当前位置: 首页 >> 检索结果
361. Effect of Biomechanical Footwear on Knee Pain in People With Knee Osteoarthritis: The BIOTOK Randomized Clinical Trial.
作者: Stephan Reichenbach.;David T Felson.;Cesar A Hincapié.;Sarah Heldner.;Lukas Bütikofer.;Armando Lenz.;Bruno R da Costa.;Harald M Bonel.;Richard K Jones.;Gillian A Hawker.;Peter Jüni.
来源: JAMA. 2020年323卷18期1802-1812页
Individually calibrated biomechanical footwear therapy may improve pain and physical function in people with symptomatic knee osteoarthritis, but the benefits of this therapy are unclear.
362. Effect of Surgery vs Functional Bracing on Functional Outcome Among Patients With Closed Displaced Humeral Shaft Fractures: The FISH Randomized Clinical Trial.
作者: Lasse Rämö.;Bakir O Sumrein.;Vesa Lepola.;Tuomas Lähdeoja.;Jonas Ranstam.;Mika Paavola.;Teppo Järvinen.;Simo Taimela.; .
来源: JAMA. 2020年323卷18期1792-1801页
Humeral shaft fractures traditionally have been treated nonsurgically, but there has been a steady increase in the rate of surgery over the past 2 decades without high-quality evidence to justify the trend.
363. Effect of Intravenous Zoledronic Acid on Tibiofemoral Cartilage Volume Among Patients With Knee Osteoarthritis With Bone Marrow Lesions: A Randomized Clinical Trial.
作者: Guoqi Cai.;Dawn Aitken.;Laura L Laslett.;Jean-Pierre Pelletier.;Johanne Martel-Pelletier.;Catherine Hill.;Lyn March.;Anita E Wluka.;Yuanyuan Wang.;Benny Antony.;Leigh Blizzard.;Tania Winzenberg.;Flavia Cicuttini.;Graeme Jones.
来源: JAMA. 2020年323卷15期1456-1466页
A proof-of-principle study suggested that intravenous zoledronic acid may reduce knee pain and the size of bone marrow lesions in people with knee osteoarthritis, but data from large trials are lacking.
364. Effect of Preemptive Therapy vs Antiviral Prophylaxis on Cytomegalovirus Disease in Seronegative Liver Transplant Recipients With Seropositive Donors: A Randomized Clinical Trial.
作者: Nina Singh.;Drew J Winston.;Raymund R Razonable.;G Marshall Lyon.;Fernanda P Silveira.;Marilyn M Wagener.;Terry Stevens-Ayers.;Bradley Edmison.;Michael Boeckh.;Ajit P Limaye.
来源: JAMA. 2020年323卷14期1378-1387页
Despite the use of a cytomegalovirus (CMV) prevention strategy of antiviral prophylaxis for high-risk CMV-seronegative liver transplant recipients with seropositive donors, high rates of delayed-onset postprophylaxis CMV disease occur. An alternate approach, preemptive therapy (initiation of antiviral therapy for early asymptomatic CMV viremia detected by surveillance testing), has not previously been directly compared with antiviral prophylaxis in these patients.
365. Effect of a Chikungunya Virus-Like Particle Vaccine on Safety and Tolerability Outcomes: A Randomized Clinical Trial.
作者: Grace L Chen.;Emily E Coates.;Sarah H Plummer.;Cristina A Carter.;Nina Berkowitz.;Michelle Conan-Cibotti.;Josephine H Cox.;Allison Beck.;Mark O'Callahan.;Charla Andrews.;Ingelise J Gordon.;Brenda Larkin.;Rebecca Lampley.;Florence Kaltovich.;Jason Gall.;Kevin Carlton.;Jason Mendy.;Doug Haney.;Jeanine May.;Amy Bray.;Robert T Bailer.;Kimberly A Dowd.;Brittanie Brockett.;David Gordon.;Richard A Koup.;Richard Schwartz.;John R Mascola.;Barney S Graham.;Theodore C Pierson.;Yeycy Donastorg.;Nicolas Rosario.;Jean William Pape.;Bruno Hoen.;André Cabié.;Clemente Diaz.;Julie E Ledgerwood.; .
来源: JAMA. 2020年323卷14期1369-1377页
Chikungunya virus (CHIKV) is a mosquito-borne Alphavirus prevalent worldwide. There are currently no licensed vaccines or therapies.
