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3521. New Bayesian discriminator for detection of atrial tachyarrhythmias.
作者: Weichao Xu.;Hung-Fat Tse.;Francis H Y Chan.;Peter Chin Wan Fung.;Kathy Lai-Fun Lee.;Chu-Pak Lau.
来源: Circulation. 2002年105卷12期1472-9页
Accurate, rapid detection of atrial tachyarrhythmias has important implications in the use of implantable devices for treatment of cardiac arrhythmia. Currently available detection algorithms for atrial tachyarrhythmias, which use the single-index method, have limited sensitivity and specificity.
3522. Baroreflex buffering and susceptibility to vasoactive drugs.
作者: Jens Jordan.;Jens Tank.;John R Shannon.;Andre Diedrich.;Axel Lipp.;Christoph Schröder.;Guy Arnold.;Arya M Sharma.;Italo Biaggioni.;David Robertson.;Friedrich C Luft.
来源: Circulation. 2002年105卷12期1459-64页
The overall effect of vasoactive drugs on blood pressure is determined by a combination of the direct effect on vascular tone and an indirect baroreflex-mediated effect, a baroreflex buffering of blood pressure. Differences in baroreflex function affect the responsiveness to vasoactive medications, particularly baroreflex buffering of blood pressure; however, the magnitude is not known.
3523. Primary prevention of sudden cardiac death in idiopathic dilated cardiomyopathy: the Cardiomyopathy Trial (CAT).
作者: Dietmar Bänsch.;Matthias Antz.;Sigrid Boczor.;Marius Volkmer.;Jürgen Tebbenjohanns.;Karlheinz Seidl.;Michael Block.;Frank Gietzen.;Jürgen Berger.;Karl Heinz Kuck.
来源: Circulation. 2002年105卷12期1453-8页
Patients with idiopathic dilated cardiomyopathy (DCM) and impaired left ventricular ejection fraction have an increased risk of dying suddenly.
3524. Effect of medroxyprogesterone acetate on vascular inflammatory markers in postmenopausal women receiving estrogen.
作者: Akihiko Wakatsuki.;Yuji Okatani.;Nobuo Ikenoue.;Takao Fukaya.
来源: Circulation. 2002年105卷12期1436-9页
Estrogen increases C-reactive protein (CRP) in postmenopausal women. Estrogen also decreases cell adhesion molecules, whereas elevated CRP stimulates the expression of cell adhesion molecules. Because androgens have antiinflammatory effects, androgenic progestins such as medroxyprogesterone acetate (MPA) may inhibit proinflammatory effects of estrogen. We investigated the effects of MPA on estrogen-induced changes in acute inflammatory proteins and cell adhesion molecules in postmenopausal women.
3525. Coronary heart disease in patients with low LDL-cholesterol: benefit of pravastatin in diabetics and enhanced role for HDL-cholesterol and triglycerides as risk factors.
作者: Frank M Sacks.;Andrew M Tonkin.;Timothy Craven.;Marc A Pfeffer.;James Shepherd.;Anthony Keech.;Curt D Furberg.;Eugene Braunwald.
来源: Circulation. 2002年105卷12期1424-8页
In two large secondary prevention trials of pravastatin, risk reduction was not significant in participants who had low baseline LDL-C concentrations (that is, <125 mg/dL). We conducted exploratory analyses of participant characteristics, lipid risk factors, and risk reduction in this group.
3526. High-dose intravascular beta-radiation after de novo stent implantation induces coronary artery spasm.
作者: D Scheinert.;V Strnad.;R Müller.;R Burckhard.;S Ropers.;R Sauer.;W G Daniel.;R Bonan.;J Ludwig.
来源: Circulation. 2002年105卷12期1420-3页
Intracoronary brachytherapy is effective in preventing restenosis after coronary interventions. However, in vitro and animal studies have shown that irradiation produces immediate and sustained endothelial dysfunction. This study assesses the clinical relevance of impaired vasomotoric function induced by brachytherapy.
3527. Acute pulmonary embolectomy: a contemporary approach.
作者: Lishan Aklog.;Christopher S Williams.;John G Byrne.;Samuel Z Goldhaber.
