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3241. Characterization of left atrial activation in the intact human heart.
作者: Vias Markides.;Richard J Schilling.;Siew Yen Ho.;Anthony W C Chow.;D Wyn Davies.;Nicholas S Peters.
来源: Circulation. 2003年107卷5期733-9页
The patterns of activation of the human left atrium (LA), how they relate to atrial myocardial architecture, and their role in arrhythmogenesis remain largely unknown.
3242. Identification of serum soluble ST2 receptor as a novel heart failure biomarker.
作者: Ellen O Weinberg.;Masahisa Shimpo.;Shelley Hurwitz.;Shin-ichi Tominaga.;Jean-Lucien Rouleau.;Richard T Lee.
来源: Circulation. 2003年107卷5期721-6页
Using genomic technology, we previously identified an interleukin-1 receptor family member, ST2, as a gene markedly induced by mechanical strain in cardiac myocytes. The soluble receptor form of ST2 is secreted and detectable in human serum. This study tested the hypothesis that soluble ST2 levels in the serum of patients with severe chronic heart failure are increased in patients with neurohormonal activation.
3243. Combined ventricular systolic and arterial stiffening in patients with heart failure and preserved ejection fraction: implications for systolic and diastolic reserve limitations.
Heart failure with preserved ejection fraction (HF-nlEF) is common in aged individuals with systolic hypertension and is frequently ascribed to diastolic dysfunction. We hypothesized that such patients also display combined ventricular-systolic and arterial stiffening that can exacerbate blood pressure lability and diastolic dysfunction under stress.
3244. Low-T3 syndrome: a strong prognostic predictor of death in patients with heart disease.
作者: Giorgio Iervasi.;Alessandro Pingitore.;Patrizia Landi.;Mauro Raciti.;Andrea Ripoli.;Maria Scarlattini.;Antonio L'Abbate.;Luigi Donato.
来源: Circulation. 2003年107卷5期708-13页
Clinical and experimental data have suggested a potential negative impact of low-T3 state on the prognosis of cardiac diseases. The aim of the present prospective study was to assess the role of thyroid hormones in the prognosis of patient population with heart disease.
3245. Detecting occult coronary disease in a high-risk asymptomatic population.
作者: Roger S Blumenthal.;Diane M Becker.;Lisa R Yanek.;Thomas R Aversano.;Taryn F Moy.;Brian G Kral.;Lewis C Becker.
来源: Circulation. 2003年107卷5期702-7页
Exercise stress testing alone or with perfusion imaging is the standard screening method to determine the presence of obstructive coronary artery disease (CAD) in people with chest pain. In asymptomatic individuals with a family history of premature CAD, it is unclear whether abnormalities on these functional exercise tests represent significant coronary disease.
3246. Association between plasma levels of monocyte chemoattractant protein-1 and long-term clinical outcomes in patients with acute coronary syndromes.
作者: James A de Lemos.;David A Morrow.;Marc S Sabatine.;Sabina A Murphy.;C Michael Gibson.;Elliott M Antman.;Carolyn H McCabe.;Christopher P Cannon.;Eugene Braunwald.
来源: Circulation. 2003年107卷5期690-5页
Monocyte chemoattractant protein-1 (MCP-1) is a chemokine responsible for the recruitment of monocytes to sites of inflammation. MCP-1 appears to play a critical role at multiple stages in atherosclerosis, including the initiation of the fatty streak, promotion of plaque instability, and remodeling after myocardial infarction.
3247. Aging and the exercise pressor reflex in humans.
作者: Troy A Markel.;Joseph C Daley.;Cynthia S Hogeman.;Michael D Herr.;Mazhar H Khan.;Kristen S Gray.;Allen R Kunselman.;Lawrence I Sinoway.
来源: Circulation. 2003年107卷5期675-8页
Blood flow limitation to exercising muscles engages the muscle reflex during exercise, evoking an increase in heart rate (HR), blood pressure (BP), and muscle sympathetic nerve activity (MSNA).
3248. Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue.
作者: Noriyuki Ouchi.;Shinji Kihara.;Tohru Funahashi.;Tadashi Nakamura.;Makoto Nishida.;Masahiro Kumada.;Yoshihisa Okamoto.;Koji Ohashi.;Hiroyuki Nagaretani.;Ken Kishida.;Hitoshi Nishizawa.;Norikazu Maeda.;Hideki Kobayashi.;Hisatoyo Hiraoka.;Yuji Matsuzawa.
