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3421. Results and long-term predictors of adverse clinical events after elective percutaneous interventions on unprotected left main coronary artery.
作者: Takuro Takagi.;Goran Stankovic.;Leo Finci.;Konstantinos Toutouzas.;Alaide Chieffo.;Vassilis Spanos.;Francesco Liistro.;Carlo Briguori.;Nicola Corvaja.;Remo Albero.;Ginevra Sivieri.;Rossella Paloschi.;Carlo Di Mario.;Antonio Colombo.
来源: Circulation. 2002年106卷6期698-702页
The safety and efficacy of percutaneous coronary intervention of de novo lesions in unprotected left main coronary arteries remains an unresolved issue.
3422. Cost-effectiveness of gamma radiation for treatment of in-stent restenosis: results from the Gamma-1 trial.
作者: David J Cohen.;Roberta S Cosgrove.;Ronna H Berezin.;Paul S Teirstein.;Martin B Leon.;Richard E Kuntz.; .
来源: Circulation. 2002年106卷6期691-7页
Recently, several randomized trials have demonstrated that intracoronary brachytherapy can reduce the rates of both angiographic and clinical restenosis in patients undergoing percutaneous coronary intervention (PCI) for in-stent restenosis. Whether this practice is cost-effective is unknown.
3423. Effect of rosiglitazone treatment on nontraditional markers of cardiovascular disease in patients with type 2 diabetes mellitus.
作者: Steven M Haffner.;Andrew S Greenberg.;Wayde M Weston.;Hongzi Chen.;Ken Williams.;Martin I Freed.
来源: Circulation. 2002年106卷6期679-84页
Markers of systemic inflammation (eg, C-reactive protein [CRP] and interleukin-6 [IL-6]) have been proposed to be "nontraditional" risk factors for cardiovascular disease in patients with type 2 diabetes mellitus. Matrix metalloproteinase-9 (MMP-9) has been implicated in the pathogenesis of atherosclerotic plaque rupture, which raises the possibility of the use of MMP-9 levels as a marker for future myocardial infarction or unstable angina. In vitro and animal studies suggest that thiazolidinediones can reduce the expression of these markers. The purpose of this analysis was to determine whether rosiglitazone alters serum concentrations of CRP, IL-6, MMP-9, and white blood cell count (WBC) and to examine the relationship of these effects with demographic and disease variables.
3424. Microalbuminuria reduction with valsartan in patients with type 2 diabetes mellitus: a blood pressure-independent effect.
Elevated urine albumin excretion (UAER) is a modifiable risk factor for renal and cardiovascular disease in type 2 diabetes. Blockade of the renin-angiotensin system lowers UAER, but whether this effect is independent of blood pressure (BP) reduction remains controversial. The MicroAlbuminuria Reduction With VALsartan (MARVAL) study was designed to evaluate the BP-independent effect of valsartan on UAER in type 2 diabetic patients with microalbuminuria.
3425. Aspirin plus coumarin versus aspirin alone in the prevention of reocclusion after fibrinolysis for acute myocardial infarction: results of the Antithrombotics in the Prevention of Reocclusion In Coronary Thrombolysis (APRICOT)-2 Trial.
作者: Marc A Brouwer.;Paul J P C van den Bergh.;Wim R M Aengevaeren.;Gerrit Veen.;Hans E Luijten.;Don P Hertzberger.;Ad J van Boven.;Ralf P J W Vromans.;Gérard J H Uijen.;Freek W A Verheugt.
来源: Circulation. 2002年106卷6期659-65页
Despite the use of aspirin, reocclusion of the infarct-related artery occurs in approximately 30% of patients within the first year after successful fibrinolysis, with impaired clinical outcome. This study sought to assess the impact of a prolonged anticoagulation regimen as adjunctive to aspirin in the prevention of reocclusion and recurrent ischemic events after fibrinolysis for ST-elevation myocardial infarction.
3426. Role of endogenous adenosine as a modulator of syncope induced during tilt testing.
作者: Alain Y Saadjian.;Samuel Lévy.;Fréderic Franceschi.;Ibrahim Zouher.;Franck Paganelli.;Régis P Guieu.
来源: Circulation. 2002年106卷5期569-74页
Previous reports that used head-up tilt testing and adenosine administration have suggested that adenosine may be an important endogenous mediator that may trigger a vasovagal response in susceptible patients. However, little is known regarding endogenous adenosine plasma levels (APLs) during vasovagal syncope provoked by tilt testing. The aim of this study was to determine whether APLs differ in patients with a positive head-up tilt test compared with those with a negative test and whether APLs are modified during tilt-induced vasovagal syncope.
