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321. Trends in the prevalence of autoimmune diseases during pregnancy in the UK, 2000-21: a retrospective cohort study.
作者: Megha Singh.;Katherine Phillips.;Jingya Wang.;Anuradhaa Subramanian.;Kelly-Ann Eastwood.;Krishnarajah Nirantharakumar.;Francesca L Crowe.
来源: Lancet Rheumatol. 2025年7卷7期e495-e504页
Autoimmune diseases are increasingly prevalent worldwide and disproportionately affect women of reproductive age, including during pregnancy. Given the association between autoimmune diseases, comorbidities, and risk factors for adverse pregnancy outcomes, we aimed to estimate the burden of autoimmune disease in pregnancy.
322. Risk of infection in patients with early inflammatory arthritis: results from a large UK prospective observational cohort study.
作者: Maryam A Adas.;Katie Bechman.;Mark D Russell.;Victoria Allen.;Samir Patel.;Mark Gibson.;Ioasaf Karafotias.;Kathryn Biddle.;Benjamin Zuckerman.;Kaiyang Song.;Deepak Nagra.;Edward Alveyn.;Suma Mahendrakar.;Meryem Nursoy.;Fabiola Atzeni.;Sarah Gallagher.;Elizabeth Price.;Mark Garton.;Andrew Rutherford.;Andrew P Cope.;Sam Norton.;James B Galloway.
来源: Rheumatology (Oxford). 2025年64卷11期5647-5655页
To identify risk of serious infections (SI) according to initial conventional synthetic DMARDs (csDMARD) and CS, in patients recruited to the National Early Inflammatory Arthritis Audit.
323. SPAG11B, a potential biomarker for rheumatoid arthritis: a two-sample bidirectional Mendelian randomization analysis.
The incidence of rheumatoid arthritis (RA) is rising. However, its pathogenesis has not been fully understood, and the current therapeutic regimens are still limited. The aim of this study was to investigate the causal effect of plasma proteins on RA using Mendelian randomization (MR) analysis.
324. Clinical and ultrasound features of a cohort of psoriasis patients without musculoskeletal symptoms: a prospective and multicentre study.
作者: Ana Belén Azuaga.;Andrea Cuervo.;Delia Reina.;Paula Estrada-Alarcón.;Lourdes Mateo.;María Aparicio.;Mireia Moreno.;Marta Arévalo.;Ana Láiz.;Patricia Moya.;Lucía Alascio.;Josep Riera.;José U Scher.;Juan D Cañete.;Julio Ramírez.
来源: Rheumatology (Oxford). 2025年64卷10期5396-5403页
To evaluate clinical and ultrasound (US) features related to psoriatic arthritis (PsA) development in psoriasis (PsO), patients without musculoskeletal (MSK) symptoms and no systemic treatment.
325. Frequency-specific microcurrent improves hand function and Raynaud's symptoms in scleroderma: results of two pilot studies.
作者: Walter M Gregory.;Katherine Bagley.;Sookhoe Eng.;Carolyn McMakin.;Francesco Del Galdo.
来源: Rheumatology (Oxford). 2025年64卷10期5504-5508页
To evaluate the efficacy of frequency-specific microcurrent as a treatment designed to improve hand function and alleviate Raynaud's symptoms in patients with systemic sclerosis.
326. Single-centre comparison of non-familial, familial and monogenic lupus.
作者: Jalila Alshekaili.;Batool S H Al Lawati.;Zahran Althuhli.;Warda Al-Azri.;Almundher Al-Maawali.;Samiya Al-Rashdi.;Farida Al-Mamari.;Mahmood Al-Kindi.;Hamad Al Balushi.;Mohammed Al-Rawahi.;Murtadha Al-Khabori.;Matthew C Cook.
来源: Rheumatology (Oxford). 2025年64卷10期5388-5395页
There is a significant genetic contribution to systemic lupus erythematosus (SLE). Monogenic SLE is a distinct form of SLE. We investigated whether familial or known monogenic lupus cases are distinguishable from non-familial lupus by clinical or laboratory phenotype in a population with high rates of consanguinity.
327. JAK inhibitors alleviate metabolic dysregulation, inflammation and fibrosis in osteoarthritis: insights from human joint cells and synovium.
作者: Geneviève Paulissen.;Olivier Malaise.;Céline Deroyer.;Edith Charlier.;Sophie Neuville.;Zelda Plener.;Thierry Thirion.;Christophe Daniel.;Clio Ribbens.;Dominique de Seny.
来源: Rheumatology (Oxford). 2025年64卷10期5539-5550页
Osteoarthritis (OA) presents a significant clinical challenge due to its heterogeneous nature, characterized by cartilage degradation, inflammation and fibrosis. Current treatments offer limited efficacy, highlighting the need for novel therapeutic approaches. Our study aimed to investigate the effects of two Janus kinase (JAK) inhibitors, tofacitinib and baricitinib, on various hallmarks of OA in human joint cells and synovium.
