Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease with increasing global prevalence. Although diabetes is a major factor in NAFLD progression, up to 75% of the patients with NAFLD do not have diabetes. Tofogliflozin (Tofo), a sodium-glucose cotransporter type-2 inhibitor, is widely used in patients with type 2 diabetes. Several clinical trials with Tofo have shown its beneficial effects in NAFLD patients with diabetes; however, currently, there are limited data on NAFLD patients without diabetes.

Very early onset inflammatory bowel disease (VEO-IBD) is a rare, severe condition with over 80 monogenic causes. These often resist conventional therapies, necessitating targeted treatments such as biologics and hematopoietic stem cell transplantation (HSCT). This study aimed to systematically review therapeutic outcomes.

Non-alcoholic fatty liver disease (NAFLD) has become the most prevalent chronic liver disease globally. The present study aims to investigate the diagnostic value of abdominal obesity and metabolism-related indicators for NAFLD in lean individuals.

Capsular invasion independently predicts poor prognosis after primary liver cancer (PLC). While maximum tumor diameter (MTD) informs staging systems, its potential nonlinear association with capsular invasion remains unquantified.

Peptic gastroduodenal stenosis is a rare but disabling condition causing gastric outlet obstruction. This study aimed to evaluate endoscopic balloon dilation in terms of treatment effectiveness, durability, and identify potential early predictors of unsatisfactory outcomes.

Timely colonoscopy completion in primary care can prevent diagnostic delays in colorectal cancer. Factors that influence why patients experience timely or delayed colonoscopy completion are unclear. We sought to identify potentially intervenable factors associated with earlier (or later) colonoscopy test completion in primary care.

Gastrointestinal bleeding is a major cause of morbidity and mortality, this study aimed to validate the performance of the new ABC score in predicting 30-day mortality in upper gastrointestinal bleeding (UGIB) and lower gastrointestinal bleeding (LGIB) in a cohort of Tanzanian patients and compare it to existing pre-endoscopy risk scores.

Developing inflammatory bowel disease (IBD) affects platelet counts (PLT), which are involved in blood coagulation. However, the predictive or diagnostic utility of platelet characteristics in assessing IBD disease activity of inflammatory bowel disease. We conducted thisremains unknown. This meta-analysis was conducted to quantitatively evaluate changes in platelet parameters during the active phase of IBD using a large sample size.

Endoscopic ultrasonography (EUS) and enhanced computed tomography (CT) can offer more image features of gastric stromal tumors with higher pathological risk, which is of great significance for determining the pathological risk degree of gastric stromal tumors (GSTs) before surgery.

Overt hepatic encephalopathy (OHE) is a common complication following transjugular intrahepatic portosystemic shunt (TIPS) procedures in patients with cirrhosis. However, the relationship between preoperative triglyceride (TG) levels and post-TIPS OHE risk remains unclear. This study aimed to investigate whether elevated preoperative TG levels are independently associated with increased risk of developing OHE following TIPS in patients with cirrhosis.

Hypertriglyceridemia is an increasingly common cause of acute pancreatitis (AP). Patients with hypertriglyceridemic acute pancreatitis (HTG-AP) have higher complication and mortality rates compared to those with other etiologies. Early prediction of disease severity remains challenging due to the lack of readily available tools specifically for HTG-AP.

Exposure to Benzo[a]pyrene (BaP) is linked to multiple autoimmune diseases. This study aims to identify the key genes associated with BaP exposure and primary biliary cholangitis (PBC), shedding light on the underlying molecular mechanisms.

Individuals with colorectal polyposis are suspected to be genetically predisposed to tumor development. However, in around half of adenomatous and the vast majority of serrated polyposis patients, no explanatory pathogenic germline variant is found in routine diagnostics. Here, we aimed to improve the characterization of the early steps of polyp formation and provide clues on the tumorigenic processes involved.

Pancreatitis, a debilitating disease, is orchestrated by many etiological factors. Besides the known causal genes, including PRSS1, SPINK1, CPA1, CFTR, etc., of late, TRPV6 has emerged as a new candidate in the list. We aimed to investigate the role of TRPV6 and its genetic variations in the etiopathology of pancreatitis.

Postprocedural pancreatitis is the most common adverse event (AE) associated with endoscopic retrograde cholangiopancreatography (ERCP). Endoscopic ultrasound-guided choledochoduodenostomy (EUS-CDS) using a lumen-apposing metal stent is emerging as a promising approach for managing malignant distal biliary obstruction, offering the potential to lower the risk of postprocedural pancreatitis.

Acute severe ulcerative colitis is a potentially life-threatening condition that requires hospitalization with early and aggressive intervention to prevent complications. Mirikizumab (an anti-IL-23 monoclonal antibody) is recommended for the treatment of adult patients with moderate-to-severe ulcerative colitis. Currently, there is lack of evidence supporting its use in acute severe colitis, and no evidence has been produced on the use of this medication in pregnant women. A 30-year-old pregnant woman, with a 4-year history of corticosteroid-refractory pancolitis, who had failure to respond to multiple biological therapies, including infliximab, adalimumab, and vedolizumab, presented with acute severe ulcerative colitis and suspected threatened preterm rupture of membranes at 18 weeks' gestation. After administering five days of intravenous corticosteroids, the patient showed an unfavorable clinical and endoscopic response. Given the corticosteroid-refractory ASUC and the significant obstetric and neonatal risks associated with colectomy, Mirikizumab was initiated as a rescue therapy. Remarkably, within one day of receiving the first dose, the patient exhibited significant clinical improvement. One month after Mirikizumab initiation, the patient maintained clinical remission with improved markers. At 35 weeks and 4 days of gestation, the patient underwent an urgent cesarean section, delivering a preterm female infant. This is the first reported case regarding the efficacy and safety of Mirikizumab as a rescue therapy in a pregnant woman with severe acute ulcerative colitis. Further research is needed to confirm its efficacy in ASUC and the safety of this drug during pregnancy.