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21. Oral Semaglutide and Cardiovascular Outcomes in People With Type 2 Diabetes, According to SGLT2i Use: Prespecified Analyses of the SOUL Randomized Trial.
作者: Nikolaus Marx.;John E Deanfield.;Johannes F E Mann.;Rosario Arechavaleta.;Stephen C Bain.;Harpreet S Bajaj.;Katrine Bayer Tanggaard.;Andreas L Birkenfeld.;John B Buse.;Zaklina Davicevic-Elez.;Cyrus Desouza.;Scott S Emerson.;Mads D M Engelmann.;G Kees Hovingh.;Silvio E Inzucchi.;Pardeep S Jhund.;Sharon L Mulvagh.;Rodica Pop-Busui.;Neil R Poulter.;Søren Rasmussen.;Shih-Te Tu.;Darren K McGuire.; .
来源: Circulation. 2025年151卷23期1639-1650页
Both GLP-1 (glucagon-like peptide-1) receptor agonists and SGLT2 (sodium-glucose cotransporter-2) inhibitors (SGLT2i) improve cardiovascular outcomes in people with type 2 diabetes and cardiovascular or chronic kidney disease. However, there are limited data about the effect of combining these agents on cardiovascular and safety outcomes.
22. Effect of Disclosing a Polygenic Risk Score for Coronary Heart Disease on Adverse Cardiovascular Events.
作者: Mohammadreza Naderian.;Marwan E Hamed.;Ali A Vaseem.;Kristjan Norland.;Ozan Dikilitas.;Azin Teymourzadeh.;Kent R Bailey.;Iftikhar J Kullo.
来源: Circ Genom Precis Med. 2025年18卷2期e004968页
In the Myocardial Infarction Genes clinical trial (URL: https://www.clinicaltrials.gov; Unique identifier: NCT01936675), participants at intermediate risk of coronary heart disease (CHD) were randomized to receive a Framingham risk score (Framingham risk score group, n=103) or an integrated risk score (integrated risk score group [IRSg], n=104) that additionally included a polygenic risk score. After 6 months, IRSg participants had higher statin initiation and lower low-density lipoprotein cholesterol. We conducted a post hoc 10-year follow-up analysis to investigate whether disclosure of a polygenic risk score for CHD was associated with a reduction in major adverse cardiovascular events (MACE).
23. Blood Transfusion in Patients With Acute Myocardial Infarction, Anemia, and Heart Failure: Lessons From MINT.
作者: Andrew M Goldsweig.;William J Kostis.;Brandon M Herbert.;Claire Bouleti.;Brian J Potter.;Jordan B Strom.;Jocelyne Benatar.;Thao Huynh.;Srikanth Vallurupalli.;Estêvão Lanna Figueiredo.;J Dawn Abbott.;Howard A Cooper.;Andrew P DeFilippis.;Dean A Fergusson.;Shaun G Goodman.;Paul C Hébert.;Renato D Lopes.;Sunil V Rao.;Tabassome Simon.;Jeffrey L Carson.;Maria Mori Brooks.;John H Alexander.; .
来源: Circ Heart Fail. 2025年18卷4期e012495页
Blood transfusion may precipitate adverse outcomes, including heart failure (HF), among patients with acute myocardial infarction (MI). This study characterizes the effects of a restrictive or liberal transfusion strategy on outcomes in patients with MI and anemia with and without baseline HF.
24. Effects of Nicorandil, Isosorbide Mononitrate, or Diltiazem on Radial Artery Grafts After CABG: The Randomized ASRAB-Pilot Trial.
作者: Yunpeng Zhu.;Wei Zhang.;Kaijie Qin.;Yun Liu.;Haoyi Yao.;Zhe Wang.;Xiaofeng Ye.;Mi Zhou.;Haiqing Li.;Jiapei Qiu.;Hong Xu.;Yanjun Sun.;Mario Gaudino.;Qiang Zhao.
来源: Circ Cardiovasc Interv. 2025年18卷4期e014542页
The optimal antispastic treatment after coronary artery bypass grafting using radial artery (RA) grafts is controversial. This clinical trial aimed to generate pilot comparative data on the effects of nicorandil, isosorbide mononitrate, or diltiazem on RA grafts.
