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3321. Low-density lipoprotein level reduction by the 3-hydroxy-3-methylglutaryl coenzyme-A inhibitor simvastatin is accompanied by a related reduction of F2-isoprostane formation in hypercholesterolemic subjects: no further effect of vitamin E.
作者: Raffaele De Caterina.;Francesco Cipollone.;Francesca Paola Filardo.;Marco Zimarino.;Walter Bernini.;Guido Lazzerini.;Tonino Bucciarelli.;Angela Falco.;Paola Marchesani.;Raffaella Muraro.;Andrea Mezzetti.;Giovanni Ciabattoni.
来源: Circulation. 2002年106卷20期2543-9页
Both statins and vitamin E, by reducing the rate of lipid peroxidation, may interfere with oxidative stress, but the impact of their combination is unknown.
3322. Non-high-density lipoprotein cholesterol levels predict five-year outcome in the Bypass Angioplasty Revascularization Investigation (BARI).
作者: Vera Bittner.;Regina Hardison.;Sheryl F Kelsey.;Bonnie H Weiner.;Alice K Jacobs.;George Sopko.; .
来源: Circulation. 2002年106卷20期2537-42页
Current National Cholesterol Education Program guidelines recommend that non-high-density lipoprotein cholesterol (non-HDL-C) be considered a secondary target of therapy among individuals with triglycerides >2.26 mmol/L. It is not known whether non-HDL-C relates to prognosis among patients with coronary heart disease.
3323. Distinctive electrophysiological properties of pulmonary veins in patients with atrial fibrillation.
作者: Pierre Jaïs.;Mélèze Hocini.;Laurent Macle.;Kee-Joon Choi.;Isabel Deisenhofer.;Rukshen Weerasooriya.;Dipen C Shah.;Stéphane Garrigue.;Florence Raybaud.;Christophe Scavee.;Philippe Le Metayer.;Jacques Clémenty.;Michel Haïssaguerre.
来源: Circulation. 2002年106卷19期2479-85页
Atrial fibrillation (AF) is frequently initiated from pulmonary veins (PVs), but little is known of the electrophysiological properties of PVs.
3324. Ambulatory electrocardiographic evidence of transmural dispersion of repolarization in patients with long-QT syndrome type 1 and 2.
作者: Matti Viitasalo.;Lasse Oikarinen.;Heikki Swan.;Heikki Väänänen.;Kathy Glatter.;Päivi J Laitinen.;Kimmo Kontula.;Hal V Barron.;Lauri Toivonen.;Melvin M Scheinman.
来源: Circulation. 2002年106卷19期2473-8页
Transmural dispersion of repolarization (TDR) may be related to the genesis of torsade de pointes (TdP) in patients with the long-QT (LQT) syndrome. Experimentally, LQT2 models show increased TDR compared with LQT1, and beta-adrenergic stimulation increases TDR in both models. Clinically, LQT1 patients experience symptoms at elevated heart rates, but LQT2 patients do so at lower rates. The interval from T-wave peak to T-wave end (TPE interval) is the clinical counterpart of TDR. We explored the relationship of TPE interval to heart rate and to the presence of symptoms in patients with LQT1 and LQT2.
3325. Paradoxical effect of sibutramine on autonomic cardiovascular regulation.
作者: Andreas L Birkenfeld.;Christoph Schroeder.;Michael Boschmann.;Jens Tank.;Gabi Franke.;Friedrich C Luft.;Italo Biaggioni.;Arya M Sharma.;Jens Jordan.
来源: Circulation. 2002年106卷19期2459-65页
Sibutramine, a serotonin and norepinephrine transporter blocker, is widely used as an adjunctive obesity treatment. Norepinephrine reuptake inhibition with sibutramine conceivably could exacerbate arterial hypertension and promote cardiovascular disease.
3326. Effects of valsartan on circulating brain natriuretic peptide and norepinephrine in symptomatic chronic heart failure: the Valsartan Heart Failure Trial (Val-HeFT).
作者: Roberto Latini.;Serge Masson.;Inder Anand.;Dianne Judd.;Aldo P Maggioni.;Yann-Tong Chiang.;Maurizio Bevilacqua.;Monica Salio.;Paola Cardano.;Peter H J M Dunselman.;Nicolaas J Holwerda.;Gianni Tognoni.;Jay N Cohn.; .
来源: Circulation. 2002年106卷19期2454-8页
Brain natriuretic peptide (BNP) and norepinephrine (NE) are strongly related to severity of and are independent predictors of outcome in heart failure. The long-term effects of angiotensin receptor blockers on BNP and NE in heart failure patients are not known.
3327. Potential role of autoantibodies belonging to the immunoglobulin G-3 subclass in cardiac dysfunction among patients with dilated cardiomyopathy.
作者: Alexander Staudt.;Marko Böhm.;Fabian Knebel.;Yvonne Grosse.;Claudia Bischoff.;Astrid Hummel.;Johannes B Dahm.;Adrian Borges.;Nicoline Jochmann.;Klaus D Wernecke.;Gerd Wallukat.;Gert Baumann.;Stephan B Felix.
