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321. Effect of e-Cigarettes Plus Counseling vs Counseling Alone on Smoking Cessation: A Randomized Clinical Trial.
作者: Mark J Eisenberg.;Andréa Hébert-Losier.;Sarah B Windle.;Todd Greenspoon.;Tim Brandys.;Tamàs Fülöp.;Thang Nguyen.;Stéphane Elkouri.;Martine Montigny.;Igor Wilderman.;Olivier F Bertrand.;Joanna Alexis Bostwick.;John Abrahamson.;Yves Lacasse.;Smita Pakhale.;Josselin Cabaussel.;Kristian B Filion.; .
来源: JAMA. 2020年324卷18期1844-1854页
Electronic cigarettes (e-cigarettes) for smoking cessation remain controversial.
322. Effect of Vitamin D Supplementation, Omega-3 Fatty Acid Supplementation, or a Strength-Training Exercise Program on Clinical Outcomes in Older Adults: The DO-HEALTH Randomized Clinical Trial.
作者: Heike A Bischoff-Ferrari.;Bruno Vellas.;René Rizzoli.;Reto W Kressig.;José A P da Silva.;Michael Blauth.;David T Felson.;Eugene V McCloskey.;Bernhard Watzl.;Lorenz C Hofbauer.;Dieter Felsenberg.;Walter C Willett.;Bess Dawson-Hughes.;JoAnn E Manson.;Uwe Siebert.;Robert Theiler.;Hannes B Staehelin.;Caroline de Godoi Rezende Costa Molino.;Patricia O Chocano-Bedoya.;Lauren A Abderhalden.;Andreas Egli.;John A Kanis.;Endel J Orav.; .
来源: JAMA. 2020年324卷18期1855-1868页
The benefits of vitamin D, omega-3 fatty acids, and exercise in disease prevention remain unclear.
323. Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial.
作者: Wesley H Self.;Matthew W Semler.;Lindsay M Leither.;Jonathan D Casey.;Derek C Angus.;Roy G Brower.;Steven Y Chang.;Sean P Collins.;John C Eppensteiner.;Michael R Filbin.;D Clark Files.;Kevin W Gibbs.;Adit A Ginde.;Michelle N Gong.;Frank E Harrell.;Douglas L Hayden.;Catherine L Hough.;Nicholas J Johnson.;Akram Khan.;Christopher J Lindsell.;Michael A Matthay.;Marc Moss.;Pauline K Park.;Todd W Rice.;Bryce R H Robinson.;David A Schoenfeld.;Nathan I Shapiro.;Jay S Steingrub.;Christine A Ulysse.;Alexandra Weissman.;Donald M Yealy.;B Taylor Thompson.;Samuel M Brown.; .;Jay Steingrub.;Howard Smithline.;Bogdan Tiru.;Mark Tidswell.;Lori Kozikowski.;Sherell Thornton-Thompson.;Leslie De Souza.;Peter Hou.;Rebecca Baron.;Anthony Massaro.;Imoigele Aisiku.;Lauren Fredenburgh.;Raghu Seethala.;Lily Johnsky.;Richard Riker.;David Seder.;Teresa May.;Michael Baumann.;Ashley Eldridge.;Christine Lord.;Nathan Shapiro.;Daniel Talmor.;Thomas O’Mara.;Charlotte Kirk.;Kelly Harrison.;Lisa Kurt.;Margaret Schermerhorn.;Valerie Banner-Goodspeed.;Katherine Boyle.;Nicole Dubosh.;Michael Filbin.;Kathryn Hibbert.;Blair Parry.;Kendall Lavin-Parsons.;Natalie Pulido.;Brendan Lilley.;Carl Lodenstein.;Justin Margolin.;Kelsey Brait.;Alan Jones.;James Galbraith.;Rebekah Peacock.;Utsav Nandi.;Taylor Wachs.;Michael Matthay.;Kathleen Liu.;Kirsten Kangelaris.;Ralph Wang.;Carolyn Calfee.;Kimberly Yee.;Gregory Hendey.;Steven Chang.;George Lim.;Nida Qadir.;Andrea Tam.;Rebecca Beutler.;Joseph Levitt.;Jenny Wilson.;Angela Rogers.;Rosemary Vojnik.;Jonasel Roque.;Timothy Albertson.;James Chenoweth.;Jason Adams.;Skyler Pearson.;Maya Juarez.;Eyad Almasri.;Mohamed Fayed.;Alyssa Hughes.;Shelly Hillard.;Ryan Huebinger.;Henry Wang.;Elizabeth Vidales.;Bela Patel.;Adit Ginde.;Marc Moss.;Amiran Baduashvili.;Jeffrey McKeehan.;Lani Finck.;Carrie Higgins.;Michelle Howell.;Ivor Douglas.;Jason Haukoos.;Terra Hiller.;Carolynn Lyle.;Alicia Cupelo.;Emily Caruso.;Claudia Camacho.;Stephanie Gravitz.;James Finigan.;Christine Griesmer.;Pauline Park.;Robert Hyzy.;Kristine Nelson.;Kelli McDonough.;Norman Olbrich.;Mark Williams.;Raj Kapoor.;Jean Nash.;Meghan Willig.;Henry Ford.;Jayna Gardner-Gray.;Mayur Ramesh.;Montefiore Moses.;Michelle Ng Gong.;Michael Aboodi.;Ayesha Asghar.;Omowunmi Amosu.;Madeline Torres.;Savneet Kaur.;Jen-Ting Chen.;Aluko Hope.;Brenda Lopez.;Kathleen Rosales.;Jee Young You.;Jarrod Mosier.;Cameron Hypes.;Bhupinder Natt.;Bryan Borg.;Elizabeth Salvagio Campbell.;R Duncan Hite.;Kristin Hudock.;Autumn Cresie.;Faysal Alhasan.;Jose Gomez-Arroyo.;Abhijit Duggal.;Omar Mehkri.;Andrei Hastings.;Debasis Sahoo.;Francois Abi Fadel.;Susan Gole.;Valerie Shaner.;Allison Wimer.;Yvonne Meli.;Alexander King.;Thomas Terndrup.;Matthew Exline.;Sonal Pannu.;Emily Robart.;Sarah Karow.;Catherine Hough.;Bryce Robinson.;Nicholas Johnson.;Daniel Henning.;Monica Campo.;Stephanie Gundel.;Sakshi Seghal.;Sarah Katsandres.;Sarah Dean.;Akram Khan.;Olivia Krol.;Milad Jouzestani.;Peter Huynh.;Alexandra Weissman.;Donald Yealy.;Denise Scholl.;Peter Adams.;Bryan McVerry.;David Huang.;Derek Angus.;Jordan Schooler.;Steven Moore.;Clark Files.;Chadwick Miller.;Kevin Gibbs.;Mary LaRose.;Lori Flores.;Lauren Koehler.;Caryn Morse.;John Sanders.;Caitlyn Langford.;Kristen Nanney.;Masiku