作者: Tsung-Chieh Yang.;Wen-Chi Chen.;Ming-Chih Hou.;Ping-Hsien Chen.;Pei-Chang Lee.;Chung-Yu Chang.;Hsiao-Sheng Lu.;Yu-Jen Chen.;Shao-Jung Hsu.;Hui-Chun Huang.;Jiing-Chyuan Luo.;Yi-Hsiang Huang.;Fa-Yauh Lee.
来源: Gut. 2024年73卷4期682-690页
This randomised trial aimed to address whether endoscopic variceal ligation (EVL) or propranolol (PPL) is more effective at preventing initial oesophageal variceal bleeding (EVB) in patients with hepatocellular carcinoma (HCC).
22. 10-year follow-up results of the European Achalasia Trial: a multicentre randomised controlled trial comparing pneumatic dilation with laparoscopic Heller myotomy.
作者: Guy Boeckxstaens.;Stefanie Elsen.;Ann Belmans.;Vito Annese.;Albert J Bredenoord.;Olivier R Busch.;Mario Costantini.;Uberto Fumagalli.;André J P M Smout.;Jan Tack.;Tim Vanuytsel.;Giovanni Zaninotto.;Renato Salvador.
来源: Gut. 2024年73卷4期582-589页
As achalasia is a chronic disorder, long-term follow-up data comparing different treatments are essential to select optimal clinical management. Here, we report on the 10-year follow-up of the European Achalasia Trial comparing endoscopic pneumodilation (PD) with laparoscopic Heller myotomy (LHM).
23. Compared to histamine-2 receptor antagonist, proton pump inhibitor induces stronger oral-to-gut microbial transmission and gut microbiome alterations: a randomised controlled trial.
作者: Jiaying Zhu.;Chuqing Sun.;Min Li.;Guoru Hu.;Xing-Ming Zhao.;Wei-Hua Chen.
来源: Gut. 2024年73卷7期1087-1097页
We aim to compare the effects of proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs) on the gut microbiota through longitudinal analysis.
24. Prebiotic diet changes neural correlates of food decision-making in overweight adults: a randomised controlled within-subject cross-over trial.
作者: Evelyn Medawar.;Frauke Beyer.;Ronja Thieleking.;Sven-Bastiaan Haange.;Ulrike Rolle-Kampczyk.;Madlen Reinicke.;Rima Chakaroun.;Martin von Bergen.;Michael Stumvoll.;Arno Villringer.;A Veronica Witte.
来源: Gut. 2024年73卷2期298-310页
Animal studies suggest that prebiotic, plant-derived nutrients could improve homoeostatic and hedonic brain functions through improvements in microbiome-gut-brain communication. However, little is known if these results are applicable to humans. Therefore, we tested the effects of high-dosed prebiotic fibre on reward-related food decision-making in a randomised controlled within-subject cross-over study and assayed potential microbial and metabolic markers.
25. Endoluminal radiofrequency ablation in patients with malignant biliary obstruction: a randomised trial.
作者: Jana Jarosova.;Lea Zarivnijova.;Ivana Cibulkova.;Jan Mares.;Peter Macinga.;Alzbeta Hujova.;Premysl Falt.;Ondrej Urban.;Jan Hajer.;Julius Spicak.;Tomas Hucl.
来源: Gut. 2023年72卷12期2286-2293页
Endoluminal radiofrequency ablation (RFA) has been promoted as palliative treatment for patients with cholangiocarcinoma (CCA) and pancreatic ductal adenocarcinoma (PDAC) in order to improve biliary drainage and eventually prolong survival. No high level evidence is, however, available on this technique.
26. Clinical care pathway to detect advanced liver disease in patients with type 2 diabetes through automated fibrosis score calculation and electronic reminder messages: a randomised controlled trial.
作者: Xinrong Zhang.;Terry Cheuk-Fung Yip.;Grace Lai-Hung Wong.;Wei-Xuan Leow.;Lilian Yan Liang.;Lee-Ling Lim.;Guanlin Li.;Luqman Ibrahim.;Huapeng Lin.;Jimmy Che To Lai.;Angel Mei-Ling Chim.;Henry Lik Yuen Chan.;Alice Pik-Shan Kong.;Wah Kheong Chan.;Vincent Wai-Sun Wong.
