322. Effects of Combining Coronary Calcium Score With Treatment on Plaque Progression in Familial Coronary Artery Disease: A Randomized Clinical Trial.
作者: Nitesh Nerlekar.;Sheran A Vasanthakumar.;Kristyn Whitmore.;Cheng Hwee Soh.;Jasmine Chan.;Vinay Goel.;Jacqueline Ryan.;Catherine Jones.;Tony Stanton.;Geoffrey Mitchell.;Andrew Tonkin.;Gerald F Watts.;Stephen J Nicholls.;Thomas H Marwick.; .
来源: JAMA. 2025年333卷16期1403-1412页
Coronary artery calcium (CAC) scoring provides prognostic information, especially in patients at intermediate risk for coronary artery disease (CAD). However, the benefit of combining CAC score with a primary prevention strategy has not been tested in a randomized trial.
332. Population-Scale Studies of Protein S Abnormalities and Thrombosis.
作者: Sharjeel A Chaudhry.;Amelia K Haj.;Justine Ryu.;Sean J Jurgens.;Alfonso Rodriguez Espada.;Xin Wang.;Seung Hoan Choi.;Simone Sanna-Cherchi.;Steven P Grover.;Kenneth A Bauer.;Patrick T Ellinor.;Pavan K Bendapudi.
来源: JAMA. 2025年333卷16期1423-1432页
Clinical decision-making in thrombotic disorders is impeded by long-standing uncertainty regarding the magnitude of venous and arterial thrombosis risk associated with low protein S. Population-scale multiomic datasets offer an unprecedented opportunity to answer questions regarding the epidemiology and clinical impacts of protein S deficiency.
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