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321. Efficacy of pharmacotherapies on pediatric patients with metabolic dysfunction-associated steatotic liver disease: a systematic review and network meta-analysis.
作者: Shehab Yaser.;Hatem Yaser.;Hazem E Mohammed.;Mohamed Nasser.;Mohamed Khalafalla Darwish.;Mohamed E Haseeb.;Anas Hussein Heiba.;Mohamed Mabrouk Ghonaim.;Heba Aboeldahab.;Zeyad Bady.
来源: BMC Gastroenterol. 2025年25卷1期853页
Metabolic dysfunction-associated steatotic liver disease (MASLD) affects children and is increasingly prevalent alongside rising childhood obesity. The MASLD spectrum spans from simple hepatic steatosis to metabolic-associated steatohepatitis (MASH), fibrosis, and cirrhosis. Despite this rising prevalence, the optimal pharmacotherapy for pediatric MASLD remains uncertain.
322. Endoscopic resection for small rectal gastrointestinal stromal tumors: a pilot study.
作者: Kedinuer Abulaiti.;Bing Li.;Yingjie Liu.;Bahejuan Jiaerken.;Yongbing Li.;Zhipeng Qi.;Yunshi Zhong.;Pinghong Zhou.;Qiang Shi.
来源: BMC Gastroenterol. 2025年26卷1期24页
Rectal gastrointestinal stromal tumors are a rare subset of gastrointestinal stromal tumors with malignant potential, making their management clinically challenging. This study sought to assess the feasibility, safety, and efficacy of endoscopic resection as a primary treatment for these tumors.
323. Integrated ultrasound radiomics and clinical data to predict PD-1 blockade efficacy in unresectable hepatocellular carcinoma.
作者: Dong Jiang.;Zonghan Liu.;Kang Wang.;Yi Qian.;Jinkai Feng.;Lin Gong.;Jialun Ren.;Yanjun Xiang.;Fangfang Zhang.;Liheng Liu.;Hongkun Zhou.;Chao Liang.;Wenjing Wei.;Boyang Zang.;Chui Kong.;Yiran Li.;Shuqun Cheng.
来源: BMC Gastroenterol. 2025年26卷1期14页
PD-1 blockade therapy has emerged as a valuable treatment option for advanced hepatocellular carcinoma (HCC), but its therapeutic response and overall efficacy vary among patients. This study develops an automated framework for predicting response to PD-1 blockade with enhanced accuracy.
324. Impact of bariatric surgery on metabolic-dysfunction associated fatty liver disease in diabetic and non-diabetic patients: a cohort study.
作者: Mohammad Sistanizad.;Niloufar Taherpour.;Peyman Alibeigi.;Soheila Sadeghi.;Mojan Shamizadehkalkhoran.;Omid Moradi.
来源: BMC Gastroenterol. 2025年26卷1期18页
Metabolic dysfunction-associated fatty liver disease (MAFLD) is highly prevalent, especially in type 2 diabetes mellitus (T2DM). This study evaluates the effect of bariatric surgery on MAFLD in patients with obesity with or without diabetes.
325. Novel urinary biomarkers to differentiate AKI etiologies and predict mortality in decompensated cirrhosis patients: a prospective cohort study.
作者: Chiranjita Phukan.;Anjan Jyoti Talukdar.;Sangitanjan Dutta.;Saptadweep Saha.;Monalisha Saikia Borah.;Pinku Mani Talukdar.;Bhaskar Jyoti Sarma.;Achyut Chandra Baishya.;Saswati Sanyal Choudhury.;Anuradha Deuri.
来源: BMC Gastroenterol. 2025年26卷1期16页
The differentiation of causes of Acute Kidney Injury (AKI) in decompensated chronic liver disease (DCLD) presents a diagnostic challenge. This study aims to evaluate the diagnostic and prognostic utility of Neutrophil gelatinase-associated lipocalin (NGAL), Kidney injury molecule-1 (KIM-1), and interleukin-18 (IL-18) in cirrhotic patients with AKI.
326. Impact of metabolic and bariatric surgery on MASLD: histological resolution and metabolic outcomes in a retrospective cohort.
作者: Rahat Longsomboon.;Pattharasai Kachornvitaya.;Thaninee Prasoppokakorn.;Sombat Treeprasertsuk.;Patchaya Boonchaya-Anant.;Naruemon Klaikaew.;Suthep Udomsawaengsup.