来源: Circulation. 2003年107卷5期671-4页
High-sensitive C-reactive protein (hs-CRP) is a well-known risk factor for coronary artery disease (CAD). Recently, we have demonstrated that adiponectin served as an antiatherogenic plasma protein which was secreted specifically from adipocytes. The present study investigated the association between adiponectin and CRP in the blood stream and adipose tissue.
3249. Detection of coronary artery stenoses with thin-slice multi-detector row spiral computed tomography and multiplanar reconstruction.
作者: Dieter Ropers.;Ulrich Baum.;Karsten Pohle.;Katharina Anders.;Stefan Ulzheimer.;Bernd Ohnesorge.;Christian Schlundt.;Werner Bautz.;Werner G Daniel.;Stephan Achenbach.
来源: Circulation. 2003年107卷5期664-6页
We analyzed the accuracy of multi-detector row spiral computed tomography (MDCT) using a 16-slice CT scanner with improved spatial and temporal resolution, as well as routine premedication with beta-blockers for detection of coronary stenoses.
3251. Matrix metalloproteinase-9 pretreatment level predicts intracranial hemorrhagic complications after thrombolysis in human stroke.
作者: Joan Montaner.;Carlos A Molina.;Jasone Monasterio.;Sonia Abilleira.;Juan F Arenillas.;Marc Ribó.;Manolo Quintana.;José Alvarez-Sabín.
来源: Circulation. 2003年107卷4期598-603页
Matrix metalloproteinase (MMP) expression is related to blood brain barrier disruption after cerebral ischemia. Moreover, MMP inhibitors reduce hemorrhagic transformation (HT) after embolic ischemia in tissue plasminogen activator (t-PA)-treated animals. We aimed to correlate plasmatic MMP levels with the appearance of intracranial bleeding complications in stroke patients treated with t-PA.
3252. Combination of a normal D-dimer concentration and a non-high pretest clinical probability score is a safe strategy to exclude deep venous thrombosis.
作者: R E G Schutgens.;P Ackermark.;F J L M Haas.;H K Nieuwenhuis.;H G Peltenburg.;A H Pijlman.;M Pruijm.;R Oltmans.;J C Kelder.;D H Biesma.
来源: Circulation. 2003年107卷4期593-7页
Serial ultrasonography is reliable for the diagnosis of deep venous thrombosis in symptomatic patients, but the low prevalence of thrombosis in this group renders the approach costly and inconvenient to patients. We studied the clinical validity of the combination of a pretest clinical probability score and a D-dimer test in the initial evaluation of patients suspected of deep venous thrombosis.
3253. Diverse effects of increasing lisinopril doses on lipid abnormalities in chronic nephropathies.
作者: Piero Ruggenenti.;Naobumi Mise.;Roberto Pisoni.;Federica Arnoldi.;Anna Pezzotta.;Annalisa Perna.;Dario Cattaneo.;Giuseppe Remuzzi.
来源: Circulation. 2003年107卷4期586-92页
Dyslipidemia frequently complicates chronic nephropathies and increases the risk of renal and cardiovascular events. This might be ameliorated by drugs, such as angiotensin-converting enzyme inhibitors, which effectively reduce proteinuria.
3254. Angiotensin-converting enzyme inhibition increases human vascular tissue-type plasminogen activator release through endogenous bradykinin.
作者: Mias Pretorius.;David Rosenbaum.;Douglas E Vaughan.;Nancy J Brown.
来源: Circulation. 2003年107卷4期579-85页
Angiotensin-converting enzyme (ACE) inhibition potentiates the tissue-type plasminogen activator (t-PA) response to exogenous bradykinin. This study tested the hypothesis that ACE inhibition increases endothelial t-PA release through endogenous bradykinin.
3255. Differential regulation of natriuresis by 20-hydroxyeicosatetraenoic Acid in human salt-sensitive versus salt-resistant hypertension.
作者: Cheryl L Laffer.;Michal Laniado-Schwartzman.;Mong-Heng Wang.;Alberto Nasjletti.;Fernando Elijovich.
