当前位置: 首页 >> 检索结果
3221. A randomized study of the prevention of sudden death in patients with coronary artery disease. Multicenter Unsustained Tachycardia Trial Investigators.
作者: A E Buxton.;K L Lee.;J D Fisher.;M E Josephson.;E N Prystowsky.;G Hafley.
来源: N Engl J Med. 1999年341卷25期1882-90页
Empirical antiarrhythmic therapy has not reduced mortality among patients with coronary artery disease and asymptomatic ventricular arrhythmias. Previous studies have suggested that antiarrhythmic therapy guided by electrophysiologic testing might reduce the risk of sudden death.
3222. Efavirenz plus zidovudine and lamivudine, efavirenz plus indinavir, and indinavir plus zidovudine and lamivudine in the treatment of HIV-1 infection in adults. Study 006 Team.
作者: S Staszewski.;J Morales-Ramirez.;K T Tashima.;A Rachlis.;D Skiest.;J Stanford.;R Stryker.;P Johnson.;D F Labriola.;D Farina.;D J Manion.;N M Ruiz.
来源: N Engl J Med. 1999年341卷25期1865-73页
Efavirenz is a nonnucleoside reverse-transcriptase inhibitor of human immunodeficiency virus type 1 (HIV-1). We compared two regimens containing efavirenz, one with a protease inhibitor and the other with two nucleoside reverse-transcriptase inhibitors, with a standard three-drug regimen.
3223. Lack of benefit of a single dose of synthetic human secretin in the treatment of autism and pervasive developmental disorder.
作者: A D Sandler.;K A Sutton.;J DeWeese.;M A Girardi.;V Sheppard.;J W Bodfish.
来源: N Engl J Med. 1999年341卷24期1801-6页
Secretin is a peptide hormone that stimulates pancreatic secretion. After recent publicity about a child with autism whose condition markedly improved after a single dose of secretin, thousands of children with autistic disorders may have received secretin injections.
3224. The effect of bisoprolol on perioperative mortality and myocardial infarction in high-risk patients undergoing vascular surgery. Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography Study Group.
作者: D Poldermans.;E Boersma.;J J Bax.;I R Thomson.;L L van de Ven.;J D Blankensteijn.;H F Baars.;T I Yo.;G Trocino.;C Vigna.;J R Roelandt.;H van Urk.
来源: N Engl J Med. 1999年341卷24期1789-94页
Cardiovascular complications are the most important causes of perioperative morbidity and mortality among patients undergoing major vascular surgery.
3225. Immediate hormonal therapy compared with observation after radical prostatectomy and pelvic lymphadenectomy in men with node-positive prostate cancer.
作者: E M Messing.;J Manola.;M Sarosdy.;G Wilding.;E D Crawford.;D Trump.
来源: N Engl J Med. 1999年341卷24期1781-8页
Because the optimal timing of the institution of antiandrogen therapy for prostate cancer is controversial, we compared immediate and delayed treatment in patients who had minimal residual disease after radical prostatectomy.
3226. A comparison of osteopathic spinal manipulation with standard care for patients with low back pain.
作者: G B Andersson.;T Lucente.;A M Davis.;R E Kappler.;J A Lipton.;S Leurgans.
来源: N Engl J Med. 1999年341卷19期1426-31页
The effect of osteopathic manual therapy (i.e., spinal manipulation) in patients with chronic and subchronic back pain is largely unknown, and its use in such patients is controversial. Nevertheless, manual therapy is a frequently used method of treatment in this group of patients.
3227. Long-term benefit of primary angioplasty as compared with thrombolytic therapy for acute myocardial infarction.
作者: F Zijlstra.;J C Hoorntje.;M J de Boer.;S Reiffers.;K Miedema.;J P Ottervanger.;A W van 't Hof.;H Suryapranata.
来源: N Engl J Med. 1999年341卷19期1413-9页
As compared with thrombolytic therapy, primary coronary angioplasty results in a higher rate of patency of the infarct-related coronary artery, lower rates of stroke and reinfarction, and higher in-hospital or 30-day survival rates. However, the comparative long-term efficacy of these two approaches has not been carefully studied.