366. Effect of Doxorubicin Plus Olaratumab vs Doxorubicin Plus Placebo on Survival in Patients With Advanced Soft Tissue Sarcomas: The ANNOUNCE Randomized Clinical Trial.
作者: William D Tap.;Andrew J Wagner.;Patrick Schöffski.;Javier Martin-Broto.;Anders Krarup-Hansen.;Kristen N Ganjoo.;Chueh-Chuan Yen.;Albiruni R Abdul Razak.;Alexander Spira.;Akira Kawai.;Axel Le Cesne.;Brian A Van Tine.;Yoichi Naito.;Se Hoon Park.;Alexander Fedenko.;Zsuzsanna Pápai.;Victoria Soldatenkova.;Ashwin Shahir.;Gary Mo.;Jennifer Wright.;Robin L Jones.; .
来源: JAMA. 2020年323卷13期1266-1276页
Patients with advanced soft tissue sarcoma (STS) have a median overall survival of less than 2 years. In a phase 2 study, an overall survival benefit in this population was observed with the addition of olaratumab to doxorubicin over doxorubicin alone.
367. Effect of Dapagliflozin on Worsening Heart Failure and Cardiovascular Death in Patients With Heart Failure With and Without Diabetes.
作者: Mark C Petrie.;Subodh Verma.;Kieran F Docherty.;Silvio E Inzucchi.;Inder Anand.;Jan Belohlávek.;Michael Böhm.;Chern-En Chiang.;Vijay K Chopra.;Rudolf A de Boer.;Akshay S Desai.;Mirta Diez.;Jaroslaw Drozdz.;Andre Dukát.;Junbo Ge.;Jonathan Howlett.;Tzvetana Katova.;Masafumi Kitakaze.;Charlotta E A Ljungman.;Béla Merkely.;Jose C Nicolau.;Eileen O'Meara.;Pham Nguyen Vinh.;Morten Schou.;Sergey Tereshchenko.;Lars Køber.;Mikhail N Kosiborod.;Anna Maria Langkilde.;Felipe A Martinez.;Piotr Ponikowski.;Marc S Sabatine.;Mikaela Sjöstrand.;Scott D Solomon.;Per Johanson.;Peter J Greasley.;David Boulton.;Olof Bengtsson.;Pardeep S Jhund.;John J V McMurray.
来源: JAMA. 2020年323卷14期1353-1368页
Additional treatments are needed for heart failure with reduced ejection fraction (HFrEF). Sodium-glucose cotransporter 2 (SGLT2) inhibitors may be an effective treatment for patients with HFrEF, even those without diabetes.
368. Effect of Apabetalone Added to Standard Therapy on Major Adverse Cardiovascular Events in Patients With Recent Acute Coronary Syndrome and Type 2 Diabetes: A Randomized Clinical Trial.
作者: Kausik K Ray.;Stephen J Nicholls.;Kevin A Buhr.;Henry N Ginsberg.;Jan O Johansson.;Kamyar Kalantar-Zadeh.;Ewelina Kulikowski.;Peter P Toth.;Norman Wong.;Michael Sweeney.;Gregory G Schwartz.; .
来源: JAMA. 2020年323卷16期1565-1573页
Bromodomain and extraterminal proteins are epigenetic regulators of gene transcription. Apabetalone is a selective bromodomain and extraterminal protein inhibitor targeting bromodomain 2 and is hypothesized to have potentially favorable effects on pathways related to atherothrombosis. Pooled phase 2 data suggest favorable effects on clinical outcomes.
369. Comparison of Abbreviated Breast MRI vs Digital Breast Tomosynthesis for Breast Cancer Detection Among Women With Dense Breasts Undergoing Screening.
作者: Christopher E Comstock.;Constantine Gatsonis.;Gillian M Newstead.;Bradley S Snyder.;Ilana F Gareen.;Jennifer T Bergin.;Habib Rahbar.;Janice S Sung.;Christina Jacobs.;Jennifer A Harvey.;Mary H Nicholson.;Robert C Ward.;Jacqueline Holt.;Andrew Prather.;Kathy D Miller.;Mitchell D Schnall.;Christiane K Kuhl.
来源: JAMA. 2020年323卷8期746-756页
Improved screening methods for women with dense breasts are needed because of their increased risk of breast cancer and of failed early diagnosis by screening mammography.
