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3401. Warfarin, aspirin, or both after myocardial infarction.
作者: Mette Hurlen.;Michael Abdelnoor.;Pål Smith.;Jan Erikssen.;Harald Arnesen.
来源: N Engl J Med. 2002年347卷13期969-74页
The role of antithrombotic therapy in secondary prevention after myocardial infarction is well established. Although the available literature suggests that warfarin is superior to aspirin, aspirin is currently the more widely used drug. We studied the efficacy and safety of warfarin, aspirin, or both after myocardial infarction.
3402. Hemofiltration and peritoneal dialysis in infection-associated acute renal failure in Vietnam.
作者: Nguyen Hoan Phu.;Tran Tinh Hien.;Nguyen Thi Hoang Mai.;Tran Thi Hong Chau.;Ly Van Chuong.;Pham Phu Loc.;Christopher Winearls.;Jeremy Farrar.;Nicholas White.;Nicholas Day.
来源: N Engl J Med. 2002年347卷12期895-902页
In some parts of the world, peritoneal dialysis is widely used for renal replacement in acute renal failure. In resource-rich countries, it has been supplanted in recent years by hemodialysis and, most recently, by hemofiltration and associated techniques. The relative efficacy of peritoneal dialysis and hemofiltration is not known.
3403. Quality of life after radical prostatectomy or watchful waiting.
作者: Gunnar Steineck.;Fred Helgesen.;Jan Adolfsson.;Paul W Dickman.;Jan-Erik Johansson.;Bo Johan Norlén.;Lars Holmberg.; .
来源: N Engl J Med. 2002年347卷11期790-6页
We evaluated symptoms and self-assessments of quality of life in men with localized prostate cancer who participated in a randomized comparison between radical prostatectomy and watchful waiting.
3404. A randomized trial comparing radical prostatectomy with watchful waiting in early prostate cancer.
作者: Lars Holmberg.;Anna Bill-Axelson.;Fred Helgesen.;Jaakko O Salo.;Per Folmerz.;Michael Häggman.;Swen-Olof Andersson.;Anders Spångberg.;Christer Busch.;Steg Nordling.;Juni Palmgren.;Hans-Olov Adami.;Jan-Erik Johansson.;Bo Johan Norlén.; .
来源: N Engl J Med. 2002年347卷11期781-9页
Radical prostatectomy is widely used in the treatment of early prostate cancer. The possible survival benefit of this treatment, however, is unclear. We conducted a randomized trial to address this question.
3405. Use of the low-molecular-weight heparin reviparin to prevent deep-vein thrombosis after leg injury requiring immobilization.
Deep-vein thrombosis is a well-recognized complication after trauma to the legs and subsequent immobilization, but there are no generally accepted approaches to preventing this complication.
3406. High-frequency oscillatory ventilation versus conventional mechanical ventilation for very-low-birth-weight infants.
作者: Sherry E Courtney.;David J Durand.;Jeanette M Asselin.;Mark L Hudak.;Judy L Aschner.;Craig T Shoemaker.; .
来源: N Engl J Med. 2002年347卷9期643-52页
The efficacy and safety of early high-frequency oscillatory ventilation as compared with conventional synchronized intermittent mandatory ventilation for the treatment of infants with very low birth weight have not been established.
3407. High-frequency oscillatory ventilation for the prevention of chronic lung disease of prematurity.
作者: Alice H Johnson.;Janet L Peacock.;Anne Greenough.;Neil Marlow.;Elizabeth S Limb.;Louise Marston.;Sandra A Calvert.; .
来源: N Engl J Med. 2002年347卷9期633-42页
There remains uncertainty concerning the safety and efficacy of high-frequency oscillatory ventilation as compared with those of conventional ventilation for the respiratory support of very preterm infants. We conducted a multicenter trial to determine whether early intervention with high-frequency oscillatory ventilation reduced mortality and the incidence of chronic lung disease among newborns with a gestational age of 28 weeks or less.
3408. Twenty-five-year follow-up of a randomized trial comparing radical mastectomy, total mastectomy, and total mastectomy followed by irradiation.
作者: Bernard Fisher.;Jong-Hyeon Jeong.;Stewart Anderson.;John Bryant.;Edwin R Fisher.;Norman Wolmark.
来源: N Engl J Med. 2002年347卷8期567-75页
In women with breast cancer, the role of radical mastectomy, as compared with less extensive surgery, has been a matter of debate. We report 25-year findings of a randomized trial initiated in 1971 to determine whether less extensive surgery with or without radiation therapy was as effective as the Halsted radical mastectomy.
