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3261. Identification of hibernating myocardium with quantitative intravenous myocardial contrast echocardiography: comparison with dobutamine echocardiography and thallium-201 scintigraphy.
作者: Sarah Shimoni.;Nikolaos G Frangogiannis.;Constadina J Aggeli.;Kesavan Shan.;Mario S Verani.;Miguel A Quinones.;Rafael Espada.;George V Letsou.;Gerald M Lawrie.;William L Winters.;Michael J Reardon.;William A Zoghbi.
来源: Circulation. 2003年107卷4期538-44页
There are currently no data on the accuracy of intravenous myocardial contrast echocardiography (MCE) in detecting myocardial hibernation in man and its comparative accuracy to dobutamine echocardiography (DE) or thallium 201 (Tl(201)) scintigraphy.
3262. Detecting acute coronary syndrome in the emergency department with cardiac magnetic resonance imaging.
作者: Raymond Y Kwong.;Adam E Schussheim.;Suresh Rekhraj.;Anthony H Aletras.;Nancy Geller.;Janice Davis.;Timothy F Christian.;Robert S Balaban.;Andrew E Arai.
来源: Circulation. 2003年107卷4期531-7页
Managing chest pain in the emergency department remains a challenge with current diagnostic strategies. We hypothesized that cardiac MRI could accurately identify patients with possible or probable acute coronary syndrome.
3263. Prognostic significance of angiogenic growth factor serum levels in patients with acute coronary syndromes.
作者: Christopher Heeschen.;Stefanie Dimmeler.;Christian W Hamm.;Eric Boersma.;Andreas M Zeiher.;Maarten L Simoons.; .
来源: Circulation. 2003年107卷4期524-30页
In patients with acute coronary syndromes, compensatory processes are initiated, including angiogenesis and endothelial regeneration of ruptured or eroded plaques. Angiogenic growth factors like vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), and basic fibroblast growth factor (bFGF) are upregulated during ischemia. However, it is unknown whether their serum levels are related to clinical outcome.
3264. Paclitaxel coating reduces in-stent intimal hyperplasia in human coronary arteries: a serial volumetric intravascular ultrasound analysis from the Asian Paclitaxel-Eluting Stent Clinical Trial (ASPECT).
作者: Myeong-Ki Hong.;Gary S Mintz.;Cheol Whan Lee.;Jong-Min Song.;Ki-Hoon Han.;Duk-Hyun Kang.;Jae-Kwan Song.;Jae-Joong Kim.;Neil J Weissman.;Neal E Fearnot.;Seong-Wook Park.;Seung-Jung Park.; .
来源: Circulation. 2003年107卷4期517-20页
The aim of this study was to use serial volumetric intravascular ultrasound (IVUS) to evaluate the effect of a paclitaxel coating on in-stent intimal hyperplasia (IH).
3265. Alcohol consumption and plasma concentration of C-reactive protein.
Moderate alcohol intake has been associated with lower cardiovascular mortality. However, data evaluating the relationship between C-reactive protein (CRP), a predictor of cardiovascular risk, and alcohol consumption are sparse.
3266. Long-term results after the glycoprotein IIb/IIIa inhibitor abciximab in unstable angina: one-year survival in the GUSTO IV-ACS (Global Use of Strategies To Open Occluded Coronary Arteries IV--Acute Coronary Syndrome) Trial.
作者: J P Ottervanger.;P Armstrong.;E S Barnathan.;E Boersma.;J S Cooper.;E M Ohman.;S James.;E Topol.;L Wallentin.;M L Simoons.; .
来源: Circulation. 2003年107卷3期437-42页
This study was designed to investigate long-term effects of the glycoprotein IIb/IIIa inhibitor abciximab in patients with acute coronary syndrome without ST elevation who were not scheduled for coronary intervention.
3267. Acute intravenous L-arginine infusion decreases endothelin-1 levels and improves endothelial function in patients with angina pectoris and normal coronary arteriograms: correlation with asymmetric dimethylarginine levels.
作者: PierMarco Piatti.;Gabriele Fragasso.;Lucilla D Monti.;Emanuela Setola.;Pietro Lucotti.;Isabella Fermo.;Rita Paroni.;Elena Galluccio.;Guido Pozza.;Sergio Chierchia.;Alberto Margonato.
来源: Circulation. 2003年107卷3期429-36页
We tested the hypothesis that asymmetric dimethylarginine (ADMA) levels could be elevated and influence endothelin-1 and nitric oxide release and action in patients with cardiac syndrome X (CSX). In addition, we evaluated whether an intravenous infusion of L-arginine would improve endothelial function in these subjects.