25. Enhancing Stroke Awareness and Activation Among High-Risk Populations: A Randomized Direct Mail Intervention in Diverse Healthcare Settings.
作者: Christine C Groves.;Teresa M Damush.;Laura J Myers.;Fitsum Baye.;Joanne K Daggy.;Anthony J Perkins.;Holly Martin.;Layne Mounsey.;Daniel O Clark.;Linda S Williams.
来源: Circ Cardiovasc Qual Outcomes. 2025年18卷5期e011425页
Many patients are unaware of their stroke risk. The purpose of this research was to compare the effect of behaviorally tailored mailed messages on patient activation to reduce stroke risk.
26. Operator Radiation Exposure Comparing the Left Radial Artery Approach and a Uniform Hyper-Adducted Right Radial Artery Approach: The HARRA Study.
作者: Richard Casazza.;Bilal Malik.;Arsalan Hashmi.;Joshua Fogel.;Enrico Montagna.;Robert Frankel.;Elliot Borgen.;Sergey Ayzenberg.;Michael Friedman.;Norbert Moskovits.;Shivani Verma.;Jamie Meng.;Nailun Chang.;Yili Huang.;Carlos Rodriguez.;Habib Hymie Chera.;Shiv Raj.;Saurav Chaterjee.;Daren Gibson.;Andres Palacios.;Chirag Agarwal.;Maria Victoria Nene.;Jacob Shani.
来源: Circ Cardiovasc Interv. 2025年18卷4期e014602页
Radiation exposure is one of the most adverse occupational hazards faced by interventional cardiologists. Various arterial access sites have shown to yield different operator radiation exposure during diagnostic cardiac catheterization.
27. Impact of Bypass Conduit and Early Technical Failure on Revascularization for Chronic Limb-Threatening Ischemia.
作者: Michael S Conte.;Alik Farber.;Andrew Barleben.;Emiliano Chisci.;Gheorghe Doros.;Vikram S Kashyap.;Ahmed Kayssi.;Philippe Kolh.;Carla C Moreira.;Timothy Nypaver.;Kenneth Rosenfield.;Vincent L Rowe.;Andres Schanzer.;Niten Singh.;Jeffrey J Siracuse.;Michael B Strong.;Matthew T Menard.
来源: Circ Cardiovasc Interv. 2025年18卷3期e014716页
The optimal strategy for lower extremity revascularization (surgical bypass versus endovascular intervention) in patients with chronic limb-threatening ischemia (CLTI) is unclear. We examined the effectiveness of open surgical bypass using single-segment great saphenous vein conduit (SSGSV), alternative conduits (AC), or endovascular interventions (ENDO) among patients with CLTI deemed acceptable for either open surgical bypass or ENDO treatment.
28. Intravascular Imaging-Guided Versus Angiography-Guided Complex PCI in Patients With High Bleeding Risk: A Secondary Analysis of the RENOVATE-COMPLEX PCI Trial.
作者: Jinhwan Jo.;Sang Yoon Lee.;Woochan Kwon.;Seung-Jae Lee.;Jong-Young Lee.;Seung Hun Lee.;Doosup Shin.;Sang Min Kim.;Kyeong Ho Yun.;Jae Young Cho.;Chan Joon Kim.;Hyo-Suk Ahn.;Chang-Wook Nam.;Hyuck-Jun Yoon.;Yong Hwan Park.;Wang Soo Lee.;Ki Hong Choi.;Taek Kyu Park.;Jeong Hoon Yang.;Seung-Hyuk Choi.;Hyeon-Cheol Gwon.;Young Bin Song.;Joo-Yong Hahn.;Sang Yeub Lee.;Joo Myung Lee.; .
来源: Circ Cardiovasc Interv. 2025年18卷3期e014952页
Although patients with high bleeding risk (HBR) often have complex coronary artery lesions, it is not known whether intravascular imaging-guided percutaneous coronary intervention (PCI) improves their prognosis. We sought to investigate the benefit of intravascular imaging-guided PCI for complex coronary artery lesions in patients with HBR.
29. Macitentan for Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Pulmonary Vascular Disease: Results of the SERENADE Randomized Clinical Trial and Open-Label Extension Study.