3228. Use of the selective oral neuraminidase inhibitor oseltamivir to prevent influenza.
作者: F G Hayden.;R L Atmar.;M Schilling.;C Johnson.;D Poretz.;D Paar.;L Huson.;P Ward.;R G Mills.
来源: N Engl J Med. 1999年341卷18期1336-43页
Safe and effective antiviral agents are needed to prevent infection with influenza A and B virus. Oseltamivir (GS4104), which can be administered orally, is the prodrug of GS4071, a potent and selective inhibitor of influenzavirus neuraminidases. We studied the use of oseltamivir for long-term prophylaxis against influenza in two placebo-controlled, double-blind trials at different U.S. sites during the winter of 1997-1998.
3229. A preliminary study of long-term treatment with interferon gamma-1b and low-dose prednisolone in patients with idiopathic pulmonary fibrosis.
Patients with idiopathic pulmonary fibrosis have progressive scarring of the lung and usually die within four to five years after symptoms develop. Treatment with oral glucocorticoids is often ineffective. We conducted an open, randomized trial of treatment with a combination of interferon gamma-1b, which has antifibrotic properties, and an oral glucocorticoid. We studied 18 patients with idiopathic pulmonary fibrosis who had not had responses to glucocorticoids or other immunosuppressive agents. Nine patients were treated for 12 months with oral prednisolone alone (7.5 mg daily, which could be increased to 25 to 50 mg daily), and nine with a combination of 200 microg of interferon gamma-1b (given three times per week subcutaneously) and 7.5 mg of prednisolone (given once a day).
3230. Lamivudine as initial treatment for chronic hepatitis B in the United States.
作者: J L Dienstag.;E R Schiff.;T L Wright.;R P Perrillo.;H W Hann.;Z Goodman.;L Crowther.;L D Condreay.;M Woessner.;M Rubin.;N A Brown.
来源: N Engl J Med. 1999年341卷17期1256-63页
Although the nucleoside analogue lamivudine has shown promise in patients with chronic hepatitis B, long-term data on patients from the United States are lacking. We randomly assigned previously untreated patients with chronic hepatitis B to receive either 100 mg of oral lamivudine or placebo daily for 52 weeks. We then followed them for an additional 16 weeks to evaluate post-treatment safety and the durability of responses. The primary end point with respect to efficacy was a reduction of at least 2 points in the score on the Histologic Activity Index. On this scale, scores can range from 0 (normal) to 22 (most severe abnormalities).
3231. Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children's Cancer Group.
作者: K K Matthay.;J G Villablanca.;R C Seeger.;D O Stram.;R E Harris.;N K Ramsay.;P Swift.;H Shimada.;C T Black.;G M Brodeur.;R B Gerbing.;C P Reynolds.
来源: N Engl J Med. 1999年341卷16期1165-73页
Children with high-risk neuroblastoma have a poor outcome. In this study, we assessed whether myeloablative therapy in conjunction with transplantation of autologous bone marrow improved event-free survival as compared with chemotherapy alone, and whether subsequent treatment with 13-cis-retinoic acid (isotretinoin) further improves event-free survival.
3232. Absence of benefit of eradicating Helicobacter pylori in patients with nonulcer dyspepsia.
The relation between Helicobacter pylori infection and nonulcer dyspepsia is uncertain. We tested the hypothesis that curing the infection will relieve symptoms of dyspepsia.
3233. Comparison of transmyocardial revascularization with medical therapy in patients with refractory angina.
作者: K B Allen.;R D Dowling.;T L Fudge.;G P Schoettle.;S L Selinger.;D M Gangahar.;W W Angell.;M R Petracek.;C J Shaar.;W W O'Neill.
来源: N Engl J Med. 1999年341卷14期1029-36页
Transmyocardial revascularization involves the creation of channels in the myocardium with a laser to relieve angina. We compared the safety and efficacy of transmyocardial revascularization performed with a holmium laser with those of medical therapy in patients with refractory class IV angina (according to the criteria of the Canadian Cardiovascular Society).