来源: Circulation. 2002年106卷19期2448-53页
Immunoadsorption capable of removing circulating autoantibodies represents an additional therapeutic approach in dilated cardiomyopathy (DCM). The role played by autoantibodies belonging to the immunoglobulin (Ig) subclass G-3 in cardiac dysfunction remains to be elucidated.
3328. Elevated numbers of tissue-factor exposing microparticles correlate with components of the metabolic syndrome in uncomplicated type 2 diabetes mellitus.
作者: Michaela Diamant.;Rienk Nieuwland.;Renée F Pablo.;Augueste Sturk.;Jan W A Smit.;Jasper K Radder.
来源: Circulation. 2002年106卷19期2442-7页
Type 2 diabetes is associated with accelerated atherosclerosis. Because cell-derived microparticles support coagulation and inflammation, they may be involved in atherogenesis. We characterized circulating microparticles both in patients with uncomplicated, well-regulated type 2 diabetes and in healthy subjects, as well as their relationship with coagulation and metabolic control.
3329. Reduced progression of early carotid atherosclerosis after antibiotic treatment and Chlamydia pneumoniae seropositivity.
作者: Dirk Sander.;Kerstin Winbeck.;Jürgen Klingelhöfer.;Thorleif Etgen.;Bastian Conrad.
来源: Circulation. 2002年106卷19期2428-33页
Chlamydia pneumoniae (Cp) infection has been associated with atherosclerosis, and a beneficial effect of antibiotic therapy on future cardiovascular events was described.
3330. Calcium antagonist lacidipine slows down progression of asymptomatic carotid atherosclerosis: principal results of the European Lacidipine Study on Atherosclerosis (ELSA), a randomized, double-blind, long-term trial.
作者: Alberto Zanchetti.;M Gene Bond.;Michael Hennig.;Albrecht Neiss.;Giuseppe Mancia.;Cesare Dal Palù.;Lennart Hansson.;Bruno Magnani.;Karl-Heinz Rahn.;John L Reid.;Josè Rodicio.;Michel Safar.;Lothar Eckes.;Paolo Rizzini.; .
来源: Circulation. 2002年106卷19期2422-7页
Most cardiovascular events associated with hypertension are complications of atherosclerosis. Some antihypertensive agents influence experimental models of atherosclerosis through mechanisms independent of blood pressure lowering.
3331. Cardiac troponin I predicts short-term mortality in vascular surgery patients.
作者: Lauren J Kim.;Elizabeth A Martinez.;Nauder Faraday.;Todd Dorman.;Lee A Fleisher.;Bruce A Perler.;G Melville Williams.;Daniel Chan.;Peter J Pronovost.
来源: Circulation. 2002年106卷18期2366-71页
Cardiac troponin I (cTnI) is a highly sensitive and specific marker for myocardial injury that predicts outcomes in patients with acute coronary syndromes. Cardiovascular complications are the leading cause of morbidity and mortality in patients who have undergone vascular surgery. However, postoperative surveillance with cardiac enzymes is not routinely performed in these patients. We evaluated the association between postoperative cTnI levels and 6-month mortality and perioperative myocardial infarction (MI) after vascular surgery.
3332. Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes.
作者: David S Goldstein.;Courtney Holmes.;Steven M Frank.;Raghuveer Dendi.;Richard O Cannon.;Yehonatan Sharabi.;Murray D Esler.;Graeme Eisenhofer.
来源: Circulation. 2002年106卷18期2358-65页
In postural tachycardia syndrome (POTS) and repeated neurocardiogenic presyncope (NCS), orthostatic intolerance occurs without persistent sympathetic neurocirculatory failure. Whether these conditions involve abnormal cardiac sympathetic innervation or function has been unclear.
3333. Left ventricular remodeling after primary coronary angioplasty: patterns of left ventricular dilation and long-term prognostic implications.
作者: Leonardo Bolognese.;Aleksandar N Neskovic.;Guido Parodi.;Giampaolo Cerisano.;Piergiovanni Buonamici.;Giovanni M Santoro.;David Antoniucci.
来源: Circulation. 2002年106卷18期2351-7页
We prospectively evaluated the prevalence, pattern, and prognostic impact of left ventricular (LV) remodeling after acute myocardial infarction (AMI) successfully treated with primary PTCA. The prevalence, course, and prognostic value of LV remodeling after primary PTCA are still to be clarified.
3334. Reproducibility of chronic infarct size measurement by contrast-enhanced magnetic resonance imaging.
作者: Heiko Mahrholdt.;Anja Wagner.;Thomas A Holly.;Michael D Elliott.;Robert O Bonow.;Raymond J Kim.;Robert M Judd.
来源: Circulation. 2002年106卷18期2322-7页
The reproducibility of contrast-enhanced MRI has not been established. We compared MRI reproducibility for infarct size determination with that of (99m)Tc-sestamibi (MIBI) single photon emission computed tomography (SPECT).
