当前位置: 首页 >> 检索结果
21. Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis.
作者: Ferenc Emil Mózes.;Jenny A Lee.;Emmanuel Anandraj Selvaraj.;Arjun Narayan Ajmer Jayaswal.;Michael Trauner.;Jerome Boursier.;Céline Fournier.;Katharina Staufer.;Rudolf E Stauber.;Elisabetta Bugianesi.;Ramy Younes.;Silvia Gaia.;Monica Lupșor-Platon.;Salvatore Petta.;Toshihide Shima.;Takeshi Okanoue.;Sanjiv Mahadeva.;Wah-Kheong Chan.;Peter J Eddowes.;Gideon M Hirschfield.;Philip Noel Newsome.;Vincent Wai-Sun Wong.;Victor de Ledinghen.;Jiangao Fan.;Feng Shen.;Jeremy F Cobbold.;Yoshio Sumida.;Akira Okajima.;Jörn M Schattenberg.;Christian Labenz.;Won Kim.;Myoung Seok Lee.;Johannes Wiegand.;Thomas Karlas.;Yusuf Yılmaz.;Guruprasad Padur Aithal.;Naaventhan Palaniyappan.;Christophe Cassinotto.;Sandeep Aggarwal.;Harshit Garg.;Geraldine J Ooi.;Atsushi Nakajima.;Masato Yoneda.;Marianne Ziol.;Nathalie Barget.;Andreas Geier.;Theresa Tuthill.;M Julia Brosnan.;Quentin Mark Anstee.;Stefan Neubauer.;Stephen A Harrison.;Patrick M Bossuyt.;Michael Pavlides.; .
来源: Gut. 2022年71卷5期1006-1019页
Liver biopsy is still needed for fibrosis staging in many patients with non-alcoholic fatty liver disease. The aims of this study were to evaluate the individual diagnostic performance of liver stiffness measurement by vibration controlled transient elastography (LSM-VCTE), Fibrosis-4 Index (FIB-4) and NAFLD (non-alcoholic fatty liver disease) Fibrosis Score (NFS) and to derive diagnostic strategies that could reduce the need for liver biopsies.
22. Long-term dietary patterns are associated with pro-inflammatory and anti-inflammatory features of the gut microbiome.
作者: Laura A Bolte.;Arnau Vich Vila.;Floris Imhann.;Valerie Collij.;Ranko Gacesa.;Vera Peters.;Cisca Wijmenga.;Alexander Kurilshikov.;Marjo J E Campmans-Kuijpers.;Jingyuan Fu.;Gerard Dijkstra.;Alexandra Zhernakova.;Rinse K Weersma.
来源: Gut. 2021年70卷7期1287-1298页
The microbiome directly affects the balance of pro-inflammatory and anti-inflammatory responses in the gut. As microbes thrive on dietary substrates, the question arises whether we can nourish an anti-inflammatory gut ecosystem. We aim to unravel interactions between diet, gut microbiota and their functional ability to induce intestinal inflammation.
23. Hepatocellular carcinoma recurrence after direct-acting antiviral therapy: an individual patient data meta-analysis.
作者: Victor Sapena.;Marco Enea.;Ferran Torres.;Ciro Celsa.;Jose Rios.;Giacomo Emanuele Maria Rizzo.;Pierre Nahon.;Zoe Mariño.;Ryosuke Tateishi.;Tatsuya Minami.;Angelo Sangiovanni.;Xavier Forns.;Hidenori Toyoda.;Stefano Brillanti.;Fabio Conti.;Elisabetta Degasperi.;Ming-Lung Yu.;Pei-Chien Tsai.;Kevin Jean.;Mohamed El Kassas.;Hend Ibrahim Shousha.;Ashraf Omar.;Claudio Zavaglia.;Hiroko Nagata.;Mina Nakagawa.;Yasuhiro Asahina.;Amit G Singal.;Caitlin Murphy.;Mohamed Kohla.;Chiara Masetti.;Jean-François Dufour.;Nicolas Merchante.;Luisa Cavalletto.;Liliana Lc Chemello.;Stanislas Pol.;Javier Crespo.;Jose Luis Calleja.;Rosanna Villani.;Gaetano Serviddio.;Alberto Zanetto.;Sarah Shalaby.;Francesco Paolo Russo.;Rob Bielen.;Franco Trevisani.;Calogero Cammà.;Jordi Bruix.;Giuseppe Cabibbo.;Maria Reig.
