当前位置: 首页 >> 检索结果
3921. Photoangioplasty for human peripheral atherosclerosis: results of a phase I trial of photodynamic therapy with motexafin lutetium (Antrin).
作者: S G Rockson.;P Kramer.;M Razavi.;A Szuba.;S Filardo.;P Fitzgerald.;J P Cooke.;S Yousuf.;A R DeVault.;M F Renschler.;D C Adelman.
来源: Circulation. 2000年102卷19期2322-4页
In photoangioplasty, light activation of a photosensitive drug offers the potential for treatment of long segments of vascular disease. This is a brief description of a study designed to evaluate the safety and tolerability of a new photosensitizer, Antrin (motexafin lutetium), in the endovascular treatment of atherosclerosis.
3922. Effect of second-phase duration on the strength-duration relation for human transvenous defibrillation.
The mechanism by which biphasic waveforms improve defibrillation efficacy is unclear. In addition, the optimal shape of the biphasic waveforms remains controversial. Animal experiments suggest that prolonging the duration of the second phase longer than the first worsens defibrillation thresholds (DFT). The purpose of this study was to determine the strength-duration relation for the second phase of a biphasic defibrillation waveform in humans.
3923. Insulin resistance and hyperinsulinemia: No independent relation to left ventricular mass in humans.
作者: A Q Galvan.;F Galetta.;A Natali.;E Muscelli.;A M Sironi.;G Cini.;S Camastra.;E Ferrannini.
来源: Circulation. 2000年102卷18期2233-8页
Hyperinsulinemia and insulin resistance may contribute to the development of cardiac hypertrophy. In humans, however, the evidence is inconclusive.
3924. Peripheral arterial disease in randomized trial of estrogen with progestin in women with coronary heart disease: the Heart and Estrogen/Progestin Replacement Study.
作者: J Hsia.;J A Simon.;F Lin.;W B Applegate.;M T Vogt.;D Hunninghake.;M Carr.
来源: Circulation. 2000年102卷18期2228-32页
Postmenopausal estrogen use has been associated with reduced carotid atherosclerosis in observational studies, but this relationship has not been confirmed in a clinical trial. The impact of estrogen on atherosclerotic disease in other peripheral arteries is unknown.
3925. Acute hemodynamic and clinical effects of levosimendan in patients with severe heart failure. Study Investigators.
作者: M T Slawsky.;W S Colucci.;S S Gottlieb.;B H Greenberg.;E Haeusslein.;J Hare.;S Hutchins.;C V Leier.;T H LeJemtel.;E Loh.;J Nicklas.;D Ogilby.;B N Singh.;W Smith.
来源: Circulation. 2000年102卷18期2222-7页
We determined the short-term hemodynamic and clinical effects of levosimendan, a novel calcium-sensitizing agent, in patients with decompensated heart failure.
3926. Quantitative general theory for periodic breathing in chronic heart failure and its clinical implications.
In patients with chronic heart failure (CHF), periodic breathing (PB) predicts poor prognosis. Clinical studies have identified numerous risk factors for PB (which also includes Cheyne-Stokes respiration). Computer simulations have shown that oscillations can arise from delayed negative feedback. However, no simple general theory quantitatively explains PB and its mechanisms of treatment using widely-understood clinical concepts. Therefore, we introduce a new approach to the quantitative analysis of the dynamic physiology governing cardiorespiratory stability in CHF.
3927. Angiotensin II receptor subtypes in the skeletal muscle vasculature of patients with severe congestive heart failure.
作者: S L Malendowicz.;P V Ennezat.;M Testa.;L Murray.;E H Sonnenblick.;T Evans.;T H LeJemtel.
