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3781. Prolonged antiplatelet therapy to prevent late thrombosis after intracoronary gamma-radiation in patients with in-stent restenosis: Washington Radiation for In-Stent Restenosis Trial plus 6 months of clopidogrel (WRIST PLUS).
作者: R Waksman.;A E Ajani.;R L White.;E Pinnow.;R Dieble.;A B Bui.;M Taaffe.;L Gruberg.;G S Mintz.;L F Satler.;A D Pichard.;K K Kent.;J Lindsay.
来源: Circulation. 2001年103卷19期2332-5页
Intracoronary gamma-radiation reduces recurrent in-stent restenosis. Late thrombosis (>30 days after radiation therapy) is identified as a serious complication. The Washington Radiation for In-Stent Restenosis Trial (WRIST) PLUS, which involved 6 months of treatment with clopidogrel and aspirin, was designed to examine the efficacy and safety of prolonged antiplatelet therapy for the prevention of late thrombosis.
3782. Effects of Abciximab on the architecture of platelet-rich clots in patients with acute myocardial infarction undergoing primary coronary intervention.
作者: J P Collet.;G Montalescot.;C Lesty.;Z Mishal.;J Soria.;R Choussat.;G Drobinski.;C Soria.;P Pinton.;P Barragan.;D Thomas.
来源: Circulation. 2001年103卷19期2328-31页
Abciximab plus aspirin improves the TIMI 3 flow rate of the infarct-related artery in patients treated with either percutaneous coronary intervention or thrombolysis. The present study investigated whether the reperfusion efficacy of abciximab relates to modifications of clot architecture in patients admitted for acute myocardial infarction (AMI).
3783. Influence of hypoxia on nitric oxide synthase activity and gene expression in children with congenital heart disease: a novel pathophysiological adaptive mechanism.
作者: C R Ferreiro.;A C Chagas.;M H Carvalho.;A P Dantas.;M B Jatene.;L C Bento De Souza.;P Lemos Da Luz.
来源: Circulation. 2001年103卷18期2272-6页
Chronic hypoxia has been shown to modulate nitric oxide (NO) responses in different cell models, but the relationship between hypoxia and NO synthase (NOS) regulation in humans was not studied. We studied the relationship between endothelial and inducible NOS (eNOS and iNOS) activities and expression and chronic hypoxia in children with cyanotic and acyanotic congenital heart defects.
3784. Atrial reentrant tachycardia after surgery for congenital heart disease: endocardial mapping and radiofrequency catheter ablation using a novel, noncontact mapping system.
作者: T Paul.;B Windhagen-Mahnert.;T Kriebel.;H Bertram.;R Kaulitz.;T Korte.;M Niehaus.;J Tebbenjohanns.
来源: Circulation. 2001年103卷18期2266-71页
The purpose of the present study was to determine the role of a novel, noncontact mapping system for assessing a variety of atrial reentrant tachycardias (ART) in patients after the surgical correction of congenital heart disease.
3785. Interleukin-6 (IL-6) and the prognosis of abdominal aortic aneurysms.
作者: K G Jones.;D J Brull.;L C Brown.;M Sian.;R M Greenhalgh.;S E Humphries.;J T Powell.
来源: Circulation. 2001年103卷18期2260-5页
Abdominal aortic aneurysm is a multifactorial disorder in which inflammation is an important pathophysiological feature. In explant culture, aneurysm biopsies secrete large amounts of interleukin-6 (IL-6), and among aneurysm patients, the circulating concentration of IL-6 appears to be increased.
3786. Controlled trial of intravenous immune globulin in recent-onset dilated cardiomyopathy.
作者: D M McNamara.;R Holubkov.;R C Starling.;G W Dec.;E Loh.;G Torre-Amione.;A Gass.;K Janosko.;T Tokarczyk.;P Kessler.;D L Mann.;A M Feldman.
来源: Circulation. 2001年103卷18期2254-9页
This prospective placebo-controlled trial was designed to determine whether intravenous immune globulin (IVIG) improves left ventricular ejection fraction (LVEF) in adults with recent onset of idiopathic dilated cardiomyopathy or myocarditis.
