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3361. The Vasodilator-Heart Failure Trials (V-HeFT). Mechanistic data from the VA Cooperative Studies. Introduction.3362. Effect of picotamide on the clinical progression of peripheral vascular disease. A double-blind placebo-controlled study. The ADEP Group.
Patients with peripheral vascular disease (PVD) undergo a clinical course that can be complicated by cardiovascular events occurring in several areas of the circulation.
3363. A randomized, prospective comparison of anterior and posterior approaches to radiofrequency catheter ablation of atrioventricular nodal reentry tachycardia.
作者: J J Langberg.;A Leon.;M Borganelli.;S J Kalbfleisch.;R el-Atassi.;H Calkins.;F Morady.
来源: Circulation. 1993年87卷5期1551-6页
Two different techniques have been developed for radiofrequency catheter ablation of typical atrioventricular nodal reentry (AVNRT). Lesions made anteriorly near the apex of the triangle of Koch usually eliminate fast pathway function, whereas lesions made posteriorly near the ostium of the coronary sinus selectively affect slow pathway function. The current study compares the safety, efficacy, and electrophysiological effects of these two techniques in a prospective, randomized fashion.
3364. Aspirin versus coumadin in the prevention of reocclusion and recurrent ischemia after successful thrombolysis: a prospective placebo-controlled angiographic study. Results of the APRICOT Study.
作者: A Meijer.;F W Verheugt.;C J Werter.;K I Lie.;J M van der Pol.;M J van Eenige.
来源: Circulation. 1993年87卷5期1524-30页
Successful coronary thrombolysis involves a risk for reocclusion that cannot be prevented by invasive strategies. Therefore, we studied the effects of three antithrombotic regimens on the angiographic and clinical courses after successful thrombolysis.
3365. Effects of captopril on ischemia and dysfunction of the left ventricle after myocardial infarction.
Treatment with angiotensin converting enzyme inhibitors has been shown to be beneficial in patients with heart failure and myocardial infarction. Experimental studies have shown beneficial effects on the ischemic myocardium.
3366. Comparison of angioplasty and surgery for unoperated coarctation of the aorta.
作者: R E Shaddy.;M M Boucek.;J E Sturtevant.;H D Ruttenberg.;R B Jaffe.;L Y Tani.;V E Judd.;L G Veasy.;E C McGough.;G S Orsmond.
来源: Circulation. 1993年87卷3期793-9页
The use of balloon coarctation angioplasty instead of surgery as treatment for unoperated coarctation of the aorta is controversial. The efficacy and complications of the two procedures have not been studied before in a prospective fashion.
3367. Determinants of predicted efficacy of antiarrhythmic drugs in the electrophysiologic study versus electrocardiographic monitoring trial. The ESVEM Investigators.
来源: Circulation. 1993年87卷2期323-9页
The Electrophysiologic Study Versus Electrocardiographic Monitoring (ESVEM) study was designed to compare the accuracy of predictions of antiarrhythmic drug efficacy made by electrophysiological study (EPS) with those made by Holter monitoring (HM) combined with exercise testing. The present study describes the baseline characteristics and the response to drug efficacy tests of 486 randomized subjects.
3368. Early effects of tissue-type plasminogen activator added to conventional therapy on the culprit coronary lesion in patients presenting with ischemic cardiac pain at rest. Results of the Thrombolysis in Myocardial Ischemia (TIMI IIIA) Trial.
来源: Circulation. 1993年87卷1期38-52页
The early effects of tissue-type plasminogen activator (t-PA) on the "culprit" coronary lesion in patients presenting with unstable angina or non-Q wave myocardial infarction were determined by quantitative arteriography.
3369. Indobufen in the prevention of thromboembolic complications in patients with heart disease. A randomized, placebo-controlled, double-blind study.
作者: G Fornaro.;P Rossi.;P G Mantica.;M E Caccia.;D Aralda.;M Lavezzari.;F Pamparana.;G Milanesi.
来源: Circulation. 1993年87卷1期162-4页
The purpose of this randomized, double-blind study was to evaluate the efficacy of indobufen, a reversible inhibitor of platelet cyclooxygenase, in the prevention of embolic events of cardiac origin.
3370. A prospective, placebo-controlled, randomized trial of intravenous streptokinase and angioplasty versus lone angioplasty therapy of acute myocardial infarction.
作者: W W O'Neill.;R Weintraub.;C L Grines.;T B Meany.;B R Brodie.;H Z Friedman.;R G Ramos.;V Gangadharan.;R N Levin.;N Choksi.
来源: Circulation. 1992年86卷6期1710-7页
The value of routine administration of intravenous thrombolytic agents during percutaneous transluminal coronary angioplasty (PTCA) therapy of acute myocardial infarction (MI) has not been determined. Therefore, we prospectively randomized 122 patients with evolving MI to PTCA therapy with or without adjunctive intravenous streptokinase therapy.
3371. Interposed abdominal compression-cardiopulmonary resuscitation and resuscitation outcome during asystole and electromechanical dissociation.
Coronary perfusion pressure has been shown to be a significant determinant of return of spontaneous circulation from cardiac arrest during asystole and electromechanical dissociation. The addition of interposed abdominal compression to otherwise standard cardiopulmonary resuscitation (CPR) increases coronary perfusion pressure in animal and human models.
3372. Alternative techniques of cardioplegia.
作者: T M Yau.;R D Weisel.;D A Mickle.;M Komeda.;J Ivanov.;S Carson.;M K Mohabeer.;L C Tumiati.