来源: Circulation. 2000年102卷18期2210-3页
Vascular remodeling occurs in the skeletal muscle of patients with severe congestive heart failure (CHF); this remodeling is mediated in part by increased activity of the renin-angiotensin system. Animal models suggest that in the vasculature, angiotensin II receptor type 2 (AT2-R) expression may be upregulated in pathological states associated with vascular remodeling. The therapeutic effects of an AT1-R antagonist may, therefore, be in part due to increased plasma angiotensin II levels, which stimulate AT2-R. However, whether AT2-R is expressed in the skeletal muscle vasculature of patients with severe CHF is unknown.
3928. Bradykinin stimulates tissue plasminogen activator release from human forearm vasculature through B(2) receptor-dependent, NO synthase-independent, and cyclooxygenase-independent pathway.
Bradykinin stimulates dose-dependent tissue plasminogen activator (tPA) release from human endothelium. Although bradykinin is known to cause vasodilation through B(2) receptor-dependent effects on NO, prostacyclin, and endothelium-derived hyperpolarizing factor production, the mechanism(s) underlying tPA release is unknown.
3929. Clinical outcome of fenestrated Fontan patients after closure: the first 10 years.
作者: D A Goff.;E D Blume.;K Gauvreau.;J E Mayer.;J E Lock.;K J Jenkins.
来源: Circulation. 2000年102卷17期2094-9页
The late clinical status of Fontan patients after fenestration closure is unknown. Data are now available on all patients who underwent closure from 1989 to 1999.
3930. Electromagnetic versus fluoroscopic mapping of the inferior isthmus for ablation of typical atrial flutter: A prospective randomized study.
作者: H Kottkamp.;B Hügl.;B Krauss.;U Wetzel.;A Fleck.;G Schuler.;G Hindricks.
来源: Circulation. 2000年102卷17期2082-6页
Radiofrequency catheter ablation within the tricuspid annulus-inferior caval vein isthmus can cure typical atrial flutter. The target for ablation, nonetheless, is relatively wide, and standard ablation procedures may require significant exposure to radiation.
3931. The effects of beta(1)-blockade on oxidative metabolism and the metabolic cost of ventricular work in patients with left ventricular dysfunction: A double-blind, placebo-controlled, positron-emission tomography study.
作者: R S Beanlands.;C Nahmias.;E Gordon.;G Coates.;R deKemp.;G Firnau.;E Fallen.
来源: Circulation. 2000年102卷17期2070-5页
The mechanism for the beneficial effect of beta-blocker therapy in patients with left ventricular (LV) dysfunction is unclear, but it may relate to an energy-sparing effect that results in improved cardiac efficiency. C-11 acetate kinetics, measured using positron-emission tomography (PET), are a proven noninvasive marker of oxidative metabolism and myocardial oxygen consumption (MVO(2)). This approach can be used to measure the work-metabolic index, which is a noninvasive estimate of cardiac efficiency.
3932. Risk stratification in patients with inferior acute myocardial infarction treated by percutaneous coronary interventions: the role of admission troponin T.
作者: E Giannitsis.;S Lehrke.;U K Wiegand.;V Kurowski.;M Müller-Bardorff.;B Weidtmann.;G Richardt.;H A Katus.
来源: Circulation. 2000年102卷17期2038-44页
Cardiac troponin T (cTnT) elevations on admission indicate a high-risk subgroup of patients with ST-segment elevation acute myocardial infarction (AMI). This finding has been attributed to less effective reperfusion after thrombolytic therapy. The aim of this study was to determine the role of admission cTnT on the efficacy of percutaneous coronary interventions (PCIs) in inferior AMI.
3933. Treatment of aortocoronary vein graft lesions with membrane-covered stents: A multicenter surveillance trial.
作者: S Baldus.;R Köster.;M Elsner.;D H Walter.;R Arnold.;W Auch-Schwelk.;J Berger.;M Rau.;T Meinertz.;A M Zeiher.;C W Hamm.
来源: Circulation. 2000年102卷17期2024-7页
Stent implantation in lesions of degenerated aortocoronary vein grafts is associated with a high risk of periprocedural thrombus embolization and in-stent restenosis.
