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3861. Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias.
作者: P J Schwartz.;S G Priori.;C Spazzolini.;A J Moss.;G M Vincent.;C Napolitano.;I Denjoy.;P Guicheney.;G Breithardt.;M T Keating.;J A Towbin.;A H Beggs.;P Brink.;A A Wilde.;L Toivonen.;W Zareba.;J L Robinson.;K W Timothy.;V Corfield.;D Wattanasirichaigoon.;C Corbett.;W Haverkamp.;E Schulze-Bahr.;M H Lehmann.;K Schwartz.;P Coumel.;R Bloise.
来源: Circulation. 2001年103卷1期89-95页
The congenital long-QT syndrome (LQTS) is caused by mutations on several genes, all of which encode cardiac ion channels. The progressive understanding of the electrophysiological consequences of these mutations opens unforeseen possibilities for genotype-phenotype correlation studies. Preliminary observations suggested that the conditions ("triggers") associated with cardiac events may in large part be gene specific.
3862. Effects of aging and cardiac denervation on heart rate variability during sleep.
作者: V Crasset.;S Mezzetti.;M Antoine.;P Linkowski.;J P Degaute.;P van de Borne.
来源: Circulation. 2001年103卷1期84-8页
Cardiac vagal predominance increases the RR interval and RR high-frequency (HF) variability during non-rapid eye movement (non-REM) sleep (stages I through IV) in young subjects. Aging suppresses deep sleep, but effects of age-related changes in sleep architecture on RR are unknown. Whether mechanical effects of changes in the breathing pattern on the sinus node during sleep affect RR variability is unclear.
3863. Evidence for joint genetic control of insulin sensitivity and systolic blood pressure in hispanic families with a hypertensive proband.
作者: A H Xiang.;S P Azen.;L J Raffel.;S Tan.;L S Cheng.;J Diaz.;E Toscano.;P C Henderson.;H N Hodis.;W A Hsueh.;J I Rotter.;T A Buchanan.
来源: Circulation. 2001年103卷1期78-83页
The clustering of hypertension, insulin resistance, and obesity remains unexplained. We tested for genetic and nongenetic influences on the association among these traits in Hispanic families with hypertension.
3864. Aldosterone production is activated in failing ventricle in humans.
作者: Y Mizuno.;M Yoshimura.;H Yasue.;T Sakamoto.;H Ogawa.;K Kugiyama.;E Harada.;M Nakayama.;S Nakamura.;T Ito.;Y Shimasaki.;Y Saito.;K Nakao.
来源: Circulation. 2001年103卷1期72-7页
Recent reports have indicated that aldosterone is produced in extra-adrenal tissues in animals. The present study was designed to examine whether aldosterone is produced in human heart.
3865. Cardiac troponin I is modified in the myocardium of bypass patients.
作者: J L McDonough.;R Labugger.;W Pickett.;M Y Tse.;S MacKenzie.;S C Pang.;D Atar.;G Ropchan.;J E Van Eyk.
来源: Circulation. 2001年103卷1期58-64页
Selective proteolysis of cardiac troponin I (cTnI) is a proposed mechanism of contractile dysfunction in stunned myocardium, and the presence of cTnI degradation products in serum may reflect the functional state of the remaining viable myocardium. However, recent swine and canine studies have not demonstrated stunning-dependent cTnI degradation.
3866. Blood donations and risk of coronary heart disease in men.
作者: A Ascherio.;E B Rimm.;E Giovannucci.;W C Willett.;M J Stampfer.
来源: Circulation. 2001年103卷1期52-7页
In experimental animals, iron overload appears to promote atherosclerosis and ischemic myocardial damage, but the results of epidemiological studies that relate iron stores to risk of coronary heart disease (CHD) have been inconsistent.
3867. Prospective study of pathogen burden and risk of myocardial infarction or death.
作者: J Zhu.;F J Nieto.;B D Horne.;J L Anderson.;J B Muhlestein.;S E Epstein.