来源: Circulation. 2002年105卷12期1416-9页
Acute pulmonary embolism confers a high mortality rate despite advances in diagnosis and therapy. Thrombolysis is often effective but has a high frequency of major bleeding complications, especially intracranial hemorrhage. Therefore, we liberalized our criteria for acute pulmonary embolectomy and considered operating on patients with anatomically extensive pulmonary embolism and concomitant moderate to severe right ventricular dysfunction despite preserved systemic arterial pressure.
3528. Strain rate imaging for assessment of regional myocardial function: results from a clinical model of septal ablation.
作者: Theodore P Abraham.;Rick A Nishimura.;David R Holmes.;Marek Belohlavek.;James B Seward.
来源: Circulation. 2002年105卷12期1403-6页
Regional myocardial function assessment is essential in the management of coronary artery disease (CAD). Tissue Doppler imaging (TDI) by depicting local myocardial motion can potentially quantify regional myocardial function. Strain rate imaging (SRI) that depicts regional deformation is less susceptible to cardiac translation and tethering and may be superior to TDI for regional function analysis. We examined regional myocardial function using TDI and SRI in a unique clinical model of a small, discrete myocardial infarction.
3529. High-density lipoprotein restores endothelial function in hypercholesterolemic men.
作者: Lukas E Spieker.;Isabella Sudano.;David Hürlimann.;Peter G Lerch.;Markus G Lang.;Christian Binggeli.;Roberto Corti.;Frank Ruschitzka.;Thomas F Lüscher.;Georg Noll.
来源: Circulation. 2002年105卷12期1399-402页
Hypercholesterolemia is a risk factor for atherosclerosis-causing endothelial dysfunction, an early event in the disease process. In contrast, high-density lipoprotein (HDL) cholesterol inversely correlates with morbidity and mortality representing a protective effect. Therefore, we investigated the effects of reconstituted HDL on endothelial function in hypercholesterolemic men.
3530. BG9719 (CVT-124), an A1 adenosine receptor antagonist, protects against the decline in renal function observed with diuretic therapy.
作者: Stephen S Gottlieb.;D Craig Brater.;Ignatius Thomas.;Edward Havranek.;Robert Bourge.;Steven Goldman.;Farere Dyer.;Miguel Gomez.;Donald Bennett.;Barry Ticho.;Evan Beckman.;William T Abraham.
来源: Circulation. 2002年105卷11期1348-53页
Adenosine may adversely affect renal function via its effects on renal arterioles and tubuloglomerular feedback, but effects of adenosine blockade in humans receiving furosemide and ACE inhibitors is unknown.
3531. Barium reduces resting blood flow and inhibits potassium-induced vasodilation in the human forearm.
作者: Matthew Dawes.;Christine Sieniawska.;Trevor Delves.;Rahul Dwivedi.;Philip J Chowienczyk.;James M Ritter.
来源: Circulation. 2002年105卷11期1323-8页
Increasing extracellular K+ concentration within and just above the physiological range hyperpolarizes and relaxes vascular smooth muscle in vitro. These actions involve inwardly rectifying potassium channels (K(IR)) and Na+/K+ ATPase, which are inhibited, respectively, by Ba2+ and ouabain. The role (if any) of K(IR) in controlling human resistance vessel tone is unknown, and we investigated this in the forearm.
3532. Left ventricular volume reduction by radiofrequency heating of chronic myocardial infarction in patients with congestive heart failure.
作者: Octavio A Victal.;John R Teerlink.;Efrain Gaxiola.;Arthur W Wallace.;Sergio Najar.;David H Camacho.;Augustin Gutierrez.;Gabriel Herrera.;Gustavo Zuniga.;Fausto Mercado-Rios.;Mark B Ratcliffe.
来源: Circulation. 2002年105卷11期1317-22页
Myocardial infarct expansion and left ventricular (LV) remodeling are integral components in the evolution of chronic heart failure and predict morbidity and mortality. Radiofrequency (RF) heating and patch placement of chronic LV aneurysms caused a sustained reduction in LV infarct area and volume in an ovine infarct model. This study evaluated the effect of RF heating and epicardial patch as an adjunct to coronary artery bypass graft on LV volumes in patients with prior myocardial infarction, evidence of akinetic/dyskinetic scar, and LV ejection fraction < or =40%.
