Sleeve gastrectomy (SG) is the most commonly performed metabolic surgery for obesity but is associated with long-term recurrent weight gain (RWG) and recurrence of comorbidities. Ring-augmented sleeve gastrectomy (RASG) has been proposed to improve weight durability by preventing gastric dilation and loss of restriction.

With the introduction of high-resolution manometry (HRM), esophageal motility disorders (EMDs) are now better understood, allowing for a more effective treatment. Carbonated water use was suggested to change esophageal motility. Hence, this study sought to determine the effect of carbonated water on esophagus HRM. In this retrospective study, we used manometry to evaluate the effects of carbonated water on esophageal movement and to investigate the potential impact on the diagnosis and interpretation of motility disorders.

To investigate the correlation between drinking patterns and the occurrence of hematemesis in patients with alcoholic cirrhosis complicated by esophagogastric variceal bleeding (EVB).

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent chronic liver condition strongly associated with overweight or obesity, often accompanied by dyslipidemia, insulin resistance, and elevated liver enzymes. Exercise is recommended as a first-line lifestyle intervention, but evidence on the effects of different modalities, frequencies, and durations on metabolic and hepatic markers remains inconsistent. This study conducted a systematic review and meta-analysis to quantify overall effects and compare intervention strategies.

Alcohol abuse is a leading cause of global health care concerns and can cause health loss, disease, and death. In addition to the liver, the pancreas is a vital organ for the metabolism of alcohol, especially nonoxidative metabolism, and alcohol abuse is the leading cause of pancreatic diseases worldwide. Epidemiologic investigations have shown that alcohol consumption is linked to a spectrum of multiple pancreatic disorders, including acute pancreatitis, chronic pancreatitis, pancreatic cancer, and diabetes. Numerous in vitro and in vivo studies have elucidated the key mechanisms related to alcohol-induced pancreatic tissue injury in recent years. Alcohol has hazardous effects on multiple organs, destroying pancreatic acinar, ductal, stellate, and β-cells. These mechanisms, mainly mediated by alcohol and alcohol metabolites, include oxidative stress, endoplasmic reticulum stress, mitochondrial dysfunction, calcium overload, premature trypsinogen activation, inflammation, and extracellular matrix remodeling, which are complex and interrelated. A deeper understanding of these processes will open new avenues for therapeutic intervention. Although behavioral strategies, such as abstinence, remain essential, pharmacologic and molecularly targeted therapies offer potential complementary approaches. Given the challenges of maintaining sustained abstinence, these adjunctive treatments are critical for slowing or preventing the progression of alcohol-driven pancreatic diseases.

Serum regenerating islet-derived protein 1 alpha (REG1A), a protein associated with pancreatic inflammation, is emerging as a potential biomarker for pancreatitis. This case-control study aimed to evaluate the diagnostic and prognostic value of REG1A in patients with acute pancreatitis (AP) and chronic pancreatitis (CP).

Cold snare polypectomy (CSP) is increasingly popular because of its safety and convenience, but it is currently recognized as the best way to remove diminutive polyps (≤ 5 mm). CSP for nonpedunculated polyps ≥ 10 mm in size has not been well examined. We evaluate the safety and efficacy of CSP for benign-looking intermediate nonpedunculated polyps.

Intestinal methanogen overgrowth (IMO) is increasingly recognized as a contributor to gastrointestinal symptoms in children. This study aimed to investigate the clinical characteristics and endoscopic features of pediatric patients with IMO.

Perinuclear anti-neutrophil cytoplasmic antibody(p-ANCA) positivity may indicate poor response to infliximab (IFX) in ulcerative colitis (UC). Nevertheless, there has been limited research on the effect of proteinase 3 anti-neutrophil cytoplasmic antibody (PR3-ANCA) in UC patients treated with IFX and vedolizumab (VDZ). This study aimed to investigate the short-term efficacy of PR3-ANCA in patients with moderate-to-severe active UC.

This study aimed to evaluate the clinical outcomes of combined transarterial chemoembolization and microwave ablation for hepatic hemangiomas, focusing on whether the benefits of this minimally invasive approach extend equally to giant (≥10 cm) as well as large (5-9.9 cm) lesions.