MdalaGausi.;Phyllis Yeboah.;Peter Morris.;Jamie Sturgill.;Sherif Seif.;Evan Cassity.;Sanjay Dhar.;Marjolein de Wit.;Jessica Mason.;Andrew Goodwin.;Greg Hall.;Abbey Grady.;Amy Chamberlain.;Samuel Brown.;Joseph Bledsoe.;Lindsay Leither.;Ithan Peltan.;Nathan Starr.;Melissa Fergus.;Valerie Aston.;Quinn Montgomery.;Rilee Smith.;Mardee Merrill.;Katie Brown.;Brent Armbruster.;Estelle Harris.;Elizabeth Middleton.;Robert Paine.;Stacy Johnson.;Macy Barrios.;John Eppensteiner.;Alexander Limkakeng.;Lauren McGowan.;Tedra Porter.;Andrew Bouffler.;J. Clancy Leahy.;Bennet deBoisblanc.;Matthew Lammi.;Kyle Happel.;Paula Lauto.;Wesley Self.;Jonathan Casey.;Matthew Semler.;Sean Collins.;Frank Harrell.;Christopher Lindsell.;Todd Rice.;William Stubblefield.;Christopher Gray.;Jakea Johnson.;Megan Roth.;Margaret Hays.;Donna Torr.;Arwa Zakaria.;David Schoenfeld.;Taylor Thompson.;Douglas Hayden.;Nancy Ringwood.;Cathryn Oldmixon.;Christine Ulysse.;Richard Morse.;Ariela Muzikansky.;Laura Fitzgerald.;Samuel Whitaker.;Adrian Lagakos.;Roy Brower.;Lora Reineck.;Neil Aggarwal.;Karen Bienstock.;Michelle Freemer.;Myron Maclawiw.;Gail Weinmann.;Laurie Morrison.;Mark Gillespie.;Richard Kryscio.;Daniel Brodie.;Wojciech Zareba.;Anne Rompalo.;Michael Boeckh.;Polly Parsons.;Jason Christie.;Jesse Hall.;Nicholas Horton.;Laurie Zoloth.;Neal Dickert.;Deborah Diercks.
来源: JAMA. 2020年324卷21期2165-2176页
Data on the efficacy of hydroxychloroquine for the treatment of coronavirus disease 2019 (COVID-19) are needed.
324. Effect of an Online Weight Management Program Integrated With Population Health Management on Weight Change: A Randomized Clinical Trial.
作者: Heather J Baer.;Ronen Rozenblum.;Barbara A De La Cruz.;E John Orav.;Matthew Wien.;Nyryan V Nolido.;Kristina Metzler.;Katherine D McManus.;Florencia Halperin.;Louis J Aronne.;Guadalupe Minero.;Jason P Block.;David W Bates.
来源: JAMA. 2020年324卷17期1737-1746页
Online programs may help with weight loss but have not been widely implemented in routine primary care.
325. Effect of Catheter Ablation With Vein of Marshall Ethanol Infusion vs Catheter Ablation Alone on Persistent Atrial Fibrillation: The VENUS Randomized Clinical Trial.
作者: Miguel Valderrábano.;Leif E Peterson.;Vijay Swarup.;Paul A Schurmann.;Akash Makkar.;Rahul N Doshi.;David DeLurgio.;Charles A Athill.;Kenneth A Ellenbogen.;Andrea Natale.;Jayanthi Koneru.;Amish S Dave.;Irakli Giorgberidze.;Hamid Afshar.;Michelle L Guthrie.;Raquel Bunge.;Carlos A Morillo.;Neal S Kleiman.
来源: JAMA. 2020年324卷16期1620-1628页
Catheter ablation of persistent atrial fibrillation (AF) has limited success. Procedural strategies beyond pulmonary vein isolation have failed to consistently improve results. The vein of Marshall contains innervation and AF triggers that can be ablated by retrograde ethanol infusion.
326. Effect of Regional Citrate Anticoagulation vs Systemic Heparin Anticoagulation During Continuous Kidney Replacement Therapy on Dialysis Filter Life Span and Mortality Among Critically Ill Patients With Acute Kidney Injury: A Randomized Clinical Trial.
作者: Alexander Zarbock.;Mira Küllmar.;Detlef Kindgen-Milles.;Carola Wempe.;Joachim Gerss.;Timo Brandenburger.;Thomas Dimski.;Bartosz Tyczynski.;Michael Jahn.;Nils Mülling.;Martin Mehrländer.;Peter Rosenberger.;Gernot Marx.;Tim Philipp Simon.;Ulrich Jaschinski.;Philipp Deetjen.;Christian Putensen.;Jens-Christian Schewe.;Stefan Kluge.;Dominik Jarczak.;Torsten Slowinski.;Marc Bodenstein.;Patrick Meybohm.;Stefan Wirtz.;Onnen Moerer.;Andreas Kortgen.;Philipp Simon.;Sean M Bagshaw.;John A Kellum.;Melanie Meersch.; .
来源: JAMA. 2020年324卷16期1629-1639页
Although current guidelines suggest the use of regional citrate anticoagulation (which involves the addition of a citrate solution to the blood before the filter of the extracorporeal dialysis circuit) as first-line treatment for continuous kidney replacement therapy in critically ill patients, the evidence for this recommendation is based on few clinical trials and meta-analyses.
327. Effect of Praliciguat on Peak Rate of Oxygen Consumption in Patients With Heart Failure With Preserved Ejection Fraction: The CAPACITY HFpEF Randomized Clinical Trial.
作者: James E Udelson.;Gregory D Lewis.;Sanjiv J Shah.;Michael R Zile.;Margaret M Redfield.;John Burnett.;John Parker.;Jelena P Seferovic.;Phebe Wilson.;Robert S Mittleman.;Albert T Profy.;Marvin A Konstam.
来源: JAMA. 2020年324卷15期1522-1531页
Heart failure with preserved ejection fraction (HFpEF) is often characterized by nitric oxide deficiency.
328. Effect of Vericiguat vs Placebo on Quality of Life in Patients With Heart Failure and Preserved Ejection Fraction: The VITALITY-HFpEF Randomized Clinical Trial.