来源: Gut. 2022年71卷3期593-604页
The benefit of direct-acting antivirals (DAAs) against HCV following successful treatment of hepatocellular carcinoma (HCC) remains controversial. This meta-analysis of individual patient data assessed HCC recurrence risk following DAA administration.
24. Non-alcoholic fatty liver disease and increased risk of incident extrahepatic cancers: a meta-analysis of observational cohort studies.
作者: Alessandro Mantovani.;Graziana Petracca.;Giorgia Beatrice.;Alessandro Csermely.;Herbert Tilg.;Christopher D Byrne.;Giovanni Targher.
来源: Gut. 2022年71卷4期778-788页
We performed a meta-analysis of observational studies to quantify the magnitude of the association between non-alcoholic fatty liver disease (NAFLD) and risk of extrahepatic cancers.
26. Genetic architectures of proximal and distal colorectal cancer are partly distinct.
作者: Jeroen R Huyghe.;Tabitha A Harrison.;Stephanie A Bien.;Heather Hampel.;Jane C Figueiredo.;Stephanie L Schmit.;David V Conti.;Sai Chen.;Conghui Qu.;Yi Lin.;Richard Barfield.;John A Baron.;Amanda J Cross.;Brenda Diergaarde.;David Duggan.;Sophia Harlid.;Liher Imaz.;Hyun Min Kang.;David M Levine.;Vittorio Perduca.;Aurora Perez-Cornago.;Lori C Sakoda.;Fredrick R Schumacher.;Martha L Slattery.;Amanda E Toland.;Fränzel J B van Duijnhoven.;Bethany Van Guelpen.;Antonio Agudo.;Demetrius Albanes.;M Henar Alonso.;Kristin Anderson.;Coral Arnau-Collell.;Volker Arndt.;Barbara L Banbury.;Michael C Bassik.;Sonja I Berndt.;Stéphane Bézieau.;D Timothy Bishop.;Juergen Boehm.;Heiner Boeing.;Marie-Christine Boutron-Ruault.;Hermann Brenner.;Stefanie Brezina.;Stephan Buch.;Daniel D Buchanan.;Andrea Burnett-Hartman.;Bette J Caan.;Peter T Campbell.;Prudence R Carr.;Antoni Castells.;Sergi Castellví-Bel.;Andrew T Chan.;Jenny Chang-Claude.;Stephen J Chanock.;Keith R Curtis.;Albert de la Chapelle.;Douglas F Easton.;Dallas R English.;Edith J M Feskens.;Manish Gala.;Steven J Gallinger.;W James Gauderman.;Graham G Giles.;Phyllis J Goodman.;William M Grady.;John S Grove.;Andrea Gsur.;Marc J Gunter.;Robert W Haile.;Jochen Hampe.;Michael Hoffmeister.;John L Hopper.;Wan-Ling Hsu.;Wen-Yi Huang.;Thomas J Hudson.;Mazda Jenab.;Mark A Jenkins.;Amit D Joshi.;Temitope O Keku.;Charles Kooperberg.;Tilman Kühn.;Sébastien Küry.;Loic Le Marchand.;Flavio Lejbkowicz.;Christopher I Li.;Li Li.;Wolfgang Lieb.;Annika Lindblom.;Noralane M Lindor.;Satu Männistö.;Sanford D Markowitz.;Roger L Milne.;Lorena Moreno.;Neil Murphy.;Rami Nassir.;Kenneth Offit.;Shuji Ogino.;Salvatore Panico.;Patrick S Parfrey.;Rachel Pearlman.;Paul D P Pharoah.;Amanda I Phipps.;Elizabeth A Platz.;John D Potter.;Ross L Prentice.;Lihong Qi.;Leon Raskin.;Gad Rennert.;Hedy S Rennert.;Elio Riboli.;Clemens Schafmayer.;Robert E Schoen.;Daniela Seminara.;Mingyang Song.;Yu-Ru Su.;Catherine M Tangen.;Stephen N Thibodeau.;Duncan C Thomas.;Antonia Trichopoulou.;Cornelia M Ulrich.;Kala Visvanathan.;Pavel Vodicka.;Ludmila Vodickova.;Veronika Vymetalkova.;Korbinian Weigl.;Stephanie J Weinstein.;Emily White.;Alicja Wolk.;Michael O Woods.;Anna H Wu.;Goncalo R Abecasis.;Deborah A Nickerson.;Peter C Scacheri.;Anshul Kundaje.;Graham Casey.;Stephen B Gruber.;Li Hsu.;Victor Moreno.;Richard B Hayes.;Polly A Newcomb.;Ulrike Peters.