This study aimed to identify the risk factors associated with Clostridioides difficile infection (CDI) in patients with ulcerative colitis (UC) and to develop a predictive nomogram.

The use of ciprofol for endoscopic sedation is relatively recent; however, no definitive conclusions have been drawn regarding its optimal dose. This study evaluated the optimal ciprofol dose for sedated endoscopy using a network meta-analysis.

This study aimed to investigate the potential of lymphocyte-to-C-reactive protein ratio (LCR) upon admission to predict therapeutic responsiveness to mesalazine in adult patients with mild-to-moderate active ulcerative colitis (UC).

Pancreatic cancer (PC) is one of the most aggressive malignancies, with a poor prognosis and a high rate of postoperative recurrence. Patients with early recurrence typically do not benefit from surgery. Therefore, identifying high-risk patients for early tumor recurrence before surgery is critical for developing personalized treatment strategies. This study is to investigate the clinical value of a multi-scale model, constructed using CT and pathological images, in predicting early recurrence risk following curative surgery for pancreatic cancer.

Pancreatic cancer (PC), a malignancy with poor prognosis, demands innovative diagnostic strategies for early detection. Current methods, such as endoscopic ultrasound and blood-based biomarkers, face limitations in accessibility, invasiveness, and accuracy, particularly for early-stage disease. Saliva, a non-invasive biofluid enriched with metabolites and proteins, offers promise as a diagnostic medium.

The urea breath test (UBT) is the clinic’s most popular and accurate non-invasive diagnostic method for Helicobacter pylori (HP) infection. Yet, it is time-consuming and unavailable to some individuals. The oral rapid urease test (RUT) is an emerging non-invasive convenience method but lacks clinical data support. A double-center, double-blind, methodological comparative design experiment is invited to evaluate the consistency of the oral RUT with UBT. 247 participants were enrolled. Their Dental plaque and tongue coating samples were collected, blind and tested with RUT. The significant association between the RUT and UBT was analyzed. The oral RUT showed a high level of agreement with the UBT. The sensitivity of the test reagent was 98.63% (95% CI: 92.64%, 99.76%), and the specificity was 96.34% (95% CI: 92.25%, 98.31%). The overall conformity rate was 97.05% (95% CI: 94.03%, 98.56%). The positive predictive value was 92.31%, and the negative predictive value was 99.37%. The positive likelihood ratio was 26.96, and the negative likelihood ratio was 0.01. The Kappa value was 0.97. The efficacy of oral RUT for HP infection diagnosis is extremely consistent with the UBT. Trial registration Clinical trial of rapid test paper (chemical reaction method) for Helicobacter pylori (NO.ChiCTR2500097395), Registration Date2025.02.19.Retrospectively registered.

Unresectable advanced or recurrent gastric and gastroesophageal junction (GC/GEJ) cancers carry poor prognoses, and several programmed death-1 (PD-1) inhibitors have shown clinical activity. However, no head-to-head trial has compared their relative efficacy and safety. This network meta-analysis aimed to evaluate and rank PD-1–based regimens in this setting.

This study aims to identify predictors of bowel resection due to bowel necrosis in patients with recent portal vein thrombosis (PVT) based on computed tomography (CT) presentations and clinical data.

To compare the diagnostic accuracy of gadoxetate disodium enhanced MRI (EOB-MRI) and contrast-enhanced CT (CE-CT) in the detection of colorectal cancer liver metastases (CRLM).

Esophageal cancer (EC) is the third leading cause of cancer-related morbidity and mortality in Malawi. Given limited imaging capacity and high costs, staging is not routinely performed. One proposed staging algorithm is to first evaluate for metastatic disease using low-cost chest radiography (CXR) and abdominal ultrasound (US) followed by confirmatory computerized tomography (CT) of the chest and abdomen if no metastases identified on initial screening. The feasibility of this approach is unknown for EC in sub–Saharan Africa and was studied in the context of a larger prospective observational cohort study of EC in Malawi.