3234. Transmyocardial revascularization with a carbon dioxide laser in patients with end-stage coronary artery disease.
The construction of subendocardial channels to perfuse ischemic areas of the myocardium has been investigated since the 1950s. We assessed the safety and efficacy of transmyocardial revascularization with a carbon dioxide laser in patients with refractory angina and left ventricular free-wall ischemia that was not amenable to direct coronary revascularization.
3235. Dehydroepiandrosterone replacement in women with adrenal insufficiency.
作者: W Arlt.;F Callies.;J C van Vlijmen.;I Koehler.;M Reincke.;M Bidlingmaier.;D Huebler.;M Oettel.;M Ernst.;H M Schulte.;B Allolio.
来源: N Engl J Med. 1999年341卷14期1013-20页
The physiologic role of dehydroepiandrosterone in humans is still unclear. Adrenal insufficiency leads to a deficiency of dehydroepiandrosterone; we therefore, investigated the effects of dehydroepiandrosterone replacement, in patients with adrenal insufficiency.
3236. Amiodarone for resuscitation after out-of-hospital cardiac arrest due to ventricular fibrillation.
作者: P J Kudenchuk.;L A Cobb.;M K Copass.;R O Cummins.;A M Doherty.;C E Fahrenbruch.;A P Hallstrom.;W A Murray.;M Olsufka.;T Walsh.
来源: N Engl J Med. 1999年341卷12期871-8页
Whether antiarrhythmic drugs improve the rate of successful resuscitation after out-of-hospital cardiac arrest has not been determined in randomized clinical trials.
3237. Dofetilide in patients with congestive heart failure and left ventricular dysfunction. Danish Investigations of Arrhythmia and Mortality on Dofetilide Study Group.
作者: C Torp-Pedersen.;M Møller.;P E Bloch-Thomsen.;L Køber.;E Sandøe.;K Egstrup.;E Agner.;J Carlsen.;J Videbaek.;B Marchant.;A J Camm.
来源: N Engl J Med. 1999年341卷12期857-65页
Atrial fibrillation occurs frequently in patients with congestive heart failure and commonly results in clinical deterioration and hospitalization. Sinus rhythm may be maintained with antiarrhythmic drugs, but some of these drugs increase the risk of death.
3238. A comparison of enoxaparin with placebo for the prevention of venous thromboembolism in acutely ill medical patients. Prophylaxis in Medical Patients with Enoxaparin Study Group.
作者: M M Samama.;A T Cohen.;J Y Darmon.;L Desjardins.;A Eldor.;C Janbon.;A Leizorovicz.;H Nguyen.;C G Olsson.;A G Turpie.;N Weisslinger.
来源: N Engl J Med. 1999年341卷11期793-800页
The efficacy and safety of thromboprophylaxis in patients with acute medical illnesses who may be at risk for venous thromboembolism have not been determined in adequately designed trials.
3239. Increased mortality associated with growth hormone treatment in critically ill adults.
作者: J Takala.;E Ruokonen.;N R Webster.;M S Nielsen.;D F Zandstra.;G Vundelinckx.;C J Hinds.
来源: N Engl J Med. 1999年341卷11期785-92页
The administration of growth hormone can attenuate the catabolic response to injury, surgery, and sepsis. However, the effect of high doses of growth hormone on the length of stay in intensive care and in the hospital, the duration of mechanical ventilation, and the outcome in critically ill adults who are hospitalized for long periods is not known.
3240. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators.
作者: B Pitt.;F Zannad.;W J Remme.;R Cody.;A Castaigne.;A Perez.;J Palensky.;J Wittes.
来源: N Engl J Med. 1999年341卷10期709-17页
Aldosterone is important in the pathophysiology of heart failure. In a doubleblind study, we enrolled 1663 patients who had severe heart failure and a left ventricular ejection fraction of no more than 35 percent and who were being treated with an angiotensin-converting-enzyme inhibitor, a loop diuretic, and in most cases digoxin. A total of 822 patients were randomly assigned to receive 25 mg of spironolactone daily, and 841 to receive placebo. The primary end point was death from all causes.
|