3934. Pulmonary capillary endothelium-bound angiotensin-converting enzyme activity in acute lung injury.
作者: S E Orfanos.;A Armaganidis.;C Glynos.;E Psevdi.;P Kaltsas.;P Sarafidou.;J D Catravas.;U G Dafni.;D Langleben.;C Roussos.
来源: Circulation. 2000年102卷16期2011-8页
Pulmonary capillary endothelium-bound (PCEB) angiotensin-converting ectoenzyme (ACE) activity alteration is an early, sensitive, and quantifiable lung injury index in animal models. We hypothesized that (1) PCEB-ACE alterations can be found in patients with acute lung injury (ALI) and (2) PCEB-ACE activity correlates with the severity of lung injury and may be used as a quantifiable marker of the underlying pulmonary capillary endothelial dysfunction.
3935. Cardiac troponin T predicts mortality in patients with end-stage renal disease.
作者: J Dierkes.;U Domröse.;S Westphal.;A Ambrosch.;H P Bosselmann.;K H Neumann.;C Luley.
来源: Circulation. 2000年102卷16期1964-9页
Patients with end-stage renal disease have a high risk of premature death, mainly as the result of cardiovascular disease (CVD), which is not sufficiently explained by the conventional risk factors. We therefore prospectively investigated total mortality and cardiovascular events in 102 patients on hemodialysis and assessed the prognostic value of baseline disease status and laboratory variables including total homocysteine and cardiac troponin T.
3936. Acute endothelin-A receptor antagonism prevents normal reduction of myocardial ischemia on repeated balloon inflations during angioplasty.
作者: Z S Kyriakides.;D T Kremastinos.;T M Kolettis.;A Tasouli.;A Antoniadis.;D J Webb.
来源: Circulation. 2000年102卷16期1937-43页
Myocardial ischemia and reperfusion are associated with increased production of endothelin (ET)-1.
3937. Modifications of cardiac autonomic profile associated with a shift schedule of work.
作者: R Furlan.;F Barbic.;S Piazza.;M Tinelli.;P Seghizzi.;A Malliani.
来源: Circulation. 2000年102卷16期1912-6页
Shift work is associated with an increased rate of cardiovascular diseases and accidents. Discordance between circadian rhythms of stress-related biological variables and the work-sleep schedule might explain the reduced efficiency of work. It is not clear whether a shift schedule of work may induce similar discordance in the 24-hour oscillatory pattern of the cardiac autonomic control in respect to the work-sleep periods.
3938. Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina: A randomized, double-blind, placebo-controlled study.
作者: K M English.;R P Steeds.;T H Jones.;M J Diver.;K S Channer.
来源: Circulation. 2000年102卷16期1906-11页
Experimental studies suggest that androgens induce coronary vasodilatation. We performed this pilot project to examine the clinical effects of long-term low-dose androgens in men with angina.
3939. Effect of pravastatin on coronary disease events in subgroups defined by coronary risk factors: the Prospective Pravastatin Pooling Project.
作者: F M Sacks.;A M Tonkin.;J Shepherd.;E Braunwald.;S Cobbe.;C M Hawkins.;A Keech.;C Packard.;J Simes.;R Byington.;C D Furberg.
来源: Circulation. 2000年102卷16期1893-900页
Previous trials have had insufficient numbers of coronary events to address definitively the effect of lipid-modifying therapy on coronary heart disease in subgroups of patients with varying baseline characteristics.
3940. VLDL, apolipoproteins B, CIII, and E, and risk of recurrent coronary events in the Cholesterol and Recurrent Events (CARE) trial.
作者: F M Sacks.;P Alaupovic.;L A Moye.;T G Cole.;B Sussex.;M J Stampfer.;M A Pfeffer.;E Braunwald.
来源: Circulation. 2000年102卷16期1886-92页
Plasma triglyceride concentration has been an inconsistent independent risk factor for coronary heart disease, perhaps because of the metabolic heterogeneity among VLDL particles, the main carriers of triglycerides in plasma.
|