作者: Paul W Armstrong.;Carolyn S P Lam.;Kevin J Anstrom.;Justin Ezekowitz.;Adrian F Hernandez.;Christopher M O'Connor.;Burkert Pieske.;Piotr Ponikowski.;Sanjiv J Shah.;Scott D Solomon.;Adriaan A Voors.;Lilin She.;Vanja Vlajnic.;Francine Carvalho.;Luke Bamber.;Robert O Blaustein.;Lothar Roessig.;Javed Butler.; .
来源: JAMA. 2020年324卷15期1512-1521页
Patients with heart failure and preserved ejection fraction (HFpEF) are at high risk of mortality, hospitalizations, and reduced functional capacity and quality of life.
329. Effect of Sustained Smoking Cessation Counseling and Provision of Medication vs Shorter-term Counseling and Medication Advice on Smoking Abstinence in Patients Recently Diagnosed With Cancer: A Randomized Clinical Trial.
作者: Elyse R Park.;Giselle K Perez.;Susan Regan.;Alona Muzikansky.;Douglas E Levy.;Jennifer S Temel.;Nancy A Rigotti.;William F Pirl.;Kelly E Irwin.;Ann H Partridge.;Mary E Cooley.;Emily R Friedman.;Julia Rabin.;Colin Ponzani.;Kelly A Hyland.;Susan Holland.;Sarah Borderud.;Kim Sprunck.;Diana Kwon.;Lisa Peterson.;Jacob Miller-Sobel.;Irina Gonzalez.;C Will Whitlock.;Laura Malloy.;Suhana de León-Sanchez.;Maureen O'Brien.;Jamie S Ostroff.
来源: JAMA. 2020年324卷14期1406-1418页
Persistent smoking may cause adverse outcomes among patients with cancer. Many cancer centers have not fully implemented evidence-based tobacco treatment into routine care.
330. Effect of Prophylactic Negative Pressure Wound Therapy vs Standard Wound Dressing on Surgical-Site Infection in Obese Women After Cesarean Delivery: A Randomized Clinical Trial.
作者: Methodius G Tuuli.;Jingxia Liu.;Alan T N Tita.;Sherri Longo.;Amanda Trudell.;Ebony B Carter.;Anthony Shanks.;Candice Woolfolk.;Aaron B Caughey.;David K Warren.;Anthony O Odibo.;Graham Colditz.;George A Macones.;Lorie Harper.
来源: JAMA. 2020年324卷12期1180-1189页
Obesity increases the risk of both cesarean delivery and surgical-site infection. Despite widespread use, it is unclear whether prophylactic negative pressure wound therapy reduces surgical-site infection after cesarean delivery in obese women.
331. Effect of Out-of-Hospital Tranexamic Acid vs Placebo on 6-Month Functional Neurologic Outcomes in Patients With Moderate or Severe Traumatic Brain Injury.
作者: Susan E Rowell.;Eric N Meier.;Barbara McKnight.;Delores Kannas.;Susanne May.;Kellie Sheehan.;Eileen M Bulger.;Ahamed H Idris.;Jim Christenson.;Laurie J Morrison.;Ralph J Frascone.;Patrick L Bosarge.;M Riccardo Colella.;Jay Johannigman.;Bryan A Cotton.;Jeannie Callum.;Jason McMullan.;David J Dries.;Brian Tibbs.;Neal J Richmond.;Myron L Weisfeldt.;John M Tallon.;John S Garrett.;Martin D Zielinski.;Tom P Aufderheide.;Rajesh R Gandhi.;Rob Schlamp.;Bryce R H Robinson.;Jonathan Jui.;Lauren Klein.;Sandro Rizoli.;Mark Gamber.;Michael Fleming.;Jun Hwang.;Laura E Vincent.;Carolyn Williams.;Audrey Hendrickson.;Robert Simonson.;Patricia Klotz.;George Sopko.;William Witham.;Michael Ferrara.;Martin A Schreiber.
来源: JAMA. 2020年324卷10期961-974页
Traumatic brain injury (TBI) is the leading cause of death and disability due to trauma. Early administration of tranexamic acid may benefit patients with TBI.
332. Effect of Multilevel Upper Airway Surgery vs Medical Management on the Apnea-Hypopnea Index and Patient-Reported Daytime Sleepiness Among Patients With Moderate or Severe Obstructive Sleep Apnea: The SAMS Randomized Clinical Trial.
作者: Stuart MacKay.;A Simon Carney.;Peter G Catcheside.;Ching Li Chai-Coetzer.;Michael Chia.;Peter A Cistulli.;John-Charles Hodge.;Andrew Jones.;Billingsley Kaambwa.;Richard Lewis.;Eng H Ooi.;Alison J Pinczel.;Nigel McArdle.;Guy Rees.;Bhajan Singh.;Nicholas Stow.;Edward M Weaver.;Richard J Woodman.;Charmaine M Woods.;Aeneas Yeo.;R Doug McEvoy.
来源: JAMA. 2020年324卷12期1168-1179页
Many adults with obstructive sleep apnea (OSA) use device treatments inadequately and remain untreated.
333. Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.