370. Effect of Intravenous Tenecteplase Dose on Cerebral Reperfusion Before Thrombectomy in Patients With Large Vessel Occlusion Ischemic Stroke: The EXTEND-IA TNK Part 2 Randomized Clinical Trial.
作者: Bruce C V Campbell.;Peter J Mitchell.;Leonid Churilov.;Nawaf Yassi.;Timothy J Kleinig.;Richard J Dowling.;Bernard Yan.;Steven J Bush.;Vincent Thijs.;Rebecca Scroop.;Marion Simpson.;Mark Brooks.;Hamed Asadi.;Teddy Y Wu.;Darshan G Shah.;Tissa Wijeratne.;Henry Zhao.;Fana Alemseged.;Felix Ng.;Peter Bailey.;Henry Rice.;Laetitia de Villiers.;Helen M Dewey.;Philip M C Choi.;Helen Brown.;Kendal Redmond.;David Leggett.;John N Fink.;Wayne Collecutt.;Thomas Kraemer.;Martin Krause.;Dennis Cordato.;Deborah Field.;Henry Ma.;Bill O'Brien.;Benjamin Clissold.;Ferdinand Miteff.;Anna Clissold.;Geoffrey C Cloud.;Leslie E Bolitho.;Luke Bonavia.;Arup Bhattacharya.;Alistair Wright.;Abul Mamun.;Fintan O'Rourke.;John Worthington.;Andrew A Wong.;Christopher R Levi.;Christopher F Bladin.;Gagan Sharma.;Patricia M Desmond.;Mark W Parsons.;Geoffrey A Donnan.;Stephen M Davis.; .
来源: JAMA. 2020年323卷13期1257-1265页
Intravenous thrombolysis with tenecteplase improves reperfusion prior to endovascular thrombectomy for ischemic stroke compared with alteplase.
371. Effect of Intravenous Interferon β-1a on Death and Days Free From Mechanical Ventilation Among Patients With Moderate to Severe Acute Respiratory Distress Syndrome: A Randomized Clinical Trial.
作者: V Marco Ranieri.;Ville Pettilä.;Matti K Karvonen.;Juho Jalkanen.;Peter Nightingale.;David Brealey.;Jordi Mancebo.;Ricard Ferrer.;Alain Mercat.;Nicolò Patroniti.;Michael Quintel.;Jean-Louis Vincent.;Marjatta Okkonen.;Ferhat Meziani.;Giacomo Bellani.;Niall MacCallum.;Jacques Creteur.;Stefan Kluge.;Antonio Artigas-Raventos.;Mikael Maksimow.;Ilse Piippo.;Kati Elima.;Sirpa Jalkanen.;Markku Jalkanen.;Geoff Bellingan.; .
来源: JAMA. 2020年323卷8期725-733页
Acute respiratory distress syndrome (ARDS) is associated with high mortality. Interferon (IFN) β-1a may prevent the underlying event of vascular leakage.
372. Effect of a Machine Learning-Derived Early Warning System for Intraoperative Hypotension vs Standard Care on Depth and Duration of Intraoperative Hypotension During Elective Noncardiac Surgery: The HYPE Randomized Clinical Trial.
作者: Marije Wijnberge.;Bart F Geerts.;Liselotte Hol.;Nikki Lemmers.;Marijn P Mulder.;Patrick Berge.;Jimmy Schenk.;Lotte E Terwindt.;Markus W Hollmann.;Alexander P Vlaar.;Denise P Veelo.
来源: JAMA. 2020年323卷11期1052-1060页
Intraoperative hypotension is associated with increased morbidity and mortality. A machine learning-derived early warning system to predict hypotension shortly before it occurs has been developed and validated.
373. Effect of Reduced Exposure to Vasopressors on 90-Day Mortality in Older Critically Ill Patients With Vasodilatory Hypotension: A Randomized Clinical Trial.
作者: François Lamontagne.;Alvin Richards-Belle.;Karen Thomas.;David A Harrison.;M Zia Sadique.;Richard D Grieve.;Julie Camsooksai.;Robert Darnell.;Anthony C Gordon.;Doreen Henry.;Nicholas Hudson.;Alexina J Mason.;Michelle Saull.;Chris Whitman.;J Duncan Young.;Kathryn M Rowan.;Paul R Mouncey.; .
来源: JAMA. 2020年323卷10期938-949页
Vasopressors are commonly administered to intensive care unit (ICU) patients to raise blood pressure. Balancing risks and benefits of vasopressors is a challenge, particularly in older patients.