328. Lung function and skin fibrosis changes as predictors of survival in SSc-associated interstitial lung disease: a EUSTAR study.
作者: Vincent Sobanski.;Jeska de Vries-Bouwstra.;Anna-Maria Hoffmann-Vold.;Dörte Huscher.;Margarida Alves.;Marco Matucci-Cerinic.;Gabriela Riemekasten.;Mengtao Li.;László Czirják.;Otylia Kowal-Bielecka.;Yannick Allanore.;Nils Schoof.;Oliver Distler.; .
来源: Rheumatology (Oxford). 2025年64卷10期5344-5353页
This study assessed how changes in lung function, skin fibrosis and digital ulceration (DU) burden predict mortality in patients with SSc-associated interstitial lung disease (SSc-ILD), the leading cause of death in SSc.
329. Temporal trends in vascular medication use in 8079 patients with systemic sclerosis: insights to inform future trials and therapeutic strategies from the EUSTAR cohort.
作者: Stefano Di Donato.;John D Pauling.;Sheila Ramjug.;Yannick Allanore.;Edward B Jude.;Marie-Elise Truchetet.;Paolo Airò.;Lidia P Ananyeva.;Andra Balanescu.;Gonçalo Boleto.;Francesco Paolo Cantatore.;Patricia E Carreira.;Carolina de Souza Müller.;Masataka Kuwana.;Gianluca Moroncini.;Marco Di Battista.;Luc Mouthon.;Madelon C Vonk.;Elisabetta Zanatta.;Marco Matucci-Cerinic.;Francesco Del Galdo.;Michael Hughes.; .
来源: Rheumatology (Oxford). 2025年64卷10期5354-5363页
Systemic sclerosis (SSc) is characterized by widespread vascular damage resulting in digital and systemic vasculopathic sequelae. Although there are effective treatments available, vascular disease remains a significant cause of morbidity and mortality in SSc. Our aim was to describe patterns of vascular medication use in SSc, including examination for potential changes over time.
330. Lung transplantation outcomes of patients with interstitial pneumonia with autoimmune features: a single-centre retrospective cohort study.
作者: Alec Chu Ming Yu.;Hyein Kim.;Robert D Levy.;Jennifer M Wilson.;Darya S Jalaledin.;James Choi.;John Yee.;Charles D Poirier.;Sabrina Anh-Tu Hoa.;Océane Landon-Cardinal.;Kun Huang.
来源: Rheumatology (Oxford). 2025年64卷10期5338-5343页
Interstitial pneumonia with autoimmune features (IPAF) describes patients with interstitial lung disease (ILD) and autoimmune features without meeting criteria for a specific rheumatic disease. No longitudinal data exist on post-transplant outcomes in IPAF patients. We compared baseline demographics, pre-transplant characteristics and post-transplant outcomes between IPAF and idiopathic pulmonary fibrosis (IPF) patients undergoing double lung transplantation.
331. Canakinumab treatment patterns in sJIA, FMF, TRAPS, and MKD/HIDS: real-world insights from a Belgian non-interventional study.
作者: Michel Moutschen.;Cécile Boulanger.;Joke Dehoorne.;Rik Joos.;Florence Roufosse.;Vito Sabato.;Jeroen van der Hilst.;Eleonore Maury.;Hilde Rabijns.;Marijn Witterzeel.;Carine Wouters.
来源: BMC Rheumatol. 2025年9卷1期64页
Canakinumab, an IL-1β inhibitor, has demonstrated long-term efficacy and safety in patients with sJIA, FMF, TRAPS, and MKD/HIDS who experience inadequate disease control with conventional treatments. This non-interventional study aimed to gain insights into canakinumab use and treatment patterns for these diseases in Belgium.
332. An exploratory trial of a single dose of CAM2043 (treprostinil subcutaneous depot) in SSc-related RP.
作者: Ariane L Herrick.;Andrea Murray.;Graham Dinsdale.;Joanne Manning.;Chukwuma Chukwu.;Marcia Alvarez Fernandez.;Ulrika Axling.;James R Seibold.;Fredrik Tiberg.
来源: Rheumatology (Oxford). 2025年64卷10期5498-5503页
Our aim was to explore the effect of a single subcutaneous dose of CAM2043, a novel extended-release subcutaneous formulation of treprostinil, on finger temperature in patients with SSc-related RP.
333. Immunoadsorption as a novel therapy for refractory idiopathic inflammatory myopathies: a retrospective observational study.
作者: Kastriot Kastrati.;Thomas Karonitsch.;Hanien Rajab.;Roman Reindl-Schwaighofer.;Farsad Eskandary.;Sahra Pajenda.;Daniel Mrak.;Peter Maximilian Heil.;Hans Peter Kiener.;Michael Bonelli.;Kurt Derfler.;Daniel Aletaha.;Josef S Smolen.;Helga Radner.
