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3501. Influenza vaccine pilot study in acute coronary syndromes and planned percutaneous coronary interventions: the FLU Vaccination Acute Coronary Syndromes (FLUVACS) Study.
作者: Enrique P Gurfinkel.;Ricardo Leon de la Fuente.;Oscar Mendiz.;Branco Mautner.
来源: Circulation. 2002年105卷18期2143-7页
Recent reports have detected an increase in the number of patients with acute coronary syndromes during the flu season. In addition, the World Health Organization recommended vaccination against influenza infection for the Southern hemisphere in the winter of 2001. We evaluated the preventive impact of vaccination on subsequent ischemic events in myocardial infarction patients and in subjects undergoing planned percutaneous coronary angioplasty.
3502. Cost-effectiveness of the implantable cardioverter-defibrillator versus antiarrhythmic drugs in survivors of serious ventricular tachyarrhythmias: results of the Antiarrhythmics Versus Implantable Defibrillators (AVID) economic analysis substudy.
作者: Greg Larsen.;Alfred Hallstrom.;John McAnulty.;Sergio Pinski.;Anna Olarte.;Sean Sullivan.;Michael Brodsky.;Judy Powell.;Christy Marchant.;Cheryl Jennings.;Toshio Akiyama.; .
来源: Circulation. 2002年105卷17期2049-57页
The implantable cardioverter-defibrillator (ICD) is an effective but expensive device. We used prospectively collected data from a large randomized clinical trial of secondary prevention of life-threatening ventricular arrhythmias to determine the cost-effectiveness of the ICD compared with antiarrhythmic drug (AAD) therapy, largely with amiodarone.
3503. Efficacy and temporal stability of reduced safety margins for ventricular defibrillation: primary results from the Low Energy Safety Study (LESS).
作者: Michael R Gold.;Steven Higgins.;Richard Klein.;F Roosevelt Gilliam.;Harry Kopelman.;Scott Hessen.;John Payne.;S Adam Strickberger.;David Breiter.;Stephen Hahn.
来源: Circulation. 2002年105卷17期2043-8页
Traditionally, a safety margin of at least 10 J between the maximum output of the pulse generator and the energy needed for ventricular defibrillation has been used because lower safety margins were associated with unacceptably high rates of failed defibrillation and sudden cardiac death. The Low Energy Safety Study (LESS) was a prospective, randomized assessment of the safety margin requirements for modern implantable cardioverter-defibrillator (ICD) systems.
3504. Incidence, morphology, angiographic findings, and outcomes of intramural hematomas after percutaneous coronary interventions: an intravascular ultrasound study.
作者: Akiko Maehara.;Gary S Mintz.;Anh B Bui.;Marco T Castagna.;Olga R Walter.;Chrysoula Pappas.;Ellen E Pinnow.;Augusto D Pichard.;Lowell F Satler.;Ron Waksman.;William O Suddath.;John R Laird.;Kenneth M Kent.;Neil J Weissman.
来源: Circulation. 2002年105卷17期2037-42页
Intramural hematomas during percutaneous coronary intervention (PCI) have not been well studied.
3505. Phase 1/2 placebo-controlled, double-blind, dose-escalating trial of myocardial vascular endothelial growth factor 2 gene transfer by catheter delivery in patients with chronic myocardial ischemia.
作者: Douglas W Losordo.;Peter R Vale.;Robert C Hendel.;Charles E Milliken.;F David Fortuin.;Nancie Cummings.;Richard A Schatz.;Takayuki Asahara.;Jeffrey M Isner.;Richard E Kuntz.
来源: Circulation. 2002年105卷17期2012-8页
This phase 1/2 study investigated the safety of percutaneous catheter-based gene transfer of naked plasmid DNA encoding for vascular endothelial growth factor 2 (phVEGF2) to left ventricular (LV) myocardium in a prospective, randomized, double-blind, placebo-controlled, dose-escalating study of inoperable patients with class III or IV angina.
3506. Does oral folic acid lower total homocysteine levels and improve endothelial function in children with chronic renal failure?
作者: K Bennett-Richards.;M Kattenhorn.;A Donald.;G Oakley.;Z Varghese.;L Rees.;J E Deanfield.