来源: Gut. 2021年70卷7期1325-1334页
An understanding of the etiologic heterogeneity of colorectal cancer (CRC) is critical for improving precision prevention, including individualized screening recommendations and the discovery of novel drug targets and repurposable drug candidates for chemoprevention. Known differences in molecular characteristics and environmental risk factors among tumors arising in different locations of the colorectum suggest partly distinct mechanisms of carcinogenesis. The extent to which the contribution of inherited genetic risk factors for CRC differs by anatomical subsite of the primary tumor has not been examined.
27. Global burden of disease: acute-on-chronic liver failure, a systematic review and meta-analysis.
作者: Gabriel Mezzano.;Adria Juanola.;Andres Cardenas.;Esteban Mezey.;James P Hamilton.;Elisa Pose.;Isabel Graupera.;Pere Ginès.;Elsa Solà.;Ruben Hernaez.
来源: Gut. 2022年71卷1期148-155页
Acute-on-chronic liver failure (ACLF) is characterised by acute decompensation of cirrhosis associated with organ failures. We systematically evaluated the geographical variations of ACLF across the world in terms of prevalence, mortality, aetiology of chronic liver disease (CLD), triggers and organ failures.
28. The influence of proton pump inhibitor therapy on the outcome of infliximab therapy in inflammatory bowel disease: a patient-level meta-analysis of randomised controlled studies.
作者: Thomas X Lu.;Matthew Dapas.;Erika Lin.;Trevor Peters.;Atsushi Sakuraba.
来源: Gut. 2021年70卷11期2076-2084页
In treating patients with inflammatory bowel disease (IBD), how concomitant medications influence the response to infliximab is largely unexplored. We aim to evaluate whether proton pump inhibitors (PPIs) affect the response to infliximab therapy in patients with IBD.
29. Non-alcoholic fatty liver disease and risk of incident chronic kidney disease: an updated meta-analysis.
作者: Alessandro Mantovani.;Graziana Petracca.;Giorgia Beatrice.;Alessandro Csermely.;Amedeo Lonardo.;Jörn M Schattenberg.;Herbert Tilg.;Christopher D Byrne.;Giovanni Targher.
来源: Gut. 2022年71卷1期156-162页
Studies reported a significant association between non-alcoholic fatty liver disease (NAFLD) and increased risk of chronic kidney disease (CKD). However, whether this risk changes with increasing severity of NAFLD remains uncertain. We performed a meta-analysis of observational studies to quantify the magnitude of the association between NAFLD and risk of incident CKD.
30. Non-alcoholic fatty liver disease and risk of incident diabetes mellitus: an updated meta-analysis of 501 022 adult individuals.
作者: Alessandro Mantovani.;Graziana Petracca.;Giorgia Beatrice.;Herbert Tilg.;Christopher D Byrne.;Giovanni Targher.