作者: Derek C Angus.;Lennie Derde.;Farah Al-Beidh.;Djillali Annane.;Yaseen Arabi.;Abigail Beane.;Wilma van Bentum-Puijk.;Lindsay Berry.;Zahra Bhimani.;Marc Bonten.;Charlotte Bradbury.;Frank Brunkhorst.;Meredith Buxton.;Adrian Buzgau.;Allen C Cheng.;Menno de Jong.;Michelle Detry.;Lise Estcourt.;Mark Fitzgerald.;Herman Goossens.;Cameron Green.;Rashan Haniffa.;Alisa M Higgins.;Christopher Horvat.;Sebastiaan J Hullegie.;Peter Kruger.;Francois Lamontagne.;Patrick R Lawler.;Kelsey Linstrum.;Edward Litton.;Elizabeth Lorenzi.;John Marshall.;Daniel McAuley.;Anna McGlothin.;Shay McGuinness.;Bryan McVerry.;Stephanie Montgomery.;Paul Mouncey.;Srinivas Murthy.;Alistair Nichol.;Rachael Parke.;Jane Parker.;Kathryn Rowan.;Ashish Sanil.;Marlene Santos.;Christina Saunders.;Christopher Seymour.;Anne Turner.;Frank van de Veerdonk.;Balasubramanian Venkatesh.;Ryan Zarychanski.;Scott Berry.;Roger J Lewis.;Colin McArthur.;Steven A Webb.;Anthony C Gordon.; .;Farah Al-Beidh.;Derek Angus.;Djillali Annane.;Yaseen Arabi.;Wilma van Bentum-Puijk.;Scott Berry.;Abigail Beane.;Zahra Bhimani.;Marc Bonten.;Charlotte Bradbury.;Frank Brunkhorst.;Meredith Buxton.;Allen Cheng.;Menno De Jong.;Lennie Derde.;Lise Estcourt.;Herman Goossens.;Anthony Gordon.;Cameron Green.;Rashan Haniffa.;Francois Lamontagne.;Patrick Lawler.;Edward Litton.;John Marshall.;Colin McArthur.;Daniel McAuley.;Shay McGuinness.;Bryan McVerry.;Stephanie Montgomery.;Paul Mouncey.;Srinivas Murthy.;Alistair Nichol.;Rachael Parke.;Kathryn Rowan.;Christopher Seymour.;Anne Turner.;Frank van de Veerdonk.;Steve Webb.;Ryan Zarychanski.;Lewis Campbell.;Andrew Forbes.;David Gattas.;Stephane Heritier.;Lisa Higgins.;Peter Kruger.;Sandra Peake.;Jeffrey Presneill.;Ian Seppelt.;Tony Trapani.;Paul Young.;Sean Bagshaw.;Nick Daneman.;Niall Ferguson.;Cheryl Misak.;Marlene Santos.;Sebastiaan Hullegie.;Mathias Pletz.;Gernot Rohde.;Kathy Rowan.;Brian Alexander.;Kim Basile.;Timothy Girard.;Christopher Horvat.;David Huang.;Kelsey Linstrum.;Jennifer Vates.;Richard Beasley.;Robert Fowler.;Steve McGloughlin.;Susan Morpeth.;David Paterson.;Bala Venkatesh.;Tim Uyeki.;Kenneth Baillie.;Eamon Duffy.;Rob Fowler.;Thomas Hills.;Katrina Orr.;Asad Patanwala.;Steve Tong.;Mihai Netea.;Shilesh Bihari.;Marc Carrier.;Dean Fergusson.;Ewan Goligher.;Ghady Haidar.;Beverley Hunt.;Anand Kumar.;Mike Laffan.;Patrick Lawless.;Sylvain Lother.;Peter McCallum.;Saskia Middeldopr.;Zoe McQuilten.;Matthew Neal.;John Pasi.;Roger Schutgens.;Simon Stanworth.;Alexis Turgeon.;Alexandra Weissman.;Neill Adhikari.;Matthew Anstey.;Emily Brant.;Angelique de Man.;Francois Lamonagne.;Marie-Helene Masse.;Andrew Udy.;Donald Arnold.;Phillipe Begin.;Richard Charlewood.;Michael Chasse.;Mark Coyne.;Jamie Cooper.;James Daly.;Iain Gosbell.;Heli Harvala-Simmonds.;Tom Hills.;Sheila MacLennan.;David Menon.;John McDyer.;Nicole Pridee.;David Roberts.;Manu Shankar-Hari.;Helen Thomas.;Alan Tinmouth.;Darrell Triulzi.;Tim Walsh.;Erica Wood.;Carolyn Calfee.;Cecilia O’Kane.;Murali Shyamsundar.;Pratik Sinha.;Taylor Thompson.;Ian Young.;Shailesh Bihari.;Carol Hodgson.;John Laffey.;Danny McAuley.;Neil Orford.;Ary Neto.;Michelle Detry.;Mark Fitzgerald.;Roger Lewis.;Anna McGlothlin.;Ashish Sanil.;Christina Saunders.;Lindsay Berry.;Elizabeth Lorenzi.;Eliza Miller.;Vanessa Singh.;Claire Zammit.;Wilma van Bentum Puijk.;Wietske Bouwman.;Yara Mangindaan.;Lorraine Parker.;Svenja Peters.;Ilse Rietveld.;Kik Raymakers.;Radhika Ganpat.;Nicole Brillinger.;Rene Markgraf.;Kate Ainscough.;Kathy Brickell.;Aisha Anjum.;Janis-Best Lane.;Alvin Richards-Belle.;Michelle Saull.;Daisy Wiley.;Julian Bion.;Jason Connor.;Simon Gates.;Victoria Manax.;Tom van der Poll.;John Reynolds.;Marloes van Beurden.;Evelien Effelaar.;Joost Schotsman.;Craig Boyd.;Cain Harland.;Audrey Shearer.;Jess Wren.;Giles Clermont.;William Garrard.;Kyle Kalchthaler.;Andrew King.;Daniel Ricketts.;Salim Malakoutis.;Oscar Marroquin.;Edvin Music.;Kevin Quinn.;Heidi Cate.;Karen Pearson.;Joanne Collins.;Jane Hanson.;Penny Williams.;Shane Jackson.;Adeeba Asghar.;Sarah Dyas.;Mihaela Sutu.;Sheenagh Murphy.;Dawn Williamson.;Nhlanhla Mguni.;Alison Potter.;David Porter.;Jayne Goodwin.;Clare Rook.;Susie Harrison.;Hannah Williams.;Hilary Campbell.;Kaatje Lomme.;James Williamson.;Jonathan Sheffield.;Willian van’t Hoff.;Phobe McCracken.;Meredith Young.;Jasmin