3787. Simvastatin depresses blood clotting by inhibiting activation of prothrombin, factor V, and factor XIII and by enhancing factor Va inactivation.
The mechanism of the antithrombotic action of statins is unclear. The aim of this study was to evaluate the effects of simvastatin on the coagulation process at sites of microvascular injury.
3788. Enhanced response of blood monocytes to in vitro lipopolysaccharide-challenge in patients with recurrent unstable angina.
作者: G Liuzzo.;D J Angiolillo.;A Buffon.;V Rizzello.;C Colizzi.;F Ginnetti.;L M Biasucci.;A Maseri.
来源: Circulation. 2001年103卷18期2236-41页
C-reactive protein (CRP) plasma levels have been associated with short- and long-term occurrence of coronary events. We investigated whether circulating inflammatory cell responsiveness to low-grade stimuli could contribute to the reported association between CRP and coronary events.
3789. Assessment of myocardial perfusion in coronary artery disease by magnetic resonance: a comparison with positron emission tomography and coronary angiography.
作者: J Schwitter.;D Nanz.;S Kneifel.;K Bertschinger.;M Büchi.;P R Knüsel.;B Marincek.;T F Lüscher.;G K von Schulthess.
来源: Circulation. 2001年103卷18期2230-5页
Monitoring contrast medium wash-in kinetics in hyperemic myocardium by magnetic resonance (MR) allows for the detection of stenosed coronary arteries. In this prospective study, the quality of a multislice MR approach with respect to the detection and sizing of compromised myocardium was determined and compared with positron emission tomography (PET) and quantitative coronary angiography.
3790. Implantation of cardioverter defibrillators without induction of ventricular fibrillation.
The upper limit of vulnerability (ULV) is the weakest shock at which ventricular fibrillation (VF) is not induced by a T-wave shock. This study tested the hypothesis that a vulnerability safety margin based on the ULV can be used as an implantable cardioverter-defibrillator implantation criterion.
3791. Randomized, single-blind, placebo-controlled pilot study of catheter-based myocardial gene transfer for therapeutic angiogenesis using left ventricular electromechanical mapping in patients with chronic myocardial ischemia.
作者: P R Vale.;D W Losordo.;C E Milliken.;M C McDonald.;L M Gravelin.;C M Curry.;D D Esakof.;M Maysky.;J F Symes.;J M Isner.
来源: Circulation. 2001年103卷17期2138-43页
Catheter-based myocardial gene transfer (GTx) has not been previously tested in human subjects. Accordingly, we performed a pilot study to investigate the feasibility and safety of catheter-based myocardial GTx of naked plasmid DNA encoding vascular endothelial growth factor-2 (phVEGF-2) in patients with chronic myocardial ischemia.
3792. Peripheral arterial responses to treadmill exercise among healthy subjects and atherosclerotic patients.
作者: A Rozanski.;E Qureshi.;M Bauman.;G Reed.;G Pillar.;G A Diamond.
来源: Circulation. 2001年103卷16期2084-9页
BACKGROUND-Peripheral cutaneous vascular beds, such as the fingertips, contain a high concentration of arteriovenous anastomoses, richly innervated by a-adrenergic nerve fibers, to control heat regulation. Nevertheless, for a variety of technical reasons, finger blood flow responses to exercise have not been well studied in health and disease. Hence, we compared finger pulse-wave amplitude (PWA) responses to exercise among 50 normal volunteers and 57 patients with atherosclerotic coronary artery disease (CAD) using a robust, modified form of volume plethysmography.
3793. High-altitude pulmonary edema is initially caused by an increase in capillary pressure.
作者: M Maggiorini.;C Mélot.;S Pierre.;F Pfeiffer.;I Greve.;C Sartori.;M Lepori.;M Hauser.;U Scherrer.;R Naeije.
来源: Circulation. 2001年103卷16期2078-83页
High-altitude pulmonary edema (HAPE) is characterized by severe pulmonary hypertension and bronchoalveolar lavage fluid changes indicative of inflammation. It is not known, however, whether the primary event is an increase in pressure or an increase in permeability of the pulmonary capillaries.
3794. Electroanatomic mapping of entrained and exit zones in patients with repaired congenital heart disease and intra-atrial reentrant tachycardia.
