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3641. Sustained suppression of neointimal proliferation by sirolimus-eluting stents: one-year angiographic and intravascular ultrasound follow-up.
作者: J E Sousa.;M A Costa.;A C Abizaid.;B J Rensing.;A S Abizaid.;L F Tanajura.;K Kozuma.;G Van Langenhove.;A G Sousa.;R Falotico.;J Jaeger.;J J Popma.;P W Serruys.
来源: Circulation. 2001年104卷17期2007-11页
We have previously reported a virtual absence of neointimal hyperplasia 4 months after implantation of sirolimus-eluting stents. The aim of the present investigation was to determine whether these results are sustained over a period of 1 year.
3642. Effect of the distal-balloon protection system on microembolization during carotid stenting.
作者: N Al-Mubarak.;G S Roubin.;J J Vitek.;S S Iyer.;G New.;M B Leon.
来源: Circulation. 2001年104卷17期1999-2002页
The distal-balloon protection system is being evaluated for its efficacy in preventing embolic neurological events during carotid stenting (CAS). We sought to determine the effect of this system on the frequency of Doppler-detected microembolic signals (MES) during CAS.
3643. Electrophysiological effects of ibutilide in patients with accessory pathways.
作者: K A Glatter.;P C Dorostkar.;Y Yang.;R J Lee.;G F Van Hare.;E Keung.;G Modin.;M M Scheinman.
来源: Circulation. 2001年104卷16期1933-9页
Atrial fibrillation (AF) may cause life-threatening ventricular arrhythmias in patients with Wolff-Parkinson-White syndrome. We prospectively evaluated the effects of ibutilide on the conduction system in patients with accessory pathways (AP).
3644. Progression of aortic valve calcification: association with coronary atherosclerosis and cardiovascular risk factors.
作者: K Pohle.;R Mäffert.;D Ropers.;W Moshage.;N Stilianakis.;W G Daniel.;S Achenbach.
来源: Circulation. 2001年104卷16期1927-32页
Recent studies demonstrated an influence of atherosclerotic risk factors on the progression of aortic valve stenosis. The extent of aortic valve calcification (AVC) was also found to be a strong predictor of stenosis progression. We investigated the influence of the LDL cholesterol level (LDL), other standard cardiovascular risk factors, and the extent of coronary calcification (CC) on the progression of AVC quantified by electron beam tomography (EBT).
3645. Treatment of isolated systolic hypertension is most effective in older patients with high-risk profile.
作者: L Ferrucci.;C D Furberg.;B W Penninx.;M DiBari.;J D Williamson.;J M Guralnik.;J G Chen.;W B Applegate.;M Pahor.
来源: Circulation. 2001年104卷16期1923-6页
Although present guidelines suggest that treatment of hypertension is more effective in patients with multiple risk factors and higher risk of cardiovascular events, this hypothesis was never verified in older patients with systolic hypertension.
3646. Fractional flow reserve compared with intravascular ultrasound guidance for optimizing stent deployment.
作者: W F Fearon.;J Luna.;H Samady.;E R Powers.;T Feldman.;N Dib.;E M Tuzcu.;M W Cleman.;T M Chou.;D J Cohen.;M Ragosta.;A Takagi.;A Jeremias.;P J Fitzgerald.;A C Yeung.;M J Kern.;P G Yock.
来源: Circulation. 2001年104卷16期1917-22页
Determination of fractional flow reserve (FFR) has been proposed as a means to assess stent deployment. In this prospective, multicenter trial, we evaluate the use of FFR to optimize stenting by comparing it with standard intravascular ultrasound (IVUS) criteria.
3647. Dysfunctional endothelial nitric oxide biosynthesis in healthy smokers with impaired endothelium-dependent vasodilatation.
作者: R S Barua.;J A Ambrose.;L J Eales-Reynolds.;M C DeVoe.;J G Zervas.;D C Saha.
