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3541. Functional and biochemical analysis of endothelial (dys)function and NO/cGMP signaling in human blood vessels with and without nitroglycerin pretreatment.
作者: Eberhard Schulz.;Nikolaus Tsilimingas.;Ruth Rinze.;Beate Reiter.;Maria Wendt.;Mathias Oelze.;Silke Woelken-Weckmüller.;Ulrich Walter.;Hermann Reichenspurner.;Thomas Meinertz.;Thomas Münzel.
来源: Circulation. 2002年105卷10期1170-5页
In experimental animal models, long-term in vivo treatment with nitroglycerin (NTG) induces both endothelial dysfunction and tolerance to nitrates. However, it is still controversial whether nitrate tolerance in humans is associated with both endothelial dysfunction and impaired vascular response to nitrovasodilator-derived NO.
3542. Smoking a single cigarette rapidly reduces combined concentrations of nitrate and nitrite and concentrations of antioxidants in plasma.
作者: Masahiko Tsuchiya.;Akira Asada.;Emiko Kasahara.;Eisuke F Sato.;Mitsuo Shindo.;Masayasu Inoue.
来源: Circulation. 2002年105卷10期1155-7页
Cigarette smoking is a well-known risk factor for the development of cardiovascular disease, yet the mechanism of action involved is not completely understood. Because cigarette smoke contains superoxide and other reactive oxygen species, it has been hypothesized that some of the adverse effects of smoking may result from oxidative damage to endothelial cells, which results in nitric oxide (NO) shortage. However, little information is available regarding the acute effects of smoking on plasma concentrations of NO and antioxidants. We measured the changes in the combined plasma concentrations of nitrate and nitrite as an index of NO concentration, as well as changes in concentrations of major serum antioxidants (ascorbic acid, cysteine, methionine, and uric acid) in smokers after smoking a single cigarette.
3543. Pulmonary vein isolation for paroxysmal and persistent atrial fibrillation.
作者: Hakan Oral.;Bradley P Knight.;Hiroshi Tada.;Mehmet Ozaydin.;Aman Chugh.;Sohail Hassan.;Christoph Scharf.;Steve W K Lai.;Radmira Greenstein.;Frank Pelosi.;S Adam Strickberger.;Fred Morady.
来源: Circulation. 2002年105卷9期1077-81页
The pulmonary veins (PVs) have been demonstrated to often play an important role in generating atrial fibrillation (AF). The purpose of this study was to determine the safety and efficacy of segmental PV isolation in patients with paroxysmal or persistent AF.
3544. Change in diastolic left ventricular filling after one year of antihypertensive treatment: The Losartan Intervention For Endpoint Reduction in Hypertension (LIFE) Study.
作者: Kristian Wachtell.;Jonathan N Bella.;Jens Rokkedal.;Vittorio Palmieri.;Vasilios Papademetriou.;Björn Dahlöf.;Tapio Aalto.;Eva Gerdts.;Richard B Devereux.
来源: Circulation. 2002年105卷9期1071-6页
It is well established that hypertensive patients with left ventricular (LV) hypertrophy have impaired diastolic filling. However, the impact of antihypertensive treatment and LV mass reduction on LV diastolic filling remains unclear.
3545. Validation of collateral fractional flow reserve by myocardial perfusion imaging.
作者: Hitoshi Matsuo.;Sachiro Watanabe.;Tohru Kadosaki.;Takahiko Yamaki.;Shinichiro Tanaka.;Shuusaku Miyata.;Tomonori Segawa.;Yukihiko Matsuno.;Masaaki Tomita.;Hisayoshi Fujiwara.
来源: Circulation. 2002年105卷9期1060-5页
Collateral fractional flow reserve (FFR(coll)) is an index to quantify collateral blood flow, derived from coronary pressure measurements. Although well defined theoretically, its direct validation by myocardial perfusion imaging has not been established so far. Validating this index by myocardial perfusion imaging is the main aim of this study.
3546. Mechanism of the blood pressure--raising effect of cocaine in humans.
作者: Meryem Tuncel.;Zhongyun Wang.;Debbie Arbique.;Paul J Fadel.;Ronald G Victor.;Wanpen Vongpatanasin.
来源: Circulation. 2002年105卷9期1054-9页
Although the sympathomimetic actions and cardiovascular complications of cocaine are ascribed to inhibition of norepinephrine (NE) reuptake, this hypothesis has not been tested in humans. We asked (a) whether cocaine can inhibit NE reuptake in the human peripheral circulation and (b) whether the NE-mediated peripheral vasoconstriction is the main mechanism mediating blood pressure-raising effect of cocaine.
3547. Patients with Glanzmann thrombasthenia lacking platelet glycoprotein alpha(IIb)beta(3) (GPIIb/IIIa) and alpha(v)beta(3) receptors are not protected from atherosclerosis.