来源: BMC Gastroenterol. 2025年25卷1期864页
Metabolic dysfunction-associated steatotic liver disease (MASLD) involves a spectrum of liver histopathological changes. Obesity is recognized as a risk factor for MASLD. Metabolic and bariatric surgery (MBS) has emerged as a promising therapeutic option.
327. Efficacy of silver-ion dressings in accelerating wound healing after hemorrhoidectomy: a dual-center randomized trial.
作者: Yun Liang.;Zheng Chen.;Ming He.;Yile Liu.;Rui Ding.;Jiangtao Huang.;Chaolun Deng.;Zehui Liu.;Runtong Chen.;Hong Cen.;Feng Yang.;Yonghui Su.
来源: BMC Gastroenterol. 2025年26卷1期15页
Hemorrhoids are a prevalent perianal disorder, with surgery being a primary treatment modality. Postoperative wound healing significantly impacts recovery and quality of life. Silver-ion dressings, known for their antimicrobial properties, are a relatively new option, but their efficacy in perianal wound healing is not well-established.
328. Global, regional, and national burden of NAFLD in adults aged 20-49 years (1990-2021): a comprehensive analysis of trends, decomposition, and health inequality.
Non-alcoholic fatty liver disease (NAFLD) is a growing global health concern, particularly among adults aged 20-49 years. However, comprehensive assessments of its burden in this demographic remain limited.
329. The prevalence and associated factors of autoimmune gastritis: single-center, hospital-based prospective study in China.
Autoimmune gastritis (AIG) is a chronic immune-mediated disease characterized by anti-parietal cell antibody (PCA) and corpus-predominant atrophy. However, epidemiological data on AIG remain limited in China where the prevalence of Helicobacter pylori (H. pylori) is high. This study aimed to estimate the prevalence and associated factors of AIG in a hospital-based population.
330. The effects of family-based Helicobacter pylori infection control and management strategies in Southwest China households: a two-year retrospective cohort study.
作者: Hengqi Liu.;Hanning Liu.;Ling Fan.;Yuntong Lan.;Ping Chen.;Ping He.;Cheng Huang.;Sai Gu.;Haofeng Li.;Qing Shi.;Chunhui Lan.;Yan Guo.
来源: BMC Gastroenterol. 2025年25卷1期852页
There is a lack of data on the effects of family-based Helicobacter pylori (H. pylori) infection control and management (FBCM) strategies in Southwest China. This study aimed to evaluate the two-year outcomes of these strategies in affected households.
331. Relationship between diet quality and inflammatory bowel disease: a systematic review of observational studies.
作者: Parisa Karimi.;Elmira Ramezani.;Shakila Dehghani.;Nastaran Mahmoudi Shirkoohi.;Ariyo Movahedi.;Mohammad Masoumvand.;Ali Jafarzadeh Esfehani.
来源: BMC Gastroenterol. 2025年25卷1期756页
Inflammatory bowel disease (IBD) is a prevalent digestive disorder, influenced by various factors, particularly dietary choices and overall diet quality. Various indices assess diet quality, yet their correlation with IBD severity and symptoms remains uncertain. This systematic review examines the relationship between IBD and diet quality, as measured by the Dietary Inflammatory Index (DII), Healthy Eating Index (HEI), and Diet Quality Index (DQI).
332. Endoscopic Histoacryl injection with clips is associated with lower early rebleeding compared to Histoacryl injection alone in the treatment of gastric varices.
作者: Yingfeng Wei.;Shenggang Huang.;Chunping Zhu.;Jiaming Huang.
来源: BMC Gastroenterol. 2025年25卷1期850页
To assess whether Histoacryl injection with clips is superior to Histoacryl injection alone in terms of efficacy and safety.
333. Research waste among randomized clinical trials in endoscopic resection of gastrointestinal lesions: a cross-sectional study of ClinicalTrials.gov.
作者: Yun Dai.;Xue-Ting Li.;Yong-Shen Zheng.;Jin-Hai Chen.;Guo-Xing Xu.;Hai-Xing Wang.
来源: BMC Gastroenterol. 2025年25卷1期851页
To determine the association between the characteristics of randomized clinical trials (RCTs) on endoscopic resection and research waste, and to explore potential targets for improvement.
334. Global, regional, and national burden of gastric cancer attributable to smoking and a high-sodium diet from 1990 to 2021: a global burden of disease study 2021.
作者: Guangying Zhao.;Yan Liu.;Haojie Wang.;Yongjian Zhang.;Liang Shang.;Leping Li.