来源: Gut. 2023年72卷12期2364-2371页
We aimed to test the hypothesis that automated fibrosis score calculation and electronic reminder messages could increase the detection of advanced liver disease in patients with type 2 diabetes.
27. Mepolizumab for treatment of adolescents and adults with eosinophilic oesophagitis: a multicentre, randomised, double-blind, placebo-controlled clinical trial.
作者: Evan S Dellon.;Kathryn A Peterson.;Benjamin L Mitlyng.;Alina Iuga.;Christine E Bookhout.;Lindsay M Cortright.;Kacie B Walker.;Timothy S Gee.;Sarah J McGee.;Brenderia A Cameron.;Joseph A Galanko.;John T Woosley.;Swathi Eluri.;Susan E Moist.;Ikuo Hirano.
来源: Gut. 2023年72卷10期1828-1837页
We aimed to determine whether mepolizumab, an anti-IL-5 antibody, was more effective than placebo for improving dysphagia symptoms and decreasing oesophageal eosinophil counts in eosinophilic oesophagitis (EoE).
28. Technical performance and diagnostic yield of motorised spiral enteroscopy compared with single-balloon enteroscopy in suspected Crohn's disease: a randomised controlled, open-label study (the MOTOR-CD trial).
作者: Partha Pal.;Mohan Ramchandani.;Rupa Banerjee.;Piyush Viswakarma.;Aniruddha Pratap Singh.;Manohar Reddy.;Hardik Rughwani.;Rajendra Patel.;Anuradha Sekaran.;Swathi Kanaganti.;Santosh Darisetty.;Zaheer Nabi.;Jagadish Singh.;Rajesh Gupta.;Sundeep Lakhtakia.;Rebala Pradeep.;G Venkat Rao.;Manu Tandan.;D Nageshwar Reddy.
来源: Gut. 2023年72卷10期1866-1874页
Recent studies have shown that motorised spiral enteroscopy (MSE) enables deeper and total small bowel evaluation compared with single-balloon enteroscopy (SBE) in suspected Crohn's disease (CD) when analysed per procedure. However, no randomised controlled study has compared bidirectional MSE with bidirectional SBE in suspected CD.
29. Gut microbiome modulates the effects of a personalised postprandial-targeting (PPT) diet on cardiometabolic markers: a diet intervention in pre-diabetes.
作者: Orly Ben-Yacov.;Anastasia Godneva.;Michal Rein.;Smadar Shilo.;Maya Lotan-Pompan.;Adina Weinberger.;Eran Segal.
来源: Gut. 2023年72卷8期1486-1496页
To explore the interplay between dietary modifications, microbiome composition and host metabolic responses in a dietary intervention setting of a personalised postprandial-targeting (PPT) diet versus a Mediterranean (MED) diet in pre-diabetes.
30. Long versus short peroral endoscopic myotomy for the treatment of achalasia: results of a non-inferiority randomised controlled trial.
作者: Pietro Familiari.;Federica Borrelli de Andreis.;Rosario Landi.;Francesca Mangiola.;Ivo Boskoski.;Andrea Tringali.;Vincenzo Perri.;Guido Costamagna.
来源: Gut. 2023年72卷8期1442-1450页
Peroral endoscopic myotomy (POEM) has become standard treatment for achalasia with comparable efficacy to surgery. In most of published series, the length of myotomy is 12-13 cm. Shorter cuts could have the advantage of shorter procedure time and possibly reduced gastro-oesophageal reflux disease (GORD) rate.
31. Standardisation of EUS-guided FNB technique for molecular profiling in pancreatic cancer: results of a randomised trial.
作者: Ji Young Bang.;Nirag Jhala.;Anjali Seth.;Konrad Krall.;Udayakumar Navaneethan.;Robert Hawes.;Charles Melbern Wilcox.;Shyam Varadarajulu.