来源: Circulation. 2001年104卷16期1905-10页
The mechanisms involved in the dysfunction of both endothelium-dependent vasodilatation (EDV) and NO biosynthesis related to smoking are unclear. In this study, EDV was assessed in healthy smokers and nonsmokers in vivo and, using serum from the same individuals, was related to the NO biosynthetic pathway in vitro.
3648. Differential characteristics of neural circulatory control: early versus late after cardiac transplantation.
作者: P van De Borne.;J Neubauer.;M Rahnama.;J L Jansens.;N Montano.;A Porta.;V K Somers.;J P Degaute.
来源: Circulation. 2001年104卷15期1809-13页
Reappearance of low-frequency (LF) (+/-0.10 Hz) oscillations in RR interval (RR) after cardiac transplantation is indicative of sympathetic efferent reinnervation. We hypothesized that restored LF oscillations in RR in heart transplant recipients (HTRs) are linked to oscillations in muscle sympathetic nerve traffic (MSNA).
3649. Vasoconstrictor effect of the angiotensin-converting enzyme-resistant, chymase-specific substrate [Pro(11)(D)-Ala(12)] angiotensin I in human dorsal hand veins: in vivo demonstration of non-ace production of angiotensin II in humans.
作者: J E McDonald.;N Padmanabhan.;M C Petrie.;C Hillier.;J M Connell.;J J McMurray.
来源: Circulation. 2001年104卷15期1805-8页
[Pro(11)(D)-Ala(12)] angiotensin I is an ACE-resistant substrate specific for chymase. We used this peptide to determine whether a functionally significant non-ACE angiotensin (Ang) II-generating pathway exists in human dorsal hand veins.
3650. Hypothermia after cardiac arrest: feasibility and safety of an external cooling protocol.
作者: R A Felberg.;D W Krieger.;R Chuang.;D E Persse.;W S Burgin.;S L Hickenbottom.;L B Morgenstern.;O Rosales.;J C Grotta.
来源: Circulation. 2001年104卷15期1799-804页
No proven neuroprotective treatment exists for ischemic brain injury after cardiac arrest. Mild-to-moderate induced hypothermia (MIH) is effective in animal models.
3651. Dysregulation of peripheral and central chemoreflex responses in Chagas' heart disease patients without heart failure.
作者: J A Soares Barreto-Filho.;F M Consolim-Colombo.;H Ferreira Lopes.;C R Martins Sobrinho.;G M Guerra-Riccio.;E M Krieger.
来源: Circulation. 2001年104卷15期1792-8页
The peripheral and central chemoreflexes are important autonomic mechanisms for regulating breathing and cardiovascular function. Although pathological inflammatory infiltration of the peripheral chemoreceptors and central nervous system has been reported in Chagas' disease, functional evaluation of chemoreflexes has not yet been performed.
3652. Parasympathetic neural activity accounts for the lowering of exercise heart rate at high altitude.
作者: R Boushel.;J A Calbet.;G Rådegran.;H Sondergaard.;P D Wagner.;B Saltin.
来源: Circulation. 2001年104卷15期1785-91页
In chronic hypoxia, both heart rate (HR) and cardiac output (Q) are reduced during exercise. The role of parasympathetic neural activity in lowering HR is unresolved, and its influence on Q and oxygen transport at high altitude has never been studied.
3653. Real-time quantification and display of skin radiation during coronary angiography and intervention.
Radiographically guided investigations may be associated with excessive radiation exposure, which may cause skin injuries. The purpose of this study was to develop and test a system that measures in real time the dose applied to each 1-cm(2) area of skin, taking into account the movement of the x-ray source and changes in the beam characteristics. The goal of such a system is to help prevent high doses that might cause skin injury.
3654. Effect of medroxyprogesterone acetate on endothelium-dependent vasodilation in postmenopausal women receiving estrogen.