3409. Comparison of stenting with minimally invasive bypass surgery for stenosis of the left anterior descending coronary artery.
作者: Anno Diegeler.;Holger Thiele.;Volkmar Falk.;Rainer Hambrecht.;Niki Spyrantis.;Peter Sick.;Klaus W Diederich.;Friedrich W Mohr.;Gerhard Schuler.
来源: N Engl J Med. 2002年347卷8期561-6页
Minimally invasive bypass surgery and coronary-artery stenting are both accepted treatments for isolated stenosis of the proximal left anterior descending coronary artery. We compared the clinical outcomes after these two procedures.
3410. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors.
作者: George D Demetri.;Margaret von Mehren.;Charles D Blanke.;Annick D Van den Abbeele.;Burton Eisenberg.;Peter J Roberts.;Michael C Heinrich.;David A Tuveson.;Samuel Singer.;Milos Janicek.;Jonathan A Fletcher.;Stuart G Silverman.;Sandra L Silberman.;Renaud Capdeville.;Beate Kiese.;Bin Peng.;Sasa Dimitrijevic.;Brian J Druker.;Christopher Corless.;Christopher D M Fletcher.;Heikki Joensuu.
来源: N Engl J Med. 2002年347卷7期472-80页
Constitutive activation of KIT receptor tyrosine kinase is critical in the pathogenesis of gastrointestinal stromal tumors. Imatinib mesylate, a selective tyrosine kinase inhibitor, has been shown in preclinical models and preliminary clinical studies to have activity against such tumors.
3411. Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis.
作者: Raoul Herbrecht.;David W Denning.;Thomas F Patterson.;John E Bennett.;Reginald E Greene.;Jörg-W Oestmann.;Winfried V Kern.;Kieren A Marr.;Patricia Ribaud.;Olivier Lortholary.;Richard Sylvester.;Robert H Rubin.;John R Wingard.;Paul Stark.;Christine Durand.;Denis Caillot.;Eckhard Thiel.;Pranatharthi H Chandrasekar.;Michael R Hodges.;Haran T Schlamm.;Peter F Troke.;Ben de Pauw.; .
来源: N Engl J Med. 2002年347卷6期408-15页
Voriconazole is a broad-spectrum triazole that is active against aspergillus species. We conducted a randomized trial to compare voriconazole with amphotericin B for primary therapy of invasive aspergillosis.
3412. Intramuscular injection of botulinum toxin for the treatment of wrist and finger spasticity after a stroke.
作者: Allison Brashear.;Mark F Gordon.;Elie Elovic.;V Daniel Kassicieh.;Christina Marciniak.;Mai Do.;Chia-Ho Lee.;Stephen Jenkins.;Catherine Turkel.; .
来源: N Engl J Med. 2002年347卷6期395-400页
Spasticity is a disabling complication of stroke, and it is uncertain whether intramuscular injections of botulinum toxin type A reduce disability in persons with spasticity of the wrist and fingers after a stroke.
3413. Inhaled iloprost for severe pulmonary hypertension.
作者: Horst Olschewski.;Gerald Simonneau.;Nazzareno Galiè.;Timothy Higenbottam.;Robert Naeije.;Lewis J Rubin.;Sylvia Nikkho.;Rudolf Speich.;Marius M Hoeper.;Jürgen Behr.;Jörg Winkler.;Olivier Sitbon.;Wladimir Popov.;H Ardeschir Ghofrani.;Alessandra Manes.;David G Kiely.;Ralph Ewert.;Andreas Meyer.;Paul A Corris.;Marion Delcroix.;Miguel Gomez-Sanchez.;Harald Siedentop.;Werner Seeger.; .
来源: N Engl J Med. 2002年347卷5期322-9页
Uncontrolled studies suggested that aerosolized iloprost, a stable analogue of prostacyclin, causes selective pulmonary vasodilatation and improves hemodynamics and exercise capacity in patients with pulmonary hypertension.
3414. Risperidone in children with autism and serious behavioral problems.
作者: James T McCracken.;James McGough.;Bhavik Shah.;Pegeen Cronin.;Daniel Hong.;Michael G Aman.;L Eugene Arnold.;Ronald Lindsay.;Patricia Nash.;Jill Hollway.;Christopher J McDougle.;David Posey.;Naomi Swiezy.;Arlene Kohn.;Lawrence Scahill.;Andres Martin.;Kathleen Koenig.;Fred Volkmar.;Deirdre Carroll.;Allison Lancor.;Elaine Tierney.;Jaswinder Ghuman.;Nilda M Gonzalez.;Marco Grados.;Benedetto Vitiello.;Louise Ritz.;Mark Davies.;James Robinson.;Don McMahon.; .