来源: Circulation. 2001年103卷1期45-51页
We previously demonstrated that the risk of coronary artery disease (CAD) increased in relation to the number of pathogens (the "pathogen burden") in a cross-sectional study. In the present prospective study with a different patient cohort, we evaluated the effect of pathogen burden on the risk of myocardial infarction (MI) or death among CAD patients.
3868. Women's Healthy Lifestyle Project: A randomized clinical trial: results at 54 months.
作者: L H Kuller.;L R Simkin-Silverman.;R R Wing.;E N Meilahn.;D G Ives.
来源: Circulation. 2001年103卷1期32-7页
The Women's Healthy Lifestyle Project Clinical Trial tested the hypothesis that reducing saturated fat and cholesterol consumption and preventing weight gain by decreased caloric and fat intake and increased physical activity would prevent the rise in LDL cholesterol and weight gain in women during perimenopause to postmenopause.
3869. Local delivery of enoxaparin to decrease restenosis after stenting: results of initial multicenter trial: Polish-American Local Lovenox NIR Assessment study (The POLONIA study).
作者: R S Kiesz.;P Buszman.;J L Martin.;E Deutsch.;M M Rozek.;E Gaszewska.;M Rewicki.;P Seweryniak.;M Kosmider.;M Tendera.
来源: Circulation. 2001年103卷1期26-31页
Enoxaparin inhibits smooth muscle cell proliferation in experimental models. Intimal hyperplasia has been found to be the principal cause of restenosis after coronary stent implantation. We sought to determine whether the intramural delivery of enoxaparin before stenting of de novo lesions decreases restenosis.
3870. Radioactive stents delay but do not prevent in-stent neointimal hyperplasia.
作者: I P Kay.;A J Wardeh.;K Kozuma.;D P Foley.;A H Knook.;A Thury.;G Sianos.;W J van der Giessen.;P C Levendag.;P W Serruys.
来源: Circulation. 2001年103卷1期14-7页
Restenosis after conventional stenting is almost exclusively caused by neointimal hyperplasia. Beta-particle-emitting radioactive stents decrease in-stent neointimal hyperplasia at 6-month follow-up. The purpose of this study was to evaluate the 1-year outcome of (32)P radioactive stents with an initial activity of 6 to 12 microCi using serial quantitative coronary angiography and volumetric ECG-gated 3D intravascular ultrasound (IVUS).
3871. Balloon pulmonary angioplasty for treatment of chronic thromboembolic pulmonary hypertension.
作者: J A Feinstein.;S Z Goldhaber.;J E Lock.;S M Ferndandes.;M J Landzberg.
来源: Circulation. 2001年103卷1期10-3页
Although pulmonary thromboendarterectomy is increasingly successful for the definitive treatment of chronic thromboembolic pulmonary hypertension (CTEPH), not all patients have surgically accessible disease. Others are poor surgical candidates because of comorbid illness. Therefore, for selected patients, we defined and implemented an alternative interventional strategy of balloon pulmonary angioplasty (BPA).
3872. Treatment of proximal deep vein thrombosis with a novel synthetic compound (SR90107A/ORG31540) with pure anti-factor Xa activity: A phase II evaluation. The Rembrandt Investigators.
来源: Circulation. 2000年102卷22期2726-31页
Patients with venous thromboembolism require initial treatment with an immediate-acting anticoagulant, low-molecular-weight heparin. We evaluated a novel synthetic factor Xa inhibitor (SR90107a/ORG31540) as an alternative treatment.
3873. Increased plasma P-selectin and decreased thrombomodulin in pulmonary arterial hypertension were improved by continuous prostacyclin therapy.
作者: F Sakamaki.;S Kyotani.;N Nagaya.;N Sato.;H Oya.;T Satoh.;N Nakanishi.
来源: Circulation. 2000年102卷22期2720-5页
Thrombosis in situ related to endothelial cell injury may contribute to the development of pulmonary hypertension (PH). P-selectin, a leukocyte adhesion receptor present in endothelial cells and platelets, reflects endothelial injury and platelet activation, and thrombomodulin (TM), a receptor for thrombin and a major anticoagulant proteoglycan on the endothelial membrane, reflects the anticoagulant activity of the endothelium.