来源: Gut. 2021年70卷5期962-969页
Follow-up studies have shown that non-alcoholic fatty liver disease (NAFLD) is associated with an increased risk of incident diabetes, but currently, it is uncertain whether this risk changes with increasing severity of NAFLD. We performed a meta-analysis of relevant studies to quantify the magnitude of the association between NAFLD and risk of incident diabetes.
31. Global prevalence of Barrett's oesophagus and oesophageal cancer in individuals with gastro-oesophageal reflux: a systematic review and meta-analysis.
作者: Leonardo Henry Eusebi.;Giovanna Grazia Cirota.;Rocco Maurizio Zagari.;Alexander Charles Ford.
来源: Gut. 2021年70卷3期456-463页
Chronic gastro-oesophageal reflux might lead to the development of Barrett's oesophagus (BO) or even oesophageal adenocarcinoma. There has been no definitive systematic review and meta-analysis of data to estimate global prevalence of BO or oesophageal adenocarcinoma in individuals with gastro-oesophageal reflux.
32. Hepatocellular carcinoma tumour volume doubling time: a systematic review and meta-analysis.
作者: Piyush Nathani.;Purva Gopal.;Nicole Rich.;Adam Yopp.;Takeshi Yokoo.;Binu John.;Jorge Marrero.;Neehar Parikh.;Amit G Singal.
来源: Gut. 2021年70卷2期401-407页
Tumour growth patterns have important implications for surveillance intervals, prognostication and treatment decisions but have not been well described for hepatocellular carcinoma (HCC). The aim of our study was to characterise HCC doubling time and identify correlates for indolent and rapid growth patterns.
33. Efficacy of psychological therapies for irritable bowel syndrome: systematic review and network meta-analysis.
作者: Christopher J Black.;Elyse R Thakur.;Lesley A Houghton.;Eamonn M M Quigley.;Paul Moayyedi.;Alexander C Ford.
来源: Gut. 2020年69卷8期1441-1451页
National guidelines for the management of irritable bowel syndrome (IBS) recommend that psychological therapies should be considered, but their relative efficacy is unknown, because there have been few head-to-head trials. We performed a systematic review and network meta-analysis to try to resolve this uncertainty.
34. Helicobacter pylori eradication therapy to prevent gastric cancer: systematic review and meta-analysis.
Gastric cancer is strongly associated with Helicobacter pylori (H. pylori). We conducted a previous systematic review and meta-analysis that suggested eradication therapy reduced future incidence of gastric cancer, but effect size was uncertain, and there was no reduction in gastric cancer-related mortality. We updated this meta-analysis, as more data has accumulated. We also evaluated impact of eradication therapy on future risk of gastric cancer in patients having endoscopic mucosal resection for gastric neoplasia.
35. Systematic meta-analyses, field synopsis and global assessment of the evidence of genetic association studies in colorectal cancer.
作者: Zahra Montazeri.;Xue Li.;Christine Nyiraneza.;Xiangyu Ma.;Maria Timofeeva.;Victoria Svinti.;Xiangrui Meng.;Yazhou He.;Yacong Bo.;Samuel Morgan.;Sergi Castellví-Bel.;Clara Ruiz-Ponte.;Ceres Fernández-Rozadilla.;Ángel Carracedo.;Antoni Castells.;Timothy Bishop.;Daniel Buchanan.;Mark A Jenkins.;Temitope O Keku.;Annika Lindblom.;Fränzel J B van Duijnhoven.;Anna Wu.;Susan M Farrington.;Malcolm G Dunlop.;Harry Campbell.;Evropi Theodoratou.;Wei Zheng.;Julian Little.
来源: Gut. 2020年69卷8期1460-1471页
To provide an understanding of the role of common genetic variations in colorectal cancer (CRC) risk, we report an updated field synopsis and comprehensive assessment of evidence to catalogue all genetic markers for CRC (CRCgene2).
36. Meta-analysis of genome-wide association studies and functional assays decipher susceptibility genes for gastric cancer in Chinese populations.