作者: Sanjiv J Shah.;Diana Bonderman.;Barry A Borlaug.;John G F Cleland.;Gabriela Lack.;Wentao Lu.;Adriaan A Voors.;Faiez Zannad.;Mark T Gladwin.
来源: Circ Heart Fail. 2025年18卷3期e011381页
Despite favorable hemodynamic and neurohormonal effects, endothelin receptor antagonists have not improved outcomes in patients with heart failure (HF), possibly because they cause fluid retention.
30. Patent Foramen Ovale Closure in Patients With and Without Nickel Hypersensitivity: A Randomized Trial.
作者: Anastasios Apostolos.;Stamatios Gregoriou.;Maria Drakopoulou.;Georgios Trantalis.;Aikaterini Tsiogka.;Nikolaos Ktenopoulos.;Konstantina Aggeli.;Alexander Stratigos.;Konstantinos Tsioufis.;Konstantinos Toutouzas.
来源: Circ Cardiovasc Interv. 2025年18卷4期e015228页
Nickel-containing devices, such as the Amplatzer PFO Occluder and Gore Cardioform Septal Occluder, are used for transcatheter patent foramen ovale closure. However, the impact of nickel hypersensitivity on postprocedural outcomes remains poorly understood. This study aimed to evaluate the risk of adverse events in patients with nickel hypersensitivity undergoing patent foramen ovale closure.
31. Heart Rate Reduction Is Associated With Reverse Left Ventricular Remodeling and Mechanism-Specific Molecular Phenotypes in Dilated Cardiomyopathy.
作者: Natasha L Altman.;Edward A Gill.;Rami Kahwash.;Leslie K Meyer.;Jessica A Wagner.;Anis Karimpour-Fard.;Amber A Berning.;Wayne A Minobe.;Ian A Carroll.;Eric R Jonas.;Dobromir Slavov.;Sitaramesh Emani.;William T Abraham.;Alexa R Gollah.;Samuel L Ellis.;Matthew R G Taylor.;Sharon L Graw.;Luisa Mestroni.;Timothy A McKinsey.;Peter M Buttrick.;David P Kao.;Michael R Bristow.
来源: Circ Heart Fail. 2025年18卷4期e012484页
Heart rate (HR) affects heart failure outcomes, via uncertain mechanisms that may include left ventricular remodeling. However, in human ventricular myocardium, HR change has not been associated with a particular remodeling molecular phenotype.
32. Evaluating the Appropriate Use Criteria for Coronary Revascularization in Stable Ischemic Heart Disease Using Randomized Data From the ISCHEMIA Trial.
作者: James Slater.;David J Maron.;Philip G Jones.;Sripal Bangalore.;Harmony R Reynolds.;Zhuxuan Fu.;Gregg W Stone.;Ruth Kirby.;Judith S Hochman.;John A Spertus.; .
来源: Circ Cardiovasc Qual Outcomes. 2025年18卷3期e010849页
The appropriate use criteria for revascularization of stable ischemic heart disease have not been evaluated using randomized data. Using data from the randomized ISCHEMIA trial (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches; July 2012 to January 2018, 37 countries), the health status benefits of an invasive strategy over a conservative one were examined within appropriate use criteria scenarios.
33. Left Ventricular Entry to Reduce Brain Lesions During Catheter Ablation: A Randomized Trial.
作者: Gregory M Marcus.;Roderick Tung.;Edward P Gerstenfeld.;Trisha F Hue.;Feng Lin.;Jing Cheng.;J Peter Weiss.;Wendy S Tzou.;Henry Hsia.;Ashkan Ehdaie.;Daniel H Cooper.;T Jared Bunch.;Jeffrey Arkles.;Babak Nazer.;Adam Lee.;Alexios Hadjis.;Duy T Nguyen.;Mihail G Chelu.;Joshua Moss.;Jonathan C Hsu.;Miguel Valderrábano.;Prashant D Bhave.;Andrew D Beaser.;Arvindh Kanagasundram.;Oussama Wazni.;Jason Bradfield.;Grace Wall.;Kathleen Chang.;Michelle Yang.;Gabrielle Montenegro.;Sabrina Jarrott.;Joel H Kramer.;Anthony S Kim.;Yvonne M Morris.;William P Dillon.