作者: O Shpilberg.;I Rabi.;K Schiller.;R Walden.;D Harats.;K S Tyrrell.;B Coller.;U Seligsohn.
来源: Circulation. 2002年105卷9期1044-8页
Platelets have been suggested to play a role in the early development of atherosclerosis. As one test of this hypothesis, we assessed whether patients with Glanzmann thrombasthenia who lack platelet glycoprotein alpha(IIb)beta(3) (GPIIb/IIIa) complexes or both alpha(IIb)beta(3) and the more ubiquitous alpha(v)beta(3) cell membrane complexes are protected from development of atherosclerosis.
3548. Selective upregulation of endothelin B receptor gene expression in severe pulmonary hypertension.
作者: Michael Bauer.;Heinrike Wilkens.;Frank Langer.;Sven O Schneider.;Henning Lausberg.;Hans-Joachim Schäfers.
来源: Circulation. 2002年105卷9期1034-6页
The pulmonary circulation is an important site for the production and clearance of endothelin (ET)-1, a potent vasoactive and mitogenic peptide. Increased plasma ET-1 levels are observed in pulmonary arterial hypertension (PHT) and may contribute to the regulation of pulmonary vascular resistance, as well as to proliferative changes in the pulmonary vascular bed.
3549. Norepinephrine turnover is increased in suprabulbar subcortical brain regions and is related to whole-body sympathetic activity in human heart failure.
作者: Anuradha Aggarwal.;Murray D Esler.;Gavin W Lambert.;Jacqueline Hastings.;Leonie Johnston.;David M Kaye.
来源: Circulation. 2002年105卷9期1031-3页
Although it is established that heightened sympathetic drive exists in congestive heart failure (CHF), the reflex processes by which this may occur and the sites in the central nervous system that may be responsible for mediating this process are not yet fully elucidated.
3550. Aging attenuates the vestibulosympathetic reflex in humans.
The vestibular system contributes to sympathetic activation by engagement of the otolith organs. However, there is a significant loss of vestibular function with aging. Therefore, the purpose of the present study was to determine if young and older individuals differ in their cardiovascular and sympathetic responses to otolithic stimulation (ie, head-down rotation, HDR). We hypothesized that responses to otolithic stimulation would be attenuated in older adults because of morphological and physiological alterations that occur in the vestibular system with aging.
3551. Peroxisome proliferator--activated receptor alpha gene regulates left ventricular growth in response to exercise and hypertension.
作者: Yalda Jamshidi.;Hugh E Montgomery.;Hans-Werner Hense.;Saul G Myerson.;Ines Pineda Torra.;Bart Staels.;Michael J World.;Angela Doering.;Jeanette Erdmann.;Christian Hengstenberg.;Steve E Humphries.;Heribert Schunkert.;David M Flavell.
来源: Circulation. 2002年105卷8期950-5页
Left ventricular hypertrophy (LVH) occurs as an adaptive response to a physiological (such as exercise) or pathological (valvular disease, hypertension, or obesity) increase in cardiac work. The molecular mechanisms regulating the LVH response are poorly understood. However, inherited defects in fatty acid oxidation are known to cause severe early-onset cardiac hypertrophy. Peroxisome proliferator--activated receptor alpha (PPARalpha) regulates genes responsible for myocardial fatty acid oxidation and is downregulated during cardiac hypertrophy, concomitant with the switch from fatty acid to glucose utilization.
3552. Remodeling of left ventricular hypertrophy in elite athletes after long-term deconditioning.
作者: Antonio Pelliccia.;Barry J Maron.;Rosanna De Luca.;Fernando M Di Paolo.;Antonio Spataro.;Franco Culasso.
来源: Circulation. 2002年105卷8期944-9页
The clinical significance and long-term consequences of left ventricular (LV) hypertrophy associated with intensive athletic conditioning remain unresolved.
3553. Effect of Abciximab on prothrombin activation and thrombin generation in acute coronary syndromes without ST-segment elevation: Global Utilization of Strategies to Open Occluded Coronary Arteries Trial IV in Acute Coronary Syndromes (GUSTO IV ACS) Italian Hematologic Substudy.
作者: Piera Angelica Merlini.;Alessandra Repetto.;Alessandro Lombardi.;Alfredo Vetrano.;Raffaela Fetiveau.;Claudio Cavallini.;Diego Sappè.;Alessandro Salvioni.;Roberto Canziani.;Stefano Savonitto.;Pier Mannuccio Mannucci.;Diego Ardissino.
来源: Circulation. 2002年105卷8期928-32页
Abciximab is very effective in reducing major cardiac events in patients undergoing interventional procedures. Its antithrombotic effect is primarily attributable to the blocking of platelet glycoprotein IIb/IIIa receptors, but recent evidence suggests that it may have a direct antithrombin effect. No data are available concerning the effect of abciximab on the in vivo markers of prothrombin activation and thrombin generation in patients with acute coronary syndromes without ST elevation.