作者: Caiwang Yan.;Meng Zhu.;Yanbing Ding.;Ming Yang.;Mengyun Wang.;Gang Li.;Chuanli Ren.;Tongtong Huang.;Wenjun Yang.;Bangshun He.;Meilin Wang.;Fei Yu.;Jinchen Wang.;Ruoxin Zhang.;Tianpei Wang.;Jing Ni.;Jiaping Chen.;Yue Jiang.;Juncheng Dai.;Erbao Zhang.;Hongxia Ma.;Yanong Wang.;Dazhi Xu.;Shukui Wang.;Yun Chen.;Zekuan Xu.;Jianwei Zhou.;Guozhong Ji.;Zhaoming Wang.;Zhengdong Zhang.;Zhibin Hu.;Qingyi Wei.;Hongbing Shen.;Guangfu Jin.
来源: Gut. 2020年69卷4期641-651页
Although a subset of genetic loci have been associated with gastric cancer (GC) risk, the underlying mechanisms are largely unknown. We aimed to identify new susceptibility genes and elucidate their mechanisms in GC development.
37. Efficacy of pharmacological therapies in patients with IBS with diarrhoea or mixed stool pattern: systematic review and network meta-analysis.
作者: Christopher J Black.;Nicholas E Burr.;Michael Camilleri.;David L Earnest.;Eamonn Mm Quigley.;Paul Moayyedi.;Lesley A Houghton.;Alexander C Ford.
来源: Gut. 2020年69卷1期74-82页
Over half of patients with IBS have either diarrhoea (IBS-D) or a mixed stool pattern (IBS-M). The relative efficacy of licenced pharmacological therapies is unclear in the absence of head-to-head trials. We conducted a network meta-analysis to resolve this uncertainty.
38. Estimating neoplasia detection rate (NDR) in patients with Barrett's oesophagus based on index endoscopy: a systematic review and meta-analysis.
作者: Sravanthi Parasa.;Madhav Desai.;Anusha Vittal.;Viveksandeep T Chandrasekar.;Asad Pervez.;Kevin F Kennedy.;Neil Gupta.;Nicholas J Shaheen.;Prateek Sharma.
来源: Gut. 2019年68卷12期2122-2128页
Biopsies are obtained to confirm intestinal metaplasia and rule out prevalent dysplasia and cancer when Barrett's oesophagus (BE) is detected at index upper endoscopy (oesophagogastroduodenoscopy [EGD]).
39. Prevalence and burden of hepatitis D virus infection in the global population: a systematic review and meta-analysis.
作者: Hai-Yan Chen.;Dan-Ting Shen.;Dong-Ze Ji.;Pei-Chun Han.;Wei-Ming Zhang.;Jian-Feng Ma.;Wen-Sen Chen.;Hemant Goyal.;Shiyang Pan.;Hua-Guo Xu.
来源: Gut. 2019年68卷3期512-521页
Hepatitis D virus (HDV) is a defective virus that completes its life cycle only with hepatitis B virus (HBV). The HBV with HDV super-infection has been considered as one of the most severe forms of the chronic viral hepatitis. However, there is a scarcity of data on the global burden of HDV infection.
40. Incidence of faecal occult blood test interval cancers in population-based colorectal cancer screening: a systematic review and meta-analysis.
作者: Els Wieten.;Eline H Schreuders.;Esmée J Grobbee.;Daan Nieboer.;Wichor M Bramer.;Iris Lansdorp-Vogelaar.;Marco J Bruno.;Ernst J Kuipers.;Manon C W Spaander.
来源: Gut. 2019年68卷5期873-881页
Faecal immunochemical tests (FITs) are replacing guaiac faecal occult blood tests (gFOBTs) for colorectal cancer (CRC) screening. Incidence of interval colorectal cancer (iCRC) following a negative stool test result is not yet known. We aimed to compare incidence of iCRC following a negative FIT or gFOBT.
|