来源: Circulation. 1992年86卷5 Suppl期II377-84页
Although normothermic cardioplegia has been used with acceptable clinical results, no studies have previously been performed to determine the metabolic consequences of these various techniques of myocardial protection. Therefore, we have performed a randomized clinical trial to assess the effects of three cardioplegic techniques on myocardial metabolic recovery.
3373. Photopheresis versus corticosteroids in the therapy of heart transplant rejection. Preliminary clinical report.
作者: M R Costanzo-Nordin.;E A Hubbell.;E J O'Sullivan.;M R Johnson.;G M Mullen.;A L Heroux.;W G Kao.;B M McManus.;R Pifarre.;J A Robinson.
来源: Circulation. 1992年86卷5 Suppl期II242-50页
Photopheresis is a technique in which reinfusion of mononuclear cells exposed to UV-A light ex vivo after in vivo treatment with 8-methoxypsoralen initiates host-immunosuppressive responses.
3374. Pharmacokinetics and pharmacodynamics of intravenous diltiazem in patients with atrial fibrillation or atrial flutter.
Diltiazem, a calcium channel blocker, has been shown to be safe and effective in the treatment of patients in atrial fibrillation and/or atrial flutter. However, there have been no pharmacokinetic/pharmacodynamic studies of diltiazem in these patients.
3375. A randomized comparison of external and internal cardioversion of chronic atrial fibrillation.
作者: S Lévy.;P Lauribe.;E Dolla.;W Kou.;A Kadish.;H Calkins.;F Pagannelli.;C Moyal.;M Bremondy.;A Schork.
来源: Circulation. 1992年86卷5期1415-20页
Delivery of shocks within the right atrium has been reported to be more effective than conventional external shocks in converting atrial fibrillation (AF), but these two cardioversion techniques have never been compared prospectively. The purpose of this study was to compare the efficacies of external and internal cardioversion in patients with chronic AF unresponsive to prior attempts at electrical and/or pharmacological cardioversion. Low-dose amiodarone was used in all patients after cardioversion to suppress recurrences of AF.
3376. Randomized trial of thrombolysis versus heparin in unstable angina.
作者: T L Schreiber.;D Rizik.;C White.;G V Sharma.;M Cowley.;G Macina.;P S Reddy.;L Kantounis.;G C Timmis.;A Margulis.
来源: Circulation. 1992年86卷5期1407-14页
The clinical usefulness of intravenous thrombolytic therapy in unstable angina is currently unknown, despite the pathogenetic similarity of this entity to acute myocardial infarction, for which thrombolysis has enjoyed great success. To compare the clinical benefit of intravenous urokinase with that of conventional antithrombotic therapy in preventing the progression of unstable angina to new myocardial infarction, intractable angina, or death within the first 96 hours after hospitalization, 149 patients with unstable angina were randomized to one of two intravenous thrombolytic strategies.
3377. Randomized trial of late elective angioplasty versus conservative management for patients with residual stenoses after thrombolytic treatment of myocardial infarction. Treatment of Post-Thrombolytic Stenoses (TOPS) Study Group.
作者: S G Ellis.;M R Mooney.;B S George.;E E da Silva.;J D Talley.;W H Flanagan.;E J Topol.
来源: Circulation. 1992年86卷5期1400-6页
After thrombolytic therapy for patients with acute myocardial infarction (MI), percutaneous transluminal coronary angioplasty (PTCA) is frequently performed because of the presence of a "significant" infarct vessel stenosis demonstrated at predischarge coronary angiography. Several studies have shown PTCA performed early after thrombolysis to be unnecessary or even harmful. However, PTCA in these trials was generally performed 1-3 days after MI, when the milieu in the infarct artery may be unsuited for PTCA, and the incidence of major ischemic complications was high. To date, no trial has assessed whether delayed PTCA (4-14 days) should be performed in patients without evidence of ischemia on stress testing.
3378. Highly variable anticoagulant response after subcutaneous administration of high-dose (12,500 IU) heparin in patients with myocardial infarction and healthy volunteers.
作者: C Kroon.;W R ten Hove.;A de Boer.;J M Kroon.;J M van der Pol.;E J Harthoorn-Lasthuizen.;H C Schoemaker.;F J van der Meer.;A F Cohen.
来源: Circulation. 1992年86卷5期1370-5页
In this study, the anticoagulant response of 12,500 IU heparin s.c. was investigated in patients with myocardial infarction and healthy volunteers to determine variabilities in response and modifying factors.
3379. Active skeletal muscle mass and cardiopulmonary reserve. Failure to attain peak aerobic capacity during maximal bicycle exercise in patients with severe congestive heart failure.
作者: G Jondeau.;S D Katz.;L Zohman.;M Goldberger.;M McCarthy.;J P Bourdarias.;T H LeJemtel.
来源: Circulation. 1992年86卷5期1351-6页
In addition to depressed cardiac reserve, peripheral factors may contribute to limit maximal exercise capacity in patients with congestive heart failure (CHF). To investigate the role of reduced active skeletal muscle mass, peak oxygen uptake (VO2, milligrams per kilogram per minute) was determined during maximal symptom-limited exercise involving the lower limbs (LL) alone and the lower limbs and upper limbs (LL+UL) combined in patients with CHF and in normal subjects of similar age and sex.
3380. Aprotinin prevents cardiopulmonary bypass-induced platelet dysfunction. A scanning electron microscope study.
Administration of aprotinin during extracorporeal circulation reduces blood loss and improves platelet function.
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