Board.;Emma Mart.;Cameron Knott.;Julie Smith.;Catherine Boschert.;Julia Affleck.;Mahesh Ramanan.;Ramsy D’Souza.;Kelsey Pateman.;Arif Shakih.;Winston Cheung.;Mark Kol.;Helen Wong.;Asim Shah.;Atul Wagh.;Joanne Simpson.;Graeme Duke.;Peter Chan.;Brittney Cartner.;Stephanie Hunter.;Russell Laver.;Tapaswi Shrestha.;Adrian Regli.;Annamaria Pellicano.;James McCullough.;Mandy Tallott.;Nikhil Kumar.;Rakshit Panwar.;Gail Brinkerhoff.;Cassandra Koppen.;Federica Cazzola.;Matthew Brain.;Sarah Mineall.;Roy Fischer.;Vishwanath Biradar.;Natalie Soar.;Hayden White.;Kristen Estensen.;Lynette Morrison.;Joanne Smith.;Melanie Cooper.;Monash Health.;Yahya Shehabi.;Wisam Al-Bassam.;Amanda Hulley.;Christina Whitehead.;Julie Lowrey.;Rebecca Gresha.;James Walsham.;Jason Meyer.;Meg Harward.;Ellen Venz.;Patricia Williams.;Catherine Kurenda.;Kirsy Smith.;Margaret Smith.;Rebecca Garcia.;Deborah Barge.;Deborah Byrne.;Kathleen Byrne.;Alana Driscoll.;Louise Fortune.;Pierre Janin.;Elizabeth Yarad.;Naomi Hammond.;Frances Bass.;Angela Ashelford.;Sharon Waterson.;Steve Wedd.;Robert McNamara.;Heidi Buhr.;Jennifer Coles.;Sacha Schweikert.;Bradley Wibrow.;Rashmi Rauniyar.;Erina Myers.;Ed Fysh.;Ashlish Dawda.;Bhaumik Mevavala.;Ed Litton.;Janet Ferrier.;Priya Nair.;Hergen Buscher.;Claire Reynolds.;John Santamaria.;Leanne Barbazza.;Jennifer Homes.;Roger Smith.;Lauren Murray.;Jane Brailsford.;Loretta Forbes.;Teena Maguire.;Vasanth Mariappa.;Judith Smith.;Scott Simpson.;Matthew Maiden.;Allsion Bone.;Michelle Horton.;Tania Salerno.;Martin Sterba.;Wenli Geng.;Pieter Depuydt.;Jan De Waele.;Liesbet De Bus.;Jan Fierens.;Stephanie Bracke.;Brenda Reeve.;William Dechert.;Michaël Chassé.;François Martin Carrier.;Dounia Boumahni.;Fatna Benettaib.;Ali Ghamraoui.;David Bellemare.;Ève Cloutier.;Charles Francoeur.;François Lamontagne.;Frédérick D’Aragon.;Elaine Carbonneau.;Julie Leblond.;Gloria Vazquez-Grande.;Nicole Marten.;Maggie Wilson.;Martin Albert.;Karim Serri.;Alexandros Cavayas.;Mathilde Duplaix.;Virginie Williams.;Bram Rochwerg.;Tim Karachi.;Simon Oczkowski.;John Centofanti.;Tina Millen.;Erick Duan.;Jennifer Tsang.;Lisa Patterson.;Shane English.;Irene Watpool.;Rebecca Porteous.;Sydney Miezitis.;Lauralyn McIntyre.;Laurent Brochard.;Karen Burns.;Gyan Sandhu.;Imrana Khalid.;Alexandra Binnie.;Elizabeth Powell.;Alexandra McMillan.;Tracy Luk.;Noah Aref.;Zdravko Andric.;Sabina Cviljevic.;Renata Đimoti.;Marija Zapalac.;Gordan Mirković.;Bruno Baršić.;Marko Kutleša.;Viktor Kotarski.;Ana Vujaklija Brajković.;Jakša Babel.;Helena Sever.;Lidija Dragija.;Ira Kušan.;Suvi Vaara.;Leena Pettilä.;Jonna Heinonen.;Anne Kuitunen.;Sari Karlsson.;Annukka Vahtera.;Heikki Kiiski.;Sanna Ristimäki.;Amine Azaiz.;Cyril Charron.;Mathieu Godement.;Guillaume Geri.;Antoine Vieillard-Baron.;Franck Pourcine.;Mehran Monchi.;David Luis.;Romain Mercier.;Anne Sagnier.;Nathalie Verrier.;Cecile Caplin.;Shidasp Siami.;Christelle Aparicio.;Sarah Vautier.;Asma Jeblaoui.;Muriel Fartoukh.;Laura Courtin.;Vincent Labbe.;Cécile Leparco.;Grégoire Muller.;Mai-Anh Nay.;Toufik Kamel.;Dalila Benzekri.;Sophie Jacquier.;Emmanuelle Mercier.;Delphine Chartier.;Charlotte Salmon.;PierreFrançois Dequin.;Francis Schneider.;Guillaume Morel.;Sylvie L’Hotellier.;Julio Badie.;Fernando Daniel Berdaguer.;Sylvain Malfroy.;Chaouki Mezher.;Charlotte Bourgoin.;Bruno Megarbane.;Sebastian Voicu.;Nicolas Deye.;Isabelle Malissin.;Laetitia Sutterlin.;Christophe Guitton.;Cédric Darreau.;Mickaël Landais.;Nicolas Chudeau.;Alain Robert.;Pierre Moine.;Nicholas Heming.;Virginie Maxime.;Isabelle Bossard.;Tiphaine Barbarin Nicholier.;Gwenhael Colin.;Vanessa Zinzoni.;Natacham Maquigneau.;André Finn.;Gabriele Kreß.;Uwe Hoff.;Carl Friedrich Hinrichs.;Jens Nee.;Mathias Pletz.;Stefan Hagel.;Juliane Ankert.;Steffi Kolanos.;Frank Bloos.;Sirak Petros.;Bastian Pasieka.;Kevin Kunz.;Peter Appelt.;Bianka Schütze.;Stefan Kluge.;Axel Nierhaus.;Dominik Jarczak.;Kevin Roedl.;Dirk Weismann.;Anna Frey.;Vivantes Klinikum Neukölln.;Lorenz Reill.;Michael Distler.;Astrid Maselli.;János Bélteczki.;István Magyar.;Ágnes Fazekas.;Sándor Kovács.;Viktória Szőke.;Gábor Szigligeti.;János Leszkoven.;Daniel Collins.;Patrick Breen.;Stephen Frohlich.;Ruth Whelan.;Bairbre McNicholas.;Michael Scully.;Siobhan Casey.;Maeve Kernan.;Peter Doran.;Michael O’Dywer.;Michelle Smyth.;Leanne Hayes.;Oscar Hoiting.;Marco