3427. Successful cardiopulmonary resuscitation after cardiac arrest as a "sepsis-like" syndrome.
作者: Christophe Adrie.;Minou Adib-Conquy.;Ivan Laurent.;Mehran Monchi.;Christophe Vinsonneau.;Catherine Fitting.;François Fraisse.;A Tuan Dinh-Xuan.;Pierre Carli.;Christian Spaulding.;Jean-François Dhainaut.;Jean-Marc Cavaillon.
来源: Circulation. 2002年106卷5期562-8页
We investigated the immunoinflammatory profile of patients successfully resuscitated after cardiac arrest, representing a model of whole-body ischemia/reperfusion syndrome.
3428. Prognostic significance of ultrasound myocardial tissue characterization in patients with cardiac amyloidosis.
Cycle-dependent variation of myocardial integrated backscatter (CV-IB) is an objective measurement that may detect myocardial abnormalities. However, no data exist about the prognostic value of CV-IB in primary cardiac amyloidosis.
3429. Two-year angiographic follow-up of intracoronary Sr90 therapy for restenosis prevention after balloon angioplasty.
作者: David Meerkin.;Michel Joyal.;Jean-Claude Tardif.;Jacques Lespérance.;André Arsenault.;Guylaine Lucier.;Raoul Bonan.
来源: Circulation. 2002年106卷5期539-43页
Postcoronary angioplasty vascular brachytherapy (VBT) has emerged as a successful intervention for restenosis prevention in some clinical scenarios. Longer-term follow-up after VBT in de novo nonstented lesions has not been reported.
3430. Plasma matrix metalloproteinase-9 as a marker of blood stasis in varicose veins.
作者: Marie-Paule Jacob.;Michèle Cazaubon.;Anthony Scemama.;Dominique Prié.;Françoise Blanchet.;Marie-Claude Guillin.;Jean-Baptiste Michel.
来源: Circulation. 2002年106卷5期535-8页
Possible intermediate circulating markers linking blood stasis to vein remodeling were explored in patients with varicose veins in the lower limbs.
3431. Gadolinium-enhanced 3-dimensional magnetic resonance angiography of pulmonary blood supply in patients with complex pulmonary stenosis or atresia: comparison with x-ray angiography.
作者: Tal Geva.;Gerald F Greil.;Audrey C Marshall.;Michael Landzberg.;Andrew J Powell.
来源: Circulation. 2002年106卷4期473-8页
In patients with complex pulmonary stenosis or atresia, a detailed delineation of all sources of pulmonary blood supply is necessary for planning surgical and transcatheter procedures and usually requires diagnostic cardiac catheterization. The goals of this study were to determine whether gadolinium-enhanced 3D magnetic resonance angiography (MRA) can provide a noninvasive alternative to diagnostic catheterization and to compare MRA and x-ray angiography measurements of pulmonary arteries and aortopulmonary collaterals (APCs).
3432. Catechol-o-methyltransferase and blood pressure in humans.
作者: Jens Jordan.;Axel Lipp.;Jens Tank.;Christoph Schröder.;Mandy Stoffels.;Gabriele Franke.;Andre Diedrich.;Guy Arnold.;David S Goldstein.;Arya M Sharma.;Friedrich C Luft.
来源: Circulation. 2002年106卷4期460-5页
Whether catechol-O-methyltransferase (COMT), the enzyme that metabolizes extraneuronal norepinephrine, contributes to blood pressure regulation in humans is unknown.
3433. Role of transcoronary ablation of septal hypertrophy in patients with hypertrophic cardiomyopathy, New York Heart Association functional class III or IV, and outflow obstruction only under provocable conditions.
作者: Frank H Gietzen.;Christian J Leuner.;Ludger Obergassel.;Claudia Strunk-Mueller.;Horst Kuhn.
来源: Circulation. 2002年106卷4期454-9页
Transcoronary ablation of septal hypertrophy (TASH) for hypertrophic cardiomyopathy seems to be an effective alternative to surgical myectomy. It remains a point of debate whether an outflow obstruction at rest is a necessary criterion for interventional therapy.
3434. Hyperemic stenosis resistance index for evaluation of functional coronary lesion severity.
作者: Martijn Meuwissen.;Maria Siebes.;Steven A J Chamuleau.;Berthe L F van Eck-Smit.;Karel T Koch.;Robbert J de Winter.;Jan G P Tijssen.;Jos A E Spaan.;Jan J Piek.