作者: J K Triedman.;M E Alexander.;C I Berul.;L M Bevilacqua.;E P Walsh.
来源: Circulation. 2001年103卷16期2060-5页
Characterization of reentrant circuits and targeting ablation sites remains difficult for intra-atrial reentrant tachycardias (IART) in congenital heart disease (CHD).
3795. Relation of a common methylenetetrahydrofolate reductase mutation and plasma homocysteine with intimal hyperplasia after coronary stenting.
作者: T Kosokabe.;K Okumura.;T Sone.;J Kondo.;H Tsuboi.;H Mukawa.;T Tomida.;T Suzuki.;H Kamiya.;H Matsui.;T Hayakawa.
来源: Circulation. 2001年103卷16期2048-54页
Hyperhomocysteinemia has been identified as an independent risk factor for coronary artery disease. Recent studies have shown that a common mutation (nucleotide 677 C-->T) in the methylenetetrahydrofolate reductase (MTHFR) gene may contribute to mild hyperhomocysteinemia and, therefore, to the incidence of coronary artery disease. No information exists, however, regarding the association between the mutation of the MTHFR gene or plasma homocysteine levels and morphological analysis of coronary atherosclerosis using intravascular ultrasound.
3796. Oral anticoagulant therapy during and after coronary angioplasty the intensity and duration of anticoagulation are essential to reduce thrombotic complications.
作者: J M ten Berg.;B A Hutten.;J C Kelder.;F W Verheugt.;H W Plokker.
来源: Circulation. 2001年103卷16期2042-7页
In the randomized Balloon Angioplasty and Anticoagulation Study (BAAS), the addition of oral anticoagulants to aspirin significantly reduced early and late events after coronary angioplasty. However, bleeding episodes were increased. The present report studied the intensity and the duration of anticoagulation as predictors of thrombotic and bleeding events.
3797. Relationship of heart rate variability to parasympathetic effect.
作者: J J Goldberger.;S Challapalli.;R Tung.;M A Parker.;A H Kadish.
来源: Circulation. 2001年103卷15期1977-83页
Baroreflex-mediated parasympathetic stimulation has variable effects on heart rate variability (HRV). We postulated that a quadratic function would describe the relationship between HRV and parasympathetic effect better than a linear function.
3798. Prognostic value of radionuclide angiography in patients with right ventricular arrhythmias.
作者: D Le Guludec.;H Gauthier.;R Porcher.;R Frank.;D Daou.;S Benelhadj.;A Leenhardt.;T Lavergne.;M Faraggi.;M S Slama.
来源: Circulation. 2001年103卷15期1972-6页
The prognosis of patients with right ventricular (RV) arrhythmias remains uncertain. This study prospectively evaluated the prognostic value of RV and left ventricular (LV) involvement assessed by radionuclide angiography (RNA) as predictors for sudden death.
3799. Vascular effects of synthetic or natural progestagen combined with conjugated equine estrogen in healthy postmenopausal women.
作者: K K Koh.;D K Jin.;S H Yang.;S K Lee.;H Y Hwang.;M H Kang.;W Kim.;D S Kim.;I S Choi.;E K Shin.
来源: Circulation. 2001年103卷15期1961-6页
Synthetic, not natural, progestagen may negate the favorable effects of estrogen. Nonetheless, observational studies report no differences in risk for clinical cardiovascular events between users of unopposed estrogen and users of estrogen combined with synthetic progestin.
3800. Elevated levels of oxidized low density lipoprotein show a positive relationship with the severity of acute coronary syndromes.
作者: S Ehara.;M Ueda.;T Naruko.;K Haze.;A Itoh.;M Otsuka.;R Komatsu.;T Matsuo.;H Itabe.;T Takano.;Y Tsukamoto.;M Yoshiyama.;K Takeuchi.;J Yoshikawa.;A E Becker.
来源: Circulation. 2001年103卷15期1955-60页
There is accumulating data that acute coronary syndromes relate to recent onset activation of inflammation affecting atherosclerotic plaques. Increased blood levels of oxidized low density lipoprotein (ox-LDL) could play a role in these circumstances.
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