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3961. Randomized comparison of GR-II stent and Palmaz-Schatz stent for elective treatment of coronary stenoses.
作者: A J Lansky.;G S Roubin.;C D O'Shaughnessy.;P B Moore.;L S Dean.;A E Raizner.;R D Safian.;J P Zidar.;J L Kerr.;J J Popma.;R Mehran.;R E Kuntz.;M B Leon.
来源: Circulation. 2000年102卷12期1364-8页
This prospective multicenter randomized clinical trial was designed to evaluate the long-term angiographic and clinical outcomes of elective treatment with the GR-II stent compared with the Palmaz-Schatz (PS) stent in patients with coronary stenoses.
3963. Differential effects of eicosapentaenoic acid and docosahexaenoic acid on vascular reactivity of the forearm microcirculation in hyperlipidemic, overweight men.
作者: T A Mori.;G F Watts.;V Burke.;E Hilme.;I B Puddey.;L J Beilin.
来源: Circulation. 2000年102卷11期1264-9页
Recent evidence supports differential effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), the 2 major omega3 fatty acids of marine origin, on blood pressure in humans and vascular reactivity in adult spontaneously hypertensive rats. We investigated possible differences in the effects of purified EPA or DHA on forearm vascular reactivity in overweight hyperlipidemic men that might contribute to the blood pressure-lowering effects of fish oils.
3964. Coronary heart disease in smokers: vitamin C restores coronary microcirculatory function.
作者: P A Kaufmann.;T Gnecchi-Ruscone.;M di Terlizzi.;K P Schäfers.;T F Lüscher.;P G Camici.
来源: Circulation. 2000年102卷11期1233-8页
Coronary endothelial function and vasomotion are impaired in smokers without coronary disease, and this is thought to be due to increased oxidative stress.
3965. Plasma homocysteine predicts mortality independently of traditional risk factors and C-reactive protein in patients with angiographically defined coronary artery disease.
作者: J L Anderson.;J B Muhlestein.;B D Horne.;J F Carlquist.;T L Bair.;T E Madsen.;R R Pearson.
来源: Circulation. 2000年102卷11期1227-32页
Plasma homocysteine (tHCY) has been associated with coronary artery disease (CAD). We tested whether tHCY also increases secondary risk, after initial CAD diagnosis, and whether it is independent of traditional risk factors, C-reactive protein (CRP), and methylenetetrahydrofolate reductase (MTHFR) genotype.
3966. Extensive troponin I and T modification detected in serum from patients with acute myocardial infarction.
Cardiac troponin I and T (cTnI and cTnT) are specific biochemical serum markers for acute myocardial infarction (AMI). However, cTnI diagnostic assays are plagued by difficulties, resulting in >/=20-fold differences in measured values. These discrepancies may result from the release of the numerous cTnI modification products that are present in ischemic myocardium. The resolution of these discrepancies requires an investigation of the exact forms of cTnI present in the bloodstream of patients after myocardial injury.
3967. Response to antihypertensive therapy in older patients with sustained and nonsustained systolic hypertension. Systolic Hypertension in Europe (Syst-Eur) Trial Investigators.
作者: R H Fagard.;J A Staessen.;L Thijs.;J Gasowski.;C J Bulpitt.;D Clement.;P W de Leeuw.;J Dobovisek.;M Jääskivi.;G Leonetti.;E O'Brien.;P Palatini.;G Parati.;J L Rodicio.;H Vanhanen.;J Webster.
来源: Circulation. 2000年102卷10期1139-44页
The goal of the present study was to assess the effect of antihypertensive therapy on clinic (CBP) and ambulatory (ABP) blood pressures, on ECG voltages, and on the incidence of stroke and cardiovascular events in older patients with sustained and nonsustained systolic hypertension.
3968. Management of patients with acute coronary syndromes in the United States by platelet glycoprotein IIb/IIIa inhibition. Insights from the platelet glycoprotein IIb/IIIa in unstable angina: receptor suppression using integrilin therapy (PURSUIT) trial.
作者: A M Lincoff.;R A Harrington.;R M Califf.;J S Hochman.;A D Guerci.;E M Ohman.;C J Pepine.;S L Kopecky.;N S Kleiman.;C M Pacchiana.;L G Berdan.;M M Kitt.;M L Simoons.;E J Topol.