3874. In vivo and in vitro evidence for impaired arginine transport in human heart failure.
The clinical features of congestive heart failure (CHF) result from a complex interaction between reduced ventricular function, neurohormonal activation, and impaired endothelial function. Although endothelial dysfunction has been well documented, the mechanisms that contribute to this abnormality remain unknown. Recent studies, however, indicate a potential therapeutic role for supplemental L-arginine, suggesting the presence of an underlying disorder of L-arginine metabolism.
3875. Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: insights from the randomized aldactone evaluation study (RALES). Rales Investigators.
In congestive heart failure (CHF), extracellular matrix turnover is a major determinant of cardiac remodeling. It has been suggested that spironolactone may decrease cardiac fibrosis. We investigated the interactions between serum markers of cardiac fibrosis and the effect of spironolactone on outcome in patients with CHF.
3876. Endovascular brachytherapy for prophylaxis of restenosis after femoropopliteal angioplasty : results of a prospective randomized study.
作者: E Minar.;B Pokrajac.;T Maca.;R Ahmadi.;C Fellner.;M Mittlböck.;W Seitz.;R Wolfram.;R Pötter.
来源: Circulation. 2000年102卷22期2694-9页
Inasmuch as endovascular brachytherapy (BT) has gained recent interest because of its inhibitory effect on mechanisms leading to restenosis after percutaneous transluminal angioplasty (PTA), we performed this randomized study to determine its efficacy for prophylaxis of restenosis after femoropopliteal PTA.
3877. Differential effects of oral and transdermal estrogen replacement therapy on endothelial function in postmenopausal women.
作者: S Vehkavaara.;T Hakala-Ala-Pietilä.;A Virkamäki.;R Bergholm.;C Ehnholm.;O Hovatta.;M R Taskinen.;H Yki-Järvinen.
来源: Circulation. 2000年102卷22期2687-93页
We determined whether the vascular effects of estradiol depend on the route of administration by comparing the effects of oral estradiol and transdermal placebo, transdermal estradiol and oral placebo, and transdermal placebo and oral placebo on in vivo endothelial function in 27 postmenopausal women.
3878. Circumferential radiofrequency ablation of pulmonary vein ostia: A new anatomic approach for curing atrial fibrillation.
作者: C Pappone.;S Rosanio.;G Oreto.;M Tocchi.;F Gugliotta.;G Vicedomini.;A Salvati.;C Dicandia.;P Mazzone.;V Santinelli.;S Gulletta.;S Chierchia.
来源: Circulation. 2000年102卷21期2619-28页
The pulmonary veins (PVs) and surrounding ostial areas frequently house focal triggers or reentrant circuits critical to the genesis of atrial fibrillation (AF). We developed an anatomic approach aimed at isolating each PV from the left atrium (LA) by circumferential radiofrequency (RF) lesions around their ostia.
3879. Severely impaired baroreflex-buffering in patients with monogenic hypertension and neurovascular contact.
作者: J Jordan.;H R Toka.;K Heusser.;O Toka.;J R Shannon.;J Tank.;A Diedrich.;C Stabroth.;M Stoffels.;R Naraghi.;W Oelkers.;H Schuster.;H P Schobel.;H Haller.;F C Luft.
来源: Circulation. 2000年102卷21期2611-8页
We identified a family with a monogenic syndrome of hypertension, brachydactyly, and neurovascular contact of the brain stem. Neurovascular contact of the ventrolateral medulla may lead to arterial hypertension by interfering with baroreflex function.
3880. Impairment of endothelium-dependent vasodilation of resistance vessels in patients with obstructive sleep apnea.
作者: M Kato.;P Roberts-Thomson.;B G Phillips.;W G Haynes.;M Winnicki.;V Accurso.;V K Somers.
来源: Circulation. 2000年102卷21期2607-10页
Patients with obstructive sleep apnea (OSA) experience repetitive episodic hypoxemia with consequent sympathetic activation and marked blood pressure surges, each of which may impair endothelial function. We tested the hypothesis that patients with OSA have impaired endothelium-dependent vasodilation, even in the absence of overt cardiovascular disease.
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