374. Effect of Vancomycin or Daptomycin With vs Without an Antistaphylococcal β-Lactam on Mortality, Bacteremia, Relapse, or Treatment Failure in Patients With MRSA Bacteremia: A Randomized Clinical Trial.
作者: Steven Y C Tong.;David C Lye.;Dafna Yahav.;Archana Sud.;J Owen Robinson.;Jane Nelson.;Sophia Archuleta.;Matthew A Roberts.;Alan Cass.;David L Paterson.;Hong Foo.;Mical Paul.;Stephen D Guy.;Adrian R Tramontana.;Genevieve B Walls.;Stephen McBride.;Narin Bak.;Niladri Ghosh.;Benjamin A Rogers.;Anna P Ralph.;Jane Davies.;Patricia E Ferguson.;Ravindra Dotel.;Genevieve L McKew.;Timothy J Gray.;Natasha E Holmes.;Simon Smith.;Morgyn S Warner.;Shirin Kalimuddin.;Barnaby E Young.;Naomi Runnegar.;David N Andresen.;Nicholas A Anagnostou.;Sandra A Johnson.;Mark D Chatfield.;Allen C Cheng.;Vance G Fowler.;Benjamin P Howden.;Niamh Meagher.;David J Price.;Sebastiaan J van Hal.;Matthew V N O'Sullivan.;Joshua S Davis.; .
来源: JAMA. 2020年323卷6期527-537页
Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia is associated with mortality of more than 20%. Combining standard therapy with a β-lactam antibiotic has been associated with reduced mortality, although adequately powered randomized clinical trials of this intervention have not been conducted.
375. Effect of Incisional Negative Pressure Wound Therapy vs Standard Wound Dressing on Deep Surgical Site Infection After Surgery for Lower Limb Fractures Associated With Major Trauma: The WHIST Randomized Clinical Trial.
作者: Matthew L Costa.;Juul Achten.;Ruth Knight.;Julie Bruce.;Susan J Dutton.;Jason Madan.;Melina Dritsaki.;Nick Parsons.;Miguel Fernandez.;Richard Grant.;Jagdeep Nanchahal.; .
来源: JAMA. 2020年323卷6期519-526页
Following surgery to treat major trauma-related fractures, deep wound infection rates are high. It is not known if negative pressure wound therapy can reduce infection rates in this setting.
376. Effects of Iron Isomaltoside vs Ferric Carboxymaltose on Hypophosphatemia in Iron-Deficiency Anemia: Two Randomized Clinical Trials.
作者: Myles Wolf.;Janet Rubin.;Maureen Achebe.;Michael J Econs.;Munro Peacock.;Erik A Imel.;Lars L Thomsen.;Thomas O Carpenter.;Thomas Weber.;Vincent Brandenburg.;Heinz Zoller.
来源: JAMA. 2020年323卷5期432-443页
Intravenous iron enables rapid correction of iron-deficiency anemia, but certain formulations induce fibroblast growth factor 23-mediated hypophosphatemia.
377. Effect of Renal Denervation and Catheter Ablation vs Catheter Ablation Alone on Atrial Fibrillation Recurrence Among Patients With Paroxysmal Atrial Fibrillation and Hypertension: The ERADICATE-AF Randomized Clinical Trial.
作者: Jonathan S Steinberg.;Vitaliy Shabanov.;Dmitry Ponomarev.;Denis Losik.;Eduard Ivanickiy.;Evgeny Kropotkin.;Konstantin Polyakov.;Pawel Ptaszynski.;Boris Keweloh.;Christopher J Yao.;Evgeny A Pokushalov.;Alexander B Romanov.
来源: JAMA. 2020年323卷3期248-255页
Renal denervation can reduce cardiac sympathetic activity that may result in an antiarrhythmic effect on atrial fibrillation.
378. Effect of Early Surgery vs Endoscopy-First Approach on Pain in Patients With Chronic Pancreatitis: The ESCAPE Randomized Clinical Trial.
