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3541. Effects of multisite biventricular pacing in patients with heart failure and intraventricular conduction delay.
作者: S Cazeau.;C Leclercq.;T Lavergne.;S Walker.;C Varma.;C Linde.;S Garrigue.;L Kappenberger.;G A Haywood.;M Santini.;C Bailleul.;J C Daubert.; .
来源: N Engl J Med. 2001年344卷12期873-80页
One third of patients with chronic heart failure have electrocardiographic evidence of a major intraventricular conduction delay, which may worsen left ventricular systolic dysfunction through asynchronous ventricular contraction. Uncontrolled studies suggest that multisite biventricular pacing improves hemodynamics and well-being by reducing ventricular asynchrony. We assessed the clinical efficacy and safety of this new therapy.
3542. ABO-incompatible heart transplantation in infants.
作者: L J West.;S M Pollock-Barziv.;A I Dipchand.;K J Lee.;C J Cardella.;L N Benson.;I M Rebeyka.;J G Coles.
来源: N Engl J Med. 2001年344卷11期793-800页
Transplantation of hearts from ABO-incompatible donors is contraindicated because of the risk of hyperacute rejection mediated by preformed antibodies in the recipient to blood-group antigens of the donor. This contraindication may not apply to newborn infants, who do not yet produce antibodies to T-cell-independent antigens, including the major blood-group antigens.
3543. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.
作者: D J Slamon.;B Leyland-Jones.;S Shak.;H Fuchs.;V Paton.;A Bajamonde.;T Fleming.;W Eiermann.;J Wolter.;M Pegram.;J Baselga.;L Norton.
来源: N Engl J Med. 2001年344卷11期783-92页
The HER2 gene, which encodes the growth factor receptor HER2, is amplified and HER2 is overexpressed in 25 to 30 percent of breast cancers, increasing the aggressiveness of the tumor.
3544. Transplantation of embryonic dopamine neurons for severe Parkinson's disease.
作者: C R Freed.;P E Greene.;R E Breeze.;W Y Tsai.;W DuMouchel.;R Kao.;S Dillon.;H Winfield.;S Culver.;J Q Trojanowski.;D Eidelberg.;S Fahn.
来源: N Engl J Med. 2001年344卷10期710-9页
Transplantation of human embryonic dopamine neurons into the brains of patients with Parkinson's disease has proved beneficial in open clinical trials. However, whether this intervention would be more effective than sham surgery in a controlled trial is not known.
3545. Efficacy and safety of recombinant human activated protein C for severe sepsis.
作者: G R Bernard.;J L Vincent.;P F Laterre.;S P LaRosa.;J F Dhainaut.;A Lopez-Rodriguez.;J S Steingrub.;G E Garber.;J D Helterbrand.;E W Ely.;C J Fisher.; .
来源: N Engl J Med. 2001年344卷10期699-709页
Drotrecogin alfa (activated), or recombinant human activated protein C, has antithrombotic, antiinflammatory, and profibrinolytic properties. In a previous study, drotrecogin alfa activated produced dose-dependent reductions in the levels of markers of coagulation and inflammation in patients with severe sepsis. In this phase 3 trial, we assessed whether treatment with drotrecogin alfa activated reduced the rate of death from any cause among patients with severe sepsis.
3546. Effects of a low-molecular-weight heparin on thrombus regression and recurrent thromboembolism in patients with deep-vein thrombosis.
Low-molecular-weight heparins are frequently used to treat venous thromboembolism, but optimal dosing regimens and clinical outcomes need further definition.
3547. A synthetic pentasaccharide for the prevention of deep-vein thrombosis after total hip replacement.
Venous thromboembolism is a frequent complication of total hip replacement. The pentasaccharide Org31540/SR90107A, a highly selective, indirect inhibitor of activated factor X, is the first of a new class of synthetic antithrombotic agents. To determine the optimal dose for phase 3 studies, we conducted a dose-ranging study in which Org31540/SR90107A was compared with a low-molecular-weight heparin, enoxaparin, in patients undergoing total hip replacement.
3548. Lack of effect of induction of hypothermia after acute brain injury.
作者: G L Clifton.;E R Miller.;S C Choi.;H S Levin.;S McCauley.;K R Smith.;J P Muizelaar.;F C Wagner.;D W Marion.;T G Luerssen.;R M Chesnut.;M Schwartz.
来源: N Engl J Med. 2001年344卷8期556-63页
Induction of hypothermia in patients with brain injury was shown to improve outcomes in small clinical studies, but the results were not definitive. To study this issue, we conducted a multicenter trial comparing the effects of hypothermia with those of normothermia in patients with acute brain injury.
3550. Botulinum toxin A for axillary hyperhidrosis (excessive sweating).
Treatment of primary focal hyperhidrosis is often unsatisfactory. Botulinum toxin A can stop excessive sweating by blocking the release of acetylcholine, which mediates sympathetic neurotransmission in the sweat glands.
3551. Noninvasive ventilation in immunosuppressed patients with pulmonary infiltrates, fever, and acute respiratory failure.
作者: G Hilbert.;D Gruson.;F Vargas.;R Valentino.;G Gbikpi-Benissan.;M Dupon.;J Reiffers.;J P Cardinaud.
来源: N Engl J Med. 2001年344卷7期481-7页
Avoiding intubation is a major goal in the management of respiratory failure, particularly in immunosuppressed patients. Nevertheless, there are only limited data on the efficacy of noninvasive ventilation in these high-risk patients.
3552. Virologic and immunologic consequences of discontinuing combination antiretroviral-drug therapy in HIV-infected patients with detectable viremia.
