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3903. Encapsulation of tumours as a modified wound healing response.
Tumour capsules may arise as the result of a modified wound healing response, consequent upon disturbance of the normal tissue architecture caused by an expanding tumour.
3912. Pathogenesis of non-traumatic fat embolism.
Like the liposomes of certain intravenous fat emulsions associated with embolic effects in acutely ill patients, chylomicrons and very low density lipoproteins (VLDL) show calcium-dependent agglutination by C-reactive protein (CRP). It is suggested that non-traumatic fat embolism may be caused by agglutination of chylomicrons and VLDL by high levels of plasma CRP. This mechanism may also cause acute pancreatitis in patients with types I, IV, and V hyperlipidaemia, and avascular necrosis of bone in patients with corticosteroid-induced hyperlipidaemia.
3917. Normal ageing, impaired cognitive function, and senile dementia of the Alzheimer's type: a continuum?
There is little evidence to support the view that senile dementia of the Alzheimer's type (SDAT) is distinct from the normal ageing process. The changes in brain function found in normal ageing, benign senescent forgetfulness, and SDAT can be seen as a continuum, which may reflect a single underlying process. The failure to account for this possibility in research design may explain why few risk factors for SDAT have been identified.
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