来源: Circulation. 2002年105卷15期1810-5页
Accelerated vascular disease is common in chronic renal failure (CRF) and accounts for significant mortality and morbidity. Elevated homocysteine levels may contribute by an effect on endothelial function.
3507. Effects of sustained-release moxonidine, an imidazoline agonist, on plasma norepinephrine in patients with chronic heart failure.
作者: Karl Swedberg.;Michael R Bristow.;Jay N Cohn.;Henry Dargie.;Matthias Straub.;Curtis Wiltse.;Theressa J Wright.; .
来源: Circulation. 2002年105卷15期1797-803页
In chronic heart failure, sympathetic activation is increased. Moxonidine acts on central nervous system receptors to decrease sympathetic activation. We investigated the dose-response relationship of a new sustained-release (SR) preparation of moxonidine and the plasma concentration of norepinephrine in patients with chronic heart failure.
3508. Continuous probabilistic prediction of angiographically significant coronary artery disease using electron beam tomography.
作者: Matthew J Budoff.;George A Diamond.;Paolo Raggi.;Yadon Arad.;Alan D Guerci.;Tracy Q Callister.;Daniel Berman.
来源: Circulation. 2002年105卷15期1791-6页
We sought to incorporate electron beam tomography-derived calcium scores in a model for prediction of angiographically significant coronary artery disease (CAD). Such a model could greatly facilitate clinical triage in symptomatic patients with no known CAD.
3509. Plasma homocysteine concentration, statin therapy, and the risk of first acute coronary events.
作者: Paul M Ridker.;Jessie Shih.;Thomas J Cook.;Michael Clearfield.;John R Downs.;Aruna D Pradhan.;Stephan E Weis.;Antonio M Gotto.; .
来源: Circulation. 2002年105卷15期1776-9页
Elevated homocysteine levels are associated with increased coronary risk, and it has been suggested that homocysteine screening may provide a method to identify high-risk patients for aggressive primary prevention.
3510. Paradoxical pressor effects of beta-blockers in standing elderly patients with mild hypertension: a beneficial side effect.
作者: T J Cleophas.;I Grabowsky.;M G Niemeyer.;W M Mäkel.;E E van der Wall.; .
来源: Circulation. 2002年105卷14期1669-71页
Baroreflex sensitivity declines with age, creating a fall in systolic blood pressure and pulse pressure when standing. If, in addition, blood pressure is reduced as a result of antihypertensive medication, compensatory mechanisms may be inadequate and orthostatic problems may occur. This may be less true in patients on beta-blockers. beta-blockers cause pressor effects in standing patients with autonomic neuropathy, but their effects on standing pulse pressures in elderly subjects with mild hypertension have not been systematically studied.
3511. Enoxaparin as adjunctive antithrombin therapy for ST-elevation myocardial infarction: results of the ENTIRE-Thrombolysis in Myocardial Infarction (TIMI) 23 Trial.
作者: Elliott M Antman.;Hans W Louwerenburg.;Hubert F Baars.;Jan C L Wesdorp.;Bas Hamer.;Jean-Pierre Bassand.;Frederique Bigonzi.;Ghislaine Pisapia.;C Michael Gibson.;Hein Heidbuchel.;Eugene Braunwald.;Frans Van de Werf.
来源: Circulation. 2002年105卷14期1642-9页
ENTIRE-TIMI 23 evaluated enoxaparin with full-dose tenecteplase (TNK) and half-dose TNK plus abciximab.
3512. Metoprolol CR/XL in female patients with heart failure: analysis of the experience in Metoprolol Extended-Release Randomized Intervention Trial in Heart Failure (MERIT-HF).
作者: Jalal K Ghali.;Ileana L Piña.;Stephen S Gottlieb.;Prakash C Deedwania.;John C Wikstrand.; .
来源: Circulation. 2002年105卷13期1585-91页
Underrepresentation of women in heart failure clinical trials has limited conclusions regarding the effect of various management strategies on survival in women with heart failure and decreased left ventricular ejection fraction (LVEF).
3513. Fragment reconstruction of coronary arteries by transesophageal echocardiography: a method for visualizing coronary arteries with ultrasound.
If transesophageal echocardiography (TEE) is to play a role in coronary diagnostics, satisfactory image documentation of the coronary status is indispensable so that the requirements for validity and quality assurance of a medical examination can be met. Our goal was to develop a suitable and valid procedure for imaging coronary arteries with 2D TEE.