3268. Effect of nifedipine and cerivastatin on coronary endothelial function in patients with coronary artery disease: the ENCORE I Study (Evaluation of Nifedipine and Cerivastatin On Recovery of coronary Endothelial function).
Endothelial dysfunction is an important feature of atherosclerosis. Inhibition of the HMG-CoA pathway and of calcium channels improves endothelial function experimentally and in the forearm circulation. Thus, we investigated the effects of a statin and/or a calcium antagonist on coronary endothelial function in patients with coronary artery disease (CAD).
3269. Xanthine oxidase inhibition reverses endothelial dysfunction in heavy smokers.
作者: Sashi Guthikonda.;Christine Sinkey.;Therese Barenz.;William G Haynes.
来源: Circulation. 2003年107卷3期416-21页
Cigarette smoking causes endothelial dysfunction, possibly through increased oxidant stress. The enzyme xanthine oxidase produces oxidative free radicals. We tested the hypothesis that xanthine oxidase contributes to endothelial dysfunction in cigarette smokers by administering the inhibitor allopurinol.
3270. Selective COX-2 inhibition improves endothelial function in coronary artery disease.
作者: Rémy Chenevard.;David Hürlimann.;Markus Béchir.;Frank Enseleit.;Lukas Spieker.;Matthias Hermann.;Walter Riesen.;Steffen Gay.;Renate E Gay.;Michel Neidhart.;Beat Michel.;Thomas F Lüscher.;Georg Noll.;Frank Ruschitzka.
来源: Circulation. 2003年107卷3期405-9页
There is an ongoing debate as to whether the gastrointestinal safety of COX-2 inhibition compared with nonsteroidal antiinflammatory drugs (NSAIDs) may come at the cost of increased cardiovascular events. In view of the large number of patients at cardiovascular risk requiring chronic analgesic therapy with COX-2 inhibitors for arthritic and other inflammatory conditions, the effects of selective COX-2 inhibition on clinically useful surrogates for cardiovascular disease, particularly endothelial function, need to be determined.
3271. Two-year angiographic and intravascular ultrasound follow-up after implantation of sirolimus-eluting stents in human coronary arteries.
作者: J Eduardo Sousa.;Marco A Costa.;Amanda G M R Sousa.;Alexandre C Abizaid.;Ana C Seixas.;Andrea S Abizaid.;Fausto Feres.;Luiz A Mattos.;Robert Falotico.;Judith Jaeger.;Jeffrey J Popma.;Patrick W Serruys.
来源: Circulation. 2003年107卷3期381-3页
The safety and efficacy of sirolimus-eluting stenting have been demonstrated, but the outcome of patients treated with this novel technology beyond the first year remains unknown. We sought to evaluate the angiographic, intravascular ultrasound (IVUS), and clinical outcomes of patients treated with sirolimus-eluting stents 2 years after implantation.
3272. Magnetocardiographic rhythm patterns at initiation and termination of fetal supraventricular tachycardia.
Using fetal magnetocardiography (fMCG), we characterize for the first time the electrophysiological patterns of initiation and termination of reentrant fetal supraventricular tachycardia (SVT), the most common form of life-threatening fetal arrhythmia.
3273. Skeletal muscle reflex in heart failure patients: role of hydrogen.
作者: Adam C Scott.;Roland Wensel.;Constantinos H Davos.;Panagiota Georgiadou.;Michael Kemp.;James Hooper.;Andrew J S Coats.;Massimo F Piepoli.
来源: Circulation. 2003年107卷2期300-6页
An important role of the increased stimulation of skeletal muscle ergoreceptors (intramuscular afferents sensitive to products of muscle work) in the genesis of symptoms of exertion intolerance in chronic heart failure (CHF) has been proposed. With the use of selective infusions and dietary manipulation methods, we sought to identify the role of H+, K+, lactate, and peripheral hemodynamics on ergoreflex overactivation.
3274. Effect of erythropoietin on exercise capacity in patients with moderate to severe chronic heart failure.
作者: Donna M Mancini.;Stuart D Katz.;Chim C Lang.;John LaManca.;Alhakam Hudaihed.;Ana-Silvia Androne.
来源: Circulation. 2003年107卷2期294-9页
Patients with chronic heart failure (CHF) are frequently anemic. An increase in hemoglobin could enhance exercise performance by increasing oxygen delivery. We investigated the effect of erythropoietin (EPO) on exercise performance in anemic patients with CHF.