来源: Rheumatology (Oxford). 2025年64卷10期5304-5312页
Idiopathic inflammatory myopathies (IIM) are autoimmune disorders characterised by muscle inflammation, high creatine kinase (CK) levels and disability. Despite immunomodulating therapies, patients often experience progressive disease, resulting in refractory conditions or dependence on glucocorticoids (GC). This study addresses the efficacy and safety of immunoadsorption (IAS) in refractory IIM.
335. Real-world evidence of biological treatments in rheumatoid arthritis and spondyloarthritis in Morocco: results of the RBSMR registry.
作者: Najlae El Ouardi.;Ihsane Hmamouchi.;Redouane Abouqal.;Fadoua Allali.;Rachid Bahiri.;Imane El Bouchti.;Imad Ghozlani.;Hasna Hassikou.;Linda Ichchou.;Saadia Janani.;Taoufik Harzy.;Radouane Niamane.;Ahmed Bezza.;Abdellah El Maghraoui.
来源: BMC Rheumatol. 2025年9卷1期62页
Regional variability in the effectiveness and safety of biologic therapies for rheumatoid arthritis (RA) and spondyloarthritis (SpA) underscores the need for comprehensive assessment. The aim of this study was to provide real-world evidence of the effectiveness and the safety of biologic for RA, SpA including psoriatic arthritis, in the daily clinical practice.
336. Does osteoarthritis physiotherapy research in South Korea align with the National Institute for Health and Care Excellence guidelines: a systematic review of English and Korean literature.
Osteoarthritis (OA) is a leading cause of lower limb disability worldwide, imposing significant socioeconomic and personal burden. Thus, many internationally recognised organisations have developed management guidelines for this condition. Among these, the National Institute for Health and Care Excellence (NICE) recommends four first-line approaches to osteoarthritis management: education, exercise, self-management, and weight management. Despite the development of guidelines, adherence to OA management recommendations appears to be suboptimal internationally, and little is known about guideline adherence in South Korea. This study aimed to explore whether research-based physiotherapy interventions for OA in South Korea align with the NICE guidelines.
337. DISH as a marker for incident diabetes mellitus in cardiovascular disease patients.
作者: Netanja I Harlianto.;Wouter Foppen.;Firdaus A A Mohamed Hoesein.;Marjolein E Hol.;Jorrit-Jan Verlaan.;Pim A de Jong.;Jan Westerink.; .
来源: Rheumatology (Oxford). 2025年64卷10期5287-5294页
DISH is a common incidental finding in medical imaging characterized by continuous vertebral ossification, which is associated with prevalent type 2 diabetes mellitus (T2DM). We hypothesized that incidental screen-detected DISH may be an actionable marker for incident diabetes screening and aimed to assess the absolute incidence rate (ratio) for T2DM in cardiovascular patients with and without DISH.
338. Personalized dose reduction strategies for biologic disease-modifying antirheumatic drugs for treating axial spondyloarthritis: a clinical and economic evaluation with predictive modeling.
作者: Bui Hai Binh.;Nguyen Thi Thu Phuong.;Vu Thi Thanh Hang.;Ngo Thi Thuc Nhan.;Nguyen Thi Nhu Hoa.;Hoang Van Dung.
来源: BMC Rheumatol. 2025年9卷1期60页
Axial spondyloarthritis (AS) is a chronic inflammatory disease that significantly affects quality of life and imposes a high economic burden on patients due to the cost of biologic disease-modifying antirheumatic drugs (bDMARDs). Dose reduction strategies for bDMARDs may offer a feasible approach to maintaining clinical efficacy while reducing costs. This study aimed to evaluate the clinical effectiveness and cost-efficiency of bDMARD dose reduction in patients with AS and apply machine learning to identify key factors influencing disease control.
339. Association between hepatitis C virus infection and rheumatoid arthritis: a nationwide cross-sectional study.
作者: Lin Tang.;Lei Zhang.;Zhonghai Ding.;Wenying Xu.;Yu Liu.;Zhenghong Yu.
来源: BMC Rheumatol. 2025年9卷1期61页
Patients infected with Hepatitis C Virus (HCV) often present with rheumatic symptoms, but its link to rheumatoid arthritis (RA) remains unclear. The purpose of this cross-sectional study was to investigate whether HCV infection is related to the risk for RA in adults.
340. Association of physicians' Big Five personality traits with shared decision-making in patients with SLE.
作者: Shigemi Morishita.;Ken-Ei Sada.;Masataka Kudo.;Naofumi Dobashi.;Sho Sasaki.;Ryusuke Yoshimi.;Natsuki Sakurai.;Chiharu Hidekawa.;Yasuhiro Shimojima.;Dai Kishida.;Takanori Ichikawa.;Yoshia Miyawaki.;Keigo Hayashi.;Kenta Shidahara.;Yuichi Ishikawa.;Nao Oguro.;Nobuyuki Yajima.;Noriaki Kurita.;Narufumi Suganuma.
来源: Rheumatology (Oxford). 2025年64卷10期5269-5276页
Recent European League Against Rheumatism guidelines highlight the importance of shared decision-making (SDM) in SLE treatment. This study investigated the relationship between physicians' personality traits and patient-rated SDM.
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