来源: Circulation. 2025年151卷15期1051-1059页
Catheter ablation of ventricular arrhythmias, one of the most rapidly growing procedures in cardiac electrophysiology, is associated with magnetic resonance imaging-detected brain lesions in more than half of cases. Although a retrograde aortic approach is conventional, modern tools enable entry through a transseptal approach that may avoid embolization of debris from the arterial system. We sought to test the hypothesis that a transseptal puncture would mitigate brain injury compared with a retrograde aortic approach.
34. Reactivation of Oxidized Soluble Guanylate Cyclase as a Novel Treatment Strategy to Slow Progression of Calcific Aortic Valve Stenosis: Preclinical and Randomized Clinical Trials to Assess Safety and Efficacy.
作者: Bin Zhang.;Maurice Enriquez-Sarano.;Hartzell V Schaff.;Hector I Michelena.;Carolyn M Roos.;Michael A Hagler.;Heyu Zhang.;Grace Casaclang-Verzosa.;Runqing Huang.;Anna Bartoo.;Sushant Ranadive.;Michael J Joyner.;Sorin Pislaru.;Vuyisile T Nkomo.;Walter K Kremers.;Philip A Araoz.;Gurpreet Singh.;Michael A Walters.;Jon Hawkinson.;Kevin Y Cunningham.;Jaeyun Sung.;Brandon Dunagan.;Zi Ye.;Jordan D Miller.
来源: Circulation. 2025年151卷13期913-930页
Pharmacological treatments for fibrocalcific aortic valve stenosis (FCAVS) have been elusive for >50 years. Here, we tested the hypothesis that reactivation of oxidized sGC (soluble guanylate cyclase), the primary receptor for nitric oxide, with ataciguat is a safe and efficacious strategy to slow progression of FCAVS.
35. Intravascular Imaging Predictors Associated With Cardiovascular Events After Complex PCIs.
作者: Joo Myung Lee.;Sang Yoon Lee.;Woochan Kwon.;Seung-Jae Lee.;Jong-Young Lee.;Seung Hun Lee.;Doosup Shin.;Sang Yeub Lee.;Sang Min Kim.;Kyeong Ho Yun.;Jae Young Cho.;Chan Joon Kim.;Hyo-Suk Ahn.;Chang-Wook Nam.;Hyuck-Jun Yoon.;Yong Hwan Park.;Wang Soo Lee.;Ki Hong Choi.;Taek Kyu Park.;Jeong Hoon Yang.;Seung-Hyuk Choi.;Hyeon-Cheol Gwon.;Young Bin Song.;Joo-Yong Hahn.; .
来源: Circ Cardiovasc Interv. 2025年18卷2期e014920页
Intravascular imaging-guided percutaneous coronary intervention (PCI) has been shown to improve clinical outcomes in patients with complex coronary artery lesions compared with angiography-guided PCI. However, the prognostic impact of suboptimal findings on intravascular imaging such as stent underexpansion, malapposition, or dissection is unclear in the era of contemporary drug-eluting stents.
36. Effect of Balloon Pulmonary Angioplasty and Riociguat on Right Ventricular Afterload and Function in CTEPH: Insights From the RACE Trial.
作者: Christian Gerges.;Mitja Jevnikar.;Philippe Brenot.;Laurent Savale.;Antoine Beurnier.;Hélène Bouvaist.;Olivier Sitbon.;Elie Fadel.;Athénaïs Boucly.;Denis Chemla.;Gérald Simonneau.;Marc Humbert.;David Montani.;Xavier Jaïs.; .
来源: Circ Cardiovasc Interv. 2025年18卷2期e014785页
Riociguat and balloon pulmonary angioplasty (BPA) improve hemodynamics in inoperable chronic thromboembolic pulmonary hypertension. Importantly, comparative effects of riociguat and BPA on different components of right ventricular (RV) afterload and function remain not fully elucidated.
37. Stepwise Provisional Versus Systematic Dual-Stent Strategies for Treatment of True Left Main Coronary Bifurcation Lesions.