3275. Vasopressor response to angiotensin II infusion in patients with chronic heart failure receiving beta-blockers.
作者: Timothy J Vittorio.;Chim C Lang.;Stuart D Katz.;Milton Packer.;Donna M Mancini.;Ulrich P Jorde.
来源: Circulation. 2003年107卷2期290-3页
A synergistic interaction between the angiotensin II (Ang II) type 1 receptor and alpha1-adrenergic receptors has been described. We hypothesized that the nonselective beta-antagonist carvedilol, through its alpha1-adrenergic blocking properties, may modulate vascular reactivity to Ang II in patients with chronic heart failure (CHF). Accordingly, we compared the vasopressor response to infused Ang II in patients treated with carvedilol and metoprolol, a selective beta-antagonist.
3276. Effect of adrenergic stimulation on action potential duration restitution in humans.
作者: Peter Taggart.;Peter Sutton.;Zaid Chalabi.;Mark R Boyett.;Ron Simon.;Donna Elliott.;Jaswinder S Gill.
来源: Circulation. 2003年107卷2期285-9页
Enhanced sympathetic activity facilitates complex ventricular arrhythmias and fibrillation. The restitution properties of action potential duration (APD) are important determinants of electrical stability in the myocardium. Steepening of the slope of APD restitution has been shown to promote wave break and ventricular fibrillation. The effect of adrenergic stimulation on APD restitution in humans is unknown.
3277. Echocardiographic predictors of survival and response to early revascularization in cardiogenic shock.
作者: Michael H Picard.;Ravin Davidoff.;Lynn A Sleeper.;Lisa A Mendes.;Christopher R Thompson.;Vladimir Dzavik.;Richard Steingart.;Ken Gin.;Harvey D White.;Judith S Hochman.; .
来源: Circulation. 2003年107卷2期279-84页
Although echocardiography is used in diagnosis and management of myocardial infarction, it has not been established whether specific features of cardiac structure or function early in the course of cardiogenic shock provide prognostic value. The purposes of this substudy of the SHould we emergently revascularize Occluded Coronaries for cardiogenic shocK (SHOCK) trial were to describe the echocardiographic features of cardiogenic shock, identify findings on early echocardiograms associated with outcome, examine the interaction of such features with treatment, and determine whether these features could provide insights into the survival benefit observed with early revascularization and guide selection of patients for this strategy.
3278. Divergent nitric oxide bioavailability in men and women with sickle cell disease.
作者: Mark T Gladwin.;Alan N Schechter.;Frederick P Ognibene.;Wynona A Coles.;Christopher D Reiter.;William H Schenke.;Gyorgy Csako.;Myron A Waclawiw.;Julio A Panza.;Richard O Cannon.
来源: Circulation. 2003年107卷2期271-8页
Although reduced endothelial nitric oxide (NO) bioavailability has been demonstrated in arteriosclerotic vascular disease, the integrity of this system in sickle cell disease remains uncertain.
3279. Serum from patients with acute coronary syndromes displays a proapoptotic effect on human endothelial cells: a possible link to pan-coronary syndromes.
作者: Marco Valgimigli.;Laura Agnoletti.;Salvatore Curello.;Laura Comini.;Gloria Francolini.;Francesca Mastrorilli.;Elisa Merli.;Roberto Pirani.;Gabriele Guardigli.;Pier Giovanni Grigolato.;Roberto Ferrari.
来源: Circulation. 2003年107卷2期264-70页
Endothelial apoptosis of atherosclerotic lesions is a possible determinant for the stable-to-vulnerable plaque transition. Recent data support the notion that plaque activation may be a pan-coronary process, advocating the existence of circulating triggers.
3280. Randomized evaluation of the safety and efficacy of enoxaparin versus unfractionated heparin in high-risk patients with non-ST-segment elevation acute coronary syndromes receiving the glycoprotein IIb/IIIa inhibitor eptifibatide.
作者: Shaun G Goodman.;David Fitchett.;Paul W Armstrong.;Mary Tan.;Anatoly Langer.; .
来源: Circulation. 2003年107卷2期238-44页
Current pharmacotherapeutic options for high-risk non-ST-segment elevation acute coronary syndrome patients include aspirin, clopidogrel, heparin, and platelet glycoprotein IIb/IIIa inhibition. A key issue of uncertainty is the safety and efficacy of combination glycoprotein IIb/IIIa inhibitor and low-molecular-weight heparin therapy.
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