Peters.;Els Rengers.;Mirjam Evers.;Anton Prinssen.;Jeroen Bosch Ziekenhuis.;Koen Simons.;Wim Rozendaal.;F Polderman.;P de Jager.;M Moviat.;A Paling.;A Salet.;Emma Rademaker.;Anna Linda Peters.;E de Jonge.;J Wigbers.;E Guilder.;M Butler.;Keri-Anne Cowdrey.;Lynette Newby.;Yan Chen.;Catherine Simmonds.;Rachael McConnochie.;Jay Ritzema Carter.;Seton Henderson.;Kym Van Der Heyden.;Jan Mehrtens.;Tony Williams.;Alex Kazemi.;Rima Song.;Vivian Lai.;Dinu Girijadevi.;Robert Everitt.;Robert Russell.;Danielle Hacking.;Ulrike Buehner.;Erin Williams.;Troy Browne.;Kate Grimwade.;Jennifer Goodson.;Owen Keet.;Owen Callender.;Robert Martynoga.;Kara Trask.;Amelia Butler.;Livia Schischka.;Chelsea Young.;Eden Lesona.;Shaanti Olatunji.;Yvonne Robertson.;Nuno José.;Teodoro Amaro dos Santos Catorze.;Tiago Nuno Alfaro de Lima Pereira.;Lucilia Maria Neves Pessoa.;Ricardo Manuel Castro Ferreira.;Joana Margarida Pereira Sousa Bastos.;Simin Aysel Florescu.;Delia Stanciu.;Miahela Florentina Zaharia.;Alma Gabriela Kosa.;Daniel Codreanu.;Yaseen Marabi.;Eman Al Qasim.;Mohamned Moneer Hagazy.;Lolowa Al Swaidan.;Hatim Arishi.;Rosana Muñoz-Bermúdez.;Judith Marin-Corral.;Anna Salazar Degracia.;Francisco Parrilla Gómez.;Maria Isabel Mateo López.;Jorge Rodriguez Fernandez.;Sheila Cárcel Fernández.;Rosario Carmona Flores.;Rafael León López.;Carmen de la Fuente Martos.;Angela Allan.;Petra Polgarova.;Neda Farahi.;Stephen McWilliam.;Daniel Hawcutt.;Laura Rad.;Laura O’Malley.;Jennifer Whitbread.;Olivia Kelsall.;Laura Wild.;Jessica Thrush.;Hannah Wood.;Karen Austin.;Adrian Donnelly.;Martin Kelly.;Sinéad O’Kane.;Declan McClintock.;Majella Warnock.;Paul Johnston.;Linda Jude Gallagher.;Clare Mc Goldrick.;Moyra Mc Master.;Anna Strzelecka.;Rajeev Jha.;Michael Kalogirou.;Christine Ellis.;Vinodh Krishnamurthy.;Vashish Deelchand.;Jon Silversides.;Peter McGuigan.;Kathryn Ward.;Aisling O’Neill.;Stephanie Finn.;Barbara Phillips.;Dee Mullan.;Laura Oritz-Ruiz de Gordoa.;Matthew Thomas.;Katie Sweet.;Lisa Grimmer.;Rebekah Johnson.;Jez Pinnell.;Matt Robinson.;Lisa Gledhill.;Tracy Wood.;Matt Morgan.;Jade Cole.;Helen Hill.;Michelle Davies.;David Antcliffe.;Maie Templeton.;Roceld Rojo.;Phoebe Coghlan.;Joanna Smee.;Euan Mackay.;Jon Cort.;Amanda Whileman.;Thomas Spencer.;Nick Spittle.;Vidya Kasipandian.;Amit Patel.;Suzanne Allibone.;Roman Mary Genetu.;Mohamed Ramali.;Alison Ghosh.;Peter Bamford.;Emily London.;Kathryn Cawley.;Maria Faulkner.;Helen Jeffrey.;Tim Smith.;Chris Brewer.;Jane Gregory.;James Limb.;Amanda Cowton.;Julie O’Brien.;Nikitas Nikitas.;Colin Wells.;Liana Lankester.;Mark Pulletz.;Patricia Williams.;Jenny Birch.;Sophie Wiseman.;Sarah Horton.;Ana Alegria.;Salah Turki.;Tarek Elsefi.;Nikki Crisp.;Louise Allen.;Iain McCullagh.;Philip Robinson.;Carole Hays.;Maite Babio-Galan.;Hannah Stevenson.;Divya Khare.;Meredith Pinder.;Selvin Selvamoni.;Amitha Gopinath.;Richard Pugh.;Daniel Menzies.;Callum Mackay.;Elizabeth Allan.;Gwyneth Davies.;Kathryn Puxty.;Claire McCue.;Susanne Cathcart.;Naomi Hickey.;Jane Ireland.;Hakeem Yusuff.;Graziella Isgro.;Chris Brightling.;Michelle Bourne.;Michelle Craner.;Malcolm Watters.;Rachel Prout.;Louisa Davies.;Suzannah Pegler.;Lynsey Kyeremeh.;Gill Arbane.;Karen Wilson.;Linda Gomm.;Federica Francia.;Stephen Brett.;Sonia Sousa Arias.;Rebecca Elin Hall.;Joanna Budd.;Charlotte Small.;Janine Birch.;Emma Collins.;Jeremy Henning.;Stephen Bonner.;Keith Hugill.;Emanuel Cirstea.;Dean Wilkinson.;Michal Karlikowski.;Helen Sutherland.;Elva Wilhelmsen.;Jane Woods.;Julie North.;Dhinesh Sundaran.;Laszlo Hollos.;Susan Coburn.;Joanne Walsh.;Margaret Turns.;Phil Hopkins.;John Smith.;Harriet Noble.;Maria Theresa Depante.;Emma Clarey.;Shondipon Laha.;Mark Verlander.;Alexandra Williams.;Abby Huckle.;Andrew Hall.;Jill Cooke.;Caroline Gardiner-Hill.;Carolyn Maloney.;Hafiz Qureshi.;Neil Flint.;Sarah Nicholson.;Sara Southin.;Andrew Nicholson.;Barbara Borgatta.;Ian Turner-Bone.;Amie Reddy.;Laura Wilding.;Loku Chamara Warnapura.;Ronan Agno Sathianathan.;David Golden.;Ciaran Hart.;Jo Jones.;Jonathan Bannard-Smith.;Joanne Henry.;Katie Birchall.;Fiona Pomeroy.;Rachael Quayle.;Arystarch Makowski.;Beata Misztal.;Iram Ahmed.;Thyra KyereDiabour.;Kevin Naiker.;Richard Stewart.;Esther Mwaura.;Louise Mew.;Lynn Wren.;Felicity Willams.;Richard Innes.;Patricia Doble.;Joanne Hutter.;Charmaine