3514. Coronary flow velocity reserve after percutaneous interventions is predictive of periprocedural outcome.
作者: M Albertal.;M Voskuil.;J J Piek.;B de Bruyne.;G Van Langenhove.;P I Kay.;M A Costa.;E Boersma.;T Beijsterveldt.;J E Sousa.;J A Belardi.;P W Serruys.; .
来源: Circulation. 2002年105卷13期1573-8页
Because heterogeneous results have been reported, we assessed coronary flow velocity changes in individuals who underwent percutaneous transluminal coronary angioplasty (PTCA) and examined their impact on clinical outcome.
3515. Risk stratification for postoperative cardiovascular events via noninvasive assessment of endothelial function: a prospective study.
作者: Noyan Gokce.;John F Keaney.;Liza M Hunter.;Michael T Watkins.;James O Menzoian.;Joseph A Vita.
来源: Circulation. 2002年105卷13期1567-72页
Brachial artery endothelial function is impaired in individuals with atherosclerosis and coronary risk factors and improves with risk reduction therapy. However, the predictive value of brachial artery endothelial dysfunction for future cardiovascular events is unknown.
3516. Effect of 3 months of antimicrobial treatment with clarithromycin in acute non-q-wave coronary syndrome.
作者: Juha Sinisalo.;Kimmo Mattila.;Ville Valtonen.;Olli Anttonen.;Jukka Juvonen.;John Melin.;Helena Vuorinen-Markkola.;Markku S Nieminen.; .
来源: Circulation. 2002年105卷13期1555-60页
Coronary artery disease, an inflammatory disease, may be caused by infection. We investigated whether the antibiotic clarithromycin would reduce morbidity and mortality in patients with acute non-Q-wave coronary syndrome.
3517. Suppression of coronary artery spasm by the Rho-kinase inhibitor fasudil in patients with vasospastic angina.
作者: Akihiro Masumoto.;Masahiro Mohri.;Hiroaki Shimokawa.;Lemmy Urakami.;Makoto Usui.;Akira Takeshita.
来源: Circulation. 2002年105卷13期1545-7页
Increased activity of Rho-kinase causes hypercontraction of vascular smooth muscle and has been implicated as playing a pathogenetic role in divergent cardiovascular diseases such as coronary artery spasm. We examined whether an intracoronary infusion of fasudil, a selective Rho-kinase inhibitor, would attenuate coronary vasoconstrictor responses to acetylcholine (ACh) in patients with vasospastic angina.
3518. Inhalation of fine particulate air pollution and ozone causes acute arterial vasoconstriction in healthy adults.
作者: Robert D Brook.;Jeffrey R Brook.;Bruce Urch.;Renaud Vincent.;Sanjay Rajagopalan.;Frances Silverman.
来源: Circulation. 2002年105卷13期1534-6页
Fine particulate air pollution and ozone are associated with increased cardiovascular events. To help explain the mechanism behind these observations, we investigated the effect of air pollution exposure on vascular function.
3519. Statin attenuates increase in C-reactive protein during estrogen replacement therapy in postmenopausal women.
作者: Kwang Kon Koh.;William H Schenke.;Myron A Waclawiw.;Gyorgy Csako.;Richard O Cannon.
来源: Circulation. 2002年105卷13期1531-3页
HMG-CoA reductase inhibitor (statin) therapy reduces cardiovascular risk, mechanisms of which may include diminished arterial inflammation, as suggested by reduction in levels of C-reactive protein (CRP). Because oral estrogens increase CRP in postmenopausal women, with potential inflammatory and thrombotic consequences that could compromise any benefit to cardiovascular risk, we determined whether the coadministration of a statin might modify the estrogenic effect on CRP.
3520. Switching off embolization from symptomatic carotid plaque using S-nitrosoglutathione.
Current antiplatelet regimens fail to prevent the majority of recurrent strokes. Asymptomatic circulating emboli can be detected by transcranial Doppler ultrasound, are frequent in patients with symptomatic carotid stenosis, and predict recurrent stroke risk. S-nitrosoglutathione (GSNO) is a nitric oxide donor that appears to have relative platelet specificity. We evaluated its effectiveness in reducing embolization in patients with symptomatic carotid stenosis who already were taking aspirin.
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