来源: Circulation. 2000年102卷10期1093-100页
A multinational, randomized, placebo-controlled trial (Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin Therapy, PURSUIT) demonstrated that the platelet glycoprotein IIb/IIIa receptor antagonist eptifibatide reduced the incidence of death or myocardial infarction among patients with acute ischemic syndromes without ST-segment elevation. Because of expected differences in practice patterns, a prospectively planned analysis of outcomes as a function of regions of the world was performed. The current study provides a detailed assessment of eptifibatide among the subgroup of patients enrolled within the United States.
3969. Biventricular pacing decreases sympathetic activity compared with right ventricular pacing in patients with depressed ejection fraction.
作者: M H Hamdan.;J D Zagrodzky.;J A Joglar.;C J Sheehan.;K Ramaswamy.;J F Erdner.;R L Page.;M L Smith.
来源: Circulation. 2000年102卷9期1027-32页
Although there have been few studies in which the hemodynamic effects of right ventricular (RV) and left ventricular (LV) pacing were compared with those of biventricular (BV) pacing, the autonomic changes during these different pacing modes remain unknown. We hypothesized that BV pacing results in improved hemodynamics and a decrease in sympathetic nerve activity (SNA) compared with single-site pacing.
3970. Red wine intake prevents nuclear factor-kappaB activation in peripheral blood mononuclear cells of healthy volunteers during postprandial lipemia.
作者: L M Blanco-Colio.;M Valderrama.;L A Alvarez-Sala.;C Bustos.;M Ortego.;M A Hernández-Presa.;P Cancelas.;J Gómez-Gerique.;J Millán.;J Egido.
来源: Circulation. 2000年102卷9期1020-6页
Several epidemiological studies have demonstrated the beneficial effect of red wine intake in reducing total and cardiovascular mortality. This effect has been attributed in part to its antioxidant properties. Because the monocytes/macrophages and the nuclear transcription factor kappaB (NF-kappaB) are implicated in the pathogenesis of atherosclerotic lesions, we examined the effect of red wine intake on the activation of NF-kappaB in peripheral blood mononuclear cells.
3971. Oxidant stress and aspirin-insensitive thromboxane biosynthesis in severe unstable angina.
作者: F Cipollone.;G Ciabattoni.;P Patrignani.;M Pasquale.;D Di Gregorio.;T Bucciarelli.;G Davì.;F Cuccurullo.;C Patrono.
来源: Circulation. 2000年102卷9期1007-13页
Unstable angina is associated with enhanced lipid peroxidation and reduced antioxidant defenses. We have previously reported aspirin failure in the suppression of enhanced thromboxane (TX) biosynthesis in a subset of episodes of platelet activation in this setting. We tested the hypothesis that the in vivo formation of the F(2)-isoprostane 8-iso-prostaglandin (PG)F(2alpha), a bioactive product of arachidonic acid peroxidation, is enhanced in unstable angina and contributes to aspirin-insensitive TX biosynthesis.
3972. Elevated C-reactive protein levels and impaired endothelial vasoreactivity in patients with coronary artery disease.
作者: S Fichtlscherer.;G Rosenberger.;D H Walter.;S Breuer.;S Dimmeler.;A M Zeiher.
来源: Circulation. 2000年102卷9期1000-6页
Elevated C-reactive protein (CRP) serum levels, an exquisitely sensitive objective marker of inflammation, relate to long-term prognosis in patients with coronary artery disease and in apparently healthy men. Because abnormalities of endothelial regulation of vascular function may contribute to the occurrence of coronary events, we tested the hypothesis that elevated CRP levels are associated with an abnormal systemic endothelial vascular reactivity.
3973. Acute systemic inflammation impairs endothelium-dependent dilatation in humans.
作者: A D Hingorani.;J Cross.;R K Kharbanda.;M J Mullen.;K Bhagat.;M Taylor.;A E Donald.;M Palacios.;G E Griffin.;J E Deanfield.;R J MacAllister.;P Vallance.
来源: Circulation. 2000年102卷9期994-9页
We tested the hypothesis that endothelial dysfunction underlies the association between an acute inflammatory episode and the transiently increased risk of a cardiovascular event by examining the effects of an experimental inflammatory stimulus on endothelium-dependent vasodilation.
3974. Left ventricular electromechanical mapping to assess efficacy of phVEGF(165) gene transfer for therapeutic angiogenesis in chronic myocardial ischemia.
作者: P R Vale.;D W Losordo.;C E Milliken.;M Maysky.;D D Esakof.;J F Symes.;J M Isner.