来源: Circulation. 2002年106卷4期441-6页
Both coronary blood flow velocity reserve (CFVR) and myocardial fractional flow reserve (FFR) are used to evaluate the hemodynamic severity of coronary lesions. However, discordant results between CFVR and FFR have been observed in 25% to 30% of intermediate coronary lesions. An index of stenosis resistance based on a combination of intracoronary pressure and flow velocity may improve the assessment of functional coronary lesion severity.
3435. Direct assessment of coronary steal and associated changes of collateral hemodynamics in chronic total coronary occlusions.
Coronary steal can occur in collateral-dependent myocardium during pharmacologically induced vasodilation. This study assessed coronary steal invasively in chronic total coronary occlusions (TCOs).
3436. B-type natriuretic peptide and clinical judgment in emergency diagnosis of heart failure: analysis from Breathing Not Properly (BNP) Multinational Study.
作者: Peter A McCullough.;Richard M Nowak.;James McCord.;Judd E Hollander.;Howard C Herrmann.;Philippe G Steg.;Philippe Duc.;Arne Westheim.;Torbjørn Omland.;Cathrine Wold Knudsen.;Alan B Storrow.;William T Abraham.;Sumant Lamba.;Alan H B Wu.;Alberto Perez.;Paul Clopton.;Padma Krishnaswamy.;Radmila Kazanegra.;Alan S Maisel.
来源: Circulation. 2002年106卷4期416-22页
We sought to determine the degree to which B-type natriuretic peptide (BNP) adds to clinical judgment in the diagnosis of congestive heart failure (CHF).
3437. Acute effect of nonsurgical septal reduction therapy on regional left ventricular asynchrony in patients with hypertrophic obstructive cardiomyopathy.
作者: Tae-Ho Park.;Nasser M Lakkis.;Katherine J Middleton.;Jennifer Franklin.;William A Zoghbi.;Miguel A Quiñones.;William H Spencer.;Sherif F Nagueh.
来源: Circulation. 2002年106卷4期412-5页
Patients with hypertrophic obstructive cardiomyopathy have left ventricular (LV) diastolic dysfunction due, in part, to temporal heterogeneity in regional function. The acute effect of the relief of LV outflow tract obstruction is unknown. Therefore, we investigated the effects of nonsurgical septal reduction therapy (NSRT) on regional function.
3438. Association between enhanced soluble CD40L and prothrombotic state in hypercholesterolemia: effects of statin therapy.
作者: Francesco Cipollone.;Andrea Mezzetti.;Ettore Porreca.;Concetta Di Febbo.;Michele Nutini.;Maria Fazia.;Angela Falco.;Franco Cuccurullo.;Giovanni Davì.
来源: Circulation. 2002年106卷4期399-402页
Hypercholesterolemia is associated with inflammation and the prothrombotic state. CD40-CD40 ligand (CD40L) interactions promote a prothrombotic response in nucleated cells. The aim of this study was to characterize the in vivo expression of soluble CD40L (sCD40L) in hypercholesterolemia, to correlate it with the extent of the prothrombotic state, and to investigate whether it may be modified by statins.
3439. Use of irbesartan to maintain sinus rhythm in patients with long-lasting persistent atrial fibrillation: a prospective and randomized study.
作者: Antonio H Madrid.;Manuel G Bueno.;Jose M G Rebollo.;Irene Marín.;Gonzalo Peña.;Enrique Bernal.;Aníbal Rodriguez.;Lucas Cano.;José M Cano.;Pedro Cabeza.;Concepción Moro.
来源: Circulation. 2002年106卷3期331-6页
Data from studies of angiotensin-converting enzyme inhibitors provide evidence that the renin-angiotensin-aldosterone system plays a role as a mediator of atrial remodeling in atrial fibrillation. The present study has evaluated the effect of treatment with the angiotensin I type 1 receptor blocker irbesartan on maintaining sinus rhythm after conversion from persistent atrial fibrillation.
3440. Integrated analysis of myocardial blush and ST-segment elevation recovery after successful primary angioplasty: Real-time grading of microvascular reperfusion and prediction of early and late recovery of left ventricular function.
作者: Arnaldo Poli.;Raffaela Fetiveau.;Pietro Vandoni.;Gianfranco del Rosso.;Maurizio D'Urbano.;Giovanni Seveso.;Francesco Cafiero.;Stefano De Servi.
来源: Circulation. 2002年106卷3期313-8页
ST-segment elevation (SigmaSTe) recovery and the angiographic myocardial blush (MB) grade are useful markers of microvascular reperfusion after recanalization of the infarct-related artery. We investigated the ability of a combined analysis of MB grade and SigmaSTe changes to identify different patterns of myocardial reperfusion shortly after primary percutaneous coronary angioplasty (PTCA) and to predict 7-day and 6-month left ventricular (LV) functional recovery.
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