作者: Yama Issa.;Marinus A Kempeneers.;Marco J Bruno.;Paul Fockens.;Jan-Werner Poley.;Usama Ahmed Ali.;Thomas L Bollen.;Olivier R Busch.;Cees H Dejong.;Peter van Duijvendijk.;Hendrik M van Dullemen.;Casper H van Eijck.;Harry van Goor.;Muhammed Hadithi.;Jan-Willem Haveman.;Yolande Keulemans.;Vincent B Nieuwenhuijs.;Alexander C Poen.;Erik A Rauws.;Adriaan C Tan.;Willem Thijs.;Robin Timmer.;Ben J Witteman.;Marc G Besselink.;Jeanin E van Hooft.;Hjalmar C van Santvoort.;Marcel G Dijkgraaf.;Marja A Boermeester.; .
来源: JAMA. 2020年323卷3期237-247页
For patients with painful chronic pancreatitis, surgical treatment is postponed until medical and endoscopic treatment have failed. Observational studies have suggested that earlier surgery could mitigate disease progression, providing better pain control and preserving pancreatic function.
379. Effect of Hydroxyethyl Starch vs Saline for Volume Replacement Therapy on Death or Postoperative Complications Among High-Risk Patients Undergoing Major Abdominal Surgery: The FLASH Randomized Clinical Trial.
作者: Emmanuel Futier.;Matthias Garot.;Thomas Godet.;Matthieu Biais.;Daniel Verzilli.;Alexandre Ouattara.;Olivier Huet.;Thomas Lescot.;Gilles Lebuffe.;Antoine Dewitte.;Anna Cadic.;Aymeric Restoux.;Karim Asehnoune.;Catherine Paugam-Burtz.;Philippe Cuvillon.;Marion Faucher.;Camille Vaisse.;Younes El Amine.;Hélène Beloeil.;Marc Leone.;Eric Noll.;Vincent Piriou.;Sigismond Lasocki.;Jean-Etienne Bazin.;Bruno Pereira.;Samir Jaber.; .;Sigismond Lasocki.;Olivier Huet.;Anna Cadic.;Christophe Jacob.;Catherine Paugam-Burtz.;Aymeric Restoux.;Alexandre Ouattara.;Ioana Feitita.;Elsa Deloge.;Mylène Defaye.;Olivier Joannes-Boyau.;Pauline Carles.;Guya Napolitano.;Simon Monziols.;Emmanuel Futier.;Marie Vignaud.;Solène Paul.;Karim Gahbiche.;Julie Fayon.;Erwan Laroche.;Jean-Etienne Bazin.;Antoine Brandely.;Charlene Le Moal.;Gilles Lebuffe.;Matthias Garot.;Vincent Piriou.;Samir Jaber.;Gérald Chanques.;Daniel Verzilli.;Audrey De Jong.;Alice Millot.;Anna Castagnoli.;Marc Leone.;Bruno Pastene.;Caroline Castelli.;Sophie Medam.;Lionel Velly.;Camille Vaisse.;Marion Faucher.;Karim Asehnoune.;Esther Samba.;Antoine Roquilly.;Marguerite Le Penndu.;Philippe Cuvillon.;Jean Yves Lefrant.;Olivier Wira.;Elisabeth Dubout.;Willy-Serge Mfam.;Thomas Lescot.;Emilie Begneu.;Julien Burey.;Teodora Cirilovic.;Hélène Beloeil.;Guillaume Allo.;Julien Pottecher.;Benjamin Lebas.;Clementine Venot.;Jean Pierre Rameau.;Florin Dimache.;Pierre Saint Léger.;Younes El Amine.
来源: JAMA. 2020年323卷3期225-236页
It is not known if use of colloid solutions containing hydroxyethyl starch (HES) to correct for intravascular deficits in high-risk surgical patients is either effective or safe.
380. Effect of Sunscreen Application on Plasma Concentration of Sunscreen Active Ingredients: A Randomized Clinical Trial.
作者: Murali K Matta.;Jeffry Florian.;Robbert Zusterzeel.;Nageswara R Pilli.;Vikram Patel.;Donna A Volpe.;Yang Yang.;Luke Oh.;Edward Bashaw.;Issam Zineh.;Carlos Sanabria.;Sarah Kemp.;Anthony Godfrey.;Steven Adah.;Sergio Coelho.;Jian Wang.;Lesley-Anne Furlong.;Charles Ganley.;Theresa Michele.;David G Strauss.
来源: JAMA. 2020年323卷3期256-267页
A prior pilot study demonstrated the systemic absorption of 4 sunscreen active ingredients; additional studies are needed to determine the systemic absorption of additional active ingredients and how quickly systemic exposure exceeds 0.5 ng/mL as recommended by the US Food and Drug Administration (FDA).
|