作者: S G Deeks.;T Wrin.;T Liegler.;R Hoh.;M Hayden.;J D Barbour.;N S Hellmann.;C J Petropoulos.;J M McCune.;M K Hellerstein.;R M Grant.
来源: N Engl J Med. 2001年344卷7期472-80页
In many patients with human immunodeficiency virus (HIV) infection, therapy with potent antiretroviral drugs does not result in complete suppression of HIV replication. The effect of cessation of therapy in these patients is unknown.
3553. Fomepizole for the treatment of methanol poisoning.
Methanol poisoning may result in metabolic acidosis, blindness, and death. The inhibition of alcohol dehydrogenase is fundamental to the treatment of methanol poisoning. We performed a multicenter study to evaluate fomepizole, an inhibitor of alcohol dehydrogenase, in the treatment of patients with methanol poisoning.
3554. Efficacy of a pneumococcal conjugate vaccine against acute otitis media.
作者: J Eskola.;T Kilpi.;A Palmu.;J Jokinen.;J Haapakoski.;E Herva.;A Takala.;H Käyhty.;P Karma.;R Kohberger.;G Siber.;P H Mäkelä.; .
来源: N Engl J Med. 2001年344卷6期403-9页
Ear infections are a common cause of illness during the first two years of life. New conjugate vaccines may be able to prevent a substantial portion of cases of acute otitis media caused by Streptococcus pneumoniae.
3555. Effect of risedronate on the risk of hip fracture in elderly women. Hip Intervention Program Study Group.
作者: M R McClung.;P Geusens.;P D Miller.;H Zippel.;W G Bensen.;C Roux.;S Adami.;I Fogelman.;T Diamond.;R Eastell.;P J Meunier.;J Y Reginster.; .
来源: N Engl J Med. 2001年344卷5期333-40页
Risedronate increases bone mineral density in elderly women, but whether it prevents hip fracture is not known.
3556. Localized intracoronary gamma-radiation therapy to inhibit the recurrence of restenosis after stenting.
作者: M B Leon.;P S Teirstein.;J W Moses.;P Tripuraneni.;A J Lansky.;S Jani.;S C Wong.;D Fish.;S Ellis.;D R Holmes.;D Kerieakes.;R E Kuntz.
来源: N Engl J Med. 2001年344卷4期250-6页
Although the frequency of restenosis after coronary angioplasty is reduced by stenting, when restenosis develops within a stent, the risk of subsequent restenosis is greater than 50 percent. We report on a multicenter, double-blind, randomized trial of intracoronary radiation therapy for the treatment of in-stent restenosis.
3557. Endoluminal beta-radiation therapy for the prevention of coronary restenosis after balloon angioplasty. The Dose-Finding Study Group.
作者: V Verin.;Y Popowski.;B de Bruyne.;D Baumgart.;W Sauerwein.;M Lins.;G Kovacs.;M Thomas.;F Calman.;C Disco.;P W Serruys.;W Wijns.; .
来源: N Engl J Med. 2001年344卷4期243-9页
Beta radiation is effective in reducing vascular neointimal proliferation in animals after injury caused by balloon angioplasty. However, the lowest dose that can prevent restenosis after coronary angioplasty has yet to be determined.
3558. Enzyme-replacement therapy in mucopolysaccharidosis I.
作者: E D Kakkis.;J Muenzer.;G E Tiller.;L Waber.;J Belmont.;M Passage.;B Izykowski.;J Phillips.;R Doroshow.;I Walot.;R Hoft.;E F Neufeld.
来源: N Engl J Med. 2001年344卷3期182-8页
Mucopolysaccharidosis I is a lysosomal storage disease caused by a deficiency of the enzyme alpha-L-iduronidase. We evaluated the effect of enzyme-replacement therapy with recombinant human alpha-L-iduronidase in patients with this disorder.
3559. Transplantation of bone marrow as compared with peripheral-blood cells from HLA-identical relatives in patients with hematologic cancers.
作者: W I Bensinger.;P J Martin.;B Storer.;R Clift.;S J Forman.;R Negrin.;A Kashyap.;M E Flowers.;K Lilleby.;T R Chauncey.;R Storb.;F R Appelbaum.
来源: N Engl J Med. 2001年344卷3期175-81页
In recipients of allogeneic hematopoietic-cell transplants, peripheral-blood cells mobilized with the use of filgrastim (recombinant granulocyte colony-stimulating factor) engraft more rapidly than bone marrow. However, the relative effects of these techniques on the rates of acute and chronic graft-versus-host disease, overall survival, and disease-free survival have not been determined in randomized studies.
3560. A randomized trial of the discontinuation of primary and secondary prophylaxis against Pneumocystis carinii pneumonia after highly active antiretroviral therapy in patients with HIV infection. Grupo de Estudio del SIDA 04/98.
作者: J C Lopez Bernaldo de Quiros.;J M Miro.;J M Peña.;D Podzamczer.;J C Alberdi.;E Martínez.;J Cosin.;X Claramonte.;J Gonzalez.;P Domingo.;J L Casado.;E Ribera.; .
来源: N Engl J Med. 2001年344卷3期159-67页
Prophylaxis against Pneumocystis carinii pneumonia is indicated in patients with human immunodeficiency virus (HIV) infection who have less than 200 CD4 cells per cubic millimeter and in those with a history of P. carinii pneumonia. However, it is not clear whether prophylaxis can be safely discontinued after CD4 cell counts increase in response to highly active antiretroviral therapy.
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