来源: Circulation. 2003年107卷4期574-8页
Twenty-hydroxyeicosatetraenoic acid (20-HETE) is a cytochrome P450 metabolite of arachidonic acid that produces vasoconstriction and inhibition of renal tubular sodium transport. In Dahl rats, a 20-HETE deficiency plays a role in salt-sensitive (SS) hypertension. In humans, there are no data on regulation of 20-HETE by salt intake or on a role for this compound in SS hypertension.
3256. Myocardial production of C-type natriuretic peptide in chronic heart failure.
作者: Paul R Kalra.;Jonathon R Clague.;Aidan P Bolger.;Stefan D Anker.;Phillip A Poole-Wilson.;Allan D Struthers.;Andrew J Coats.
来源: Circulation. 2003年107卷4期571-3页
C-type natriuretic peptide (CNP) is a vasodilator produced by the vascular endothelium. It shares structural and physiological properties with the cardiac hormones atrial natriuretic peptide and brain natriuretic peptide (BNP), but little is known about its pathophysiological role in chronic heart failure (CHF). We assessed the hypothesis that CNP is produced by the heart in patients with CHF.
3257. Short-term heart rate variability strongly predicts sudden cardiac death in chronic heart failure patients.
作者: Maria Teresa La Rovere.;Gian Domenico Pinna.;Roberto Maestri.;Andrea Mortara.;Soccorso Capomolla.;Oreste Febo.;Roberto Ferrari.;Mariella Franchini.;Marco Gnemmi.;Cristina Opasich.;Pier Giorgio Riccardi.;Egidio Traversi.;Franco Cobelli.
来源: Circulation. 2003年107卷4期565-70页
The predictive value of heart rate variability (HRV) in chronic heart failure (CHF) has never been tested in a comprehensive multivariate model using short-term laboratory recordings designed to avoid the confounding effects of respiration and behavioral factors.
3258. TAXUS III Trial: in-stent restenosis treated with stent-based delivery of paclitaxel incorporated in a slow-release polymer formulation.
作者: Kengo Tanabe.;Patrick W Serruys.;Eberhard Grube.;Pieter C Smits.;Guido Selbach.;Willem J van der Giessen.;Manfred Staberock.;Pim de Feyter.;Ralf Müller.;Evelyn Regar.;Muzaffer Degertekin.;Jurgen M R Ligthart.;Clemens Disco.;Bianca Backx.;Mary E Russell.
来源: Circulation. 2003年107卷4期559-64页
The first clinical study of paclitaxel-eluting stent for de novo lesions showed promising results. We performed the TAXUS III trial to evaluate the feasibility and safety of paclitaxel-eluting stent for the treatment of in-stent restenosis (ISR).
3259. Effects of AGI-1067 and probucol after percutaneous coronary interventions.
作者: Jean-Claude Tardif.;Jean Grégoire.;Leonard Schwartz.;Lawrence Title.;Louise Laramée.;François Reeves.;Jacques Lespérance.;Martial G Bourassa.;Philippe L L'Allier.;Mitchell Glass.;Jean Lambert.;Marie-Claude Guertin.; .
来源: Circulation. 2003年107卷4期552-8页
AGI-1067, a metabolically stable modification of probucol, is an equipotent antioxidant to probucol but is pharmacologically distinct. In a multicenter trial, we studied whether AGI-1067 reduces restenosis assessed by intravascular ultrasound (IVUS) after percutaneous coronary intervention (PCI) compared with placebo and probucol used as a positive control.
3260. Intravascular ultrasound-guided balloon angioplasty compared with stent: immediate and 6-month results of the multicenter, randomized Balloon Equivalent to Stent Study (BEST).
作者: François Schiele.;Nicolas Meneveau.;Martine Gilard.;Jacques Boschat.;Philippe Commeau.;Liu Pin Ming.;Pradip Sewoke.;Marie-France Seronde.;Mariette Mercier.;Sanjiv Gupta.;Jean-Pierre Bassand.; .
来源: Circulation. 2003年107卷4期545-51页
Balloon angioplasty guided by intravascular ultrasound (IVUS) makes it possible to choose the balloon size according to the true vessel diameter and to detect suboptimal results requiring subsequent stent implantation. The Balloon Equivalent to STent (BEST) study aimed to assess whether this strategy would give the same results as systematic stenting.
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