来源: Circulation. 2000年102卷9期965-74页
NOGA left ventricular (LV) electromechanical mapping (EMM) can be used to distinguish among infarcted, ischemic, and normal myocardium. We investigated the use of percutaneous LV EMM to assess the efficacy of myocardial gene transfer (GTx) of naked plasmid DNA encoding for vascular endothelial growth factor (phVEGF(165)), administered during surgery by direct myocardial injection in patients with chronic myocardial ischemia.
3975. Visualization of fibrous cap thickness and rupture in human atherosclerotic carotid plaque in vivo with high-resolution magnetic resonance imaging.
The results of studies of advanced lesions of atherosclerosis suggest that the thickness of the fibrous cap that overlies the necrotic core distinguishes the stable lesion from one that is at high risk for rupture and thromboembolic events. We have developed a high-resolution MRI technique that can identify the fine structure of the lesion, including the fibrous cap, in vivo. The aim of the present study was to determine the agreement between in vivo MRI and lesion architecture as seen on histology and gross tissue examination to identify fibrous cap thickness and rupture.
3976. Inhibition of restenosis with beta-emitting radiotherapy: Report of the Proliferation Reduction with Vascular Energy Trial (PREVENT).
作者: A E Raizner.;S N Oesterle.;R Waksman.;P W Serruys.;A Colombo.;Y L Lim.;A C Yeung.;W J van der Giessen.;L Vandertie.;J K Chiu.;L R White.;P J Fitzgerald.;G L Kaluza.;N M Ali.
来源: Circulation. 2000年102卷9期951-8页
Intracoronary gamma- and beta-radiation have reduced restenosis in animal models. In the clinical setting, the effectiveness of beta-emitters has not been studied in a broad spectrum of patients, particularly those receiving stents.
3977. The elusive link between LQT3 and Brugada syndrome: the role of flecainide challenge.
作者: S G Priori.;C Napolitano.;P J Schwartz.;R Bloise.;L Crotti.;E Ronchetti.
来源: Circulation. 2000年102卷9期945-7页
Defects of the SCN5A gene encoding the cardiac sodium channel are associated with both the LQT3 subtype of long-QT syndrome and Brugada syndrome (BS). The typical manifestations of long-QT syndrome (QT interval prolongation) and BS (ST segment elevation in leads V1 through V3) may coexist in the same patients, which raises questions about the actual differences between LQT3 and BS. Intravenous flecainide is the standard provocative test used to unmask BS in individuals with concealed forms of the disease, and oral flecainide has been proposed as a treatment option for LQT3 patients because it may shorten their QT interval.
3978. Does folic acid decrease plasma homocysteine and improve endothelial function in patients with predialysis renal failure?
作者: J Thambyrajah.;M J Landray.;F J McGlynn.;H J Jones.;D C Wheeler.;J N Townend.
来源: Circulation. 2000年102卷8期871-5页
Considerable evidence suggests that hyperhomocysteinemia is an independent vascular risk factor that promotes atherosclerosis by inducing endothelial dysfunction. Although folic acid reduces hyperhomocysteinemia, the effect on adverse vascular events is unknown. We hypothesized that in patients with chronic renal failure, a condition associated with both hyperhomocysteinemia and atherosclerosis, treatment with folic acid would improve endothelial function.
3979. Plasma brain natriuretic peptide as a prognostic indicator in patients with primary pulmonary hypertension.
作者: N Nagaya.;T Nishikimi.;M Uematsu.;T Satoh.;S Kyotani.;F Sakamaki.;M Kakishita.;K Fukushima.;Y Okano.;N Nakanishi.;K Miyatake.;K Kangawa.
来源: Circulation. 2000年102卷8期865-70页
Plasma brain natriuretic peptide (BNP) level increases in proportion to the degree of right ventricular dysfunction in pulmonary hypertension. We sought to assess the prognostic significance of plasma BNP in patients with primary pulmonary hypertension (PPH).
3980. Effect of dietary patterns on serum homocysteine: results of a randomized, controlled feeding study.
作者: L J Appel.;E R Miller.;S H Jee.;R Stolzenberg-Solomon.;P H Lin.;T Erlinger.;M R Nadeau.;J Selhub.
来源: Circulation. 2000年102卷8期852-7页
Elevated blood levels of homocysteine are associated with an increased risk of atherosclerotic cardiovascular disease. Although numerous studies have assessed the impact of vitamin supplements on homocysteine, the effect of dietary patterns on homocysteine has not been well studied.
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