Shovelton.;Benjamin Plumb.;Tamas Szakmany.;Vincent Hamlyn.;Nancy Hawkins.;Sarah Lewis.;Amanda Dell.;Shameer Gopal.;Saibal Ganguly.;Andrew Smallwood.;Nichola Harris.;Stella Metherell.;Juan Martin Lazaro.;Tabitha Newman.;Simon Fletcher.;Jurgens Nortje.;Deirdre Fottrell-Gould.;Georgina Randell.;Mohsin Zaman.;Einas Elmahi.;Andrea Jones.;Kathryn Hall.;Gary Mills.;Kim Ryalls.;Helen Bowler.;Jas Sall.;Richard Bourne.;Zoe Borrill.;Tracey Duncan.;Thomas Lamb.;Joanne Shaw.;Claire Fox.;Jeronimo Moreno Cuesta.;Kugan Xavier.;Dharam Purohit.;Munzir Elhassan.;Dhanalakshmi Bakthavatsalam.;Matthew Rowland.;Paula Hutton.;Archana Bashyal.;Neil Davidson.;Clare Hird.;Manish Chhablani.;Gunjan Phalod.;Amy Kirkby.;Simon Archer.;Kimberley Netherton.;Henrik Reschreiter.;Julie Camsooksai.;Sarah Patch.;Sarah Jenkins.;David Pogson.;Steve Rose.;Zoe Daly.;Lutece Brimfield.;Helen Claridge.;Dhruv Parekh.;Colin Bergin.;Michelle Bates.;Joanne Dasgin.;Christopher McGhee.;Malcolm Sim.;Sophie Kennedy Hay.;Steven Henderson.;Mandeep-Kaur Phull.;Abbas Zaidi.;Tatiana Pogreban.;Lace Paulyn Rosaroso.;Daniel Harvey.;Benjamin Lowe.;Megan Meredith.;Lucy Ryan.;Anil Hormis.;Rachel Walker.;Dawn Collier.;Sarah Kimpton.;Susan Oakley.;Kevin Rooney.;Natalie Rodden.;Emma Hughes.;Nicola Thomson.;Deborah McGlynn.;Andrew Walden.;Nicola Jacques.;Holly Coles.;Emma Tilney.;Emma Vowell.;Martin Schuster-Bruce.;Sally Pitts.;Rebecca Miln.;Laura Purandare.;Luke Vamplew.;Michael Spivey.;Sarah Bean.;Karen Burt.;Lorraine Moore.;Christopher Day.;Charly Gibson.;Elizabeth Gordon.;Letizia Zitter.;Samantha Keenan.;Evelyn Baker.;Shiney Cherian.;Sean Cutler.;Anna Roynon-Reed.;Kate Harrington.;Ajay Raithatha.;Kris Bauchmuller.;Norfaizan Ahmad.;Irina Grecu.;Dawn Trodd.;Jane Martin.;Caroline Wrey Brown.;Ana-Marie Arias.;Thomas Craven.;David Hope.;Jo Singleton.;Sarah Clark.;Nicola Rae.;Ingeborg Welters.;David Oliver Hamilton.;Karen Williams.;Victoria Waugh.;David Shaw.;Zudin Puthucheary.;Timothy Martin.;Filipa Santos.;Ruzena Uddin.;Alastair Somerville.;Kate Colette Tatham.;Shaman Jhanji.;Ethel Black.;Arnold Dela Rosa.;Ryan Howle.;Redmond Tully.;Andrew Drummond.;Joy Dearden.;Jennifer Philbin.;Sheila Munt.;Alain Vuylsteke.;Charles Chan.;Saji Victor.;Ramprasad Matsa.;Minerva Gellamucho.;Ben Creagh-Brown.;Joe Tooley.;Laura Montague.;Fiona De Beaux.;Laetitia Bullman.;Ian Kersiake.;Carrie Demetriou.;Sarah Mitchard.;Lidia Ramos.;Katie White.;Phil Donnison.;Maggie Johns.;Ruth Casey.;Lehentha Mattocks.;Sarah Salisbury.;Paul Dark.;Andrew Claxton.;Danielle McLachlan.;Kathryn Slevin.;Stephanie Lee.;Jonathan Hulme.;Sibet Joseph.;Fiona Kinney.;Ho Jan Senya.;Aneta Oborska.;Abdul Kayani.;Bernard Hadebe.;Rajalakshmi Orath Prabakaran.;Lesley Nichols.;Matt Thomas.;Ruth Worner.;Beverley Faulkner.;Emma Gendall.;Kati Hayes.;Colin Hamilton-Davies.;Carmen Chan.;Celina Mfuko.;Hakam Abbass.;Vineela Mandadapu.;Susannah Leaver.;Daniel Forton.;Kamal Patel.;Elankumaran Paramasivam.;Matthew Powell.;Richard Gould.;Elizabeth Wilby.;Clare Howcroft.;Dorota Banach.;Ziortza Fernández de Pinedo Artaraz.;Leilani Cabreros.;Ian White.;Maria Croft.;Nicky Holland.;Rita Pereira.;Ahmed Zaki.;David Johnson.;Matthew Jackson.;Hywel Garrard.;Vera Juhaz.;Alistair Roy.;Anthony Rostron.;Lindsey Woods.;Sarah Cornell.;Suresh Pillai.;Rachel Harford.;Tabitha Rees.;Helen Ivatt.;Ajay Sundara Raman.;Miriam Davey.;Kelvin Lee.;Russell Barber.;Manish Chablani.;Farooq Brohi.;Vijay Jagannathan.;Michele Clark.;Sarah Purvis.;Bill Wetherill.;Ahilanandan Dushianthan.;Rebecca Cusack.;Kim de Courcy-Golder.;Simon Smith.;Susan Jackson.;Ben Attwood.;Penny Parsons.;Valerie Page.;Xiao Bei Zhao.;Deepali Oza.;Jonathan Rhodes.;Tom Anderson.;Sheila Morris.;Charlotte Xia Le Tai.;Amy Thomas.;Alexandra Keen.;Stephen Digby.;Nicholas Cowley.;Laura Wild.;David Southern.;Harsha Reddy.;Andy Campbell.;Claire Watkins.;Sara Smuts.;Omar Touma.;Nicky Barnes.;Peter Alexander.;Tim Felton.;Susan Ferguson.;Katharine Sellers.;Joanne Bradley-Potts.;David Yates.;Isobel Birkinshaw.;Kay Kell.;Nicola Marshall.;Lisa Carr-Knott.;Charlotte Summers.
来源: JAMA. 2020年324卷13期1317-1329页
Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited.
334. Effect of Dexamethasone on Days Alive and Ventilator-Free in Patients With Moderate or Severe Acute Respiratory Distress Syndrome and COVID-19: The CoDEX Randomized Clinical Trial.