作者: Sandeep Arunothayaraj.;Mohaned Egred.;Adrian P Banning.;Philippe Brunel.;Miroslaw Ferenc.;Thomas Hovasse.;Adrian Wlodarczak.;Manuel Pan.;Thomas Schmitz.;Marc Silvestri.;Andreis Erglis.;Evgeny Kretov.;Jens Flensted Lassen.;Alaide Chieffo.;Thierry Lefèvre.;Francesco Burzotta.;James Cockburn.;Olivier Darremont.;Goran Stankovic.;Marie-Claude Morice.;Yves Louvard.;David Hildick-Smith.
来源: Circulation. 2025年151卷9期612-622页
The optimal coronary stenting technique for true left main bifurcation lesions is uncertain. EBC MAIN (European Bifurcation Club Left Main Trial) aimed to evaluate clinical outcomes of a stepwise provisional strategy compared with a systematic dual-stent approach.
38. Efficacy of Irbesartan in Celiprolol-Treated Patients With Vascular Ehlers-Danlos Syndrome.
作者: Xavier Jeunemaitre.;Elie Mousseaux.;Michael Frank.;Salma Adham.;Francesca Pitocco.;Clarisse Billon.;Molka Ben Yakhlef.;Mohamed El Hachmi.;Alessandra Bura-Rivière.;François-Xavier Lapébie.;Claire Le Hello.;Damien Laneelle.;Christophe Seinturier.;Klaus Dieterich.;Marc Lambert.;Sophie Dupuis-Girod.;Stéphane Zuily.;Laurence Bal-Theoleyre.;Carine Boulon.;Pierrick Henneton.;Estelle Lu.;Nicolas Denarié.;Pierre Boutouyrie.;Tristan Mirault.;Gilles Chatellier.;Michel Azizi.
来源: Circulation. 2025年151卷10期686-695页
Vascular Ehlers-Danlos syndrome is a rare genetic disorder characterized by defective type III collagen and a high risk of arterial morbidity and mortality. Several cardiovascular drugs are used for treatment, including celiprolol, but no controlled trial in this condition has been conducted to date. We hypothesized the benefit of the addition of an angiotensin II receptor blocker.
39. First-In-Human Study of [64Cu]Cu-DOTATATE PET/CT in Infective Endocarditis: A Prospective Head-to-Head Comparison With [18F]FDG.
作者: Katra Hadji-Turdeghal.;Marie Øbro Fosbøl.;Philip Hasbak.;Johan Löfgren.;Ida Bull Rasmussen.;Henning Bundgaard.;Kasper Iversen.;Niels Eske Bruun.;Christian H Møller.;Christian Tuxen.;Helle Hjorth Johannesen.;Lars Køber.;Andreas Kjær.;Rasmus Sejersten Ripa.;Emil Loldrup Fosbøl.
来源: Circ Cardiovasc Imaging. 2025年18卷2期e017156页
Infective endocarditis (IE) can be challenging to diagnose. Positron emission tomography/computed tomography (PET/CT) with 2-deoxy-2-[18F]-fluoro-d-glucose ([18F]FDG) is recommended as a diagnostic tool in the guidelines, but holds limitations. The aim of this study was to compare the tracer uptake between the novel [64Cu]Cu-DOTATATE, which has low cardiac uptake and does not require fasting or dietary restrictions, and [18F]FDG in patients with IE and examine the sensitivity and specificity.
40. Economic Outcomes With Precision Diagnostic Testing Versus Usual Testing in Stable Chest Pain: Results From the PRECISE Randomized Trial.
作者: Derek S Chew.;Daniel B Mark.;Yanhong Li.;Michael G Nanna.;Michelle D Kelsey.;Melanie R Daniels.;Linda Davidson-Ray.;Khaula N Baloch.;Campbell Rogers.;Manesh R Patel.;Kevin J Anstrom.;Nick Curzen.;Sreekanth Vemulapalli.;Pamela S Douglas.; .
来源: Circ Cardiovasc Qual Outcomes. 2025年18卷2期e011008页
The PRECISE (Prospective Randomized Trial of the Optimal Evaluation of Cardiac Symptoms and Revascularization) demonstrated that a precision diagnostic strategy reduced the primary composite of death, nonfatal myocardial infarction, or catheterization without obstructive coronary artery disease by 65% in patients with nonacute chest pain compared with usual testing. Medical cost was a prespecified secondary end point.
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