来源: BMC Gastroenterol. 2025年26卷1期52页
This study comprehensively assesses the global, regional, and national burden of gastric cancer (GC) attributable to smoking and a high-sodium diet from 1990 to 2021, aiming to promote healthy lifestyle habits and provide scientific evidence for policy-making.
335. Benchmarking sessile serrated lesion detection in colonoscopy: individual endoscopist performance has greater impact than specialty training - a retrospective analysis of 12,064 procedures.
Sessile serrated lesions (SSLs) are implicated in up to 30% of colorectal cancers through the serrated neoplasia pathway. Current guidelines lack established benchmarks for SSL detection rates (SSL-DR), with significant geographic variation reported internationally. The 2024 American Society for Gastrointestinal Endoscopy (ASGE) and American College of Gastroenterology (ACG) recommend a minimum SSL-DR of > 6% for patients aged ≥ 45, while the Gastroenterological Society of Australia (GESA) maintains a 4% minimum. This study aimed to determine optimal SSL-DR benchmarks for clinical practice, compare detection rates between gastroenterologists and general surgeons, and identify whether specialty training or individual endoscopist performance primarily drives detection variability.
336. Risk factors and prediction model for submucosal invasion in early protruding-type esophagogastric junction adenocarcinoma: conventional endoscopy combines with endoscopic ultrasonography.
作者: Lei Zhang.;Nana An.;Zhongfei Jia.;Xiuli Zheng.;Wenqian Ma.;Juntao Lu.;Limian Er.
来源: BMC Gastroenterol. 2025年26卷1期10页
Precise depth evaluation of protruding-type early esophagogastric junction adenocarcinoma (EGJAC) is critical for therapeutic planning. This study evaluated the diagnostic value of conventional endoscopy (CE) and endoscopic ultrasonography (EUS) for identifying suspected submucosal-invasive carcinomas and established a predictive model for SM2 invasion.
337. Prevalence and risk factors of metabolic dysfunction-associated fatty liver disease in the adult Georgian population: a nationwide multiregional clinic-based study.
In Georgia, the prevalence of MAFLD remains poorly defined, as evidence largely stems from small-scale hospital studies. This research used a nationwide multiregional clinic-based sample to estimate MAFLD prevalence and its associated factors.
338. The role of fecal calprotectin in assessing response to advanced medical treatments for inflammatory bowel diseases: a review of the literature.
作者: Alessandro Vitello.;Olga M Nardone.;Giulio Calabrese.;Salvatore M Carnazzo.;Carlo D Maida.;Daryl Ramai.;Antonio Facciorusso.;Federico Bonomo.;Marcello Maida.
来源: Minerva Gastroenterol (Torino). 2026年72卷1期51-59页
In the era of treat-to-target (T2T), there is an urgent need for surrogate non-invasive markers to monitor patients with inflammatory bowel diseases (IBD). Fecal calprotectin (FC), a non-invasive biomarker reflecting intestinal inflammation, holds potential for improving treatment monitoring. This narrative review aims to provide an overview of the role of FC in assessing responses to biological therapies and the new small molecules.
339. Comprehensive nutritional management incorporating home-based dietary consultation improves hepatic encephalopathy in cirrhotic patients: a retrospective cohort study.
作者: Qing Zhao.;Jiangqiang Xiao.;Qin Yin.;Yue Xu.;Jiashu Yao.;Xiaotian Chen.;Ming Zhang.;Bo Gao.
来源: BMC Gastroenterol. 2025年26卷1期6页
Few studies have clinically demonstrated the benefits of comprehensive nutritional management incorporating home-based dietary consultation in patients with cirrhosis. This study investigates whether such management can improve the prognosis of cirrhotic patients.
340. Comparative efficacy of neoadjuvant imatinib therapy in gastric versus rectal gastrointestinal stromal tumors: a two-center retrospective cohort study.
作者: Jin-Hu Chen.;Zhi-Ming Cai.;Zhen-Rong Yang.;Tao Lin.;Shi-Chai Hong.;Xin-Cheng Su.;Yue-Ming Lin.;Lu Lin.;Zai-Sheng Ye.;Yong-Jian Zhou.
来源: BMC Gastroenterol. 2025年26卷1期8页
This study aimed to evaluate and compare tumor response, survival outcomes, and prognostic factors in gastric versus rectal GIST patients treated with neoadjuvant IM.
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