来源: N Engl J Med. 2002年347卷5期314-21页
Atypical antipsychotic agents, which block postsynaptic dopamine and serotonin receptors, have advantages over traditional antipsychotic medications in the treatment of adults with schizophrenia and may be beneficial in children with autistic disorder who have serious behavioral disturbances. However, data on the safety and efficacy of atypical antipsychotic agents in children are limited.
3415. Regression of splenic lymphoma with villous lymphocytes after treatment of hepatitis C virus infection.
作者: Olivier Hermine.;François Lefrère.;Jean-Pierre Bronowicki.;Xavier Mariette.;Katayoun Jondeau.;Virginie Eclache-Saudreau.;Béatrice Delmas.;Françoise Valensi.;Patrice Cacoub.;Christian Brechot.;Bruno Varet.;Xavier Troussard.
来源: N Engl J Med. 2002年347卷2期89-94页
Some epidemiologic studies suggest a link between hepatitis C virus (HCV) infection and some B-cell non-Hodgkin's lymphomas. We undertook this study after a patient with splenic lymphoma with villous lymphocytes had a hematologic response after antiviral treatment of HCV infection.
3416. A controlled trial of arthroscopic surgery for osteoarthritis of the knee.
作者: J Bruce Moseley.;Kimberly O'Malley.;Nancy J Petersen.;Terri J Menke.;Baruch A Brody.;David H Kuykendall.;John C Hollingsworth.;Carol M Ashton.;Nelda P Wray.
来源: N Engl J Med. 2002年347卷2期81-8页
Many patients report symptomatic relief after undergoing arthroscopy of the knee for osteoarthritis, but it is unclear how the procedure achieves this result. We conducted a randomized, placebo-controlled trial to evaluate the efficacy of arthroscopy for osteoarthritis of the knee.
3417. Use of an inactivated varicella vaccine in recipients of hematopoietic-cell transplants.
作者: Atsuko Hata.;Hideomi Asanuma.;Mary Rinki.;Margaret Sharp.;Ruby M Wong.;Karl Blume.;Ann M Arvin.
来源: N Engl J Med. 2002年347卷1期26-34页
The reactivation of varicella-zoster virus from latency causes zoster and is common among recipients of hematopoietic-cell transplants.
3418. Lopinavir-ritonavir versus nelfinavir for the initial treatment of HIV infection.
作者: Sharon Walmsley.;Barry Bernstein.;Martin King.;José Arribas.;Gildon Beall.;Peter Ruane.;Margaret Johnson.;David Johnson.;Richard Lalonde.;Anthony Japour.;Scott Brun.;Eugene Sun.; .
来源: N Engl J Med. 2002年346卷26期2039-46页
Lopinavir is a newly developed inhibitor of human immunodeficiency virus (HIV) protease that, when formulated with ritonavir, yields mean trough plasma lopinavir concentrations that are at least 75 times as high as that needed to inhibit replication of wild-type HIV by 50 percent.
3419. Lansoprazole for the prevention of recurrences of ulcer complications from long-term low-dose aspirin use.
作者: Kam Chuen Lai.;Shiu Kum Lam.;Kent Man Chu.;Benjamin C Y Wong.;Wai Mo Hui.;Wayne H C Hu.;George K K Lau.;Wai Man Wong.;Man Fung Yuen.;Annie O O Chan.;Ching Lung Lai.;John Wong.
来源: N Engl J Med. 2002年346卷26期2033-8页
The role of gastric acid suppression in preventing the recurrence of ulcer complications after the eradication of Helicobacter pylori infection in patients taking long-term low-dose aspirin is uncertain.
3420. Fumagillin treatment of intestinal microsporidiosis.
作者: Jean-Michel Molina.;Muriel Tourneur.;Claudine Sarfati.;Sylvie Chevret.;Amaury de Gouvello.;Jean-Gérard Gobert.;Suna Balkan.;Francis Derouin.; .
来源: N Engl J Med. 2002年346卷25期1963-9页
Intestinal microsporidiosis due to Enterocytozoon bieneusi is a cause of chronic diarrhea, malabsorption, and wasting in immunocompromised patients. Currently, there is no effective treatment.
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