来源: Gut. 2023年72卷7期1255-1257页 32. Three double-dose reinforced hepatitis B revaccination scheme for patients with cirrhosis unresponsive to the standard regimen: an open-label randomised clinical trial.
作者: Álvaro Giráldez-Gallego.;Elisa Del Pilar Rodríguez-Seguel.;Raquel Valencia-Martín.;Áurea Morillo-García.;Celia Salamanca-Rivera.;Ricardo Ruiz-Pérez.;María Cuaresma-Duque.;Clara Rosso-Fernández.;María Teresa Ferrer-Ríos.;José Manuel Sousa-Martín.;Juan Manuel Praena-Fernández.;Trinidad Desongles-Corrales.;Aitana Rodríguez-Pérez.;Francisco Camino-Durán.;Antonia Gasch-Illescas.;Javier Ampuero-Herrojo.;Juan Manuel Pascasio-Acevedo.
来源: Gut. 2023年73卷1期166-174页
We aimed to compare the response rates between two different hepatitis B virus vaccination schedules for cirrhotic subjects who were non-responders to the first three 40 µg doses (month 0-1-2), and identify factors associated with the final response.
33. Dose escalation randomised study of efmarodocokin alfa in healthy volunteers and patients with ulcerative colitis.
作者: Frank Wagner.;John C Mansfield.;Annemarie N Lekkerkerker.;Yehong Wang.;Mary Keir.;Ajit Dash.;Brandon Butcher.;Brandon Harder.;Luz D Orozco.;Jordan S Mar.;Hao Chen.;Michael E Rothenberg.
来源: Gut. 2023年72卷8期1451-1461页
The interleukin-22 cytokine (IL-22) has demonstrated efficacy in preclinical colitis models with non-immunosuppressive mechanism of action. Efmarodocokin alfa (UTTR1147A) is a fusion protein agonist that links IL-22 to the crystallisable fragment (Fc) of human IgG4 for improved pharmacokinetic characteristics, but with a mutation to minimise Fc effector functions.
34. Randomised phase 2 study (JADE) of the HBV capsid assembly modulator JNJ-56136379 with or without a nucleos(t)ide analogue in patients with chronic hepatitis B infection.
作者: Harry L A Janssen.;Jinlin Hou.;Tarik Asselah.;Henry L Y Chan.;Fabien Zoulim.;Yasuhito Tanaka.;Ewa Janczewska.;Ronald G Nahass.;Stefan Bourgeois.;Maria Buti.;Pietro Lampertico.;Oliver Lenz.;Thierry Verbinnen.;Joris Vandenbossche.;Willem Talloen.;Ronald Kalmeijer.;Maria Beumont.;Michael Biermer.;Umesh Shukla.
来源: Gut. 2023年72卷7期1385-1398页
We present the final analysis results of the phase 2 JADE study (ClinicalTrials.gov Identifier: NCT03361956).
35. EUS-guided drainage of large walled-off pancreatic necroses using plastic versus lumen-apposing metal stents: a single-centre randomised controlled trial.
作者: John Gásdal Karstensen.;Srdan Novovic.;Erik Feldager Hansen.;Annette Bojer Jensen.;Henrik Lovendahl Jorgensen.;Morten Laksafoss Lauritsen.;Mikkel Parsberg Werge.;Palle Nordblad Schmidt.
来源: Gut. 2023年72卷6期1167-1173页
In treating pancreatic walled-off necrosis (WON), lumen-apposing metal stents (LAMS) have not proven superior to the traditional double pigtail technique (DPT). Among patients with large WON (>15 cm) and their associated substantial risk of treatment failure, the increased drainage capacity of a novel 20-mm LAMS might improve clinical outcomes. Hence, we conducted a study comparing the DPT and 20-mm LAMS in patients with large WON.
36. Hypophosphataemia following ferric derisomaltose and ferric carboxymaltose in patients with iron deficiency anaemia due to inflammatory bowel disease (PHOSPHARE-IBD): a randomised clinical trial.
作者: Heinz Zoller.;Myles Wolf.;Irina Blumenstein.;Christian Primas.;Stefan Lindgren.;Lars L Thomsen.;Walter Reinisch.;Tariq Iqbal.