Estrogen increases endothelium-dependent vasodilation in postmenopausal women. However, use of progestins in combination with estrogen may counter beneficial effects of estrogen on endothelium. We investigated the effect of medroxyprogesterone acetate (MPA) on estrogen-induced increase in endothelium-dependent vasodilation in postmenopausal women.
3655. Early outcome after off-pump versus on-pump coronary bypass surgery: results from a randomized study.
作者: D van Dijk.;A P Nierich.;E W Jansen.;H M Nathoe.;W J Suyker.;J C Diephuis.;W J van Boven.;C Borst.;E Buskens.;D E Grobbee.;E O Robles De Medina.;P P de Jaegere.; .
来源: Circulation. 2001年104卷15期1761-6页
The use of cardiopulmonary bypass during coronary artery bypass surgery (CABG) has been associated with substantial morbidity. The recent introduction of cardiac stabilizers facilitates CABG without cardiopulmonary bypass (off-pump CABG), but it is unknown whether cardiac outcome after off-pump surgery is similar to that for the on-pump procedure.
3656. Reduction of cardiovascular risk by regression of electrocardiographic markers of left ventricular hypertrophy by the angiotensin-converting enzyme inhibitor ramipril.
作者: J Mathew.;P Sleight.;E Lonn.;D Johnstone.;J Pogue.;Q Yi.;J Bosch.;B Sussex.;J Probstfield.;S Yusuf.; .
来源: Circulation. 2001年104卷14期1615-21页
Electrocardiographic markers of left ventricular hypertrophy (LVH) predict poor prognosis. We determined whether the ACE inhibitor ramipril prevents the development and causes regression of ECG-LVH and whether these changes are associated with improved prognosis independent of blood pressure reduction.
3657. Long-term clinical outcomes after unprotected left main trunk percutaneous revascularization in 279 patients.
作者: W A Tan.;H Tamai.;S J Park.;H W Plokker.;M Nobuyoshi.;T Suzuki.;A Colombo.;C Macaya.;D R Holmes.;D J Cohen.;P L Whitlow.;S G Ellis.; .
来源: Circulation. 2001年104卷14期1609-14页
Percutaneous coronary revascularization (PCI) has been increasingly applied to unprotected left main trunk (LMT) lesions, with varied long-term success. This study attempts to define the predictors of outcome in this population.
3658. Stent placement compared with balloon angioplasty for small coronary arteries: in-hospital and 6-month clinical and angiographic results.
作者: R Koning.;H Eltchaninoff.;P Commeau.;K Khalife.;M Gilard.;J Lipiecki.;P Coste.;M Bedossa.;T Lefèvre.;P Brunel.;M C Morice.;L Maillard.;P Guyon.;J Puel.;A Cribier.; .
来源: Circulation. 2001年104卷14期1604-8页
Stenting has been demonstrated to be superior to balloon angioplasty in de novo focal lesions located in large native vessels. However, in small vessels, the benefit of stenting remains questionable.
3659. Severely impaired cardiac autonomic nervous activity after the Fontan operation.
Elevated neurohumoral activity and an abnormal cardiopulmonary response to exercise are well-established characteristics in patients after the Fontan operation. However, there have been few studies addressing cardiac autonomic nervous activity (CANA) in these patients.
3660. Regional cerebral hyperperfusion and nitric oxide pathway dysregulation in Fabry disease: reversal by enzyme replacement therapy.
作者: D F Moore.;L T Scott.;M T Gladwin.;G Altarescu.;C Kaneski.;K Suzuki.;M Pease-Fye.;R Ferri.;R O Brady.;P Herscovitch.;R Schiffmann.
来源: Circulation. 2001年104卷13期1506-12页
Fabry disease is an X-linked lysosomal deficiency of alpha-galactosidase A that results in cellular accumulation of galacto-conjugates such as globotriosylceramide, particularly in blood vessels. It is associated with early-onset stroke and kidney and heart failure.
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