作者: Bruno M Tomazini.;Israel S Maia.;Alexandre B Cavalcanti.;Otavio Berwanger.;Regis G Rosa.;Viviane C Veiga.;Alvaro Avezum.;Renato D Lopes.;Flavia R Bueno.;Maria Vitoria A O Silva.;Franca P Baldassare.;Eduardo L V Costa.;Ricardo A B Moura.;Michele O Honorato.;Andre N Costa.;Lucas P Damiani.;Thiago Lisboa.;Letícia Kawano-Dourado.;Fernando G Zampieri.;Guilherme B Olivato.;Cassia Righy.;Cristina P Amendola.;Roberta M L Roepke.;Daniela H M Freitas.;Daniel N Forte.;Flávio G R Freitas.;Caio C F Fernandes.;Livia M G Melro.;Gedealvares F S Junior.;Douglas Costa Morais.;Stevin Zung.;Flávia R Machado.;Luciano C P Azevedo.; .
来源: JAMA. 2020年324卷13期1307-1316页
Acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19) is associated with substantial mortality and use of health care resources. Dexamethasone use might attenuate lung injury in these patients.
335. Effect of Hydrocortisone on 21-Day Mortality or Respiratory Support Among Critically Ill Patients With COVID-19: A Randomized Clinical Trial.
作者: Pierre-François Dequin.;Nicholas Heming.;Ferhat Meziani.;Gaëtan Plantefève.;Guillaume Voiriot.;Julio Badié.;Bruno François.;Cécile Aubron.;Jean-Damien Ricard.;Stephan Ehrmann.;Youenn Jouan.;Antoine Guillon.;Marie Leclerc.;Carine Coffre.;Hélène Bourgoin.;Céline Lengellé.;Caroline Caille-Fénérol.;Elsa Tavernier.;Sarah Zohar.;Bruno Giraudeau.;Djillali Annane.;Amélie Le Gouge.; .
来源: JAMA. 2020年324卷13期1298-1306页
Coronavirus disease 2019 (COVID-19) is associated with severe lung damage. Corticosteroids are a possible therapeutic option.
336. Effect of Intraoperative Low Tidal Volume vs Conventional Tidal Volume on Postoperative Pulmonary Complications in Patients Undergoing Major Surgery: A Randomized Clinical Trial.
作者: Dharshi Karalapillai.;Laurence Weinberg.;Philip Peyton.;Louise Ellard.;Raymond Hu.;Brett Pearce.;Chong O Tan.;David Story.;Mark O'Donnell.;Patrick Hamilton.;Chad Oughton.;Jonathan Galtieri.;Anthony Wilson.;Ary Serpa Neto.;Glenn Eastwood.;Rinaldo Bellomo.;Daryl A Jones.
来源: JAMA. 2020年324卷9期848-858页
In patients who undergo mechanical ventilation during surgery, the ideal tidal volume is unclear.
337. Effect of Genotype-Guided Oral P2Y12 Inhibitor Selection vs Conventional Clopidogrel Therapy on Ischemic Outcomes After Percutaneous Coronary Intervention: The TAILOR-PCI Randomized Clinical Trial.
作者: Naveen L Pereira.;Michael E Farkouh.;Derek So.;Ryan Lennon.;Nancy Geller.;Verghese Mathew.;Malcolm Bell.;Jang-Ho Bae.;Myung Ho Jeong.;Ivan Chavez.;Paul Gordon.;J Dawn Abbott.;Charles Cagin.;Linnea Baudhuin.;Yi-Ping Fu.;Shaun G Goodman.;Ahmed Hasan.;Erin Iturriaga.;Amir Lerman.;Mandeep Sidhu.;Jean-Francois Tanguay.;Liewei Wang.;Richard Weinshilboum.;Robert Welsh.;Yves Rosenberg.;Kent Bailey.;Charanjit Rihal.
来源: JAMA. 2020年324卷8期761-771页
After percutaneous coronary intervention (PCI), patients with CYP2C19*2 or *3 loss-of-function (LOF) variants treated with clopidogrel have increased risk of ischemic events. Whether genotype-guided selection of oral P2Y12 inhibitor therapy improves ischemic outcomes is unknown.
338. Effect of Vitamin D3 Supplementation on Severe Asthma Exacerbations in Children With Asthma and Low Vitamin D Levels: The VDKA Randomized Clinical Trial.
作者: Erick Forno.;Leonard B Bacharier.;Wanda Phipatanakul.;Theresa W Guilbert.;Michael D Cabana.;Kristie Ross.;Ronina Covar.;James E Gern.;Franziska J Rosser.;Joshua Blatter.;Sandy Durrani.;Yueh-Ying Han.;Stephen R Wisniewski.;Juan C Celedón.
来源: JAMA. 2020年324卷8期752-760页
Severe asthma exacerbations cause significant morbidity and costs. Whether vitamin D3 supplementation reduces severe childhood asthma exacerbations is unclear.
339. Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19: A Randomized Clinical Trial.
作者: Christoph D Spinner.;Robert L Gottlieb.;Gerard J Criner.;José Ramón Arribas López.;Anna Maria Cattelan.;Alex Soriano Viladomiu.;Onyema Ogbuagu.;Prashant Malhotra.;Kathleen M Mullane.;Antonella Castagna.;Louis Yi Ann Chai.;Meta Roestenberg.;Owen Tak Yin Tsang.;Enos Bernasconi.;Paul Le Turnier.;Shan-Chwen Chang.;Devi SenGupta.;Robert H Hyland.;Anu O Osinusi.;Huyen Cao.;Christiana Blair.;Hongyuan Wang.;Anuj Gaggar.;Diana M Brainard.;Mark J McPhail.;Sanjay Bhagani.;Mi Young Ahn.;Arun J Sanyal.;Gregory Huhn.;Francisco M Marty.; .
来源: JAMA. 2020年324卷11期1048-1057页
Remdesivir demonstrated clinical benefit in a placebo-controlled trial in patients with severe coronavirus disease 2019 (COVID-19), but its effect in patients with moderate disease is unknown.
340. Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
作者: Ari Moskowitz.;David T Huang.;Peter C Hou.;Jonathan Gong.;Pratik B Doshi.;Anne V Grossestreuer.;Lars W Andersen.;Long Ngo.;Robert L Sherwin.;Katherine M Berg.;Maureen Chase.;Michael N Cocchi.;Jessica B McCannon.;Mark Hershey.;Ayelet Hilewitz.;Maksim Korotun.;Lance B Becker.;Ronny M Otero.;Junior Uduman.;Ayan Sen.;Michael W Donnino.; .
来源: JAMA. 2020年324卷7期642-650页
The combination of ascorbic acid, corticosteroids, and thiamine has been identified as a potential therapy for septic shock.
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