3554. Coronary magnetic resonance angiography in adolescents and young adults with kawasaki disease.
作者: Gerald F Greil.;Matthias Stuber.;René M Botnar.;Kraig V Kissinger.;Tal Geva.;Jane W Newburger.;Warren J Manning.;Andrew J Powell.
来源: Circulation. 2002年105卷8期908-11页
In patients with Kawasaki disease, serial evaluation of the distribution and size of coronary artery aneurysms (CAA) is necessary for risk stratification and therapeutic management. Although transthoracic echocardiography is often sufficient for this purpose initially, visualization of the coronary arteries becomes progressively more difficult as children grow. We sought to prospectively compare coronary magnetic resonance angiography (MRA) and x-ray coronary angiography findings in patients with CAA caused by Kawasaki disease.
3555. Effects of selective autonomic blockade on T-wave alternans in humans.
作者: Eric J Rashba.;Michael Cooklin.;Karen MacMurdy.;Neal Kavesh.;Malcolm Kirk.;Samantha Sarang.;Robert W Peters.;Stephen R Shorofsky.;Michael R Gold.
来源: Circulation. 2002年105卷7期837-42页
T-wave alternans (TWA) is an important noninvasive measure of ventricular arrhythmia vulnerability. This study tested the hypothesis that the autonomic nervous system influences TWA measurement in high-risk subjects with coronary artery disease.
3556. Relationship between treatment-induced changes in left ventricular mass and blood pressure in black african hypertensive patients: results of the Baragwanath Trial.
作者: Daniel Skudicky.;Pinhas Sareli.;Elena Libhaber.;Geoffrey Candy.;Ivo Radevski.;Zdravska Valtchanova.;Elizabeth Tshele.;Lutgarde Thijs.;Ji-Guang Wang.;Jan A Staessen.
来源: Circulation. 2002年105卷7期830-6页
In a single-center study, we compared to what extent changes in conventional and ambulatory blood pressure (BP) predicted regression of left ventricular mass (LVM) index in response to antihypertensive treatment in previously untreated and treated patients with sustained hypertension.
3557. Value of stress myocardial perfusion single photon emission computed tomography in patients with normal resting electrocardiograms: an evaluation of incremental prognostic value and cost-effectiveness.
作者: Rory Hachamovitch.;Daniel S Berman.;Hosen Kiat.;Ishac Cohen.;John D Friedman.;Leslee J Shaw.
来源: Circulation. 2002年105卷7期823-9页
The incremental value and cost-effectiveness of stress single photon emission computed tomography (SPECT) is of unclear added value over clinical and exercise treadmill testing data in patients with normal resting ECGs, a patient subset known to be at relatively lower risk.
3558. Fibrillin-1 genotype is associated with aortic stiffness and disease severity in patients with coronary artery disease.
作者: Tanya L Medley.;Timothy J Cole.;Christoph D Gatzka.;William Y S Wang.;Anthony M Dart.;Bronwyn A Kingwell.
来源: Circulation. 2002年105卷7期810-5页
Elevated pulse pressure is associated strongly with adverse cardiovascular outcome; however, the genetic basis of this condition is unknown. This study examined whether genotypic variation in the extracellular matrix protein fibrillin-1, the Marfan gene, was associated with aortic stiffening and therefore could contribute to cardiovascular risk associated with pulse pressure elevation in coronary disease.
3559. Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year.
作者: Patrizia Ziccardi.;Francesco Nappo.;Giovanni Giugliano.;Katherine Esposito.;Raffaele Marfella.;Michele Cioffi.;Francesco D'Andrea.;Anna Maria Molinari.;Dario Giugliano.
来源: Circulation. 2002年105卷7期804-9页
Visceral fat is a key regulator site for the process of inflammation, and atherosclerotic lesions are essentially an inflammatory response.
3560. Risk of myocardial infarction and angina in patients with severe peripheral vascular disease: predictive role of C-reactive protein.
作者: Elisabetta Rossi.;Luigi M Biasucci.;Franco Citterio.;Simona Pelliccioni.;Claudia Monaco.;Francesca Ginnetti.;Dominick J Angiolillo.;Gianni Grieco.;Giovanna Liuzzo.;Attilio Maseri.
来源: Circulation. 2002年105卷7期800-3页
Patients undergoing revascularization procedures for peripheral vascular disease (PVD) have a greatly increased risk for coronary artery disease (CAD) that is predicted only partly by clinical data and cardiovascular risk factors. We investigated whether the prognostic assessment in PVD patients could be improved by preoperative measurements of C-reactive protein (CRP).
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