3533. Effects of long-term biventricular stimulation for resynchronization on echocardiographic measures of remodeling.
作者: Leslie A Saxon.;Teresa De Marco.;Jill Schafer.;Kanu Chatterjee.;Uday N Kumar.;Elyse Foster.; .
来源: Circulation. 2002年105卷11期1304-10页
Long-term ventricular resynchronization therapy improves symptom status. Changes in left ventricular remodeling have not been adequately evaluated.
3534. Effect of azithromycin treatment on endothelial function in patients with coronary artery disease and evidence of Chlamydia pneumoniae infection.
作者: Nikhil Parchure.;Emmanouil G Zouridakis.;Juan Carlos Kaski.
来源: Circulation. 2002年105卷11期1298-303页
It has been suggested that infection with Chlamydia pneumoniae(CPn) can trigger inflammatory mechanisms that may in turn impair vascular endothelial function. The aim of the present study was to assess whether treatment with the macrolide antibiotic azithromycin improves endothelial function in patients with coronary artery disease and antibodies positive to CPn.
3535. Angiogenic Gene Therapy (AGENT) trial in patients with stable angina pectoris.
作者: Cindy L Grines.;Matthew W Watkins.;Greg Helmer.;William Penny.;Jeffrey Brinker.;Jonathan D Marmur.;Andrew West.;Jeffery J Rade.;Pran Marrott.;H Kirk Hammond.;Robert L Engler.
来源: Circulation. 2002年105卷11期1291-7页
The angiogenic response to myocardial ischemia can be augmented in animal models by gene transfer with the use of a replication defective adenovirus (Ad) containing a human fibroblast growth factor (FGF) gene.
3536. Randomized trial of a distal embolic protection device during percutaneous intervention of saphenous vein aorto-coronary bypass grafts.
作者: Donald S Baim.;Dennis Wahr.;Barry George.;Martin B Leon.;Joel Greenberg.;Donald E Cutlip.;Unsal Kaya.;Jeffrey J Popma.;Kalon K L Ho.;Richard E Kuntz.; .
来源: Circulation. 2002年105卷11期1285-90页
Stents provide effective treatment for stenotic saphenous venous aorto-coronary bypass grafts, but their placement carries a 20% incidence of procedure-related complications, which potentially are related to the distal embolization of atherosclerotic debris. We report the first multicenter randomized trial to evaluate use of a distal embolic protection device during stenting of such lesions.
3537. Immunopathogenesis of atherosclerosis.3538. Intravenous pulse administration of cyclophosphamide is an effective and safe treatment for sensitized cardiac allograft recipients.
作者: Silviu Itescu.;Elizabeth Burke.;Katherine Lietz.;Ranjit John.;Donna Mancini.;Robert Michler.;Eric Rose.;Mehmet Oz.;Niloo Edwards.
来源: Circulation. 2002年105卷10期1214-9页
The proportion of cardiac transplant recipients with preexisting sensitization to HLA alloantigens has been increasing. Sensitization prolongs duration to obtaining a donor and predicts poorer long-term allograft survival because of increased risk of cellular rejections. We investigated the effect of cyclophosphamide pulse therapy in sensitized cardiac allograft recipients.
3539. Progression of systolic abnormalities in patients with "isolated" diastolic heart failure and diastolic dysfunction.
作者: Cheuk-Man Yu.;Hong Lin.;Hua Yang.;Shun-Ling Kong.;Qing Zhang.;Steven Wai-Luen Lee.
来源: Circulation. 2002年105卷10期1195-201页
The definition of diastolic heart failure (DHF) relies on the use of sensitive tools to exclude the presence of systolic dysfunction. The use of ejection fraction (EF) of 50% as the cutoff point may not be adequate to address such a task. We believe that systolic dysfunction is common in DHF.
3540. Tolerability of beta-blocker initiation and titration in the Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure (MERIT-HF).
作者: Stephen S Gottlieb.;Michael L Fisher.;John Kjekshus.;Prakash Deedwania.;Lars Gullestad.;Jiri Vitovec.;John Wikstrand.; .
来源: Circulation. 2002年105卷10期1182-8页
beta-Blockade improves survival when administered over a long period of time to patients with heart failure. However, the time course of any possible deterioration during the titration phase has not been reported.
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