3335. Efficacy and safety of statin therapy in children with familial hypercholesterolemia: a randomized, double-blind, placebo-controlled trial with simvastatin.
作者: Saskia de Jongh.;Leiv Ose.;Tamás Szamosi.;Claude Gagné.;M Lambert.;Russell Scott.;P Perron.;Dries Dobbelaere.;M Saborio.;Mary B Tuohy.;Michael Stepanavage.;Aditi Sapre.;Barry Gumbiner.;Michele Mercuri.;A S Paul van Trotsenburg.;Henk D Bakker.;John J P Kastelein.; .
来源: Circulation. 2002年106卷17期2231-7页
A multicenter, randomized, double-blind, placebo-controlled study was conducted to evaluate LDL cholesterol-lowering efficacy, overall safety, and tolerability and the influence on growth and pubertal development of simvastatin in a large cohort of boys and girls with heterozygous familial hypercholesterolemia (heFH).
3336. Effect of carvedilol on the morbidity of patients with severe chronic heart failure: results of the carvedilol prospective randomized cumulative survival (COPERNICUS) study.
作者: Milton Packer.;Michael B Fowler.;Ellen B Roecker.;Andrew J S Coats.;Hugo A Katus.;Henry Krum.;Paul Mohacsi.;Jean L Rouleau.;Michal Tendera.;Christoph Staiger.;Terry L Holcslaw.;Ildiko Amann-Zalan.;David L DeMets.; .
来源: Circulation. 2002年106卷17期2194-9页
Beta-blocking agents improve functional status and reduce morbidity in mild-to-moderate heart failure, but it is not known whether they produce such benefits in severe heart failure.
3337. Anti-tumor necrosis factor-alpha treatment improves endothelial function in patients with rheumatoid arthritis.
作者: David Hürlimann.;Adrian Forster.;Georg Noll.;Frank Enseleit.;Rémy Chenevard.;Oliver Distler.;Markus Béchir.;Lukas E Spieker.;Michel Neidhart.;Beat A Michel.;Renate E Gay.;Thomas F Lüscher.;Steffen Gay.;Frank Ruschitzka.
来源: Circulation. 2002年106卷17期2184-7页
Rheumatoid arthritis (RA) is associated with accelerated atherosclerosis and increased cardiovascular morbidity and mortality. Striking similarities exist in the inflammatory and immunologic response in RA and atherosclerosis. Indeed, adhesion molecules and cytokines, tumor necrosis factor (TNF)-alpha in particular, are key mediators of joint inflammation and of vascular dysfunction and progression of atherosclerotic vascular disease. Hence, the aim of the present study was to assess the effect of chronic antiinflammatory treatment with the anti-TNF-alpha antibody infliximab on disease activity and endothelial function in patients with active RA.
3338. Preprocedural statin medication reduces the extent of periprocedural non-Q-wave myocardial infarction.
作者: Joerg Herrmann.;Amir Lerman.;Dietrich Baumgart.;Lothar Volbracht.;Rainer Schulz.;Clemens von Birgelen.;Michael Haude.;Gerd Heusch.;Raimund Erbel.
来源: Circulation. 2002年106卷17期2180-3页
Stenting-related myocardial injury has been recognized as a frequent and prognostically important event, the extent of which depends on microcirculatory impairment in association with platelet aggregation, inflammation, and increased oxidative stress. Recent studies underscored the non-lipid-lowering effects of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) with antithrombotic, antiinflammatory, and antioxidative aspects. Thus, we tested the hypothesis that preprocedural statin therapy is associated with a reduction in the extent of stenting-related myocardial injury.
3339. Sequential versus simultaneous biventricular resynchronization for severe heart failure: evaluation by tissue Doppler imaging.
作者: Peter Sogaard.;Henrik Egeblad.;Anders K Pedersen.;Won Yong Kim.;Bent O Kristensen.;Peter S Hansen.;Peter T Mortensen.
来源: Circulation. 2002年106卷16期2078-84页
Cardiac resynchronization therapy (CRT) by means of simultaneous biventricular pacing improves left ventricular systolic performance and synchrony in patients with heart failure and bundle-branch block. We used tissue tracking and 3D echocardiography to evaluate the impact of sequential CRT with individualized interventricular delay programming.
3340. ARBITER: Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol: a randomized trial comparing the effects of atorvastatin and pravastatin on carotid intima medial thickness.
作者: Allen J Taylor.;Steven M Kent.;Patrick J Flaherty.;Louis C Coyle.;Thor T Markwood.;Marina N Vernalis.
来源: Circulation. 2002年106卷16期2055-60页
Whether marked LDL reduction to levels well below 100 mg/dL would further reduce the burden of cardiovascular disease is controversial. We compared the effects of 2 statins with widely differing potencies for LDL reduction (pravastatin 40 mg/d and atorvastatin 80 mg/d) on carotid intima-media thickness (CIMT).
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