来源: Gut. 2023年72卷4期644-653页
Intravenous iron-a common treatment for anaemia and iron deficiency due to inflammatory bowel disease (IBD)-can cause hypophosphataemia. This trial compared the incidence of hypophosphataemia after treatment with ferric carboxymaltose (FCM) or ferric derisomaltose (FDI).
37. Use of over-the-scope clip (OTSC) versus standard therapy for the prevention of rebleeding in large peptic ulcers (size ≥1.5 cm): an open-labelled, multicentre international randomised controlled trial.
作者: Shannon Chan.;Rapat Pittayanon.;Hsiu-Po Wang.;Jiann-Hwa Chen.;Anthony Yb Teoh.;Yu Ting Kuo.;Raymond Sy Tang.;Hon Chi Yip.;Stephen Ka Kei Ng.;Sunny Wong.;Joyce Wing Yan Mak.;Heyson Chan.;Louis Lau.;Rashid N Lui.;Marc Wong.;Rungsun Rerknimitr.;Enders K Ng.;Philip Wai Yan Chiu.
来源: Gut. 2023年72卷4期638-643页
Over-the-scope clip (OTSC) has been used recently for primary haemostasis of peptic ulcers. This study aimed to compare the efficacy of OTSC to standard endoscopic therapy in primary treatment of patients with peptic ulcer bleeding that are of size ≥1.5 cm. The target population accounts for only 2.5% of all upper GI bleeders.
38. Effect of endoscopic sleeve gastroplasty on gastric emptying, motility and hormones: a comparative prospective study.
作者: Eric J Vargas.;Monika Rizk.;Jacky Gomez-Villa.;Phillip K Edwards.;Veeravich Jaruvongvanich.;Andrew C Storm.;Andres Acosta.;David Lake.;Jeff Fidler.;Adil E Bharucha.;Michael Camilleri.;Barham K Abu Dayyeh.
来源: Gut. 2023年72卷6期1073-1080页
Endoscopic sleeve gastroplasty (ESG) has gained global adoption but our understanding of its mechanism(s) of action and durability of efficacy is limited. We sought to determine changes in gastric emptying (GE), gastric motility (GM), hormones and eating behaviours after ESG.
39. Faecal microbiota transplantation with anti-inflammatory diet (FMT-AID) followed by anti-inflammatory diet alone is effective in inducing and maintaining remission over 1 year in mild to moderate ulcerative colitis: a randomised controlled trial.
作者: Saurabh Kedia.;Shubi Virmani.;Sudheer K Vuyyuru.;Peeyush Kumar.;Bhaskar Kante.;Pabitra Sahu.;Kanav Kaushal.;Mariyam Farooqui.;Mukesh Singh.;Mahak Verma.;Aditya Bajaj.;Manasvini Markandey.;Karan Sachdeva.;Prasenjit Das.;Govind K Makharia.;Vineet Ahuja.
来源: Gut. 2022年71卷12期2401-2413页
Microbiome and dietary manipulation therapies are being explored for treating ulcerative colitis (UC). We aimed to examine the efficacy of multidonor faecal microbiota transplantation (FMT) and anti-inflammatory diet in inducing remission followed by long-term maintenance with anti-inflammatory diet in patients with mild-moderate UC.
40. Double-blinded randomised placebo controlled trial of enterosgel (polymethylsiloxane polyhydrate) for the treatment of IBS with diarrhoea (IBS-D).
作者: Carol Angela Howell.;Anu Kemppinen.;Victoria Allgar.;Matthew Dodd.;Charles H Knowles.;John McLaughlin.;Preeti Pandya.;Peter Whorwell.;Elena Markaryan.;Yan Yiannakou.
来源: Gut. 2022年71卷12期2430-2438页
Irritable bowel syndrome with diarrhoea (IBS-D) is a common and challenging condition that significantly reduces quality of life. Enterosgel (polymethylsiloxane polyhydrate) is an intestinal adsorbent which sequesters harmful molecules and is safe and effective in acute infective diarrhoea. This randomised controlled multicentre trial aimed to investigate its safety and efficacy in patients with IBS-D.
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